Reaction

Procedural Complication reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,614 reports · 181 co-occurring drugs

As of the last recalculation, Procedural Complication appears in 7,614 FAERS reports alongside 181 co-occurring drug terms. The strongest observed disproportionality signal is SEVOFLURANE (PRR 22.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Sevoflurane	67	22.2	22.4
Propofol	181	13.8	13.9
Bupivacaine	39	11.5	11.5
Rocuronium Bromide	45	10.5	10.5
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	94	8.4	8.4
Cefazolin	27	8.1	8.1
Heparin Sodium	39	7.8	7.8
Atropine Sulfate	30	7.6	7.6
Cefazolin Sodium	30	6.8	6.8
Midazolam Hydrochloride	62	6.3	6.4
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	18	6.0	6.0
Atropine	18	6.0	6.0
Calcium Gluconate	23	5.2	5.2
Fentanyl Citrate	34	5.2	5.2
Midazolam	47	5.1	5.1
Lidocaine Hydrochloride	105	4.8	4.8
Peginterferon Alfa-2A	94	4.8	4.8
Lidocaine Hydrochloride And Epinephrine Bitartrate	92	4.8	4.8
Meperidine Hydrochloride	15	4.5	4.5
Adalimumab	1,026	4.4	4.4
0Xygen	75	4.2	4.2
Oxygen	75	4.2	4.2
Fentanyl	148	4.2	4.2
Lidicaine	72	4.1	4.1
Burn Relief	72	4.1	4.1
Lidocaine Hydrochloride And Epinephrine	72	4.0	4.0
Lidocaine, Menthol	72	4.0	4.0
Lidocaine 4%	78	3.9	3.9
Epoetin Alfa	17	3.9	3.9
Cefuroxime	16	3.8	3.8
Lidocaine	79	3.7	3.7
Tolterodine Tartrate	12	3.7	3.7
Diphenhydramine Hydrochloride Capsule, Liquid Filled	28	3.6	3.6
Zinc	32	3.6	3.6
Zinc Chloride	32	3.5	3.5
Zinc Gluconate	33	3.5	3.5
Valsartan And Hydrochlorothiazide	17	3.4	3.4
Epoprostenol	15	3.1	3.1
Captopril	11	3.1	3.1
Lovastatin	29	3.1	3.1
Human Immunoglobulin G	23	3.1	3.1
Fexofenadine Hcl	10	3.0	3.0
Phytonadione	9	2.9	2.9
Riociguat	34	2.9	2.9
Interferon Beta-1A	198	2.8	2.9
Timolol Maleate	10	2.8	2.8
Dicyclomine Hydrochloride	14	2.7	2.7
Indomethacin	13	2.7	2.7
Bosentan	49	2.7	2.7
Norepinephrine Bitartrate	14	2.7	2.7
Teduglutide	13	2.6	2.6
Morphine	71	2.6	2.6
Ribavirin	60	2.6	2.6
Selexipag	24	2.5	2.5
Levonorgestrel	184	2.5	2.5
Misoprostol	9	2.5	2.5
Adrenalinum	38	2.5	2.5
Octreotide Acetate	28	2.5	2.5
Palivizumab	14	2.5	2.5
Paliperidone Palmitate	29	2.5	2.5
Insulin	50	2.5	2.5
Testosterone	21	2.5	2.5
Insulin Human	35	2.4	2.4
Sildenafil Powder,	31	2.4	2.4
Isosorbide Dinitrate	17	2.4	2.4
Anti-Thymocyte Globulin (Rabbit)	7	2.4	2.4
Celecoxib	113	2.4	2.4
Vitamin E	27	2.4	2.4
Enoxaparin Sodium	49	2.3	2.3
Paricalcitol	12	2.3	2.3
Enalapril Maleate	21	2.3	2.3
Naltrexone	26	2.3	2.3
Norepinephrine	9	2.3	2.3
Nitroglycerin	45	2.3	2.3
Risperidone	111	2.3	2.3
Pancrelipase	32	2.3	2.3
Tizanidine Hydrochloride	15	2.3	2.3
Enalapril	46	2.3	2.3
Risankizumab-Rzaa	67	2.3	2.3
Baclofen	69	2.2	2.2
Amiodarone Hydrochloride	9	2.2	2.2
Magnesium Sulfate In Water For	10	2.1	2.1
Digoxin	56	2.1	2.1
Interferon Beta-1B	15	2.1	2.1
Macitentan	54	2.1	2.1
Sildenafil	45	2.1	2.1
Magnesium Sulfate Heptahydrate	10	2.1	2.1
