Reaction

Type Iv Hypersensitivity Reaction reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,688 reports · 82 co-occurring drugs

As of the last recalculation, Type Iv Hypersensitivity Reaction appears in 2,688 FAERS reports alongside 82 co-occurring drug terms. The strongest observed disproportionality signal is AMPICILLIN (PRR 97.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Ampicillin	100	97.1	98.2
Ampicillin Sodium	100	97.1	98.2
Cefuroxime	77	53.7	54.0
Clindamycin	142	40.8	41.0
Clindamycin Phosphate	151	37.0	37.2
Rifampin	45	24.3	24.3
Amoxicillin	168	18.1	18.1
Vancomycin	109	15.2	15.2
Vancomycin Hydrochloride	123	15.1	15.1
Cefazolin	17	14.5	14.5
Brentuximab Vedotin	19	14.4	14.5
Meropenem	57	14.0	14.1
Ceftriaxone	51	12.2	12.3
Cefazolin Sodium	18	11.6	11.7
Moxifloxacin	21	11.6	11.6
Ceftriaxone Sodium	56	11.5	11.5
Piperacillin Sodium,Tazobactam Sodium	38	11.2	11.3
Pyrazinamide	13	10.8	10.8
Piperacillin And Tazobactam	17	10.3	10.4
Iohexol	11	10.3	10.3
Desloratadine	14	10.2	10.2
Gentamicin	17	10.1	10.1
Metronidazole Topical	58	9.6	9.6
Cephalexin	26	9.4	9.4
Infliximab	243	9.4	9.4
Gentamicin Sulfate	19	9.4	9.4
Moxifloxacin Hydrochloride	23	8.9	8.9
Rocuronium Bromide	13	8.6	8.6
Rifampicin	11	8.4	8.5
Insulin Glulisine	11	8.4	8.4
Isoniazid	17	8.2	8.2
Canakinumab	11	7.9	7.9
Metronidazole	63	7.8	7.8
Daptomycin	9	7.6	7.6
Anakinra	16	7.5	7.5
Heparin Sodium	13	7.3	7.4
Dalteparin Sodium	10	7.3	7.3
Minocycline	11	7.3	7.3
Norepinephrine	10	7.3	7.3
Piperacillin Sodium And Tazobactam Sodium	18	7.1	7.2
Colchicine	23	6.8	6.8
Leucovorin Calcium	16	6.5	6.5
Amoxicillin And Clavulanate Potassium	22	6.3	6.3
Mercaptopurine	14	6.3	6.3
Amikacin	13	5.9	5.9
Daspone	7	5.6	5.6
Dapsone Gel, 5%	7	5.6	5.6
Clobazam	17	5.4	5.4
Adalimumab-Fkjp	32	5.4	5.4
Norepinephrine Bitartrate	10	5.4	5.4
Mesalamine	38	5.3	5.3
Bendamustine Hydrochloride	8	5.2	5.2
Bendamustine Hcl	10	5.0	5.0
Instalax Polyethylene Glycol 3350	8	5.0	5.0
Triamcinolone Acetonide Ointment Usp, 0.05%	15	5.0	5.0
Polyethylene Glycol 400	8	4.9	4.9
Cefepime	9	4.9	4.9
Diclofenac Sodium 1%	22	4.8	4.8
Diclofenac Sodium Topical	22	4.8	4.8
Diclofenac Sodium Topical Gel, 1%	22	4.8	4.8
Aprepitant	11	4.6	4.6
Lacosamide	22	4.6	4.6
Fosaprepitant Dimeglumine	8	4.5	4.5
Granisetron Hydrochloride	6	4.5	4.5
Granisetron	6	4.4	4.4
Oxaliplatin	35	3.7	3.7
Linezolid	14	3.7	3.7
Paclitaxel (Aibumin-Bound)	36	3.4	3.4
Abiraterone	6	3.4	3.4
Carboplatin	55	3.4	3.4
Pemetrexed	9	3.3	3.3
Docetaxel Anhydrous	27	3.1	3.1
Docetaxel	27	3.1	3.1
Azacitidine For	7	3.0	3.0
Ivacaftor	3	2.9	2.9
Apalutamide	4	2.6	2.6
Olaparib	7	2.6	2.6
Botulinum Toxin Type A	4	2.5	2.5
Pseudoephedrine Hydrochloride	3	2.3	2.3
Pseudoephedrine Hcl	3	2.1	2.1
Abiraterone Acetate	9	1.7	1.7
Galcanezumab-Gnlm	5	1.2	1.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.