Reaction

Periorbital Swelling reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,415 reports · 154 co-occurring drugs

As of the last recalculation, Periorbital Swelling appears in 5,415 FAERS reports alongside 154 co-occurring drug terms. The strongest observed disproportionality signal is AVAPRITINIB (PRR 140.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Avapritinib	410	140.7	145.6
Cenegermin-Bkbj	144	47.0	47.5
Botulinum Toxin Type A	66	20.7	20.8
Lifitegrast	68	16.2	16.3
Carboxymethylcellulose Sodium	28	11.5	11.5
Onabotulinumtoxina	213	11.0	11.0
Dorzolamide Hydrochloride And Timolol Maleate	22	10.7	10.8
Dupilumab	1,047	10.1	10.1
Dimenhydrinate	27	9.8	9.8
Timolol Maleate	22	8.6	8.6
Hydroxyzine Hydrochloride	25	7.3	7.3
Hydroxyzine Hydrochloride Oral	25	7.3	7.3
Prednisolone Acetate	19	7.1	7.1
Triamcinolone Acetonide Ointment Usp, 0.05%	41	6.8	6.8
Cetirizine Hydrochloride Allergy	52	6.7	6.7
Cetirizine Hydrochloride Tablets	52	6.7	6.7
Bimatoprost	48	6.5	6.5
Diphenhydramine Hydrochloride Capsule, Liquid Filled	33	6.0	6.0
Fexofenadine	25	5.8	5.8
Fexofenadine Hcl	14	5.8	5.8
Methylprednisolone Acetate	12	5.8	5.8
Imatinib	25	5.5	5.5
Triamcinolone Acetonide	43	5.4	5.4
Erythromycin	26	5.3	5.4
Moxifloxacin	19	5.2	5.2
Hydroxyzine	63	5.1	5.1
Omalizumab	111	5.1	5.1
Moxifloxacin Hydrochloride	26	4.9	5.0
Polyethylene Glycol 400	16	4.9	4.9
Crisaborole	12	4.8	4.8
Tobramycin Solution	15	4.8	4.8
Ketoconazole Foam	18	4.7	4.7
Ketoconazole Cream, 2%	18	4.7	4.7
Tobramycin Sulfate	15	4.7	4.7
Iohexol	10	4.6	4.6
Brimonidine Tartrate	21	4.5	4.5
Azelastine	21	4.5	4.5
Minoxidil Foam 5% (Womens)	38	4.5	4.5
Instalax Polyethylene Glycol 3350	14	4.3	4.3
Tretinoin	9	4.3	4.3
Ketoconazole	19	4.2	4.2
Cefazolin	10	4.2	4.2
Mometasone	20	4.2	4.2
Ozanimod Hydrochloride	9	4.2	4.2
Minoxidil	48	4.1	4.1
Clobetasol Propionate Ointment Usp, 0.05%	11	4.1	4.1
Clobetasol Propionate	11	4.1	4.1
Fexofenadine Hydrochloride	23	4.1	4.1
Doxyclycline Hyclate	18	4.1	4.1
Cetirizine	81	4.1	4.1
Latanoprost	52	4.0	4.0
Infliximab-Dyyb	30	4.0	4.0
Methimazole	8	3.9	3.9
Cetirizine Hydrochloride	161	3.8	3.8
Vitamin C	89	3.8	3.8
Prochlorperazine Maleate	9	3.8	3.8
Doxepin Hydrochloride	12	3.7	3.7
Nemolizumab-Ilto	12	3.6	3.6
Thyroid, Porcine	10	3.6	3.6
Doxycycline Hyclate	62	3.6	3.6
Zinc Gluconate	24	3.5	3.5
Famotidine	106	3.5	3.5
Montelukast	76	3.5	3.5
Cefazolin Sodium	11	3.5	3.5
Psyllium Husk	9	3.5	3.5
Rabeprazole	20	3.5	3.5
