Reaction

Gastrointestinal Perforation reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,099 reports · 97 co-occurring drugs

As of the last recalculation, Gastrointestinal Perforation appears in 4,099 FAERS reports alongside 97 co-occurring drug terms. The strongest observed disproportionality signal is BEVACIZUMAB (PRR 60.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Bevacizumab	1,090	60.5	61.1
Lenvatinib	146	23.4	23.5
Oxaliplatin	295	21.7	21.8
Fluorouracil Cream, 0.5%	270	19.2	19.2
Fluorouracil	271	19.0	19.0
Leucovorin Calcium	68	18.4	18.4
Irinotecan Hydrochloride	39	15.5	15.6
Paclitaxel (Aibumin-Bound)	236	15.4	15.5
Paclitaxel	270	14.7	14.8
Regorafenib	33	14.5	14.6
Capecitabine	240	14.1	14.1
Erlotinib	26	13.7	13.7
Polatuzumab Vedotin	26	13.6	13.6
Erlotinib Hydrochloride	31	12.7	12.7
Dexamethasone Sodium Phosphate	21	10.5	10.6
Brentuximab Vedotin	20	10.0	10.0
Pembrolizumab	196	9.9	9.9
Tocilizumab	204	9.5	9.5
Atezolizumab	70	9.3	9.3
Carboplatin	219	9.2	9.2
Sorafenib	37	9.1	9.1
Granisetron Hydrochloride	18	8.8	8.8
Ampicillin	14	8.6	8.6
Ampicillin Sodium	14	8.6	8.6
Cisplatin	121	8.1	8.1
Cetuximab	46	7.5	7.5
Pemetrexed Disodium	55	7.4	7.4
Granisetron	15	7.3	7.3
Panitumumab	22	7.2	7.2
Indomethacin	18	6.9	6.9
Ipilimumab	58	6.9	6.9
Doxorubicin Hydrochloride	43	6.7	6.8
Aprepitant	23	6.4	6.4
Encorafenib	12	6.2	6.2
Gemcitabine	46	6.0	6.0
Hydrocortisone Sodium Succinate	11	6.0	6.0
Fosaprepitant Dimeglumine	16	5.9	5.9
Baricitinib	11	5.8	5.8
Gemcitabine Hydrochloride	59	5.7	5.7
Pemetrexed	24	5.7	5.7
Axicabtagene Ciloleucel	11	5.7	5.7
Temozolomide	22	5.3	5.3
Upadacitinib	83	5.3	5.3
Axitinib	20	5.2	5.2
Magnesium Oxide	42	5.1	5.1
Docetaxel Anhydrous	67	5.1	5.1
Docetaxel	67	5.1	5.1
Nivolumab	94	5.0	5.0
Anakinra	16	4.9	4.9
Pazopanib Hydrochloride	25	4.7	4.7
Canakinumab	10	4.7	4.7
Nintedanib	28	4.6	4.6
Tolvaptan	13	4.6	4.6
Durvalumab	18	4.5	4.5
Prednisolone	154	4.5	4.5
Prednisolone Oral	154	4.5	4.5
Prednisolone Oral Solution	154	4.5	4.5
Isoniazid	14	4.4	4.4
Doxorubicin	75	4.3	4.3
Cabozantinib	40	4.3	4.3
Misoprostol	8	4.2	4.2
Loperamide Hydrochloride Oral	8	4.0	4.0
Piperacillin And Tazobactam	10	4.0	4.0
Itraconazole	9	3.9	3.9
Sunitinib Malate	30	3.9	3.9
Ketoprofen	10	3.9	3.9
Bendamustine Hydrochloride	9	3.8	3.8
Amphetamine	6	3.7	3.7
Piperacillin Sodium And Tazobactam Sodium	14	3.6	3.6
Loperamide Hcl	9	3.6	3.6
Pitavastatin Calcium	7	3.5	3.5
Trifluridine And Tipiracil	7	3.3	3.3
Etoposide	47	3.3	3.3
Crizotinib	8	3.2	3.2
Teduglutide	8	3.0	3.0
Cyclophosphamide Injection, Solution	103	3.0	3.0
Cyclophosphamide	103	3.0	3.0
Cyclophosphamide For Injection	103	3.0	3.0
Pyrazinamide	5	2.7	2.7
Dexamethasone 1.5 Mg	152	2.7	2.7
Dexamethasone	152	2.7	2.7
Fentanyl Citrate	9	2.6	2.6
Imatinib Mesylate	14	2.6	2.6
Tofacitinib Citrate	6	2.3	2.3
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	14	2.3	2.3
Ifosfamide	9	2.1	2.1
Sarilumab	11	2.1	2.1
Tofacitinib	71	2.0	2.0
Suvorexant	5	2.0	2.0
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	3	1.9	1.9
Olaparib	7	1.7	1.7
Dabrafenib	7	1.7	1.7
Gefitinib	3	1.7	1.7
Lapatinib	5	1.6	1.6
Remdesivir	4	1.5	1.5
Methoxy Polyethylene Glycol-Epoetin Beta	3	1.4	1.4
Osimertinib	6	1.0	1.0

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.