Reaction

Paradoxical Drug Reaction reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,624 reports · 130 co-occurring drugs

As of the last recalculation, Paradoxical Drug Reaction appears in 3,624 FAERS reports alongside 130 co-occurring drug terms. The strongest observed disproportionality signal is PYRAZINAMIDE (PRR 365.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Pyrazinamide	513	365.2	386.4
Isoniazid	554	231.7	239.9
Rifampicin	296	182.9	188.4
Rifampin	386	169.8	174.5
Moxifloxacin	112	47.1	47.5
Eszopiclone	196	46.7	47.0
Moxifloxacin Hydrochloride	129	37.9	38.1
Dimenhydrinate	68	37.3	37.6
Rizatriptan Benzoate	64	36.8	37.0
Midazolam Hydrochloride	131	29.0	29.1
Botulinum Toxin Type A	60	28.2	28.3
Midazolam	118	27.8	27.9
Clobazam	112	27.2	27.3
Levetiracetam In Sodium Chloride	276	22.1	22.1
Levetiracetam Oral	276	22.1	22.1
Levetiracetam Injection	276	22.1	22.1
Adalimumab-Fkjp	162	21.0	21.1
Adalimumab-Aaty	163	20.7	20.7
Valproic Acid	109	20.4	20.5
Efavirenz	36	18.7	18.8
Adalimumab-Adaz	163	18.5	18.6
Amikacin	54	18.4	18.5
Valproate Sodium	64	18.1	18.1
Clarithromycin	103	17.7	17.8
Cenobamate	25	17.3	17.4
Linezolid	77	15.2	15.2
Trazodone Hydrochloride	40	14.8	14.9
Aripiprazole Oral	99	14.1	14.1
Aripiprazole Orally Disintegrating	99	14.1	14.1
Levetiracetam	294	13.7	13.7
Itraconazole	27	13.4	13.4
Clonidine	107	12.3	12.4
Prochlorperazine	56	11.8	11.8
Dronabinol	15	10.8	10.8
Candesartan	63	10.3	10.3
Brivaracetam	16	10.3	10.3
Lamivudine Oral	43	9.9	9.9
Haloperidol	38	9.1	9.1
Haloperidol Lactate	38	8.9	8.9
Levofloxacin	91	8.9	8.9
Levofloxacin In 5% Dextrose	91	8.9	8.9
Phenytoin	30	8.3	8.3
Nifedipine	66	8.2	8.2
Propofol	51	8.1	8.1
Lamivudine	43	8.1	8.1
Divalproex Sodium	64	8.0	8.0
Propranolol Hydrochloride	96	7.8	7.8
Rocuronium Bromide	16	7.8	7.8
Venlafaxine	91	7.5	7.5
Amphotericin B	16	7.4	7.4
Lithium	32	7.3	7.4
Lithium Bromatum	32	7.3	7.4
Topiramate	114	7.2	7.2
Daspone	12	7.1	7.1
Dapsone Gel, 5%	12	7.1	7.1
Olanzapine	128	7.1	7.1
Aripiprazole	142	6.9	6.9
Lamotirigine	83	6.8	6.8
Lamotrigine Extended-Release	83	6.8	6.8
Lamotrigine Chewable Dispersible	83	6.8	6.8
Bupivacaine	11	6.8	6.8
Rivastigmine	22	6.7	6.7
Paliperidone	27	6.7	6.7
Diazepam Oral Solution (Concentrate)	101	6.7	6.7
Diazepam Oral	101	6.7	6.7
Carbamazepine	76	6.6	6.6
Oxcarbazepine	37	6.6	6.6
Dapsone	12	6.5	6.5
Zidovudine	15	6.5	6.5
Diazepam	132	6.4	6.4
Suvorexant	14	6.2	6.2
Risperidone	139	6.2	6.2
Lorazepam	179	6.0	6.0
Abacavir Sulfate	10	5.9	5.9
Lidicaine	49	5.8	5.8
Burn Relief	49	5.8	5.8
Lidocaine Hydrochloride And Epinephrine	49	5.8	5.8
Lidocaine, Menthol	49	5.7	5.7
Darunavir	15	5.7	5.7
Melatonin	52	5.6	5.6
Erenumab-Aooe	52	5.5	5.5
Quetiapine Fumarate	28	5.5	5.5
Naproxen	73	5.4	5.4
Lamotrigine	121	5.4	5.4
Tofacitinib Citrate	12	5.3	5.3
Lidocaine 4%	49	5.2	5.2
Lidocaine Hydrochloride And Epinephrine Bitartrate	48	5.2	5.2
Piperacillin Sodium,Tazobactam Sodium	23	5.0	5.0
Lidocaine Hydrochloride	51	4.9	4.9
Prednisolone	149	4.9	4.9
Prednisolone Oral	149	4.9	4.9
Prednisolone Oral Solution	149	4.9	4.9
Lidocaine	49	4.9	4.9
Paroxetine Hydrochloride Hemihydrate	28	4.9	4.9
Venlafaxine Hydrochloride	109	4.8	4.8
Paroxetine	28	4.8	4.8
Quetiapine	152	4.7	4.7
Metoclopramide Hydrochloride	62	4.7	4.7
Tranexamic Acid	7	4.5	4.5
Piperacillin And Tazobactam	10	4.5	4.5
Nevirapine	7	4.5	4.5
Cefazolin	7	4.4	4.4
Norepinephrine	8	4.3	4.3
Donepezil Hydrochloride	26	4.1	4.1
Tenofovir Disoproxil Fumarate Tablets	6	4.0	4.0
Terbinafine Hydrochloride	6	3.9	3.9
Lacosamide	25	3.9	3.9
Fexofenadine	11	3.8	3.8
Guanfacine	5	3.7	3.7
Meropenem	20	3.6	3.6
Infliximab	132	3.6	3.6
Raltegravir	10	3.5	3.5
Ritonavir 100 Mg	9	3.5	3.5
Sevoflurane	5	3.5	3.5
Clozapine	72	3.3	3.3
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	23	3.2	3.2
Dexamethasone 1.5 Mg	151	3.0	3.0
Dexamethasone	152	3.0	3.0
Ziprasidone	9	2.9	2.9
Fentanyl Citrate	9	2.9	2.9
Ziprasidone Mesylate	7	2.8	2.8
Iohexol	4	2.8	2.8
Calcium, Magnesium, Potassium, And Sodium Oxybates	4	2.7	2.7
Methylphenidate	13	2.6	2.6
Sodium Oxybate	29	2.5	2.5
Ixekizumab	15	2.3	2.3
Isotretinoin	13	1.5	1.5
Pimavanserin Tartrate	11	1.1	1.1
Paliperidone Palmitate	6	1.1	1.1
Galcanezumab-Gnlm	4	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.