Reaction

Paranasal Sinus Hypersecretion reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,794 reports · 122 co-occurring drugs

As of the last recalculation, Paranasal Sinus Hypersecretion appears in 3,794 FAERS reports alongside 122 co-occurring drug terms. The strongest observed disproportionality signal is ELEXACAFTOR, TEZACAFTOR, AND IVACAFTOR (PRR 33.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Elexacaftor, Tezacaftor, And Ivacaftor	75	33.6	33.8
Theophylline	29	13.9	14.0
Theophylline Anhydrous	30	13.4	13.4
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	40	10.8	10.8
Naproxen Sodium, Pseudoephedrine Hydrochloride	40	10.8	10.8
Etanercept	827	9.4	9.4
Diphenhydramine Hydrochloride Capsule, Liquid Filled	35	9.1	9.1
0Xygen	73	8.3	8.3
Oxygen	73	8.3	8.3
Human Immunoglobulin G	30	8.0	8.0
Guaifenesin	43	7.8	7.8
Nintedanib	44	7.8	7.8
Treprostinil	162	7.4	7.4
Azelastine	23	7.1	7.1
Dornase Alfa	24	6.8	6.8
Cyclobenzaprine Hydrochloride	11	6.7	6.7
Chlorhexidine Gluconate	11	6.6	6.6
Adrenalinum	49	6.5	6.6
Fexofenadine Hcl	11	6.5	6.6
Doxyclycline Hyclate	20	6.5	6.5
Macitentan	79	6.4	6.4
Riociguat	37	6.3	6.3
Moxifloxacin	16	6.3	6.3
Zinc Chloride	27	6.0	6.0
Cetirizine Hcl	10	6.0	6.0
Zinc Gluconate	28	5.9	5.9
Zinc	26	5.8	5.8
Fluticasone Propionate	127	5.5	5.5
Tizanidine Hydrochloride	18	5.5	5.5
Fluticasone Furoate And Vilanterol Trifenatate	35	5.4	5.4
Mupirocin	13	5.3	5.3
Mupirocin Calcium	13	5.2	5.2
Pirfenidone	38	5.2	5.2
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	46	5.1	5.1
Fexofenadine Hydrochloride	20	5.1	5.1
Epoprostenol	12	5.0	5.0
Dicyclomine Hydrochloride	13	5.0	5.0
Fluticasone Propionate Nasal	27	4.9	4.9
Selexipag	23	4.9	4.9
Loratadine And Pseudoephedrine Sulfate	7	4.8	4.8
Tobramycin	21	4.8	4.8
Hyoscyamine Sulfate	8	4.8	4.8
Sildenafil	50	4.8	4.8
Epinephrine	56	4.7	4.8
Vitamin C	77	4.7	4.7
Moxifloxacin Hydrochloride	17	4.6	4.6
Magnesium	68	4.6	4.6
Baricitinib	8	4.6	4.6
Fluticasone Furoate	10	4.5	4.5
Adalimumab	511	4.4	4.4
Sucralfate	19	4.4	4.4
Rucaparib	7	4.4	4.4
Fluticasone Propionate And Salmeterol Xinafoate	47	4.3	4.3
Evolocumab	124	4.3	4.3
Ambrisentan	96	4.3	4.3
Lidocaine	45	4.3	4.3
Sucralfate Oral	11	4.3	4.3
Sucralfate Oral Suspension	11	4.2	4.2
Loratadine Tablet	41	4.2	4.2
Iron	50	4.1	4.1
Methocarbamol	17	4.1	4.1
Tobramycin Solution	9	4.1	4.1
Montelukast Sodium	88	4.0	4.0
Tobramycin Sulfate	9	4.0	4.0
Sodium Chloride	56	3.9	3.9
Sodium Chloride Tablet	52	3.9	3.9
Sodium Chloride Tablets	52	3.9	3.9
Meloxicam	41	3.9	3.9
Montelukast	59	3.9	3.9
Mometasone Furoate And Formoterol Fumarate Dihydrate	11	3.9	3.9
Sildenafil Powder,	25	3.9	3.9
Icosapent Ethyl	6	3.9	3.9
Sildenafil Citrate	87	3.8	3.8
Fish Oil	62	3.8	3.8
Benzonatate	11	3.7	3.7
Thyroid, Porcine	7	3.6	3.6
Losartan Potassium	50	3.5	3.5
Quinapril Hydrochloride	5	3.5	3.5
Tadalafil	62	3.4	3.4
Pravastatin Sodium	12	3.3	3.3
Alirocumab	15	3.3	3.3
Niraparib	13	3.2	3.2
Levocetirizine Dihydrochloride	14	3.2	3.2
Loratadine	62	3.2	3.2
Multivitamin	29	3.2	3.2
Nirmatrelvir And Ritonavir	31	3.2	3.2
Armodafinil	12	3.1	3.1
Testosterone Cypionate	5	3.1	3.1
Exenatide	29	3.0	3.0
Vilazodone Hydrochloride	5	3.0	3.0
Tiotropium Bromide Inhalation Spray	6	2.9	2.9
Bimatoprost	15	2.9	2.9
Pancrelipase	20	2.9	2.9
Regorafenib	6	2.8	2.8
Teriparatide	57	2.8	2.8
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	21	2.8	2.8
Ibrutinib	40	2.7	2.7
Lifitegrast	8	2.7	2.7
Budesonide, Glycopyrrolate, And Formoterol Fumarate	5	2.6	2.6
Omalizumab	40	2.6	2.6
Travoprost	4	2.5	2.5
Cabozantinib	20	2.3	2.3
Linaclotide	11	2.3	2.3
Sodium Oxybate	27	2.3	2.3
Sacubitril And Valsartan	47	2.2	2.2
Acetaminophen, Aspirin, And Caffeine	8	2.1	2.1
Inclisiran	3	2.1	2.1
Ocrelizumab	23	2.0	2.0
Umeclidinium Bromide And Vilanterol Trifenatate	6	2.0	2.0
Lumacaftor And Ivacaftor	3	1.9	1.9
Tofacitinib	64	1.9	1.9
Palbociclib	31	1.8	1.8
Peginterferon Alfa-2A	17	1.7	1.7
Ravulizumab	4	1.6	1.6
Dupilumab	126	1.4	1.4
Natalizumab	45	1.4	1.4
Cenegermin-Bkbj	3	1.4	1.4
Sarilumab	6	1.2	1.2
Dimethyl Fumarate	27	1.2	1.2
Relugolix	4	0.9	0.9
Apremilast	22	0.8	0.8
Tirzepatide	23	0.8	0.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.