Reaction

Feeling Of Despair reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,591 reports · 167 co-occurring drugs

As of the last recalculation, Feeling Of Despair appears in 4,591 FAERS reports alongside 167 co-occurring drug terms. The strongest observed disproportionality signal is PAROXETINE HYDROCHLORIDE HEMIHYDRATE (PRR 15.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Paroxetine Hydrochloride Hemihydrate	113	15.7	15.8
Paroxetine	113	15.4	15.5
Lurasidone Hydrochloride	61	13.4	13.4
Naltrexone	89	13.3	13.4
Paroxetine Hydrochloride	235	12.3	12.3
Mirtazapine	174	8.9	8.9
Amitriptyline Hydrochloride	33	8.6	8.6
Ziprasidone Mesylate	26	8.3	8.3
Ozanimod Hydrochloride	14	7.7	7.7
Lisdexamfetamine Dimesylate	55	7.6	7.6
Fluoxetine	105	7.3	7.3
Clonazepam	241	7.1	7.2
Ziprasidone	27	7.0	7.0
Vortioxetine	26	7.0	7.0
Ribociclib	47	6.8	6.8
Rizatriptan Benzoate	15	6.7	6.7
Diazepam Oral Solution (Concentrate)	126	6.6	6.6
Diazepam Oral	126	6.6	6.6
Bupropion Hydrochloride	135	6.4	6.4
Escitslopram	77	6.1	6.1
Venlafaxine Hydrochloride	171	6.0	6.1
Fluoxetine Hydrochloride	165	6.0	6.1
Nilotinib	39	6.0	6.0
Duloxetine Hydrochloride	236	5.9	6.0
Escitalopram Oxalate	94	5.9	6.0
Diazepam	152	5.8	5.8
Varenicline Tartrate	99	5.7	5.7
Quetiapine Fumarate	36	5.6	5.6
Desloratadine	13	5.5	5.5
Eptinezumab-Jjmr	11	5.5	5.5
Duloxetine	83	5.5	5.5
Phenytoin	25	5.5	5.5
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	42	5.4	5.4
Escitalopram	160	5.3	5.3
Quetiapine	216	5.3	5.3
Desvenlafaxine Succinate	31	5.2	5.2
Trazodone Hydrochloride	18	5.2	5.2
Hydroxyzine Hydrochloride	15	5.2	5.2
Hydroxyzine Hydrochloride Oral	15	5.2	5.2
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	47	5.2	5.2
Esketamine Hydrochloride	20	5.1	5.1
Buprenorphine Hydrochloride, Naloxone Hydrochloride	27	5.1	5.1
Sertraline	125	4.9	4.9
Lithium	27	4.9	4.9
Lithium Bromatum	27	4.9	4.9
Carbamazepine	70	4.8	4.8
Oxcarbazepine	34	4.8	4.8
Captopril	10	4.7	4.7
Lorazepam	181	4.7	4.7
Bupropion	45	4.6	4.6
Buspirone Hydrochloride	11	4.5	4.5
Lamotirigine	70	4.5	4.5
Lamotrigine Extended-Release	70	4.5	4.5
Lamotrigine Chewable Dispersible	70	4.5	4.5
Doxepin	10	4.5	4.5
Anastrozole Tablets	20	4.2	4.2
Sertraline Hydrochloride	107	4.2	4.2
Eltrombopag Olamine	21	4.1	4.1
Amlodipine Besylate And Valsartan	10	4.1	4.1
Lamotrigine	115	4.0	4.0
Tramadol Hydrochloride	33	4.0	4.0
Doxepin Hydrochloride	11	4.0	4.0
Sorafenib	18	3.9	3.9
Vilazodone Hydrochloride	8	3.9	3.9
Brexpiprazole	14	3.8	3.8
Pregabalin	221	3.8	3.8
Peginterferon Beta-1A	11	3.8	3.8
Midazolam Hydrochloride	22	3.7	3.7
Venlafaxine	58	3.7	3.7
Montelukast Sodium	97	3.7	3.7
Cetiirizine	33	3.6	3.6
Quinapril Hydrochloride	6	3.5	3.5
Citalopram	102	3.4	3.4