Doxycycline	61	3.5	3.5
Imatinib Mesylate	25	3.5	3.5
Zinc	22	3.4	3.4
Fluticasone Propionate Nasal	27	3.4	3.4
Doxepin	9	3.4	3.4
Zinc Chloride	22	3.4	3.4
Vibegron	7	3.4	3.4
Faricimab	7	3.3	3.3
Salicylic Acid	44	3.2	3.2
Levocetirizine Dihydrochloride	20	3.2	3.2
Timolol	10	3.2	3.2
Calcium, Magnesium, Potassium, And Sodium Oxybates	7	3.1	3.1
Brinzolamide	7	3.1	3.1
Elexacaftor, Tezacaftor, And Ivacaftor	10	3.1	3.1
Siponimod	7	3.0	3.0
Epinephrine	49	2.9	2.9
Abaloparatide	22	2.9	2.9
Cyclosporine	82	2.9	2.9
Fluticasone Furoate	9	2.9	2.9
Mupirocin	10	2.9	2.9
Biotin	23	2.8	2.8
Riociguat	24	2.8	2.8
Dasatinib	27	2.8	2.8
Nitrofurantoin	12	2.8	2.8
Mupirocin Calcium	10	2.8	2.8
Buspirone Hydrochloride	8	2.8	2.8
Adapalene	130	2.8	2.8
Zoledronic Acid	29	2.8	2.8
Atorvastatin Calcium, Film Coated	50	2.8	2.8
Travoprost	6	2.7	2.7
Liothyronine Sodium	6	2.7	2.7
Alpelisib	6	2.6	2.6
Rizatriptan Benzoate	7	2.6	2.6
Entecavir	8	2.6	2.6
Umeclidinium	6	2.6	2.6
Macitentan	46	2.6	2.6
Tobramycin	16	2.6	2.6
Propofol	24	2.5	2.5
Ondansetron Hydrochloride	80	2.5	2.5
Memantine	9	2.5	2.5
Memantine Hydrochloride	9	2.5	2.5
Metoprolol Succinate Er Tablets	39	2.4	2.4
Loratadine Oral	30	2.4	2.4
Loperamide Hydrochloride Oral	6	2.3	2.3
Teduglutide	7	2.0	2.0
Ibuprofen Tablets, Coated	22	2.0	2.0
Ocrelizumab	32	2.0	2.0
Bimekizumab	11	2.0	2.0
Pemetrexed	11	2.0	2.0
Tafamidis	6	2.0	2.0
Selexipag	13	1.9	1.9
Acalabrutinib	6	1.9	1.9
Acetaminophen And Codeine	6	1.9	1.9
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	19	1.8	1.8
Rucaparib	4	1.7	1.7
Romosozumab-Aqqg	6	1.7	1.7
Eptinezumab-Jjmr	4	1.7	1.7
Fremanezumab-Vfrm	5	1.7	1.7
Vilazodone Hydrochloride	4	1.7	1.7
Tadalafil	42	1.6	1.6
Linaclotide	11	1.6	1.6
Upadacitinib	33	1.6	1.6
Rimegepant Sulfate	5	1.5	1.5
Fentanyl Citrate	7	1.5	1.5
Pseudoephedrine Hydrochloride	4	1.5	1.5
Pseudoephedrine Hcl	4	1.4	1.4
Treprostinil	44	1.4	1.4
Benralizumab	7	1.3	1.3
Voclosporin	3	1.3	1.3
Diroximel Fumarate	4	1.3	1.3
Nirmatrelvir And Ritonavir	18	1.3	1.3
Oral Semaglutide	24	1.3	1.3
Risankizumab-Rzaa	26	1.2	1.2
Voxelotor	7	1.2	1.2
Sarilumab	7	1.0	1.0
Sacubitril And Valsartan	30	1.0	1.0
Aflibercept	8	1.0	1.0
Apalutamide	3	1.0	1.0
Ambrisentan	31	1.0	1.0
Ixazomib	7	0.9	0.9
Galcanezumab-Gnlm	7	0.9	0.9
Pomalidomide	22	0.8	0.8
Ixekizumab	7	0.7	0.7
Tirzepatide	29	0.7	0.7
Somatropin	13	0.7	0.7
Evolocumab	28	0.7	0.7
Guselkumab	6	0.6	0.6
Valbenazine	3	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.