Reaction

Potentiating Drug Interaction reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,239 reports · 187 co-occurring drugs

As of the last recalculation, Potentiating Drug Interaction appears in 3,239 FAERS reports alongside 187 co-occurring drug terms. The strongest observed disproportionality signal is PEGASPARGASE (PRR 41.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Pegaspargase	77	41.4	41.6
Oxazepam	68	20.7	20.8
Nebivolol	42	17.2	17.2
Clarithromycin	88	16.9	16.9
Trimethoprim	29	15.9	16.0
Indapamide	39	14.1	14.2
Voriconazole Injection	46	13.8	13.8
Terazosin Hydrochloride	18	13.1	13.1
Derma Foam Excel Hand Sanitizer	14	11.3	11.3
Ethanol	14	11.3	11.3
Voriconazole	52	11.2	11.2
Ethyl Alcohol	44	10.5	10.6
Candesartan Cilexetil	42	10.4	10.4
Lithium	39	10.0	10.1
Lithium Bromatum	39	10.0	10.1
Alcohol	59	9.9	9.9
Human Immunoglobulin G	30	9.4	9.4
Gefitinib	12	8.6	8.6
Diazepam Oral Solution (Concentrate)	114	8.5	8.5
Diazepam Oral	114	8.5	8.5
Isopropyl Alcohol	44	8.5	8.5
Haloperidol Lactate	32	8.4	8.4
Nebivolol Hydrochloride	43	8.3	8.3
Labetalol	17	8.2	8.2
Rocuronium Bromide	15	8.2	8.2
Acetylcysteine	12	8.2	8.2
Paroxetine Hydrochloride Hemihydrate	42	8.2	8.2
Gentamicin Sulfate	20	8.2	8.2
Bisoprolol Fumarate	164	8.1	8.1
Captopril	12	8.0	8.1
Paroxetine	42	8.0	8.0
Fentanyl Citrate	22	8.0	8.0
Dutasteride	10	7.9	7.9
Gentamicin	16	7.9	7.9
Aripiprazole Oral	50	7.9	7.9
Aripiprazole Orally Disintegrating	50	7.9	7.9
Warfarin	149	7.9	7.9
Desloratadine	13	7.8	7.8
Amphetamine	10	7.8	7.8
Methadone	51	7.8	7.8
Sevoflurane	10	7.8	7.8
Haloperidol	29	7.7	7.7
Rifampicin	12	7.6	7.7
Diazepam	139	7.6	7.6
Febuxostat Tablets 40 Mg	12	7.6	7.6
Febuxostat Tablets 80 Mg	12	7.6	7.6
Phytonadione	10	7.6	7.6
Temazepam	44	7.6	7.6
Meropenem	37	7.5	7.5
Quetiapine Fumarate	34	7.5	7.5
Ritonavir 100 Mg	17	7.3	7.4
Warfarin Sodium	52	7.3	7.3
Erythromycin	21	7.2	7.2
Donepezil Hydrochloride	40	7.1	7.1
Eplerenone	14	7.1	7.1
Posaconazole Delayed-Release	12	7.0	7.1
Ramipril	127	6.8	6.8
Tacrolimus Ointment 0.1%	127	6.8	6.8
Tacrolimus Extended-Release Capsules	127	6.8	6.8
Iron Sucrose	10	6.8	6.8
Methimazole	8	6.6	6.6
Carbamazepine	67	6.5	6.5
Calcitriol Capsules 0.25 Mcg	20	6.4	6.5
Calcitriol Capsules 0.5 Mcg	20	6.4	6.5
Propofol	36	6.4	6.4
Quetiapine	182	6.4	6.4
Calcitriol	20	6.4	6.4
Rasagiline Mesylate	11	6.4	6.4
Tretinoin	8	6.3	6.4
Amiodarone Hydrochloride	11	6.3	6.3
Amantadine	15	6.3	6.3
Bupropion	42	6.1	6.1
Venlafaxine	67	6.1	6.1
Escitslopram	54	6.1	6.1
Metformin Hydrochloride Tablets	53	6.0	6.0
Metformin Hydrochloride Extended-Release Tablets	53	6.0	6.0
Metformin Hydrochloride Tablet	53	6.0	6.0
Nicotine Polacrilex Mini	14	6.0	6.0
Nicotine Polarilex	14	6.0	6.0
Posaconazole	15	6.0	6.0
Valproate Sodium	19	5.9	5.9
Hydroxyzine Hydrochloride	12	5.9	5.9
Hydroxyzine Hydrochloride Oral	12	5.9	5.9
Mirtazapine	82	5.9	5.9
