Reaction

Lyme Disease reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,276 reports · 119 co-occurring drugs

As of the last recalculation, Lyme Disease appears in 3,276 FAERS reports alongside 119 co-occurring drug terms. The strongest observed disproportionality signal is MEPERIDINE HYDROCHLORIDE (PRR 72.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Meperidine Hydrochloride	102	72.6	73.4
Misoprostol	75	50.1	50.4
Erythromycin	99	34.5	34.7
Doxyclycline Hyclate	58	22.0	22.1
Thyroid, Porcine	33	19.9	19.9
Diclofenac Potassium, Film Coated	25	19.0	19.1
Diclofenac Potassium Tablets	25	19.0	19.1
Liothyronine Sodium	24	17.6	17.7
Doxycycline	173	17.0	17.0
Doxycycline Hyclate	171	16.9	17.0
Human Immunoglobulin G	54	16.9	16.9
Diclofenac Potassium	28	16.6	16.6
Calcium, Magnesium, Potassium, And Sodium Oxybates	22	16.3	16.4
Atovaquone	18	14.3	14.3
Metronidazole Topical	101	13.9	13.9
Sodium Oxybate	133	13.3	13.3
Metronidazole	113	11.6	11.6
Adalimumab-Fkjp	82	11.5	11.5
Adalimumab-Aaty	82	11.3	11.3
Adalimumab-Adaz	87	10.7	10.7
Minocycline	19	10.4	10.4
Levofloxacin	95	10.3	10.3
Levofloxacin In 5% Dextrose	95	10.3	10.3
Diphenhydramine Hydrochloride Capsule, Liquid Filled	34	10.2	10.2
Sulfasalazine	118	9.9	9.9
Adrenalinum	63	9.8	9.8
Hydroxychloroquine Sulfate	133	9.6	9.6
Diclofenac Sodium 1%	48	8.6	8.7
Diclofenac Sodium Topical	48	8.6	8.7
Diclofenac Sodium Topical Gel, 1%	48	8.6	8.6
Cortisone Acetate	15	7.8	7.8
Leflunomide	118	7.4	7.4
Epinephrine	72	7.1	7.1
Celecoxib	141	7.1	7.1
Modafinil	35	7.0	7.0
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	38	6.9	6.9
Cefuroxime	12	6.7	6.7
Armodafinil	22	6.7	6.7
Rifampin	15	6.6	6.6
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	42	6.5	6.5
Nystatin Ointment	25	6.1	6.1
Nystatin Cream	25	6.1	6.1
Nystatin	26	6.1	6.1
Butalbital, Acetaminophen, And Caffeine	10	6.0	6.0
Lidocaine	52	5.7	5.7
Doxepin	9	5.7	5.7
Doxepin Hydrochloride	11	5.5	5.6
Dapsone	9	5.4	5.4
Desoximetasone	16	5.4	5.4
Carisoprodol	16	5.3	5.4
Cladribine	8	5.3	5.3
Tizanidine Hydrochloride	15	5.3	5.3
Lidocaine Hydrochloride And Epinephrine	40	5.2	5.2
Daspone	8	5.2	5.2
Dapsone Gel, 5%	8	5.2	5.2
Diphenhydramine	51	5.2	5.2
Bisoprolol Fumarate	108	5.2	5.2
Lidicaine	39	5.1	5.1
Burn Relief	39	5.1	5.1
Golimumab	64	4.8	4.8
Oxycodone And Acetaminophen Tablets	9	4.8	4.8
Diclofenac	63	4.7	4.7
Progesterone	16	4.5	4.5
Pregabalin	179	4.4	4.4
Sarilumab	18	4.3	4.4
Etonogestrel And Ethinyl Estradiol	15	4.3	4.3
Hydroxychloroquine	50	4.3	4.3
Sodium Chloride Tablet	49	4.3	4.3
Sodium Chloride Tablets	49	4.3	4.3
Ocrelizumab	41	4.2	4.2
Extended Phenytoin Sodium	11	4.2	4.2
Naltrexone	20	4.1	4.1
Methylphenidate Hydrochloride	37	4.0	4.0
Lisdexamfetamine Dimesylate	20	3.9	3.9
Ofatumumab	19	3.6	3.6
Certolizumab Pegol	65	3.6	3.6
Agalsidase Beta	5	3.4	3.4
Adalimumab	338	3.3	3.3
Interferon Beta-1A	97	3.3	3.3
Esketamine Hydrochloride	9	3.2	3.2
Fluticasone Furoate And Vilanterol Trifenatate	18	3.2	3.2
Levocetirizine Dihydrochloride	12	3.2	3.2
Asfotase Alfa	5	3.2	3.2
Avapritinib	6	3.2	3.2
Methylphenidate	14	3.1	3.1
Secukinumab	77	3.1	3.1
Amphetamine	4	3.1	3.1
Ustekinumab	49	3.1	3.1
Isopropyl Alcohol	16	3.0	3.0
Vortioxetine	8	3.0	3.0
Bimekizumab	10	3.0	3.0
Canakinumab	5	2.9	2.9
Naproxen Sodium Tablet	24	2.9	2.9
Linaclotide	12	2.9	2.9
Tofacitinib	81	2.8	2.8
Etanercept	252	2.8	2.8
Oxycodone And Acetaminophen	10	2.7	2.7
Interferon Beta-1B	8	2.7	2.7
Natalizumab	65	2.3	2.3
Alcohol	14	2.3	2.3
Isotretinoin	15	1.9	1.9
Benralizumab	6	1.9	1.9
Ravulizumab	4	1.9	1.9
Dalfampridine	20	1.8	1.8
Alirocumab	7	1.8	1.8
Dimethyl Fumarate	34	1.8	1.8
Ixekizumab	10	1.7	1.7
Diroximel Fumarate	3	1.6	1.6
Onabotulinumtoxina	17	1.4	1.4
Apremilast	29	1.3	1.3
Orlistat	5	1.2	1.2
Galcanezumab-Gnlm	6	1.2	1.2
Relugolix	4	1.1	1.1
Guselkumab	6	1.1	1.1
Etonogestrel	7	0.9	0.9
Erenumab-Aooe	8	0.9	0.9
Copper	6	0.9	0.9
Droxidopa	3	0.9	0.9
Dupilumab	60	0.8	0.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.