Reaction

Non-Cardiac Chest Pain reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,140 reports · 152 co-occurring drugs

As of the last recalculation, Non-Cardiac Chest Pain appears in 3,140 FAERS reports alongside 152 co-occurring drug terms. The strongest observed disproportionality signal is PRASUGREL HYDROCHLORIDE (PRR 15.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Prasugrel Hydrochloride	24	15.8	15.8
Nitroglycerin	82	10.4	10.4
Mesna Injection	11	8.9	8.9
Mesna	11	8.7	8.7
Standardized Senna Concentrate	16	8.5	8.5
Granisetron Hydrochloride	13	8.3	8.3
Granisetron	13	8.2	8.3
Biscodyl	16	8.2	8.2
Amlodipine Besylate And Benazepril Hydrochloride	11	7.9	7.9
Exenatide	61	7.8	7.8
Bisacodyl Suppositories	15	7.7	7.7
Bisacodyl	16	7.6	7.6
Promethazine Hydrochloride	21	7.5	7.5
Gemfibrozil	17	7.5	7.5
Losartan Potassium And Hydrochlorothiazide	13	7.4	7.5
Tolterodine Tartrate	10	7.4	7.4
Polyethylene Glycol	12	7.4	7.4
Aprepitant	20	7.2	7.2
Pegaspargase	13	7.1	7.1
Salmeterol Xinafoate	9	6.9	6.9
Magnesium Hydroxide	14	6.9	6.9
Docusate Sodium - Sennosides	33	6.8	6.9
Metoclopramide	55	6.7	6.7
Docusate Sodium 100Mg	24	6.7	6.7
Dronabinol	8	6.6	6.6
Pemetrexed	21	6.5	6.5
Docusate Sodium	56	6.5	6.5
Hyoscyamine Sulfate	9	6.5	6.5
Metolazone	11	6.5	6.5
Brentuximab Vedotin	10	6.5	6.5
Benzonatate	16	6.4	6.5
Human Insulin	12	6.4	6.4
Bumetanide	25	6.3	6.3
Drospirenone And Ethinyl Estradiol	41	6.2	6.2
Metoclopramide Hydrochloride	71	6.2	6.2
Cimetidine	9	6.2	6.2
Selinexor	8	6.1	6.1
Ezetimibe And Simvastatin	14	6.1	6.1
Timolol Maleate	9	6.0	6.0
Diltiazem Hydrochloride	31	6.0	6.0
Meclizine Hcl 12.5Mg	12	5.9	5.9
Meclizine Hcl 25Mg	12	5.9	5.9
Meclizine Hcl 12.5 Mg	12	5.9	5.9
Meclizine Hcl 25 Mg	12	5.9	5.9
Lisinopril And Hydrochlorothiazide	9	5.9	5.9
Pemetrexed Disodium	33	5.8	5.8
Isosorbide Mononitrate	18	5.8	5.8
Eplerenone	11	5.7	5.7
Apalutamide	10	5.7	5.7
Basiliximab	10	5.7	5.7
Epoprostenol	11	5.6	5.6
Carisoprodol	16	5.6	5.6
Prochlorperazine	23	5.5	5.5
Tizanidine Hydrochloride	15	5.5	5.5
Atezolizumab	32	5.5	5.5
Ibuprofen And Diphenhydramine Citrate	19	5.4	5.4
Abiraterone	11	5.4	5.4
Nicotine Polacrilex Mini	12	5.3	5.3
Nicotine Polarilex	12	5.3	5.3
Niacin	9	5.1	5.2
Isosorbide Dinitrate	15	5.1	5.1
Aspirin 81 Mg	358	5.1	5.1
Pioglitazone	33	5.1	5.1
Aspirin 325 Mg	357	5.1	5.1
Aspirin	372	5.1	5.1
Methocarbamol	17	5.0	5.0
Filgrastim	28	5.0	5.0
Conjugated Estrogens	43	4.9	4.9
Lubiprostone	7	4.9	4.9
