Reaction

Depressive Symptom reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,468 reports · 180 co-occurring drugs

As of the last recalculation, Depressive Symptom appears in 3,468 FAERS reports alongside 180 co-occurring drug terms. The strongest observed disproportionality signal is ATAZANAVIR (PRR 66.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Atazanavir	153	66.8	67.5
Ritonavir 100 Mg	131	54.7	55.1
Lopinavir And Ritonavir	118	54.1	54.5
Quinapril Hydrochloride	61	47.2	47.6
Raltegravir	120	45.1	45.5
Dimenhydrinate	64	36.7	36.9
Ritonavir	156	33.5	33.7
Theophylline	61	32.4	32.6
Theophylline Anhydrous	63	31.0	31.2
Lamivudine Oral	125	30.7	30.9
Lamivudine	137	27.7	27.8
Diltiazem Hydrochloride Extended-Release Tablets	50	26.7	26.9
Valproic Acid	129	25.5	25.6
Quetiapine Fumarate	115	24.2	24.2
Nitrofurantoin	59	21.8	21.9
Nitrofurantoin (Monohydrate/Macrocrystals)	59	21.5	21.6
Bupropion	152	21.4	21.4
Tenofovir Disoproxil Fumarate Tablets	29	20.3	20.4
Efavirenz	35	19.0	19.1
Valproate Sodium	59	17.4	17.5
Lithium Carbonate	47	16.8	16.9
Tenofovir Disoproxil Fumarate	87	16.2	16.2
Aripiprazole Oral	103	15.4	15.4
Aripiprazole Orally Disintegrating	103	15.4	15.4
Amitriptyline Hydrochloride	44	15.2	15.3
Insulin Degludec	58	15.1	15.1
Citalopram Hydrobromide	245	14.7	14.7
Mometasone	43	14.2	14.3
Vortioxetine	36	12.8	12.8
Isotretinoin	102	12.7	12.7
Escitslopram	119	12.7	12.7
Esketamine Hydrochloride	36	12.2	12.3
Risperidone	244	11.8	11.8
Citalopram	250	11.7	11.8
Escitalopram Oxalate	134	11.4	11.5
Ipratropium Bromide	65	11.1	11.1
Cariprazine	17	11.0	11.0
Lurasidone Hydrochloride	38	11.0	11.0
Quetiapine	315	10.7	10.7
Lithium	43	10.4	10.4
Lithium Bromatum	43	10.4	10.4
Tiotropium Bromide Inhalation Spray	19	10.2	10.2
Sertraline	189	10.2	10.2
Lamotirigine	116	10.0	10.0
Lamotrigine Extended-Release	116	10.0	10.0
Lamotrigine Chewable Dispersible	116	10.0	10.0
Pramipexole	25	9.9	9.9
Mirtazapine	144	9.8	9.8
Lactulose	60	9.5	9.6
Loperamide Hydrochloride Oral	16	9.4	9.5
Diltiazem Hydrochloride	53	9.3	9.3
Rasagiline Mesylate	17	9.2	9.2
Fluoxetine	99	9.1	9.2
Venlafaxine	104	9.0	9.0
Aripiprazole	173	8.9	8.9
Bupropion Hydrochloride	140	8.8	8.8
Clonazepam	219	8.7	8.7
Olanzapine	149	8.7	8.7
Paroxetine Hydrochloride Hemihydrate	47	8.6	8.6
Paliperidone	33	8.6	8.6
Haloperidol	34	8.5	8.5
Paroxetine	47	8.4	8.4
Haloperidol Lactate	34	8.3	8.3
Primidone	14	8.3	8.3
Elexacaftor, Tezacaftor, And Ivacaftor	17	8.2	8.2
Cabotegravir	11	8.2	8.2
Goserelin	18	8.1	8.1
Paroxetine Hydrochloride	117	8.0	8.0
Rifampin	19	7.8	7.9
Fluticasone Propionate And Salmeterol Xinafoate	77	7.8	7.9
Mepolizumab	63	7.7	7.7
Methylprednisolone Acetate	10	7.5	7.5
Loperamide Hcl	16	7.5	7.5
Cyanocobalamin	40	7.4	7.4
Zonisamide	18	7.3	7.3
Escitalopram	162	7.2	7.2
Lamotrigine	152	7.2	7.2
Fluoxetine Hydrochloride	147	7.2	7.2
Mometasone Furoate	47	6.8	6.9
Moxifloxacin	16	6.8	6.9
Abacavir Sulfate	11	6.8	6.8
Azithromycin	45	6.8	6.8
