Reaction

Nonspecific Reaction reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,320 reports · 107 co-occurring drugs

As of the last recalculation, Nonspecific Reaction appears in 5,320 FAERS reports alongside 107 co-occurring drug terms. The strongest observed disproportionality signal is PIMAVANSERIN TARTRATE (PRR 104.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Pimavanserin Tartrate	1,156	104.2	106.4
Naltrexone Hydrochloride And Bupropion Hydrochloride	78	36.3	36.6
Rasagiline Mesylate	50	17.7	17.8
Carbidopa And Levodopa	199	17.0	17.1
Orlistat	107	16.5	16.5
Memantine	51	14.7	14.8
Memantine Hydrochloride	51	14.7	14.8
Amantadine	57	14.6	14.6
Rivastigmine	57	12.0	12.0
Ciclesonide	38	11.0	11.0
Donepezil Hydrochloride	101	11.0	11.0
Ropinirole	41	10.5	10.6
Levodopa	30	9.8	9.8
Pramipexole	35	9.0	9.0
Desvenlafaxine Succinate	58	8.5	8.5
Glycerin, Lidocaine	29	8.1	8.2
Dornase Alfa	40	8.0	8.0
Docosanol	29	7.8	7.8
Nicotine	62	6.1	6.1
Nicotine Polacrilex	55	5.7	5.7
Mepolizumab	71	5.7	5.7
Mirabegron	48	4.9	4.9
Rotigotine	18	4.9	4.9
Melatonin	67	4.9	4.9
Paliperidone Palmitate	38	4.6	4.7
Belimumab	36	4.5	4.5
Doxepin	11	4.3	4.3
Oxybutynin Chloride	9	4.0	4.0
Quetiapine	187	3.9	3.9
Bimekizumab	20	3.7	3.7
Droxidopa	20	3.6	3.6
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	45	3.5	3.5
Finasteride	54	3.5	3.5
Magnesium Hydroxide	12	3.5	3.5
Primidone	9	3.5	3.5
Doxepin Hydrochloride	11	3.4	3.4
Ibuprofen And Diphenhydramine Citrate	20	3.4	3.4
Lubiprostone	8	3.3	3.3
Venlafaxine Hydrochloride	110	3.3	3.3
Sumatriptan	32	3.3	3.3
Trazodone Hydrochloride	13	3.3	3.3
Abiraterone	11	3.2	3.2
Clonazepam	126	3.1	3.1
Linaclotide	21	3.1	3.1
Rizatriptan Benzoate	8	3.1	3.1
Divalproex Sodium	36	3.0	3.0
Mycophenilic Acid	16	3.0	3.0
Meclizine Hydrochloride	15	3.0	3.0
Alendronate Sodium Tablet	14	3.0	3.0
Bendamustine Hydrochloride	9	2.9	2.9
Vancomycin Hydrochloride	49	2.9	2.9
Anti-Thymocyte Globulin (Rabbit)	6	2.9	2.9
Vancomycin	42	2.9	2.9
Omalizumab	58	2.7	2.7
Conjugated Estrogens And Medroxyprogesterone Acetate	16	2.7	2.7
Bupropion Hydrochloride	63	2.5	2.5
Deferasirox	17	2.5	2.5
Lisdexamfetamine Dimesylate	21	2.5	2.5
Buspirone Hydrochloride	7	2.5	2.5
Sumatriptan Succinate	16	2.5	2.5
Phenobarbital	9	2.4	2.4
Esketamine Hydrochloride	11	2.4	2.4
Abiraterone Acetate	25	2.4	2.4
Timolol Maleate	6	2.4	2.4
Paliperidone	14	2.4	2.4
Apalutamide	7	2.3	2.3
Travoprost	5	2.3	2.3
Asenapine Maleate	5	2.3	2.3
Fluticasone Propionate And Salmeterol	24	2.3	2.3
Pazopanib Hydrochloride	15	2.2	2.2
Vilazodone Hydrochloride	5	2.1	2.1
Cariprazine	5	2.1	2.1
Guanfacine	4	2.0	2.0
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	21	2.0	2.0
Vibegron	4	2.0	2.0
Glatiramer Acetate	28	1.8	1.8
Bendamustine Hcl	7	1.8	1.8
Ustekinumab	46	1.8	1.8
Agalsidase Beta	4	1.7	1.7
Umeclidinium Bromide And Vilanterol Trifenatate	7	1.6	1.6
Vigabatrin	6	1.6	1.6
Canagliflozin	12	1.6	1.6
Asfotase Alfa	4	1.6	1.6
Lapatinib	6	1.5	1.5
Cabotegravir	3	1.5	1.5
Teriparatide	40	1.4	1.4
Acetaminophen, Aspirin (Nsaid) And Caffeine	6	1.4	1.4
Certolizumab Pegol	41	1.4	1.4
Bimatoprost	10	1.4	1.4
Alpelisib	3	1.3	1.3
Tafamidis	4	1.3	1.3
Ixekizumab	12	1.3	1.3
Abemaciclib	6	1.2	1.2
Dasatinib	11	1.2	1.2
Ravulizumab	4	1.2	1.2
Guselkumab	10	1.1	1.1
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	5	1.1	1.1
Voxelotor	6	1.0	1.0
Nirmatrelvir And Ritonavir	14	1.0	1.0
Lifitegrast	4	1.0	1.0
Velpatasvir And Sofosbuvir	3	0.9	0.9
Onabotulinumtoxina	18	0.9	0.9
Galcanezumab-Gnlm	6	0.7	0.7
Minoxidil Foam 5% (Womens)	6	0.7	0.7
Minoxidil	8	0.7	0.7
Abaloparatide	5	0.7	0.7
Apremilast	19	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.