Reaction

Immunosuppressant Drug Level Increased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,251 reports · 132 co-occurring drugs

As of the last recalculation, Immunosuppressant Drug Level Increased appears in 3,251 FAERS reports alongside 132 co-occurring drug terms. The strongest observed disproportionality signal is TACROLIMUS (PRR 368.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Tacrolimus	2,394	368.4	374.2
Tacrolimus Ointment 0.1%	1,838	216.1	219.4
Tacrolimus Extended-Release Capsules	1,839	215.8	219.0
Basiliximab	172	98.8	100.3
Valganciclovir Hydrochloride Powder,	134	73.3	74.1
Mycophenolate Mofetil	1,007	68.3	68.8
Mycophenolate Mofetil Hydrochloride	1,008	68.3	68.8
Valganciclovir	185	66.6	67.2
Valganciclovir Hydrochloride	185	66.6	67.2
Mycophenolic Acid	257	55.7	56.2
Sirolimus	110	54.1	54.5
Ritonavir 100 Mg	121	53.8	54.3
Mycophenilic Acid	159	51.6	52.0
Voriconazole Injection	118	36.1	36.3
Everolimus Tablets	86	33.7	33.9
Posaconazole Delayed-Release	55	32.6	32.8
Ganciclovir	50	31.8	31.9
Voriconazole	144	31.7	31.9
Ganciclovir Sodium	51	31.3	31.5
Itraconazole	55	30.7	30.8
Clarithromycin	155	30.3	30.4
Ritonavir	123	28.0	28.1
Anti-Thymocyte Globulin (Rabbit)	34	27.3	27.4
Cyclosporine	409	26.8	26.9
Micafungin Sodium	34	25.9	26.0
Posaconazole	64	25.7	25.8
Nirmatrelvir And Ritonavir	189	23.7	23.7
Eplerenone	41	20.7	20.8
Abacavir Sulfate	31	20.6	20.6
Prednisolone	490	20.3	20.3
Prednisolone Oral	490	20.3	20.3
Prednisolone Oral Solution	490	20.3	20.3
Amphotericin B	39	20.2	20.2
Dextrose	35	17.2	17.2
Dextrose Monohydrate	35	16.9	17.0
Lopinavir And Ritonavir	35	16.7	16.7
Cefuroxime	29	16.4	16.4
Methylprednisolone	315	16.0	16.1
Fluconazole	162	15.5	15.6
Atovaquone	19	15.2	15.2
Entecavir	22	12.1	12.2
Darunavir	28	11.9	12.0
Everolimus	91	11.8	11.8
Sodium Bicarbonate	42	11.7	11.7
Sodium Bicarbonate Injection,	42	11.7	11.7
Meropenem	57	11.6	11.6
Sennosides 8.6 Mg Tablets	37	11.4	11.4
Nystatin Ointment	46	11.4	11.4
Azathioprine	150	11.4	11.4
Nystatin Cream	46	11.4	11.4
Senna	37	11.4	11.4
Senna Leaf	40	11.2	11.2
Nystatin	46	10.9	10.9
Sulfamethoxazole And Trimethoprim	136	10.7	10.7
Piperacillin And Tazobactam	21	10.6	10.6
Sennosides	42	9.1	9.1
Prednisone	591	9.0	9.0
Calcitriol Capsules 0.25 Mcg	27	8.7	8.7
Calcitriol Capsules 0.5 Mcg	27	8.7	8.7
Lamivudine Oral	34	8.7	8.7
Calcitriol	27	8.6	8.6
Cefepime	19	8.5	8.5
Doxazosin	36	8.3	8.3
Ursodiol	28	8.3	8.3
Ursosiol	25	8.3	8.3
Trimethoprim	15	8.2	8.2
Methylprednisolone Sodium Succinate	58	8.1	8.1
Vancomycin	70	7.9	7.9
Piperacillin Sodium,Tazobactam Sodium	32	7.8	7.8
Nifedipine	56	7.7	7.7
Cefepime Hydrochloride	19	7.6	7.6
Piperacillin Sodium And Tazobactam Sodium	23	7.6	7.6
Vancomycin Hydrochloride	74	7.3	7.3
Lamivudine	35	7.3	7.3
Rifaximin	23	7.1	7.1
Icosapent Ethyl	9	6.8	6.8
Doxazosin Mesylate	37	6.6	6.6
Phenytoin	21	6.5	6.5
Linezolid	29	6.3	6.3
Dalteparin Sodium	10	6.1	6.1
Phytonadione	8	6.0	6.1
Norepinephrine	10	6.0	6.0
Antacid	44	6.0	6.0
Midazolam Hydrochloride	25	6.0	6.0
Midazolam	23	5.9	5.9
Erythromycin	17	5.8	5.8
Anti-Itch	58	5.6	5.6
Anti-Pruritic	58	5.6	5.6
Antipruritic (Anti-Itch)	58	5.6	5.6
Cool Relief Gel With Aloe	58	5.6	5.6
Drs. Hydrocortisone	58	5.6	5.6
Hydrocortisone Continuous Spray	58	5.6	5.6
Hydrocortisone Spray	58	5.6	5.6
Anti-Itch Cream	58	5.6	5.6
Hydrocortisone Lotion	58	5.6	5.6
Hydrocortisone Cream 1%	58	5.6	5.6
Hydrocortisone Cream 1/2%	58	5.6	5.6
Hydrocortisone 1%	58	5.6	5.6
Hydrocortisone Cream	58	5.6	5.6
Rabeprazole	19	5.5	5.5
Azithromycin	34	5.5	5.5
Norepinephrine Bitartrate	12	5.4	5.4
Remdesivir	11	5.3	5.3
Azithromycin Monohydrate	34	5.3	5.3
Nebivolol	13	5.2	5.2
Elexacaftor, Tezacaftor, And Ivacaftor	10	5.1	5.1
Magnesium Sulfate In Water For	10	5.0	5.0
Erythropoietin	16	5.0	5.0
Linagliptin	14	4.9	4.9
Magnesium Sulfate Heptahydrate	10	4.9	4.9
Magnesium Sulfate	10	4.9	4.9
Enalapril	42	4.9	4.9
Dorzolamide Hydrochloride And Timolol Maleate	6	4.9	4.9
Oseltamivir	6	4.8	4.8
Magnesium Oxide	31	4.8	4.8
Raltegravir	12	4.7	4.7
Methoxy Polyethylene Glycol-Epoetin Beta	8	4.6	4.7
Daptomycin	6	4.2	4.2
Bumetanide	17	4.1	4.1
Guanfacine	5	4.1	4.1
Ivacaftor	5	4.0	4.0
Rifampin	8	3.5	3.5
Cannabidiol	12	3.3	3.3
Bendamustine Hydrochloride	6	3.2	3.2
Sevoflurane	4	3.1	3.1
Miconazole Nitrate	4	2.9	2.9
Oseltamivir Phosphate	11	2.9	2.9
Ticagrelor	13	2.6	2.6
Dronedarone	4	2.5	2.5
Ribavirin	21	2.1	2.1
Ledipasvir And Sofosbuvir	4	1.3	1.3
Cinacalcet Hydrochloride	5	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.