OpenPV Signal Explorer
FAERS disproportionality dashboard
Reaction

Localised Oedema reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,571 reports · 140 co-occurring drugs

As of the last recalculation, Localised Oedema appears in 4,571 FAERS reports alongside 140 co-occurring drug terms. The strongest observed disproportionality signal is RIOCIGUAT (PRR 18.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.
DrugCo-reportsPRRROR
Riociguat12718.218.3
Selexipag7513.413.5
Metolazone3213.013.1
Epoprostenol3713.013.0
Treprostinil27810.710.7
Macitentan1147.77.7
Sildenafil Powder,577.47.4
Brentuximab Vedotin167.17.1
Sildenafil897.17.1
Bosentan756.96.9
Ambrisentan1796.86.8
Captopril146.66.7
Torsemide476.56.5
Bisacodyl Suppositories186.46.4
Biscodyl186.36.3
0Xygen676.36.3
Oxygen676.36.3
Tadalafil1306.16.1
Bisacodyl185.85.8
Epoetin Alfa155.85.8
Sotalol Hydrochloride215.85.8
Iron Sucrose125.75.7
Sildenafil Citrate1495.55.5
Itraconazole135.15.1
Spironolactone1434.84.8
Cladribine104.74.7
Amitriptyline Hydrochloride184.74.7
Axicabtagene Ciloleucel104.64.6
Amoxicillin And Clavulanate Potassium274.54.5
Amoxicillin734.44.4
Dalteparin Sodium104.34.3
Avapritinib114.14.1
Lanreotide Acetate74.14.1
Loperamide Hydrochloride And Dimethicone284.04.0
Sumatriptan Succinate224.04.0
Docusate Sodium - Sennosides284.04.0
Bicalutamide133.93.9
Iohexol73.83.9
Irbesartan373.83.8
Furosemide3153.83.8
Iron543.73.7
Diphenoxylate Hydrochloride And Atropine Sulfate113.73.7
Filgrastim303.63.7
Oxybutynin Chloride73.63.6
Ezetimibe And Simvastatin123.63.6
Magnesium Sulfate In Water For103.63.6
Eplerenone103.63.6
Ursosiol153.53.5
Magnesium Sulfate Heptahydrate103.53.5
Magnesium Sulfate103.53.5
Bumetanide203.53.5
Sodium Chloride Tablet543.43.4
Sodium Chloride Tablets543.43.4
Ursodiol163.43.4
Mesna Injection63.33.3
Loperamide Hydrochloride323.33.3
Rifaximin153.33.3
Mesna63.23.2
Durvalumab143.13.1
Doxycycline Hyclate463.13.1
Rocuronium Bromide83.13.1
Sodium Chloride533.13.1
Everolimus Tablets113.03.0
Cetuximab202.92.9
Amlodipine Besylate And Valsartan72.92.9
Crizotinib82.92.9
Allopurinol972.92.9
Trametinib152.82.8
Encorafenib62.82.8
Ifosfamide132.82.8
Ipilimumab262.82.8
Entecavir72.72.7
Vancomycin Hydrochloride392.72.7
Fosaprepitant Dimeglumine82.72.7
Pemetrexed Disodium222.62.6
Sorafenib122.62.6
Brinzolamide52.62.6
Ceftriaxone Sodium222.62.6
Everolimus292.62.6
Docetaxel Anhydrous382.62.6
Docetaxel382.62.6
Sunitinib Malate222.62.6
Methadone232.52.5
Imatinib Mesylate152.52.5
Gemcitabine Hydrochloride282.42.4
Dabrafenib112.42.4
Teduglutide72.42.4
Erlotinib52.42.4
Panitumumab82.32.3
Oseltamivir42.32.3
Vemurafenib62.32.3
Fam-Trastuzumab Deruxtecan-Nxki52.32.3
Paricalcitol72.32.3
Omalizumab422.32.3
Gemcitabine192.22.2
Dexlansoprazole202.22.2
Pertuzumab132.22.2
Sacubitril And Valsartan542.12.1
Pemetrexed102.12.1
Carfilzomib132.12.1
Nintedanib142.02.0
Romosozumab-Aqqg62.02.0
Regorafenib52.02.0
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride131.91.9
Dapagliflozin131.91.9
Carboplatin521.91.9
Darbepoetin Alfa221.91.9
Alteplase61.81.8
Erlotinib Hydrochloride51.81.8
Paclitaxel391.81.8
Nivolumab381.81.8
Lapatinib61.81.8
Azacitidine For71.81.8
Olaparib81.71.7
Azacitidine111.71.7
Peginterferon Alfa-2A201.71.7
Ledipasvir And Sofosbuvir71.71.7
Atezolizumab141.61.6
Sofosbuvir71.61.6
Acetaminophen, Aspirin (Nsaid) And Caffeine61.61.6
Leuprolide Acetate271.61.6
Tolvaptan51.61.6
Apalutamide41.51.5
Siponimod31.51.5
Temozolomide71.51.5
Acetaminophen, Aspirin, And Caffeine71.51.5
Romiplostim51.51.5
Teriparatide371.51.5
Ribavirin211.51.5
Dasatinib121.51.5
Ixazomib91.41.4
Polatuzumab Vedotin31.41.4
Lenvatinib101.41.4
Venetoclax181.31.3
Lutetium Lu 177 Vipivotide Tetraxetan31.01.0
Abiraterone Acetate91.01.0
Palivizumab30.90.9
Cinacalcet Hydrochloride70.70.7
Droxidopa30.60.6
Salicylic Acid30.30.3

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.