Magnesium Sulfate	10	2.1	2.1
Clopidogrel	150	2.1	2.1
Amlodipine Besylate And Benazepril Hydrochloride	7	2.1	2.1
Agalsidase Beta	7	2.1	2.1
Mercaptopurine	13	2.1	2.1
Folic Acid	184	2.0	2.0
Fondaparinux Sodium	6	2.0	2.0
Carisoprodol	14	2.0	2.0
Alteplase	11	2.0	2.0
Extended Phenytoin Sodium	12	2.0	2.0
Lithium Carbonate	12	1.9	1.9
Sodium Chloride	55	1.9	1.9
Calcium, Magnesium, Potassium, And Sodium Oxybates	6	1.9	1.9
Warfarin Sodium	32	1.9	1.9
Prasugrel Hydrochloride	7	1.9	1.9
Valsartan	72	1.9	1.9
Hydroxyzine Hydrochloride	9	1.9	1.9
Hydroxyzine Hydrochloride Oral	9	1.9	1.9
Sodium Chloride Tablet	50	1.9	1.9
Sodium Chloride Tablets	50	1.9	1.9
Ranibizumab	18	1.9	1.9
Upadacitinib	55	1.9	1.9
Vancomycin	39	1.8	1.8
Tranexamic Acid	6	1.8	1.8
Epinephrine	44	1.8	1.8
Ranolazine	7	1.8	1.8
Leuprolide Acetate	51	1.8	1.8
Cetirizine Hcl	6	1.8	1.8
Aspirin 325 Mg	326	1.8	1.8
Aspirin 81 Mg	326	1.8	1.8
Nintedanib	20	1.7	1.7
Erythropoietin	13	1.7	1.7
Temozolomide	13	1.7	1.7
Carbidopa And Levodopa	29	1.7	1.7
Aflibercept	19	1.7	1.7
Teriparatide	67	1.6	1.6
Vancomycin Hydrochloride	39	1.6	1.6
Treprostinil	74	1.6	1.6
Naproxen Sodium Tablet, Coated	8	1.6	1.6
Naproxen Sodium, Coated Tablets	8	1.6	1.6
Estrogens, Conjugated	35	1.6	1.6
Naproxen Sodium 220Mg	8	1.6	1.6
Atorvastatin Calcium, Film Coated	41	1.6	1.6
Vedolizumab	50	1.6	1.6
Dabigatran Etexilate Mesylate	42	1.6	1.6
Avapritinib	7	1.6	1.6
Dabigatran Etexilate	44	1.6	1.6
Sildenafil Citrate	72	1.6	1.6
Dextrose Monohydrate, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	5	1.5	1.5
Glipizide	34	1.5	1.5
Vigabatrin	8	1.5	1.5
Cytarabine	32	1.5	1.5
Cisplatin	41	1.4	1.4
Etoposide	38	1.4	1.4
Entecavir	6	1.4	1.4
Ivacaftor	4	1.4	1.4
Tadalafil	49	1.3	1.3
Iohexol	4	1.3	1.3
Vincristine Sulfate	14	1.3	1.3
Methoxy Polyethylene Glycol-Epoetin Beta	5	1.2	1.2
Panitumumab	7	1.2	1.2
Ravulizumab	6	1.2	1.2
Emtricitabine And Tenofovir Alafenamide	5	1.2	1.2
Abiraterone	6	1.2	1.2
Natalizumab	78	1.2	1.2
Rifaximin	9	1.2	1.2
Insulin Degludec	10	1.2	1.2
Belimumab	13	1.1	1.1
Ibrutinib	32	1.1	1.1
Guselkumab	14	1.1	1.1
Ustekinumab	40	1.1	1.1
Insulin Lispro	53	1.0	1.0
Dofetilide	4	1.0	1.0
Acetaminophen, Aspirin, And Caffeine	8	1.0	1.0
Deferasirox	10	1.0	1.0
Ambrisentan	47	1.0	1.0
Romosozumab-Aqqg	5	1.0	1.0
Acetaminophen, Aspirin (Nsaid) And Caffeine	6	1.0	1.0
Sevelamer Carbonate	4	1.0	1.0
Tafamidis	4	0.9	0.9
Esketamine Hydrochloride	6	0.9	0.9
Pazopanib Hydrochloride	9	0.9	0.9
Elexacaftor, Tezacaftor, And Ivacaftor	4	0.9	0.9
Abiraterone Acetate	13	0.9	0.9
Onabotulinumtoxina	24	0.8	0.8
Drospirenone And Ethinyl Estradiol	13	0.8	0.8
Pseudoephedrine Hcl	3	0.7	0.7
Diroximel Fumarate	3	0.7	0.7
Etonogestrel	12	0.7	0.7
Emicizumab	3	0.7	0.7
Ranitidine Hydrochloride	13	0.7	0.7
Erenumab-Aooe	9	0.4	0.4
Cinacalcet Hydrochloride	6	0.4	0.4
Copper	4	0.3	0.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.