Reaction

Hyperreflexia reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,454 reports · 163 co-occurring drugs

As of the last recalculation, Hyperreflexia appears in 3,454 FAERS reports alongside 163 co-occurring drug terms. The strongest observed disproportionality signal is LITHIUM (PRR 24.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Lithium	101	24.8	24.9
Lithium Bromatum	101	24.8	24.9
Haloperidol Lactate	99	24.8	24.9
Haloperidol	97	24.7	24.8
Lithium Carbonate	65	23.5	23.6
Venlafaxine	206	18.4	18.4
Phenytoin	57	16.7	16.8
Bupropion	119	16.6	16.7
Paroxetine Hydrochloride Hemihydrate	88	16.3	16.4
Paroxetine	88	16.0	16.0
Quetiapine Fumarate	75	15.6	15.7
Lamotirigine	172	15.2	15.2
Lamotrigine Extended-Release	172	15.2	15.2
Lamotrigine Chewable Dispersible	172	15.2	15.2
Rocuronium Bromide	29	14.9	15.0
Fluoxetine	158	14.9	14.9
Escitslopram	135	14.5	14.5
Propofol	79	13.3	13.3
Escitalopram Oxalate	152	13.1	13.1
Venlafaxine Hydrochloride	245	11.9	12.0
Aripiprazole Oral	80	11.9	11.9
Aripiprazole Orally Disintegrating	80	11.9	11.9
Amphetamine	16	11.7	11.7
Paroxetine Hydrochloride	162	11.2	11.2
Felodipine Extended-Release Tablets	21	11.2	11.2
Felodipine	21	11.2	11.2
Quetiapine	316	10.8	10.8
Duloxetine	120	10.7	10.7
Citalopram Hydrobromide	180	10.6	10.6
Fluoxetine Hydrochloride	212	10.6	10.6
Sevoflurane	14	10.2	10.2
Sertraline	188	10.2	10.2
Sumatriptan Succinate	41	9.9	9.9
Dutasteride	13	9.7	9.7
Lamotrigine	197	9.5	9.5
Citalopram	191	8.8	8.9
Dimenhydrinate	15	8.5	8.5
Pyrazinamide	13	8.4	8.4
Valproate Sodium	28	8.2	8.2
Diphenhydramine Hcl	15	8.1	8.2
Midazolam Hydrochloride	36	8.1	8.1
Midazolam	33	8.0	8.0
Dextrose	17	7.8	7.8
Valproic Acid	40	7.7	7.7
Mirtazapine	114	7.7	7.7
Dextrose Monohydrate	17	7.7	7.7
Escitalopram	171	7.7	7.7
Amitriptyline Hydrochloride	22	7.6	7.6
Olanzapine	130	7.5	7.5
Levodopa	15	7.5	7.5
Metoclopramide	65	7.3	7.3
Efavirenz	13	7.0	7.1
Rabeprazole	25	6.8	6.8
Derma Foam Excel Hand Sanitizer	9	6.8	6.8
Ethanol	9	6.8	6.8
Phenobarbital	16	6.7	6.7
Diazepam Oral Solution (Concentrate)	94	6.5	6.5
Diazepam Oral	94	6.5	6.5
Thiamine Hydrochloride	13	6.3	6.3
Morphine	76	6.3	6.3
Sumatriptan	39	6.2	6.2
Tranexamic Acid	9	6.1	6.1
Metoclopramide Hydrochloride	76	6.0	6.1
Lorazepam	172	6.0	6.0
Isoniazid	16	6.0	6.0
Doxepin	10	6.0	6.0
Primidone	10	5.9	5.9
Prochlorperazine	27	5.9	5.9
Fentanyl	94	5.9	5.9
Clonidine	49	5.8	5.8
Ethyl Alcohol	26	5.8	5.8
Metronidazole Topical	45	5.8	5.8
Doxepin Hydrochloride	12	5.7	5.7
Memantine	13	5.7	5.7
Memantine Hydrochloride	13	5.7	5.7
