Reaction

Paranasal Sinus Discomfort reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,718 reports · 206 co-occurring drugs

As of the last recalculation, Paranasal Sinus Discomfort appears in 3,718 FAERS reports alongside 206 co-occurring drug terms. The strongest observed disproportionality signal is MOMETASONE (PRR 19.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Mometasone	64	19.9	19.9
Diltiazem Hydrochloride Extended-Release Tablets	36	17.9	17.9
Diphenhydramine Hydrochloride Capsule, Liquid Filled	56	14.9	14.9
Elexacaftor, Tezacaftor, And Ivacaftor	32	14.5	14.5
Fluticasone Furoate	31	14.4	14.5
Omalizumab	193	13.3	13.3
Dicyclomine Hydrochloride	31	12.3	12.3
Human Immunoglobulin G	42	11.5	11.5
Ado-Trastuzumab Emtansine	17	11.3	11.4
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	40	11.0	11.0
Naproxen Sodium, Pseudoephedrine Hydrochloride	40	11.0	11.0
Doxyclycline Hyclate	33	10.9	11.0
Cyclobenzaprine Hydrochloride	17	10.6	10.7
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	86	9.8	9.8
Zinc Chloride	43	9.8	9.8
Zinc	42	9.6	9.6
Adrenalinum	70	9.6	9.6
Fluticasone Propionate	209	9.5	9.5
Cefuroxime	19	9.3	9.4
Azelastine	29	9.1	9.1
Zinc Gluconate	42	9.1	9.1
Fluticasone Propionate Nasal	48	9.0	9.0
Guaifenesin	47	8.7	8.7
Epinephrine	97	8.5	8.5
Selexipag	38	8.3	8.3
Mometasone Furoate	60	8.2	8.2
Botulinum Toxin Type A	18	8.2	8.2
Hyoscyamine Sulfate	13	7.9	8.0
Mupirocin	19	7.9	7.9
Rosuvastatin Calcium	39	7.8	7.8
Theophylline	16	7.8	7.8
Mupirocin Calcium	19	7.8	7.8
Theophylline Anhydrous	17	7.7	7.7
Ciclesonide	18	7.4	7.4
Fluticasone Propionate And Salmeterol Xinafoate	78	7.4	7.4
Thyroid, Porcine	14	7.4	7.4
Nirmatrelvir And Ritonavir	70	7.4	7.4
Cetirizine Hcl	12	7.3	7.4
Epoprostenol	17	7.3	7.3
Ipratropium Bromide	46	7.3	7.3
0Xygen	63	7.3	7.3
Oxygen	63	7.3	7.3
Diltiazem Hydrochloride	44	7.2	7.2
Benzonatate	21	7.1	7.2
Loratadine And Pseudoephedrine Sulfate	10	7.1	7.1
Montelukast Sodium	148	7.0	7.1
Mepolizumab	61	7.0	7.0
Treprostinil	150	6.9	6.9
Metformin Hydrochloride Tablets	69	6.8	6.9
Metformin Hydrochloride Extended-Release Tablets	69	6.8	6.9
Metformin Hydrochloride Tablet	69	6.8	6.9
Azithromycin	48	6.8	6.8
Metformin Hydrochloride	69	6.6	6.6
Indapamide	21	6.6	6.6
Levocetirizine Dihydrochloride	28	6.6	6.6
Azithromycin Monohydrate	48	6.5	6.5
Cephalexin	25	6.5	6.5
Cenegermin-Bkbj	14	6.5	6.5
Macitentan	78	6.4	6.4
Oxybutynin Chloride	10	6.4	6.4
Cetirizine Hydrochloride Allergy	34	6.3	6.3
Cetirizine Hydrochloride Tablets	34	6.3	6.3
Albuterol Sulfate	310	6.3	6.3
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	33	6.1	6.1
Azithromycin Dihydrate	63	6.1	6.1
Niraparib	24	6.1	6.1
Vilazodone Hydrochloride	10	6.1	6.1
Fenofibrate	38	6.1	6.1
Clobetasol Propionate Ointment Usp, 0.05%	11	6.0	6.0
Clobetasol Propionate	11	6.0	6.0
Budesonide And Formoterol Fumarate Dihydrate	100	5.9	5.9
Triamcinolone Acetonide	32	5.8	5.8
Irbesartan	46	5.8	5.8
Nitrofurantoin	17	5.8	5.8
Infliximab-Dyyb	30	5.8	5.8
Atorvastatin Calcium, Film Coated	71	5.8	5.8
Diphenhydramine	64	5.8	5.8
Nitrofurantoin (Monohydrate/Macrocrystals)	17	5.7	5.7
Pantoprazole Sodium In 0.9% Sodium Chloride	62	5.7	5.7
Pantoprazole Sodium Injection	62	5.7	5.7
Lifitegrast	16	5.5	5.5
Drs. Clotrimazole	11	5.3	5.3
Family Wellness Clotrimazole	11	5.3	5.3
Clotrimazole Topical	11	5.3	5.3
Diphenoxylate Hydrochloride And Atropine Sulfate	13	5.3	5.3
Budesonide	55	5.3	5.3
Loratadine Tablet	50	5.3	5.3
Tadalafil	92	5.2	5.3
Cetirizine Hydrochloride	149	5.2	5.2
Vitamin C	84	5.2	5.2
Magnesium	75	5.2	5.2
Oxycodone And Acetaminophen Tablets	11	5.2	5.2
