Reaction

Hypertonia reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,678 reports · 143 co-occurring drugs

As of the last recalculation, Hypertonia appears in 5,678 FAERS reports alongside 143 co-occurring drug terms. The strongest observed disproportionality signal is ZIDOVUDINE (PRR 18.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Zidovudine	65	18.0	18.1
Haloperidol Lactate	108	16.3	16.4
Haloperidol	94	14.4	14.5
Valproate Sodium	73	13.1	13.1
Baclofen	279	12.4	12.5
Dimenhydrinate	27	9.3	9.3
Paroxetine Hydrochloride Hemihydrate	80	8.9	8.9
Paroxetine	80	8.7	8.8
Phenobarbital	33	8.4	8.4
Valproic Acid	70	8.2	8.2
Escitslopram	125	8.0	8.0
Aripiprazole Oral	80	7.2	7.2
Aripiprazole Orally Disintegrating	80	7.2	7.2
Escitalopram Oxalate	139	7.1	7.2
Amitriptyline Hydrochloride	32	6.7	6.7
Methimazole	14	6.6	6.6
Lithium Carbonate	30	6.5	6.5
Risperidone	221	6.3	6.3
Olanzapine	174	6.1	6.1
Fluoxetine	109	6.1	6.1
Lithium	41	6.0	6.0
Lithium Bromatum	41	6.0	6.0
Lamotirigine	113	5.9	5.9
Lamotrigine Extended-Release	113	5.9	5.9
Lamotrigine Chewable Dispersible	113	5.9	5.9
Oxazepam	34	5.8	5.8
Sevoflurane	13	5.7	5.8
Quinine	13	5.6	5.6
Diazepam	175	5.4	5.4
Midazolam Hydrochloride	39	5.3	5.3
Midazolam	36	5.3	5.3
Lamivudine	44	5.3	5.3
Venlafaxine	101	5.2	5.3
Bupivacaine	13	5.1	5.1
Mirtazapine	125	5.1	5.1
Paroxetine Hydrochloride	124	5.1	5.1
Dextrose	18	5.0	5.0
Lamotrigine	174	5.0	5.0
Dextrose Monohydrate	18	4.9	5.0
Amantadine	20	4.8	4.8
Diazepam Oral Solution (Concentrate)	111	4.6	4.6
Diazepam Oral	111	4.6	4.6
Quetiapine	234	4.6	4.6
Citalopram Hydrobromide	132	4.6	4.6
Cefuroxime	14	4.5	4.5
Theophylline	14	4.5	4.5
Tizanidine	29	4.5	4.5
Trazodone Hydrochloride	19	4.5	4.5
Propofol	44	4.4	4.4
Polyethylene Glycol	13	4.4	4.4
Fluoxetine Hydrochloride	149	4.4	4.4
Escitalopram	159	4.2	4.2
Venlafaxine Hydrochloride	149	4.2	4.2
Theophylline Anhydrous	14	4.1	4.2
Siponimod	10	4.1	4.1
Atropine Sulfate	12	4.1	4.1
Sumatriptan Succinate	28	4.1	4.1
Methadone	47	4.1	4.1
Clonazepam	172	4.0	4.0
Paliperidone	25	3.9	3.9
Citalopram	143	3.9	3.9
Aripiprazole	128	3.9	3.9
Sertraline	122	3.9	3.9
Captopril	10	3.8	3.8
Vigabatrin	15	3.8	3.8
Rocuronium Bromide	12	3.7	3.7
Prochlorperazine	28	3.7	3.7
Metoclopramide	55	3.7	3.7
Dronabinol	8	3.7	3.7
Quetiapine Fumarate	29	3.6	3.6
Atropine	8	3.5	3.5
Ethyl Alcohol	26	3.5	3.5
Olanzapine Pamoate	39	3.5	3.5
Donepezil Hydrochloride	34	3.4	3.4
Levodopa	11	3.3	3.3
Clarithromycin	31	3.3	3.3
Sodium Bicarbonate	21	3.3	3.3
Sodium Bicarbonate Injection,	21	3.3	3.3
Lorazepam	158	3.3	3.3
Isopropyl Alcohol	30	3.3	3.3
Tizanidine Hydrochloride	16	3.3	3.3
Bupropion	39	3.2	3.2
Felodipine Extended-Release Tablets	10	3.2	3.2
Felodipine	10	3.2	3.2
Metoclopramide Hydrochloride	67	3.2	3.2
Oxcarbazepine	28	3.2	3.2
Dalteparin Sodium	9	3.1	3.1
Rivastigmine	16	3.1	3.1
Ropinirole	13	3.1	3.1
Clobazam	20	3.0	3.0
Carbamazepine	54	3.0	3.0
Rasagiline Mesylate	9	3.0	3.0
Divalproex Sodium	37	2.9	2.9
Doxepin	8	2.9	2.9
Rizatriptan Benzoate	8	2.9	2.9
Fingolimod Hcl	67	2.9	2.9
Nevirapine	7	2.8	2.8
Gentamicin	10	2.8	2.8
Zonisamide	11	2.7	2.7
Levetiracetam	98	2.7	2.7
Phenytoin	15	2.6	2.6
Lamivudine Oral	18	2.6	2.6
Alcohol	27	2.6	2.6
Duloxetine	48	2.5	2.5
Levetiracetam In Sodium Chloride	53	2.5	2.5
Levetiracetam Oral	53	2.5	2.5
Levetiracetam Injection	53	2.5	2.5
Darunavir	10	2.4	2.4
Methadone Hydrochloride	7	2.4	2.4
Sumatriptan	24	2.3	2.3
Nebivolol	10	2.3	2.3
Norepinephrine Bitartrate	9	2.3	2.3
Amphetamine	5	2.2	2.2
Lacosamide	22	2.2	2.2
Ondansetron	64	2.2	2.2
Ondansetron Tablets	64	2.2	2.2
Methylphenidate	17	2.2	2.2
Carbidopa And Levodopa	27	2.1	2.1
Instalax Polyethylene Glycol 3350	7	2.1	2.1
Fentanyl Citrate	10	2.1	2.1
Methylphenidate Hydrochloride	33	2.0	2.0
Polyethylene Glycol 400	7	2.0	2.0
Linezolid	16	2.0	2.0
Entecavir	6	1.9	1.9
Vemurafenib	6	1.8	1.8
Polyethylene Glycol 3350	47	1.8	1.8
Botulinum Toxin Type A	6	1.8	1.8
Granisetron	5	1.7	1.7
Miconazole Nitrate	4	1.7	1.7
Palivizumab	7	1.7	1.7
Vilazodone Hydrochloride	4	1.6	1.6
Cariprazine	4	1.6	1.6
Interferon Beta-1B	8	1.5	1.5
Clozapine	52	1.5	1.5
Onabotulinumtoxina	32	1.5	1.5
Lurasidone Hydrochloride	8	1.4	1.4
Dalfampridine	27	1.4	1.4
Paliperidone Palmitate	12	1.4	1.4
Iohexol	3	1.3	1.3
Travoprost	3	1.3	1.3
Buprenorphine	28	1.1	1.1
Medroxyprogesterone Acetate	14	1.0	1.0
Glatiramer Acetate	15	0.9	0.9

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.