Selexipag	19	4.9	4.9
0Xygen	36	4.9	4.9
Oxygen	36	4.9	4.9
Estrogens, Conjugated	43	4.9	4.9
Ipilimumab	31	4.8	4.8
Ondansetron	77	4.8	4.8
Ondansetron Tablets	77	4.8	4.8
Meclizine Hydrochloride	14	4.8	4.8
Azacitidine For	13	4.8	4.8
Metformin Hcl	39	4.7	4.7
Icosapent Ethyl	6	4.7	4.7
Metoroprolol Tartrate	46	4.7	4.7
Trazodone Hydrochloride	11	4.7	4.7
Nivolumab	66	4.6	4.6
Guaifenesin	21	4.6	4.6
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	14	4.5	4.5
Naproxen Sodium, Pseudoephedrine Hydrochloride	14	4.5	4.5
Ondansetron Hydrochloride	80	4.4	4.4
Ticagrelor	21	4.4	4.4
Bendamustine Hcl	10	4.3	4.3
Lisinopril	188	4.3	4.3
Lisinopril And Hydrochlorothiazide Tablets	5	4.2	4.2
Loratadine Tablet	33	4.1	4.1
Clopidogrel	119	4.1	4.1
Raloxifene Hydrochloride	9	4.1	4.1
Obinutuzumab	10	4.0	4.0
Fingolimod Hcl	52	4.0	4.0
Sumatriptan	23	4.0	4.0
Ezetimibe	45	4.0	4.0
Bevacizumab	73	4.0	4.0
Naproxen Sodium Tablet, Coated	8	3.9	3.9
Naproxen Sodium, Coated Tablets	8	3.9	3.9
Naproxen Sodium 220Mg	8	3.9	3.9
Desoximetasone	11	3.8	3.8
Blinatumomab	6	3.8	3.8
Azacitidine	17	3.8	3.8
Macitentan	39	3.8	3.8
Carfilzomib	16	3.8	3.8
Dextrose Monohydrate, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	5	3.8	3.8
Bortezomib	50	3.7	3.8
Glipizide	34	3.7	3.7
Polyethylene Glycol 3350	53	3.7	3.7
Erlotinib Hydrochloride	7	3.7	3.7
Loratadine	59	3.7	3.7
Erlotinib	5	3.4	3.4
Axicabtagene Ciloleucel	5	3.4	3.4
Encorafenib	5	3.4	3.4
Cytarabine	30	3.3	3.3
Carboplatin	62	3.3	3.3
Cisplatin	38	3.3	3.3
Doxorubicin	42	3.2	3.2
Oxycodone And Acetaminophen	11	3.1	3.1
Tadalafil	46	3.1	3.1
Bosentan	23	3.0	3.0
Rucaparib	4	3.0	3.0
Vismodegib	4	3.0	3.0
Ibrutinib	36	3.0	3.0
Paclitaxel	44	3.0	3.0
Ambrisentan	55	3.0	3.0
Venetoclax	27	2.9	2.9
Lenvatinib	14	2.8	2.8
Conjugated Estrogens And Medroxyprogesterone Acetate	10	2.8	2.8
Paclitaxel (Aibumin-Bound)	32	2.6	2.6
Isopropyl Alcohol	13	2.6	2.6
Ranolazine	4	2.5	2.5
Pegfilgrastim	37	2.5	2.5
Loratadine And Pseudoephedrine Sulfate	3	2.5	2.5
Iohexol	3	2.4	2.4
Daratumumab	14	2.3	2.3
Acalabrutinib	4	2.2	2.2
Abiraterone Acetate	13	2.1	2.1
Crizotinib	4	2.1	2.1
Teriparatide	35	2.1	2.1
Ethyl Alcohol	8	2.0	2.0
Treprostinil	36	1.9	1.9
Enzalutamide	16	1.8	1.8
Glatiramer Acetate	16	1.8	1.8
Dornase Alfa	5	1.7	1.7
Alirocumab	6	1.6	1.6
Hydrocodone Bitartrate	10	1.5	1.5
Esketamine Hydrochloride	4	1.5	1.5
Aflibercept	6	1.3	1.3
Pomalidomide	18	1.2	1.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.