Sildenafil	52	5.1	5.1
Clotrimazole	11	5.0	5.0
Albuterol	105	5.0	5.0
Sodium Chloride	69	5.0	5.0
Sodium Chloride Tablet	64	4.9	4.9
Sodium Chloride Tablets	64	4.9	4.9
Ambrisentan	107	4.9	4.9
Cetirizine	67	4.9	4.9
Diphenhydramine Hydrochloride	140	4.9	4.9
Biotin	27	4.9	4.9
Dornase Alfa	17	4.9	4.9
Triamcinolone Acetonide Ointment Usp, 0.05%	20	4.8	4.8
Lidocaine	49	4.8	4.8
Clonazepam	131	4.7	4.7
Crisaborole	8	4.7	4.7
Tizanidine Hydrochloride	15	4.7	4.7
Fexofenadine Hydrochloride	18	4.7	4.7
Cyclobenzaprine	41	4.6	4.6
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	29	4.6	4.6
Montelukast	68	4.6	4.6
Calcium, Magnesium, Potassium, And Sodium Oxybates	7	4.6	4.6
Amoxicillin And Clavulanate Potassium	22	4.6	4.6
Fluticasone Furoate And Vilanterol Trifenatate	29	4.5	4.5
Loratadine	85	4.5	4.5
Lidicaine	39	4.5	4.5
Burn Relief	39	4.5	4.5
Lidocaine Hydrochloride And Epinephrine	39	4.5	4.5
Metolazone	9	4.5	4.5
Erythromycin	15	4.5	4.5
Riociguat	26	4.5	4.5
Doxycycline	54	4.5	4.5
Doxycycline Hyclate	53	4.4	4.4
Ergocalciferol	287	4.4	4.4
Sildenafil Powder,	28	4.4	4.4
Methocarbamol Tablets	13	4.4	4.4
Sucralfate Oral	11	4.3	4.3
Sucralfate Oral Suspension	11	4.3	4.3
Mometasone Furoate And Formoterol Fumarate Dihydrate	12	4.3	4.3
Dupilumab	345	4.3	4.3
Ibuprofen Tablets, Coated	32	4.2	4.2
Ibuprofen Sodium	32	4.2	4.2
Sodium Oxybate	49	4.2	4.2
Atovaquone	6	4.2	4.2
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	30	4.1	4.1
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	30	4.1	4.1
Abaloparatide	21	4.0	4.0
Sildenafil Citrate	89	4.0	4.0
Mirabegron	27	3.9	3.9
Lisdexamfetamine Dimesylate	23	3.9	3.9
Ezetimibe	51	3.8	3.8
Hydroxyzine Hydrochloride	9	3.8	3.8
Hydroxyzine Hydrochloride Oral	9	3.8	3.8
Ketoconazole Foam	10	3.8	3.8
Loratadine Oral	33	3.8	3.8
Diclofenac Sodium 1%	24	3.8	3.8
Ketoconazole Cream, 2%	10	3.8	3.8
Diclofenac Sodium Topical	24	3.8	3.8
Diclofenac Sodium Topical Gel, 1%	24	3.8	3.8
Umeclidinium	6	3.8	3.8
Acetaminophen, Aspirin, And Caffeine	14	3.7	3.7
Progesterone	15	3.7	3.7
Acetaminophen, Aspirin (Nsaid) And Caffeine	11	3.6	3.6
Piperacillin Sodium,Tazobactam Sodium	17	3.6	3.6
Alirocumab	16	3.6	3.6
Tizanidine	15	3.5	3.5
Iron Sucrose	6	3.5	3.5
Mesalamine	35	3.5	3.5
Tocilizumab	69	3.4	3.4
Linaclotide	16	3.4	3.4
Pertuzumab	16	3.3	3.3
Pseudoephedrine Hydrochloride	6	3.3	3.3
Lumacaftor And Ivacaftor	5	3.3	3.3
Tobramycin	14	3.3	3.3
Budesonide, Glycopyrrolate, And Formoterol Fumarate	6	3.2	3.2
Rucaparib	5	3.2	3.2
Multivitamin	28	3.1	3.1
Onabotulinumtoxina	43	3.1	3.1
Risankizumab-Rzaa	45	3.1	3.1
Eptinezumab-Jjmr	5	3.1	3.1
Pseudoephedrine Hcl	6	3.1	3.1
Ofatumumab	18	3.0	3.0
Vortioxetine	9	3.0	3.0
Armodafinil	11	2.9	2.9
Ledipasvir And Sofosbuvir	10	2.9	2.9
Oxycodone And Acetaminophen	12	2.9	2.9
Teriflunomide	23	2.9	2.9
Tiotropium Bromide	69	2.9	2.9
Tofacitinib	92	2.8	2.8
Avapritinib	6	2.8	2.8
Pegvaliase-Pqpz	4	2.7	2.7
Rimegepant Sulfate	6	2.7	2.7
Brimonidine Tartrate	8	2.5	2.5
Agalsidase Beta	4	2.4	2.4
Vedolizumab	37	2.4	2.4
Fingolimod Hcl	37	2.4	2.4
Diroximel Fumarate	5	2.4	2.4
Umeclidinium Bromide And Vilanterol Trifenatate	7	2.3	2.3
Ruxolitinib	28	2.2	2.2
Secukinumab	61	2.1	2.1
Bimekizumab	8	2.1	2.1
Ocrelizumab	23	2.1	2.1
Iohexol	3	2.0	2.0
Diclofenac Potassium, Film Coated	3	2.0	2.0
Diclofenac Potassium Tablets	3	2.0	2.0
Benralizumab	7	2.0	2.0
Etanercept	200	1.9	1.9
Ravulizumab	4	1.7	1.7
Olaparib	6	1.6	1.6
Apremilast	41	1.6	1.6
Pirfenidone	10	1.4	1.4
Erenumab-Aooe	13	1.3	1.3
Evolocumab	38	1.3	1.3
Droxidopa	3	0.8	0.8
Etonogestrel	6	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.