Reaction

Immune Reconstitution Inflammatory Syndrome reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,941 reports · 130 co-occurring drugs

As of the last recalculation, Immune Reconstitution Inflammatory Syndrome appears in 4,941 FAERS reports alongside 130 co-occurring drug terms. The strongest observed disproportionality signal is EFAVIRENZ (PRR 155.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Efavirenz	379	155.0	160.5
Lamivudine Oral	700	135.6	139.5
Pyrazinamide	262	124.0	127.6
Lamivudine	762	122.7	125.7
Tenofovir Disoproxil Fumarate Tablets	217	110.7	113.5
Abacavir Sulfate	223	100.9	103.3
Isoniazid	283	78.0	79.4
Zidovudine	234	77.3	78.7
Darunavir	232	67.8	68.8
Raltegravir	251	67.4	68.4
Rifampin	210	63.2	64.2
Dolutegravir Sodium	124	59.4	60.2
Ritonavir 100 Mg	197	57.8	58.6
Amphotericin B	156	54.1	54.8
Rifampicin	118	50.3	50.9
Tenofovir Disoproxil Fumarate	335	45.7	46.2
Nevirapine	87	41.3	41.7
Ritonavir	267	40.6	41.0
Natalizumab	1,182	35.7	35.9
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	130	31.0	31.2
Atovaquone	57	30.2	30.4
Atazanavir	93	27.8	27.9
Emtricitabine And Tenofovir Alafenamide	68	25.6	25.8
Ganciclovir	60	25.0	25.1
Ganciclovir Sodium	60	24.2	24.3
Amikacin	92	23.1	23.3
Moxifloxacin	75	22.8	22.9
Itraconazole	62	22.6	22.8
Valganciclovir Hydrochloride Powder,	63	22.0	22.1
Lopinavir And Ritonavir	66	20.8	20.9
Emtricitabine And Tenofovir Disoproxil Fumarate	209	20.1	20.2
Fluconazole	314	20.1	20.2
Moxifloxacin Hydrochloride	86	18.2	18.2
Valganciclovir	80	18.2	18.2
Valganciclovir Hydrochloride	80	18.2	18.2
Ceftriaxone	113	14.8	14.9
Clarithromycin	118	14.8	14.9
Ceftriaxone Sodium	131	14.8	14.8
Mycophenilic Acid	69	14.2	14.3
Thiotepa	31	13.8	13.8
Alemtuzumab	60	13.2	13.3
Tacrolimus Ointment 0.1%	323	11.6	11.6
Tacrolimus Extended-Release Capsules	323	11.6	11.6
Fludarabine Phosphate	102	11.1	11.2
Fingolimod Hcl	210	10.6	10.7
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	25	10.5	10.5
Anti-Thymocyte Globulin (Rabbit)	20	10.5	10.5
Filgrastim	92	10.5	10.5
Piperacillin And Tazobactam	30	9.9	10.0
Meropenem	73	9.7	9.7
Ampicillin	19	9.7	9.7
Ampicillin Sodium	19	9.7	9.7
Levofloxacin	133	9.5	9.5
Levofloxacin In 5% Dextrose	133	9.5	9.5
Piperacillin Sodium,Tazobactam Sodium	59	9.5	9.5
Mycophenolic Acid	71	9.5	9.5
Tacrolimus	329	9.4	9.4
Azithromycin	85	9.0	9.1
Voriconazole Injection	45	8.8	8.8
Azithromycin Monohydrate	85	8.7	8.7
Linezolid	60	8.6	8.6
Mycophenolate Mofetil	240	7.8	7.8
Mycophenolate Mofetil Hydrochloride	240	7.8	7.8
Adalimumab-Fkjp	83	7.7	7.7
Azithromycin Dihydrate	103	7.5	7.5
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate	16	7.5	7.5
Adalimumab-Aaty	83	7.5	7.5
Vancomycin	101	7.5	7.5
Micafungin Sodium	15	7.5	7.5
Prednisolone	293	7.2	7.2
Prednisolone Oral	293	7.2	7.2
Prednisolone Oral Solution	293	7.2	7.2
Vancomycin Hydrochloride	109	7.1	7.1
Gentamicin	21	6.8	6.8
Adalimumab-Adaz	83	6.7	6.7
Methylprednisolone	212	6.7	6.7
Piperacillin Sodium And Tazobactam Sodium	31	6.7	6.7
Voriconazole	47	6.6	6.6
Melphalan	35	6.5	6.5
Melphalan Hydrochloride	35	5.9	5.9
Gentamicin Sulfate	22	5.9	5.9
Sulfamethoxazole And Trimethoprim	112	5.7	5.7
Busulfan	21	5.6	5.6
Cefuroxime	15	5.5	5.5
Sirolimus	17	5.3	5.3
Cefepime	18	5.3	5.3
Cefepime Hydrochloride	20	5.2	5.3
Bendamustine Hcl	19	5.2	5.2
Anakinra	19	4.8	4.8
Tofacitinib Citrate	15	4.8	4.8
Posaconazole Delayed-Release	12	4.6	4.6
Ciprofolxacin	75	4.5	4.5
Ciprofloxacin Tablets	75	4.5	4.5
Cytarabine	63	4.5	4.5
Hydroxychloroquine	75	4.3	4.3
Glatiramer Acetate	57	4.1	4.1
Mirtazapine	85	4.0	4.0
Daspone	9	3.9	3.9
Dapsone Gel, 5%	9	3.9	3.9
Bleomycin Sulfate	9	3.7	3.7
Ciprofloxacin	77	3.6	3.6
Dapsone	9	3.6	3.6
Ciprofloxacin Hydrochloride	78	3.4	3.4
Baclofen	68	3.4	3.4
Posaconazole	12	3.1	3.1
Imatinib	13	3.1	3.1
Everolimus Tablets	12	3.0	3.0
Doxycycline Hyclate	48	3.0	3.0
Thalidomide	26	3.0	3.0
Doxycycline	47	2.9	2.9
Remdesivir	9	2.8	2.8
Modafinil	21	2.7	2.7
Amantadine	10	2.7	2.7
Ofatumumab	21	2.7	2.7
Leucovorin Calcium	12	2.6	2.6
Cyclophosphamide Injection, Solution	108	2.6	2.6
Cyclophosphamide	108	2.6	2.6
Cyclophosphamide For Injection	108	2.6	2.6
Cladribine	5	2.2	2.2
Doxorubicin Hydrochloride	16	2.1	2.1
Brentuximab Vedotin	5	2.1	2.1
Etoposide	34	2.0	2.0
Doxorubicin	39	1.9	1.9
Abatacept	59	1.8	1.8
Axicabtagene Ciloleucel	4	1.7	1.7
Dalfampridine	27	1.6	1.6
Sofosbuvir	7	1.5	1.5
Dasatinib	12	1.4	1.4
Ledipasvir And Sofosbuvir	5	1.1	1.1
Dimethyl Fumarate	31	1.1	1.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.