Reaction

Cardiac Dysfunction reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,611 reports · 145 co-occurring drugs

As of the last recalculation, Cardiac Dysfunction appears in 3,611 FAERS reports alongside 145 co-occurring drug terms. The strongest observed disproportionality signal is TRASTUZUMAB (PRR 37.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Trastuzumab	398	37.4	37.7
Sacubitril And Valsartan	524	30.3	30.4
Pertuzumab	134	29.5	29.6
Ado-Trastuzumab Emtansine	22	15.1	15.2
Fam-Trastuzumab Deruxtecan-Nxki	26	15.0	15.0
Doxorubicin	182	12.3	12.4
Osimertinib	66	12.1	12.1
Bleomycin Sulfate	21	11.8	11.8
Paclitaxel (Aibumin-Bound)	156	11.4	11.4
Carfilzomib	51	10.5	10.5
Paclitaxel	160	9.7	9.7
Eplerenone	21	9.5	9.5
Polatuzumab Vedotin	16	9.5	9.5
Norepinephrine	17	9.2	9.2
Norepinephrine Bitartrate	22	8.9	8.9
Encorafenib	15	8.8	8.8
Doxorubicin Hydrochloride	48	8.6	8.6
Febuxostat Tablets 40 Mg	15	8.5	8.5
Febuxostat Tablets 80 Mg	15	8.5	8.5
Tolvaptan	21	8.4	8.4
Cyclophosphamide Injection, Solution	241	8.3	8.3
Cyclophosphamide	241	8.3	8.3
Cyclophosphamide For Injection	241	8.3	8.3
Lenvatinib	44	7.8	7.8
Amiodarone Hydrochloride	15	7.7	7.8
Trametinib	32	7.7	7.7
Pramipexole	20	7.6	7.6
Thiamine Hydrochloride	16	7.4	7.4
Dabrafenib	27	7.4	7.4
Tafamidis	14	6.9	6.9
Colchicine	31	6.8	6.8
Docetaxel Anhydrous	74	6.4	6.4
Docetaxel	74	6.4	6.4
Rocuronium Bromide	13	6.4	6.4
Axitinib	21	6.2	6.3
Spironolactone	146	6.2	6.2
Posaconazole	17	6.1	6.1
Thiotepa	10	6.0	6.1
Ganciclovir Sodium	11	6.0	6.0
Phenobarbital	15	6.0	6.0
Ifosfamide	22	5.9	5.9
Busulfan	16	5.9	5.9
Febuxostat	17	5.9	5.9
Posaconazole Delayed-Release	11	5.8	5.8
Cefepime Hydrochloride	16	5.7	5.8
Haloperidol	24	5.7	5.7
Cytarabine	58	5.6	5.6
Haloperidol Lactate	24	5.6	5.6
Torsemide	32	5.6	5.6
Bendamustine Hcl	15	5.6	5.6
Pembrolizumab	97	5.4	5.4
Cefepime	13	5.2	5.2
Anakinra	15	5.2	5.2
Valganciclovir Hydrochloride Powder,	11	5.2	5.2
Ganciclovir	9	5.1	5.1
Atovaquone	7	5.0	5.0
Agalsidase Beta	8	5.0	5.0
Selexipag	22	4.9	4.9
Enalapril	46	4.8	4.8
Dapagliflozin	26	4.8	4.8
Carvedilol	107	4.7	4.7
Bisoprolol Fumarate	107	4.6	4.7
0Xygen	38	4.5	4.5
Oxygen	38	4.5	4.5
Guanfacine	6	4.4	4.4
Propofol	27	4.3	4.3
Pazopanib Hydrochloride	20	4.3	4.3
Fludarabine Phosphate	28	4.1	4.1
Azacitidine	21	4.1	4.1
Valganciclovir	13	4.0	4.0
Valganciclovir Hydrochloride	13	4.0	4.0
Etoposide	50	4.0	4.0
Metformin Hydrochloride Tablets	39	4.0	4.0
Metformin Hydrochloride Extended-Release Tablets	39	4.0	4.0
Metformin Hydrochloride Tablet	39	4.0	4.0
Brentuximab Vedotin	7	3.9	3.9
Mycophenilic Acid	14	3.9	3.9
Midazolam	17	3.9	3.9
Blinatumomab	7	3.9	3.9
Gefitinib	6	3.8	3.8
Metformin Hydrochloride	39	3.8	3.8
Midazolam Hydrochloride	17	3.7	3.7
Inclisiran	5	3.6	3.6
Erlotinib	6	3.6	3.6
Riociguat	20	3.5	3.6
Macitentan	42	3.5	3.5
Dexamethasone Sodium Phosphate	6	3.4	3.4
Pegaspargase	7	3.3	3.3
Canakinumab	6	3.2	3.2
Prochlorperazine Maleate	5	3.1	3.1
Atezolizumab	21	3.1	3.1
Carboplatin	68	3.1	3.1
Epoprostenol	7	3.1	3.1
Ticagrelor	17	3.1	3.1
Sorafenib	11	3.1	3.1
Remdesivir	7	3.0	3.0
Bevacizumab	64	3.0	3.0
Cladribine	5	3.0	3.0
Empagliflozin	33	2.8	2.8
Insulin Glulisine	5	2.8	2.8
Pitavastatin Calcium	5	2.8	2.8
Iohexol	4	2.8	2.8
Erlotinib Hydrochloride	6	2.8	2.8
Dofetilide	5	2.7	2.7
Oxaliplatin	35	2.7	2.7
Venetoclax	29	2.7	2.7
Gemcitabine Hydrochloride	25	2.7	2.7
Micafungin Sodium	4	2.7	2.7
Gemcitabine	18	2.6	2.6
Fluorouracil Cream, 0.5%	34	2.6	2.6
Fluorouracil	34	2.5	2.5
Azacitidine For	8	2.5	2.5
Memantine	6	2.5	2.5
Memantine Hydrochloride	6	2.5	2.5
Apalutamide	5	2.5	2.5
Brexpiprazole	7	2.4	2.4
Acalabrutinib	5	2.4	2.4
Cisplatin	32	2.4	2.4
Axicabtagene Ciloleucel	4	2.3	2.3
Cabozantinib	19	2.3	2.3
Treprostinil	48	2.2	2.2
Nivolumab	37	2.2	2.2
Ixazomib	11	2.2	2.2
Oseltamivir	3	2.2	2.2
Pemetrexed	8	2.2	2.2
Ipilimumab	16	2.1	2.1
Umeclidinium Bromide And Vilanterol Trifenatate	6	2.1	2.1
Nintedanib	11	2.0	2.0
Selinexor	3	2.0	2.0
Bosutinib	3	1.9	1.9
Clozapine	40	1.8	1.8
Risankizumab-Rzaa	25	1.8	1.8
Durvalumab	6	1.7	1.7
Ranolazine	3	1.7	1.7
Budesonide, Glycopyrrolate, And Formoterol Fumarate	3	1.7	1.7
Daratumumab	11	1.6	1.6
Glecaprevir And Pibrentasvir	3	1.6	1.6
Palivizumab	4	1.5	1.5
Enzalutamide	15	1.5	1.5
Abemaciclib	5	1.4	1.4
Ambrisentan	29	1.3	1.3
Romosozumab-Aqqg	3	1.3	1.3
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	5	0.9	0.9
Pomalidomide	16	0.9	0.9
Pimavanserin Tartrate	5	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.