Reaction

Hyperacusis reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,686 reports · 121 co-occurring drugs

As of the last recalculation, Hyperacusis appears in 3,686 FAERS reports alongside 121 co-occurring drug terms. The strongest observed disproportionality signal is TRIMETHOPRIM (PRR 15.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Trimethoprim	32	15.5	15.5
Ciprofolxacin	141	11.5	11.5
Ciprofloxacin Tablets	141	11.5	11.5
Ciprofloxacin	155	9.9	9.9
Ciprofloxacin Hydrochloride	163	9.9	9.9
Valproate Sodium	33	9.1	9.1
Paroxetine Hydrochloride	138	8.9	8.9
Clarithromycin	52	8.7	8.7
Sumatriptan	55	8.3	8.3
Esketamine Hydrochloride	24	7.6	7.7
Rizatriptan Benzoate	13	7.2	7.2
Basiliximab	15	7.2	7.2
Lisdexamfetamine Dimesylate	41	7.1	7.1
Vortioxetine	21	7.0	7.0
Amikacin	21	7.0	7.0
Atomoxetine Hydrochloride	29	6.9	6.9
Fremanezumab-Vfrm	14	6.9	6.9
Desvenlafaxine Succinate	31	6.5	6.5
Botulinum Toxin Type A	14	6.4	6.4
Lithium Carbonate	19	6.3	6.4
Sumatriptan Succinate	28	6.3	6.3
Valproic Acid	34	6.1	6.1
Mirtazapine	97	6.1	6.1
Venlafaxine Hydrochloride	135	5.9	5.9
Liothyronine Sodium	9	5.8	5.9
Methimazole	8	5.8	5.8
Brivaracetam	9	5.7	5.7
Paroxetine Hydrochloride Hemihydrate	33	5.6	5.6
Primidone	10	5.6	5.6
Paroxetine	33	5.5	5.5
Thyroid, Porcine	10	5.3	5.3
Diazepam Oral Solution (Concentrate)	82	5.3	5.3
Diazepam Oral	82	5.3	5.3
Magnesium	75	5.2	5.2
Venlafaxine	65	5.2	5.2
Oxybutynin Chloride	8	5.2	5.2
Diazepam	108	5.1	5.1
Duloxetine Hydrochloride	164	5.1	5.1
Tranexamic Acid	8	5.1	5.1
Clotrimazole	11	5.1	5.1
Amphotericin B	11	5.0	5.0
Drs. Clotrimazole	10	4.9	4.9
Family Wellness Clotrimazole	10	4.9	4.9
Clotrimazole Topical	10	4.9	4.9
Escitslopram	49	4.8	4.8
Dicyclomine Hydrochloride	12	4.8	4.8
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	25	4.7	4.7
Propranolol Hydrochloride	58	4.6	4.6
Clonazepam	127	4.6	4.6
Amoxicillin And Clavulanate Potassium	22	4.6	4.6
Topiramate	74	4.6	4.6
Sertraline	92	4.5	4.5
Lithium	20	4.5	4.5
Lithium Bromatum	20	4.5	4.5
Sucralfate	19	4.5	4.5
Rimegepant Sulfate	10	4.5	4.5
Lamotrigine	101	4.4	4.4
Escitalopram Oxalate	56	4.4	4.4
Ibuprofen Capsule	149	4.4	4.4
Ibuprofen Tablet, Film Coated	149	4.4	4.4
Ibupfrofen	149	4.4	4.4
Ibuprofen Tablets Usp, 200Mg	149	4.4	4.4
Ibuprofen Oral	149	4.4	4.4
Ibuprofen Capsules 200 Mg	149	4.4	4.4
Ibuprofen 200 Mg	149	4.4	4.4
Ibuprofen 200Mg	149	4.3	4.4
Guanfacine	6	4.3	4.3
Lamotirigine	54	4.3	4.3
Lamotrigine Extended-Release	54	4.3	4.3
Lamotrigine Chewable Dispersible	54	4.3	4.3
Butalbital, Acetaminophen, And Caffeine	8	4.2	4.2
Methylphenidate Hydrochloride	44	4.2	4.2
Sertraline Hydrochloride	87	4.2	4.2
Progesterone	17	4.2	4.2
Metronidazole Topical	35	4.2	4.2
Onabotulinumtoxina	56	4.1	4.1
Buspirone Hydrochloride	8	4.1	4.1
Miconazole Nitrate	6	3.9	3.9
Lurasidone Hydrochloride	14	3.8	3.8
Estradiol Gel 0.1%	30	3.8	3.8
Estradiol Transdermal	30	3.8	3.8
Ocrelizumab	41	3.8	3.8
Dolutegravir Sodium	6	3.8	3.8
Armodafinil	14	3.8	3.8
Carbamazepine	44	3.7	3.7
Acetaminophen, Aspirin (Nsaid) And Caffeine	11	3.7	3.7
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	26	3.6	3.6
Modafinil	20	3.5	3.5
Amphetamine	5	3.4	3.4
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	21	3.4	3.4
Eszopiclone	15	3.3	3.3
Acetaminophen, Aspirin, And Caffeine	12	3.2	3.2
Eptinezumab-Jjmr	5	3.1	3.1
Emtricitabine And Tenofovir Alafenamide	6	3.0	3.0
Methylphenidate	14	2.7	2.7
Galcanezumab-Gnlm	15	2.7	2.7
Naltrexone Hydrochloride And Bupropion Hydrochloride	4	2.7	2.7
Erenumab-Aooe	25	2.6	2.6
Ofatumumab	15	2.6	2.6
Clobazam	11	2.5	2.5
Lacosamide	16	2.4	2.4
Sodium Oxybate	28	2.4	2.4
Naltrexone	13	2.4	2.4
Diroximel Fumarate	5	2.4	2.4
Cannabidiol	9	2.2	2.2
Ravulizumab	5	2.1	2.1
Methadone Hydrochloride	4	2.1	2.1
Bosutinib	3	1.9	1.9
Peginterferon Alfa-2A	18	1.9	1.9
Cariprazine	3	1.8	1.8
Elexacaftor, Tezacaftor, And Ivacaftor	4	1.8	1.8
Brexpiprazole	5	1.7	1.7
Paliperidone	7	1.7	1.7
Natalizumab	52	1.6	1.6
Medroxyprogesterone Acetate	14	1.6	1.6
Drospirenone And Ethinyl Estradiol	12	1.5	1.5
Bimekizumab	4	1.1	1.1
Paliperidone Palmitate	6	1.1	1.1
Nirmatrelvir And Ritonavir	10	1.0	1.0
Levonorgestrel	34	1.0	1.0
Copper	4	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.