Reaction

International Normalised Ratio Decreased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,034 reports · 117 co-occurring drugs

As of the last recalculation, International Normalised Ratio Decreased appears in 4,034 FAERS reports alongside 117 co-occurring drug terms. The strongest observed disproportionality signal is WARFARIN SODIUM (PRR 105.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Warfarin Sodium	767	105.1	106.9
Warfarin	1,368	83.6	84.5
Enoxaparin Sodium	204	19.2	19.3
Digoxin	219	16.6	16.6
Dalteparin Sodium	30	14.7	14.8
Etonogestrel And Ethinyl Estradiol	61	14.4	14.4
Rifampicin	19	9.7	9.7
Dronedarone	19	9.6	9.7
Fondaparinux Sodium	15	9.6	9.6
Enalapril Maleate	43	9.0	9.0
Dofetilide	18	8.9	8.9
Phytonadione	14	8.5	8.6
Sotalol Hydrochloride	27	8.4	8.4
Metolazone	17	7.8	7.8
Primidone	15	7.6	7.6
Pirfenidone	58	7.4	7.5
Standardized Senna Concentrate	16	6.6	6.6
Niacin	14	6.2	6.2
Extended Phenytoin Sodium	20	6.2	6.2
Nitroglycerin	63	6.1	6.1
Furosemide	428	6.0	6.1
Rifampin	17	6.0	6.0
Captopril	11	5.9	5.9
Felodipine Extended-Release Tablets	13	5.9	5.9
Felodipine	13	5.9	5.9
Potassium Chloride, Dextrose Monohydrate	103	5.9	5.9
Potassium Chloride Oral	103	5.9	5.9
Potassium Chloride Extended-Release	103	5.9	5.9
Isosorbide Dinitrate	22	5.8	5.8
Ipratropium Bromide	39	5.7	5.7
Potassium Chloride	122	5.7	5.7
Amlodipine Besylate And Benazepril Hydrochloride	10	5.6	5.6
Ascorbic Acid	25	5.6	5.6
Gemfibrozil	16	5.5	5.5
Docusate Sodium - Sennosides	33	5.3	5.3
Lisinopril And Hydrochlorothiazide Tablets	8	5.3	5.3
Febuxostat	17	5.3	5.3
Psyllium Husk	10	5.2	5.2
Vitamin E	31	5.1	5.1
Bumetanide	26	5.1	5.1
Sucralfate Oral	14	5.1	5.1
Sucralfate Oral Suspension	14	5.1	5.1
Atenolol	127	5.0	5.0
Diltiazem Hydrochloride	33	5.0	5.0
Spironolactone	128	4.8	4.8
Metformin Hcl	51	4.8	4.8
Enalapril	51	4.8	4.8
Ezetimibe And Simvastatin	14	4.8	4.8
Colchicine	24	4.7	4.7
Terbinafine Hydrochloride	8	4.7	4.7
Simvastatin	215	4.6	4.6
Tolterodine Tartrate	8	4.6	4.6
Lisinopril And Hydrochlorothiazide	9	4.6	4.6
Metoprolol Tartrate	221	4.4	4.4
Bosentan	42	4.3	4.3
Docusate Sodium	48	4.3	4.3
Glyburide	20	4.3	4.3
Cholestyramine	10	4.3	4.3
Metoroprolol Tartrate	54	4.3	4.3
Sucralfate	19	4.1	4.1
Metoprolol	195	4.1	4.1
Carvedilol	105	4.1	4.1
Metoprolol Tartrate Injection	145	4.1	4.1
Isosorbide Mononitrate	16	4.0	4.0
Ferrous Sulfate	38	3.9	3.9
Insulin	42	3.9	3.9
Nebivolol	12	3.9	3.9
Butalbital, Acetaminophen, And Caffeine	8	3.9	3.9
Rabeprazole Sodium	20	3.8	3.8
Heparin Sodium	10	3.8	3.8
Sildenafil Powder,	25	3.6	3.6
Eplerenone	9	3.6	3.6
Aspirin 325 Mg	338	3.6	3.6
Aspirin 81 Mg	338	3.6	3.6
Atorvastatin Calcium	168	3.6	3.6
Aspirin	347	3.6	3.6
Finasteride	40	3.4	3.4
Valsartan And Hydrochlorothiazide	9	3.4	3.4
Hydroxyurea	14	3.4	3.4
Metoprolol Succinate Er Tablets	41	3.4	3.4
Sildenafil	37	3.3	3.3
Allopurinol	98	3.3	3.3
Metoprolol Succinate	54	3.2	3.2
Guaifenesin	19	3.2	3.2
Nebivolol Hydrochloride	21	3.2	3.2
Atovaquone	5	3.2	3.2
Ezetimibe	45	3.1	3.1
Tafamidis	7	3.1	3.1
Lovastatin	15	3.0	3.0
Lisinopril	173	3.0	3.0
Thalidomide	21	3.0	3.0
Multivitamin	28	2.9	2.9
Irinotecan Hydrochloride	7	2.8	2.8
Dabigatran Etexilate	41	2.7	2.7
Sildenafil Citrate	64	2.6	2.6
Dorzolamide Hydrochloride And Timolol Maleate	4	2.6	2.6
Inclisiran	4	2.6	2.6
Ruxolitinib	35	2.5	2.5
Pioglitazone	21	2.5	2.5
Treprostinil	59	2.4	2.4
Eculizumab	25	2.4	2.4
Enzalutamide	27	2.4	2.4
Dabigatran Etexilate Mesylate	33	2.4	2.4
Ribavirin	29	2.3	2.3
Sofosbuvir	8	2.1	2.1
Cortisone Acetate	5	2.1	2.1
Patiromer	5	1.9	1.9
Apalutamide	4	1.8	1.8
Rucaparib	3	1.8	1.8
Alteplase	5	1.7	1.7
Ledipasvir And Sofosbuvir	6	1.6	1.6
Sacubitril And Valsartan	32	1.4	1.4
Ambrisentan	30	1.2	1.2
Velpatasvir And Sofosbuvir	3	1.2	1.2
Droxidopa	4	1.0	1.0
Minoxidil Foam 5% (Womens)	5	0.8	0.8
Nirmatrelvir And Ritonavir	8	0.8	0.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.