Reaction

Autonomic Nervous System Imbalance reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,841 reports · 131 co-occurring drugs

As of the last recalculation, Autonomic Nervous System Imbalance appears in 2,841 FAERS reports alongside 131 co-occurring drug terms. The strongest observed disproportionality signal is HALOPERIDOL (PRR 24.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Haloperidol	80	24.8	24.9
Haloperidol Lactate	81	24.6	24.7
Rasagiline Mesylate	31	20.6	20.7
Bupivacaine	25	19.8	19.8
Midazolam	65	19.3	19.4
Midazolam Hydrochloride	65	18.1	18.1
Calcium, Magnesium, Potassium, And Sodium Oxybates	19	16.3	16.3
Valproate Sodium	43	15.5	15.5
Dutasteride	16	14.5	14.5
Amantadine	30	14.3	14.4
Lithium	47	13.9	13.9
Lithium Bromatum	47	13.9	13.9
Propofol	64	13.1	13.1
Dronabinol	14	12.8	12.8
Aripiprazole Oral	58	10.5	10.5
Aripiprazole Orally Disintegrating	58	10.5	10.5
Trazodone Hydrochloride	22	10.4	10.4
Guanfacine	11	10.3	10.3
Atropine Sulfate	15	10.2	10.2
Olanzapine	143	10.2	10.2
Human Immunoglobulin G	28	10.0	10.0
Levodopa	15	9.1	9.1
Instalax Polyethylene Glycol 3350	15	8.9	8.9
Sodium Oxybate	78	8.9	8.9
Atropine	10	8.9	8.9
Diazepam Oral	104	8.8	8.9
Diazepam Oral Solution (Concentrate)	103	8.8	8.8
Rocuronium Bromide	14	8.7	8.8
Polyethylene Glycol 400	15	8.7	8.7
Baclofen	95	8.3	8.3
Magnesium Sulfate In Water For	14	8.1	8.1
Magnesium Sulfate Heptahydrate	14	7.9	7.9
Magnesium Sulfate	14	7.9	7.9
Phenytoin	22	7.8	7.8
Ranolazine	11	7.7	7.8
Fluoxetine	69	7.7	7.8
Diazepam	122	7.6	7.6
Norepinephrine	11	7.6	7.6
Droxidopa	22	7.5	7.5
Tranexamic Acid	9	7.4	7.4
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	35	7.3	7.3
Asfotase Alfa	10	7.3	7.3
Buspirone Hydrochloride	11	7.3	7.3
Valproic Acid	31	7.3	7.3
Rizatriptan Benzoate	10	7.2	7.2
Ciprofolxacin	69	7.2	7.2
Ciprofloxacin Tablets	69	7.2	7.2
Norepinephrine Bitartrate	14	7.2	7.2
Levetiracetam In Sodium Chloride	73	7.1	7.1
Levetiracetam Oral	73	7.1	7.1
Levetiracetam Injection	73	7.1	7.1
Bupropion	42	7.0	7.0
Rivastigmine	17	6.6	6.7
Nitrofurantoin (Monohydrate/Macrocrystals)	15	6.6	6.6
Phenobarbital	13	6.6	6.6
Melphalan	20	6.5	6.5
Melphalan Hydrochloride	22	6.5	6.5
Ciprofloxacin Hydrochloride	83	6.4	6.4
Doxepin Hydrochloride	11	6.4	6.4
Topiramate	79	6.4	6.4
Ciprofloxacin	77	6.3	6.3
Nitrofurantoin	14	6.2	6.2
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	35	6.2	6.2
Pramipexole	13	6.2	6.2
Risperidone	109	6.2	6.2
Dicyclomine Hydrochloride	12	6.2	6.2
Oxcarbazepine	27	6.1	6.1
Clonidine	41	5.9	5.9
Asenapine Maleate	7	5.9	5.9
Doxepin	8	5.8	5.8
Clonazepam	122	5.8	5.8
Quetiapine Fumarate	23	5.7	5.8
Bortezomib	68	5.7	5.7
Fluoxetine Hydrochloride	96	5.7	5.7
Hydroxyzine Hydrochloride	10	5.6	5.6
Hydroxyzine Hydrochloride Oral	10	5.6	5.6
Fexofenadine Hcl	7	5.6	5.6
Modafinil	24	5.5	5.5
Mirtazapine	65	5.3	5.3
Hydroxyzine	34	5.3	5.3
Armodafinil	15	5.2	5.2
Donepezil Hydrochloride	26	5.2	5.2
Duloxetine	49	5.2	5.2
Liothyronine Sodium	6	5.1	5.1
Fentanyl	66	5.0	5.0
Escitalopram Oxalate	49	5.0	5.0
Escitslopram	39	5.0	5.0
Zonisamide	10	5.0	5.0
Tizanidine	16	4.9	4.9
Aripiprazole	80	4.9	4.9
Oxazepam	14	4.8	4.8
Methylphenidate Hydrochloride	38	4.7	4.8
Levetiracetam	83	4.7	4.7
Rotigotine	9	4.6	4.6
Paliperidone	14	4.4	4.4
Sevoflurane	5	4.4	4.4
Clobazam	14	4.2	4.2
Sumatriptan Succinate	14	4.1	4.1
Fexofenadine Hydrochloride	12	4.1	4.1
Carbidopa And Levodopa	25	3.9	3.9
Cladribine	5	3.8	3.8
Methylphenidate	15	3.8	3.8
Clozapine	64	3.8	3.8
Memantine	7	3.8	3.8
Memantine Hydrochloride	7	3.8	3.8
Ziprasidone	9	3.8	3.8
Naltrexone	15	3.6	3.6
Iohexol	4	3.5	3.5
Fentanyl Citrate	8	3.3	3.3
Desvenlafaxine Succinate	12	3.3	3.3
Eptinezumab-Jjmr	4	3.2	3.2
Lacosamide	16	3.2	3.2
Insulin Degludec	10	3.1	3.1
Lisdexamfetamine Dimesylate	14	3.1	3.1
Avapritinib	5	3.0	3.0
Botulinum Toxin Type A	5	3.0	3.0
Cannabidiol	9	2.8	2.8
Vigabatrin	5	2.5	2.5
Tafamidis	4	2.5	2.5
Bosutinib	3	2.4	2.4
Ipilimumab	14	2.4	2.4
Onabotulinumtoxina	22	2.1	2.1
Paliperidone Palmitate	8	1.8	1.8
Dalfampridine	17	1.7	1.7
Rimegepant Sulfate	3	1.7	1.7
Erenumab-Aooe	13	1.7	1.7
Esketamine Hydrochloride	4	1.6	1.6
Galcanezumab-Gnlm	6	1.4	1.4
Relugolix	4	1.2	1.2
Minoxidil Foam 5% (Womens)	5	1.1	1.1
Pimavanserin Tartrate	6	0.8	0.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.