Ciprofolxacin	64	5.8	5.8
Ciprofloxacin Tablets	64	5.8	5.8
Metformin Hydrochloride	53	5.8	5.8
Escitalopram Oxalate	65	5.8	5.8
Tacrolimus	137	5.8	5.8
Umeclidinium	8	5.8	5.8
Clopidogrel Bisulfate	88	5.7	5.7
Colchicine	23	5.6	5.6
Midazolam	22	5.6	5.6
Insulin Glargine-Yfgn	19	5.6	5.6
Metformin	288	5.6	5.6
Rabeprazole	19	5.5	5.5
Midazolam Hydrochloride	23	5.5	5.5
Irbesartan	38	5.5	5.5
Vincristine Sulfate	25	5.5	5.5
Itraconazole	10	5.5	5.5
Bupivacaine	8	5.5	5.5
Rivastigmine	16	5.5	5.5
Fluoxetine	56	5.5	5.5
Everolimus Tablets	14	5.4	5.4
Fesoterodine Fumarate	9	5.3	5.4
Metformin Er 500 Mg	235	5.3	5.3
Metformin Er 750 Mg	235	5.3	5.3
Glimepiride	32	5.3	5.3
Isosorbide Mononitrate	17	5.3	5.3
Lovastatin	21	5.3	5.3
Digoxin	58	5.3	5.3
Phenytoin	17	5.3	5.3
Citalopram Hydrobromide	84	5.1	5.1
Ezetimibe	57	5.0	5.0
Trazodone Hydrochloride	12	4.9	4.9
Dapagliflozin	24	4.9	4.9
Daptomycin	7	4.9	4.9
Venlafaxine Hydrochloride	98	4.9	4.9
Sulfamethoxazole And Trimethoprim	63	4.9	4.9
Amlodipine	193	4.8	4.8
Goserelin	10	4.8	4.8
Pyrazinamide	7	4.8	4.8
Levodopa	9	4.8	4.8
Valsartan Oral	40	4.8	4.8
Simvastatin	177	4.8	4.8
Valproic Acid	23	4.7	4.7
Levetiracetam In Sodium Chloride	56	4.7	4.7
Levetiracetam Oral	56	4.7	4.7
Levetiracetam Injection	56	4.7	4.7
Sitagliptin	52	4.7	4.7
Atenolol	95	4.7	4.7
Febuxostat	12	4.6	4.6
Oxcarbazepine	23	4.6	4.6
Mercaptopurine	12	4.5	4.5
Phenobarbital	10	4.4	4.4
Rosuvastatin	136	4.4	4.4
Risperidone	89	4.4	4.4
Ketoconazole Foam	10	4.4	4.4
Ketoconazole Cream, 2%	10	4.3	4.3
Clopidogrel	126	4.2	4.2
Rivaroxaban	132	4.2	4.2
Fenofibrate	23	4.2	4.2
Bumetanide	17	4.2	4.2
Olanzapine	68	4.1	4.1
Doxazosin Mesylate	23	4.1	4.1
Pregabalin	167	4.1	4.1
Sertraline	73	4.1	4.1
Desvenlafaxine Succinate	17	4.1	4.1
Velpatasvir And Sofosbuvir	8	4.0	4.0
Ritonavir	18	4.0	4.0
Aripiprazole	72	3.8	3.8
Bicalutamide	9	3.8	3.8
Insulin Glulisine	6	3.8	3.8
Levetiracetam	77	3.8	3.8
Timolol	7	3.7	3.7
Liraglutide	28	3.7	3.7
Dabigatran Etexilate	43	3.6	3.6
Atazanavir	8	3.6	3.6
Bosutinib	5	3.6	3.6
Methadone Hydrochloride	6	3.6	3.6
Nicotine Polacrilex	21	3.5	3.5
Clobazam	13	3.4	3.4
Daratumumab	21	3.4	3.4
Durvalumab	10	3.2	3.2
Dronedarone	5	3.2	3.2
Apixaban	32	3.1	3.1
Ranolazine	5	3.1	3.1
Ticagrelor	15	3.0	3.0
Voclosporin	4	3.0	3.0
Clozapine	54	2.8	2.8
Temozolomide	9	2.7	2.8
Atomoxetine Hydrochloride	10	2.7	2.7
Dabigatran Etexilate Mesylate	30	2.7	2.7
Buprenorphine Hydrochloride, Naloxone Hydrochloride	10	2.7	2.7
Vigabatrin	5	2.2	2.2
Alteplase	5	2.1	2.1
Rimegepant Sulfate	4	2.0	2.0
Ledipasvir And Sofosbuvir	6	2.0	2.0
Brexpiprazole	5	1.9	1.9
Cannabidiol	7	1.9	1.9
Tapentadol Hydrochloride	10	1.9	1.9
Abiraterone	4	1.9	1.9
Buprenorphine	27	1.9	1.9
Olaparib	6	1.8	1.8
Nirmatrelvir And Ritonavir	15	1.8	1.8
Methoxy Polyethylene Glycol-Epoetin Beta	3	1.7	1.7
Relugolix	4	1.1	1.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.