Reaction

Leukoencephalopathy reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,693 reports · 139 co-occurring drugs

As of the last recalculation, Leukoencephalopathy appears in 3,693 FAERS reports alongside 139 co-occurring drug terms. The strongest observed disproportionality signal is CYTARABINE (PRR 38.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Cytarabine	369	38.3	38.6
Mercaptopurine	97	32.3	32.5
Thiotepa	53	31.7	31.9
Pegaspargase	62	29.0	29.2
Fludarabine Phosphate	155	23.1	23.2
Methadone Hydrochloride	39	20.5	20.6
Blinatumomab	37	20.2	20.2
Mesna Injection	26	17.9	17.9
Mesna	26	17.5	17.6
Vincristine Sulfate	87	17.1	17.2
Leucovorin Calcium	54	16.1	16.2
Methotrexate Sodium	1,008	15.7	15.7
Ifosfamide	57	15.2	15.2
Gefitinib	22	13.8	13.8
Methotrexate	808	13.6	13.6
Posaconazole Delayed-Release	26	13.4	13.5
Methadone	94	12.7	12.7
Ganciclovir Sodium	23	12.3	12.3
Ganciclovir	22	12.2	12.2
Basiliximab	25	12.1	12.1
Fluorouracil Cream, 0.5%	154	11.8	11.9
Fluorouracil	155	11.7	11.8
Busulfan	31	11.2	11.2
Posaconazole	32	11.2	11.2
Anti-Itch	120	10.4	10.4
Anti-Pruritic	120	10.4	10.4
Antipruritic (Anti-Itch)	120	10.4	10.4
Cool Relief Gel With Aloe	120	10.4	10.4
Drs. Hydrocortisone	120	10.4	10.4
Hydrocortisone Continuous Spray	120	10.4	10.4
Hydrocortisone Spray	120	10.4	10.4
Anti-Itch Cream	120	10.4	10.4
Hydrocortisone Lotion	120	10.4	10.4
Hydrocortisone Cream 1%	120	10.4	10.4
Hydrocortisone Cream 1/2%	120	10.4	10.4
Hydrocortisone 1%	120	10.4	10.4
Hydrocortisone Cream	120	10.3	10.4
Cyclophosphamide Injection, Solution	300	10.3	10.3
Cyclophosphamide	300	10.3	10.3
Cyclophosphamide For Injection	300	10.3	10.3
Hydrocortisone Acetate	126	10.1	10.1
Dexamethasone Sodium Phosphate	17	9.5	9.5
Oxaliplatin	121	9.5	9.5
Etoposide	119	9.4	9.4
Cisplatin	125	9.3	9.3
Melphalan	36	9.0	9.0
Cyclosporine	165	8.7	8.7
Melphalan Hydrochloride	36	8.2	8.2
Hydrocortisone	125	8.1	8.1
Bevacizumab	166	7.9	7.9
Amphetamine	11	7.5	7.5
Capecitabine	118	7.5	7.5
Ado-Trastuzumab Emtansine	11	7.4	7.4
Voriconazole Injection	28	7.3	7.3
Doxorubicin Hydrochloride	41	7.1	7.2
Voriconazole	38	7.1	7.1
Methylprednisolone Acetate	10	7.1	7.1
Abacavir Sulfate	12	7.0	7.0
Tacrolimus	184	6.9	6.9
Daratumumab	47	6.7	6.7
Daspone	11	6.4	6.4
Dapsone Gel, 5%	11	6.4	6.4
Metronidazole Topical	53	6.3	6.4
Fentanyl Citrate	20	6.3	6.3
Sirolimus	15	6.3	6.3
Mycophenolate Mofetil	139	6.0	6.0
Mycophenolate Mofetil Hydrochloride	139	5.9	5.9
Doxorubicin	92	5.9	5.9
Amphotericin B	13	5.9	5.9
Alemtuzumab	20	5.9	5.9
Dapsone	11	5.8	5.8
Itraconazole	12	5.8	5.8
Axicabtagene Ciloleucel	10	5.7	5.7
Irinotecan Hydrochloride	13	5.7	5.7
Tacrolimus Ointment 0.1%	119	5.5	5.5
Tacrolimus Extended-Release Capsules	119	5.5	5.5
Erlotinib Hydrochloride	12	5.4	5.4
Methylprednisolone	129	5.4	5.4
Micafungin Sodium	8	5.3	5.3
Prednisolone	163	5.3	5.3
Prednisolone Oral	163	5.3	5.3
Prednisolone Oral Solution	163	5.3	5.3
Metronidazole	59	5.3	5.3
Pemetrexed Disodium	35	5.2	5.2
Lamivudine Oral	23	5.1	5.2
Lamivudine	28	5.1	5.1
Nevirapine	8	5.0	5.0
Meropenem	27	4.8	4.8
Rituximab	172	4.8	4.8
Fentanyl	81	4.7	4.7
Erlotinib	8	4.7	4.7
Phenytoin	17	4.6	4.6
Temozolomide	17	4.6	4.6
Dexamethasone 1.5 Mg	221	4.5	4.5
Dexamethasone	221	4.4	4.4
Granisetron Hydrochloride	8	4.3	4.3
Piperacillin Sodium And Tazobactam Sodium	15	4.3	4.3
Ceftriaxone	25	4.3	4.3
Sunitinib Malate	29	4.2	4.2
Carboplatin	88	4.0	4.0
Piperacillin And Tazobactam	9	4.0	4.0
Brentuximab Vedotin	7	3.9	3.9
Ceftriaxone Sodium	26	3.8	3.8
Docetaxel Anhydrous	45	3.8	3.8
Docetaxel	45	3.8	3.8
Axitinib	13	3.8	3.8
Propofol	24	3.7	3.7
Bendamustine Hcl	10	3.6	3.6
Piperacillin Sodium,Tazobactam Sodium	17	3.6	3.6
Sorafenib	13	3.5	3.5
Fondaparinux Sodium	5	3.5	3.5
Carfilzomib	17	3.4	3.4
Trastuzumab	41	3.4	3.4
Lopinavir And Ritonavir	8	3.3	3.3
Metoclopramide	32	3.3	3.3
Bendamustine Hydrochloride	7	3.3	3.3
Ethyl Alcohol	15	3.1	3.1
Ritonavir 100 Mg	8	3.0	3.0
Cladribine	5	2.9	2.9
Bortezomib	45	2.9	2.9
Levetiracetam In Sodium Chloride	39	2.9	2.9
Levetiracetam Oral	39	2.9	2.9
Levetiracetam Injection	39	2.9	2.9
Iohexol	4	2.7	2.7
Granisetron	5	2.7	2.7
Isopropyl Alcohol	16	2.7	2.7
Alcohol	18	2.6	2.6
Lenvatinib	15	2.6	2.6
Brivaracetam	4	2.5	2.5
Crizotinib	5	2.2	2.2
Paclitaxel (Aibumin-Bound)	32	2.2	2.2
Paclitaxel	38	2.2	2.2
Derma Foam Excel Hand Sanitizer	3	2.1	2.1
Osimertinib	12	2.1	2.1
Ethanol	3	2.1	2.1
Lapatinib	5	1.8	1.8
Dasatinib	11	1.7	1.7
Pazopanib Hydrochloride	8	1.7	1.7
Pomalidomide	15	0.8	0.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.