Vigabatrin	11	3.4	3.4
Methylphenidate Hydrochloride	44	3.4	3.4
Alprazolam	150	3.4	3.4
Hydroxyzine	35	3.3	3.3
Testosterone	17	3.3	3.3
Fexofenadine	12	3.3	3.3
Citalopram Hydrobromide	77	3.3	3.3
Atomoxetine Hydrochloride	17	3.2	3.2
Sumatriptan Succinate	18	3.2	3.2
Montelukast	59	3.2	3.2
Rotigotine	10	3.1	3.1
Divalproex Sodium	32	3.1	3.1
Loratadine Oral	33	3.1	3.1
Aripiprazole	81	3.0	3.0
Losartan	115	3.0	3.0
Brivaracetam	6	3.0	3.0
Dabrafenib	14	3.0	3.0
Ethyl Alcohol	18	3.0	3.0
Anastrozole	24	3.0	3.0
Aripiprazole Oral	26	2.9	2.9
Aripiprazole Orally Disintegrating	26	2.9	2.9
Trametinib	15	2.8	2.8
Fulvestrant	20	2.8	2.8
Letrozole	37	2.7	2.7
Isopropyl Alcohol	20	2.7	2.7
Hydrocodone Bitartrate And Acetaminophen	33	2.7	2.7
Letrozole Tablets	28	2.6	2.6
Dimethyl Fumarate	70	2.6	2.6
Rimegepant Sulfate	7	2.5	2.5
Sumatriptan	21	2.5	2.5
Rasagiline Mesylate	6	2.4	2.4
Cariprazine	5	2.4	2.4
Sildenafil Powder,	19	2.4	2.4
Omalizumab	45	2.4	2.4
Acetaminophen, Aspirin (Nsaid) And Caffeine	9	2.4	2.4
Risperidone	69	2.4	2.4
Armodafinil	11	2.4	2.4
Amantadine	8	2.3	2.3
Eszopiclone	13	2.3	2.3
Levodopa	6	2.3	2.3
Prasugrel Hydrochloride	5	2.2	2.2
Dalfampridine	35	2.2	2.2
Lacosamide	18	2.2	2.2
Amphetamine	4	2.2	2.2
Drospirenone And Ethinyl Estradiol	21	2.2	2.2
Acetaminophen, Aspirin, And Caffeine	10	2.2	2.2
Paliperidone Palmitate	15	2.1	2.1
Isotretinoin	23	2.1	2.1
Teriflunomide	21	2.1	2.1
Alcohol	18	2.1	2.1
Asenapine Maleate	4	2.1	2.1
Etonogestrel And Ethinyl Estradiol	10	2.0	2.0
Dolutegravir Sodium	4	2.0	2.0
Interferon Beta-1A	83	2.0	2.0
Peginterferon Alfa-2A	23	1.9	1.9
Paricalcitol	6	1.9	1.9
Bimekizumab	9	1.9	1.9
Ruxolitinib	30	1.9	1.9
Diroximel Fumarate	5	1.9	1.9
Oxycodone Hydrochloride	88	1.9	1.9
Fingolimod Hcl	34	1.8	1.8
Natalizumab	71	1.8	1.8
Liraglutide	19	1.7	1.7
Budesonide, Glycopyrrolate, And Formoterol Fumarate	4	1.7	1.7
Ribavirin	24	1.7	1.7
Secukinumab	59	1.7	1.7
Interferon Beta-1B	7	1.7	1.7
Naltrexone Hydrochloride And Bupropion Hydrochloride	3	1.6	1.6
Methylphenidate	10	1.6	1.6
Avapritinib	4	1.5	1.5
Risankizumab-Rzaa	26	1.4	1.4
Valbenazine	8	1.4	1.4
Orlistat	8	1.4	1.4
Suvorexant	4	1.4	1.4
Enzalutamide	18	1.4	1.4
Paliperidone	7	1.4	1.4
Pimavanserin Tartrate	16	1.3	1.3
Tapentadol Hydrochloride	9	1.2	1.2
Leuprolide Acetate	20	1.2	1.2
Apalutamide	3	1.2	1.2
Tafamidis	3	1.2	1.2
Abemaciclib	5	1.1	1.1
Buprenorphine	23	1.1	1.1
Sacubitril And Valsartan	26	1.0	1.0
Onabotulinumtoxina	17	1.0	1.0
Guselkumab	7	0.9	0.9
Droxidopa	4	0.8	0.8
Levonorgestrel	37	0.8	0.8
Nirmatrelvir And Ritonavir	9	0.8	0.8
Erenumab-Aooe	9	0.7	0.7
Tirzepatide	26	0.7	0.7
Copper	6	0.6	0.6
Galcanezumab-Gnlm	4	0.6	0.6
Apremilast	18	0.6	0.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.