Venlafaxine Hydrochloride	141	6.6	6.6
Nitroglycerin	58	6.6	6.6
Azithromycin Monohydrate	45	6.6	6.6
Moxifloxacin Hydrochloride	22	6.5	6.6
Sumatriptan Succinate	27	6.5	6.5
Ketoprofen	14	6.4	6.4
Duloxetine	72	6.3	6.3
Levetiracetam In Sodium Chloride	78	6.2	6.2
Levetiracetam Oral	78	6.2	6.2
Levetiracetam Injection	78	6.2	6.2
Sertraline Hydrochloride	118	6.2	6.2
Guanfacine	8	6.1	6.1
Lisdexamfetamine Dimesylate	33	6.0	6.1
Dolutegravir Sodium	9	6.0	6.0
Olanzapine Pamoate	39	5.8	5.8
Montelukast	78	5.7	5.7
Suvorexant	12	5.6	5.6
Asenapine Maleate	8	5.6	5.6
Montelukast Sodium	106	5.4	5.4
Doxyclycline Hyclate	15	5.3	5.3
Ivacaftor	7	5.3	5.3
Desvenlafaxine Succinate	23	5.1	5.1
Duloxetine Hydrochloride	155	5.1	5.1
Lubiprostone	8	5.1	5.1
Brexpiprazole	14	5.1	5.1
Methylphenidate Hydrochloride	49	5.0	5.0
Fesoterodine Fumarate	9	5.0	5.0
Metformin Hydrochloride Tablets	47	5.0	5.0
Metformin Hydrochloride Extended-Release Tablets	47	5.0	5.0
Metformin Hydrochloride Tablet	47	5.0	5.0
Azithromycin Dihydrate	48	5.0	5.0
Metformin Hydrochloride	47	4.8	4.8
Diazepam Oral Solution (Concentrate)	70	4.8	4.8
Diazepam Oral	70	4.8	4.8
Ganciclovir	8	4.7	4.7
Cyclobenzaprine Hydrochloride	7	4.7	4.7
Brivaracetam	7	4.7	4.7
Levetiracetam	101	4.6	4.6
Itraconazole	9	4.6	4.6
Sumatriptan	29	4.6	4.6
Atomoxetine Hydrochloride	18	4.6	4.6
Ganciclovir Sodium	8	4.5	4.5
Lacosamide	28	4.5	4.5
Carbamazepine	50	4.5	4.5
Oxcarbazepine	24	4.5	4.5
Teriflunomide	33	4.4	4.4
Instalax Polyethylene Glycol 3350	9	4.4	4.4
Insulin Aspart	47	4.3	4.3
Polyethylene Glycol 400	9	4.3	4.3
Melatonin	38	4.2	4.2
Entecavir	8	4.1	4.1
Donepezil Hydrochloride	25	4.1	4.1
Valbenazine	17	4.1	4.1
Finasteride	40	4.0	4.0
Progesterone	15	3.9	4.0
Ropinirole	10	3.9	3.9
Atorvastatin Calcium, Film Coated	43	3.7	3.7
Ribavirin	39	3.7	3.7
Sildenafil	35	3.7	3.7
Belimumab	19	3.6	3.6
Lumacaftor And Ivacaftor	5	3.5	3.5
Levodopa	7	3.5	3.5
Ethyl Alcohol	14	3.1	3.1
Memantine	7	3.1	3.1
Memantine Hydrochloride	7	3.1	3.1
Ziprasidone	9	3.1	3.1
Methylphenidate	14	2.9	2.9
Rotigotine	7	2.9	2.9
Varenicline Tartrate	38	2.9	2.9
Sofosbuvir	9	2.7	2.7
Clozapine	56	2.7	2.7
Siponimod	4	2.7	2.7
Isopropyl Alcohol	15	2.7	2.7
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	8	2.7	2.7
Oral Semaglutide	32	2.6	2.6
Fremanezumab-Vfrm	5	2.6	2.6
Interferon Beta-1B	8	2.5	2.5
Fingolimod Hcl	35	2.4	2.4
Pertuzumab	11	2.4	2.4
Brimonidine Tartrate	7	2.4	2.4
Peginterferon Alfa-2A	21	2.3	2.3
Alcohol	14	2.2	2.2
Dornase Alfa	7	2.1	2.1
Emtricitabine And Tenofovir Alafenamide	4	2.1	2.1
Apremilast	51	2.1	2.1
Olaparib	7	2.0	2.0
Emtricitabine And Tenofovir Disoproxil Fumarate	15	2.0	2.0
Naltrexone	10	1.9	2.0
Ixazomib	9	1.9	1.9
Drospirenone And Ethinyl Estradiol	12	1.6	1.6
Bimekizumab	5	1.4	1.4
Levonorgestrel	46	1.4	1.4
Paliperidone Palmitate	7	1.3	1.3
Etonogestrel	9	1.1	1.1
Ranitidine Hydrochloride	10	1.1	1.1
Relugolix	4	1.0	1.0
Galcanezumab-Gnlm	5	1.0	1.0
Tirzepatide	18	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.