Reaction

Cheilitis reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,336 reports · 136 co-occurring drugs

As of the last recalculation, Cheilitis appears in 5,336 FAERS reports alongside 136 co-occurring drug terms. The strongest observed disproportionality signal is ISOTRETINOIN (PRR 42.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Isotretinoin	487	42.2	42.6
Glycerin, Lidocaine	144	41.2	41.6
Docosanol	145	39.6	40.0
Tretinoin	20	9.6	9.7
Crisaborole	22	9.0	9.0
Lapatinib	35	8.9	8.9
Mupirocin Calcium	30	8.6	8.6
Voriconazole	65	8.4	8.5
Mupirocin	29	8.4	8.4
Voriconazole Injection	44	8.0	8.0
Daspone	17	6.8	6.8
Dapsone Gel, 5%	17	6.8	6.8
Dronabinol	13	6.3	6.3
Dapsone	17	6.2	6.2
Panitumumab	24	6.0	6.0
Alpelisib	13	5.8	5.8
Nystatin Ointment	38	5.7	5.7
Nystatin Cream	38	5.7	5.7
Naltrexone Hydrochloride And Bupropion Hydrochloride	12	5.5	5.5
Quinine	12	5.5	5.5
Nystatin	38	5.5	5.5
Terbinafine Hydrochloride	12	5.3	5.3
Lamotrigine	172	5.2	5.2
Capecitabine	117	5.1	5.1
Peginterferon Alfa-2A	69	5.0	5.0
Rifampicin	13	5.0	5.0
Amikacin	21	4.8	4.8
Amoxicillin And Clavulanate Potassium	33	4.8	4.8
Everolimus	61	4.7	4.7
Minocycline	14	4.7	4.7
Cabozantinib	55	4.5	4.5
Cetuximab	35	4.4	4.4
Ursodiol	23	4.1	4.1
Regorafenib	12	4.0	4.0
Ribavirin	65	4.0	4.0
Sorafenib	21	4.0	4.0
Fluticasone Furoate	12	3.9	3.9
Cefuroxime	11	3.8	3.8
Exemestane	20	3.7	3.7
Sunitinib Malate	36	3.6	3.6
Amoxicillin	69	3.6	3.6
Sulfamethoxazole And Trimethoprim	75	3.5	3.5
Clotrimazole	11	3.5	3.5
Trametinib	21	3.4	3.4
Drs. Clotrimazole	10	3.4	3.4
Family Wellness Clotrimazole	10	3.4	3.4
Clotrimazole Topical	10	3.4	3.4
Irinotecan Hydrochloride	11	3.3	3.3
Carbamazepine	56	3.3	3.3
Desloratadine	9	3.3	3.3
Fesoterodine Fumarate	9	3.2	3.2
Rifampin	12	3.2	3.2
Valacyclovir	34	3.2	3.2
Valacyclovir Hydrochloride	57	3.2	3.2
Fluconazole	56	3.1	3.1
Diphenoxylate Hydrochloride And Atropine Sulfate	11	3.1	3.1
Clarithromycin	27	3.1	3.1
Ursosiol	15	3.0	3.0
Doxycycline	52	3.0	3.0
Doxycycline Hyclate	51	3.0	3.0
Oseltamivir	6	2.9	2.9
Mercaptopurine	13	2.9	2.9
Zidovudine	10	2.9	2.9
Erlotinib Hydrochloride	9	2.8	2.8
Ibuprofen Tablets, Coated	30	2.8	2.8
Ceftriaxone Sodium	27	2.8	2.8
Ibuprofen Sodium	30	2.7	2.7
Lamotirigine	50	2.7	2.7
Lamotrigine Extended-Release	50	2.7	2.7
Lamotrigine Chewable Dispersible	50	2.7	2.7
Salmeterol Xinafoate	6	2.7	2.7
Clobetasol Propionate Ointment Usp, 0.05%	7	2.7	2.7
Clobetasol Propionate	7	2.6	2.6
Azelastine	12	2.6	2.6
Vemurafenib	8	2.6	2.6
Oseltamivir Phosphate	16	2.6	2.6
Imatinib Mesylate	18	2.5	2.5
Letrozole	39	2.5	2.5
Loratadine And Pseudoephedrine Sulfate	5	2.5	2.5
Raloxifene Hydrochloride	9	2.4	2.4
Timolol Maleate	6	2.4	2.4
Loratadine Tablet	32	2.3	2.3
Palbociclib	56	2.3	2.3
Acalabrutinib	7	2.3	2.3
Ibrutinib	46	2.2	2.2
Rucaparib	5	2.2	2.2
Multivitamin	28	2.2	2.2
Fluorouracil	43	2.2	2.2
Fluticasone Propionate And Salmeterol	23	2.2	2.2
Raltegravir	9	2.1	2.1
Prochlorperazine Maleate	5	2.1	2.1
Darunavir	8	2.1	2.1
Oxaliplatin	39	2.1	2.1
Erlotinib	5	2.0	2.0
Fluorouracil Cream, 0.5%	39	2.0	2.0
Nicotine Polacrilex	19	1.9	1.9
Pembrolizumab	52	1.9	1.9
Nivolumab	47	1.9	1.9
Axitinib	9	1.8	1.8
Miconazole Nitrate	4	1.8	1.8
Levocetirizine Dihydrochloride	11	1.8	1.8
Sofosbuvir	9	1.8	1.8
Dupilumab	215	1.8	1.8
Pazopanib Hydrochloride	12	1.7	1.7
Trastuzumab	30	1.7	1.7
Osimertinib	14	1.7	1.7
Entecavir	5	1.7	1.7
Dabrafenib	9	1.7	1.7
Umeclidinium Bromide And Vilanterol Trifenatate	7	1.6	1.6
Bevacizumab	51	1.6	1.6
Niraparib	9	1.6	1.6
Pemetrexed Disodium	15	1.5	1.5
Brimonidine Tartrate	7	1.5	1.5
Desvenlafaxine Succinate	10	1.4	1.4
Ixekizumab	13	1.4	1.4
Gefitinib	3	1.3	1.3
Avapritinib	4	1.3	1.3
Bimekizumab	7	1.3	1.3
Mometasone Furoate And Formoterol Fumarate Dihydrate	5	1.3	1.3
Belimumab	10	1.2	1.2
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	13	1.2	1.2
Lenvatinib	10	1.2	1.2
Conjugated Estrogens And Medroxyprogesterone Acetate	7	1.2	1.2
Nirmatrelvir And Ritonavir	15	1.1	1.1
Drospirenone And Ethinyl Estradiol	12	1.1	1.1
Sarilumab	7	1.0	1.0
Varenicline Tartrate	20	1.0	1.0
Benralizumab	5	1.0	1.0
Durvalumab	5	1.0	1.0
Onabotulinumtoxina	17	0.9	0.9
Ledipasvir And Sofosbuvir	4	0.8	0.8
Pirfenidone	8	0.8	0.8
Etonogestrel	7	0.6	0.6
Evolocumab	22	0.5	0.5
Salicylic Acid	3	0.2	0.2
Adapalene	8	0.2	0.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.