Reaction

Therapeutic Agent Toxicity reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,337 reports · 121 co-occurring drugs

As of the last recalculation, Therapeutic Agent Toxicity appears in 3,337 FAERS reports alongside 121 co-occurring drug terms. The strongest observed disproportionality signal is LITHIUM CARBONATE (PRR 186.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Lithium Carbonate	441	186.5	191.4
Digoxin	1,178	157.7	160.4
Metolazone	47	26.4	26.5
Warfarin Sodium	163	23.0	23.1
Lithium	88	22.3	22.4
Lithium Bromatum	88	22.3	22.4
Enalapril Maleate	85	21.9	22.0
Phenytoin	69	21.0	21.1
Extended Phenytoin Sodium	47	17.8	17.8
Isosorbide Dinitrate	51	16.5	16.6
Tolterodine Tartrate	23	16.1	16.1
Atropine	19	14.4	14.4
Captopril	20	13.0	13.1
Amiodarone Hydrochloride	23	12.9	12.9
Diltiazem Hydrochloride	64	11.7	11.8
Cephalexin	40	11.7	11.7
Nitroglycerin	96	11.5	11.5
Temazepam	67	11.3	11.3
Atropine Sulfate	19	11.0	11.0
Amlodipine Besylate And Benazepril Hydrochloride	16	10.9	10.9
Gemfibrozil	26	10.8	10.8
Potassium Chloride, Dextrose Monohydrate	149	10.5	10.5
Potassium Chloride Oral	149	10.5	10.5
Potassium Chloride Extended-Release	149	10.5	10.5
Theophylline	19	10.4	10.4
Valproate Sodium	34	10.4	10.4
Lisinopril And Hydrochlorothiazide Tablets	13	10.4	10.4
Potassium Chloride	178	10.2	10.3
Enalapril	88	10.1	10.1
Warfarin	192	9.9	10.0
Theophylline Anhydrous	19	9.6	9.6
Olanzapine Pamoate	62	9.6	9.6
Candesartan Cilexetil	40	9.6	9.6
Bumetanide	40	9.5	9.6
Ezetimibe And Simvastatin	23	9.5	9.5
Lactulose	57	9.4	9.4
Spironolactone	199	9.3	9.3
Lisinopril And Hydrochlorothiazide	15	9.2	9.2
Haloperidol Lactate	35	8.9	8.9
Haloperidol	34	8.8	8.8
Furosemide	482	8.6	8.6
Indomethacin	18	8.5	8.5
Glyburide	32	8.3	8.3
Meclizine Hcl 12.5Mg	18	8.3	8.3
Meclizine Hcl 25Mg	18	8.3	8.3
Meclizine Hcl 12.5 Mg	18	8.3	8.3
Meclizine Hcl 25 Mg	18	8.3	8.3
Quinine	11	8.0	8.0
Carvedilol	166	8.0	8.0
Olanzapine	129	7.7	7.8
Felodipine Extended-Release Tablets	14	7.7	7.7
Felodipine	14	7.7	7.7
Ipratropium Bromide	41	7.2	7.3
Docusate Sodium - Sennosides	37	7.2	7.2
Metformin Hcl	63	7.2	7.2
Human Insulin	14	7.0	7.0
Divalproex Sodium	51	6.9	6.9
Meclizine	18	6.9	6.9
Hyoscyamine Sulfate	10	6.8	6.8
Azithromycin Dihydrate	63	6.8	6.8
Gentamicin	14	6.7	6.7
Glipizide	62	6.5	6.5
Azithromycin	41	6.4	6.4
Promethazine Hydrochloride	19	6.4	6.4
Metoclopramide	55	6.3	6.3
Levothyroxine Sodium Anhydrous	99	6.3	6.3
Derma Foam Excel Hand Sanitizer	8	6.3	6.3
Carisoprodol	19	6.2	6.2
Ethanol	8	6.2	6.2
Azithromycin Monohydrate	41	6.2	6.2
Metoclopramide Hydrochloride	75	6.2	6.2
Aspirin 325 Mg	446	6.1	6.1
Aspirin 81 Mg	446	6.1	6.1
Gentamicin Sulfate	15	5.9	5.9
Aspirin	449	5.9	5.9
Isopropyl Alcohol	31	5.8	5.8
Meclizine Hydrochloride	18	5.8	5.8
Ziprasidone Mesylate	13	5.7	5.7
Oxybutynin Chloride	8	5.7	5.7
Pioglitazone	39	5.7	5.7
Carbamazepine	60	5.7	5.7
Insulin	50	5.7	5.7
Morphine	66	5.6	5.6
Leucovorin Calcium	17	5.6	5.6
Meperidine Hydrochloride	8	5.4	5.4
Ciprofloxacin Hydrochloride And Hydrocortisone	18	5.4	5.4
Niacin	10	5.4	5.4
Donepezil Hydrochloride	31	5.3	5.3
Busulfan	13	5.2	5.2
Clonazepam	127	5.1	5.1
Erythromycin	15	5.0	5.0
0Xygen	39	5.0	5.0
Oxygen	39	5.0	5.0
Metoroprolol Tartrate	52	5.0	5.0
Sucralfate	19	5.0	5.0
Lisinopril	229	4.9	4.9
Pantoprazole Sodium	114	4.9	4.9
Irbesartan	35	4.9	4.9
Atenolol	102	4.9	4.9
Losartan Potassium And Hydrochlorothiazide	9	4.8	4.8
Norepinephrine Bitartrate	11	4.8	4.8
Diazepam Oral Solution (Concentrate)	67	4.8	4.8
Diazepam Oral	67	4.8	4.8
Clarithromycin	26	4.8	4.8
Quinapril Hydrochloride	6	4.8	4.8
Ziprasidone	13	4.6	4.6
Diazepam	87	4.6	4.6
Sotalol Hydrochloride	12	4.5	4.5
Enoxaparin Sodium	39	4.3	4.3
Valproic Acid	21	4.2	4.2
Conjugated Estrogens	38	4.1	4.1
Simvastatin	158	4.1	4.1
Estrogens, Conjugated	38	4.0	4.0
Eplerenone	8	3.9	3.9
Bleomycin Sulfate	6	3.6	3.6
Risperidone	70	3.3	3.3
Thiotepa	5	3.3	3.3
Alcohol	16	2.6	2.6
Pseudoephedrine Hcl	4	2.3	2.3
Ethyl Alcohol	8	1.8	1.8
Hydrocodone Bitartrate	12	1.7	1.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.