Sodium Bicarbonate	22	5.7	5.7
Sodium Bicarbonate Injection,	22	5.7	5.7
Duloxetine Hydrochloride	171	5.7	5.7
Diphenhydramine	59	5.7	5.7
Linezolid	28	5.7	5.7
Alcohol	36	5.6	5.6
Baclofen	77	5.5	5.5
Buspirone Hydrochloride	10	5.5	5.5
Diazepam	107	5.4	5.4
Methadone	38	5.4	5.4
Rifampicin	9	5.4	5.4
Aripiprazole	106	5.3	5.4
Propranolol Hydrochloride	63	5.3	5.4
Atomoxetine Hydrochloride	21	5.3	5.3
Lisdexamfetamine Dimesylate	29	5.3	5.3
Meclizine Hcl 12.5Mg	12	5.3	5.3
Meclizine Hcl 25Mg	12	5.3	5.3
Fingolimod Hcl	75	5.3	5.3
Meclizine Hcl 12.5 Mg	12	5.3	5.3
Meclizine Hcl 25 Mg	12	5.3	5.3
Cefazolin	8	5.3	5.3
Hydroxyzine	40	5.1	5.1
Ampicillin	7	5.1	5.1
Ampicillin Sodium	7	5.1	5.1
Carisoprodol	16	5.1	5.1
Isopropyl Alcohol	28	5.0	5.0
Risperidone	108	5.0	5.0
Metronidazole	52	5.0	5.0
Ondansetron Hydrochloride	96	4.8	4.8
Clonazepam	124	4.8	4.8
Bupropion Hydrochloride	76	4.7	4.7
Nevirapine	7	4.7	4.7
Tizanidine Hydrochloride	14	4.7	4.7
Cefepime	11	4.6	4.6
Zidovudine	10	4.5	4.5
Cefepime Hydrochloride	12	4.5	4.5
Ziprasidone	13	4.5	4.5
Sertraline Hydrochloride	86	4.5	4.5
Methylphenidate Hydrochloride	43	4.4	4.4
Fentanyl Citrate	13	4.4	4.4
Meclizine Hydrochloride	14	4.3	4.3
Amantadine	11	4.3	4.3
Ondansetron	76	4.3	4.3
Ondansetron Tablets	76	4.3	4.3
Rizatriptan Benzoate	7	4.2	4.2
Olanzapine Pamoate	28	4.1	4.1
Lamivudine	21	4.1	4.1
Carbamazepine	45	4.1	4.1
Valacyclovir	28	4.1	4.1
Lopinavir And Ritonavir	9	4.0	4.0
Norepinephrine	7	4.0	4.0
Methadone Hydrochloride	7	3.9	3.9
Doxazosin	18	3.9	3.9
Bupivacaine	6	3.9	3.9
Thiotepa	6	3.8	3.8
Interferon Beta-1B	12	3.8	3.8
Piperacillin And Tazobactam	8	3.8	3.8
Loperamide Hcl	8	3.8	3.8
Ceftriaxone	20	3.7	3.7
Oxazepam	13	3.7	3.7
Norepinephrine Bitartrate	8	3.4	3.4
Lamivudine Oral	14	3.3	3.3
Rasagiline Mesylate	6	3.3	3.3
Dabrafenib	11	3.2	3.2
Desvenlafaxine Succinate	14	3.1	3.1
Aprepitant	9	2.9	2.9
Methylphenidate	14	2.9	2.9
Rivastigmine	9	2.9	2.9
Ifosfamide	10	2.8	2.8
Dalfampridine	33	2.8	2.8
Trametinib	11	2.7	2.7
Levetiracetam In Sodium Chloride	35	2.7	2.7
Levetiracetam Oral	35	2.7	2.7
Levetiracetam Injection	35	2.7	2.7
Vortioxetine	7	2.5	2.5
Ocrelizumab	25	2.4	2.4
Paliperidone	9	2.3	2.3
Buprenorphine Hydrochloride, Naloxone Hydrochloride	9	2.3	2.3
Asenapine Maleate	3	2.1	2.1
Cariprazine	3	1.9	1.9
Botulinum Toxin Type A	4	1.9	1.9
Brexpiprazole	5	1.8	1.8
Vigabatrin	4	1.7	1.7
Ofatumumab	9	1.6	1.6
Medroxyprogesterone Acetate	13	1.6	1.6
Dimethyl Fumarate	27	1.3	1.3
Buprenorphine	19	1.2	1.2
Droxidopa	3	0.8	0.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.