Reaction

Which drugs are most reported with Nasal discomfort?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,863 reports · 190 co-occurring drugs

As of the last recalculation, Nasal Discomfort appears in 7,863 FAERS reports alongside 190 co-occurring drug terms. The strongest observed disproportionality signal is ACETAMINOPHEN, CHLORPHENIRAMINE MALEATE, PHENYLEPHRINE HCL (PRR 21.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	384	21.3	21.5
Fluticasone Furoate	83	18.3	18.4
Fluticasone Propionate	776	17.4	17.5
Fluticasone Propionate Nasal	156	13.9	13.9
Esketamine Hydrochloride	72	10.8	10.8
Mometasone Furoate	159	10.3	10.3
Azelastine	66	9.8	9.8
Triamcinolone Acetonide	102	8.8	8.9
Mupirocin	37	7.3	7.3
Mupirocin Calcium	37	7.2	7.2
Lifitegrast	36	5.9	5.9
Cenegermin-Bkbj	26	5.7	5.7
Dicyclomine Hydrochloride	30	5.6	5.6
0Xygen	94	5.1	5.1
Oxygen	94	5.1	5.1
Sumatriptan	69	4.8	4.8
Mometasone	33	4.8	4.8
Desloratadine	19	4.7	4.7
Loratadine And Pseudoephedrine Sulfate	14	4.7	4.7
Fexofenadine Hcl	15	4.3	4.3
Epoprostenol	20	4.1	4.1
Thyroid, Porcine	16	4.0	4.0
Levodopa	18	3.9	4.0
Carboxymethylcellulose Sodium	14	3.9	4.0
Loratadine Tablet	79	3.9	3.9
Sunitinib Malate	58	3.9	3.9
Desoximetasone	28	3.9	3.9
Nicotine	58	3.8	3.8
Butalbital, Acetaminophen, And Caffeine	15	3.7	3.7
Gentamicin	18	3.6	3.7
Fexofenadine Hydrochloride	28	3.4	3.4
Loratadine	134	3.3	3.3
Levocetirizine Dihydrochloride	30	3.3	3.3
Montelukast Sodium	148	3.3	3.3
Psyllium Husk	12	3.2	3.2
Anastrozole Tablets	25	3.1	3.1
Guaifenesin	35	3.0	3.0
Oxybutynin Chloride	10	3.0	3.0
Gentamicin Sulfate	18	3.0	3.0
Dorzolamide Hydrochloride And Timolol Maleate	9	3.0	3.0
Umeclidinium	10	3.0	3.0
Timolol Maleate	11	2.9	2.9
Ipratropium Bromide	39	2.9	2.9
Budesonide	63	2.8	2.8
Epinephrine	69	2.8	2.8
Sucralfate Oral	15	2.8	2.8
Sucralfate Oral Suspension	15	2.8	2.8
Zinc Chloride	26	2.8	2.8
Zinc Gluconate	27	2.7	2.7
Pertuzumab	28	2.7	2.7
Benzonatate	17	2.7	2.7
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	21	2.7	2.7
Loratadine Oral	50	2.7	2.7
Naproxen Sodium, Pseudoephedrine Hydrochloride	21	2.7	2.7
Budesonide And Formoterol Fumarate Dihydrate	98	2.7	2.7
Zinc	25	2.7	2.7
Riociguat	33	2.7	2.7
Cyclobenzaprine Hydrochloride	9	2.7	2.7
Fenofibrate	35	2.6	2.6
Testosterone	23	2.6	2.6
Fexofenadine	16	2.6	2.6
Botulinum Toxin Type A	12	2.6	2.6
Sucralfate	23	2.5	2.5
Sildenafil	55	2.5	2.5
Treprostinil	117	2.5	2.5
Azithromycin Dihydrate	53	2.4	2.4
Buspirone Hydrochloride	10	2.4	2.4
Mometasone Furoate And Formoterol Fumarate Dihydrate	14	2.4	2.4
Tiotropium Bromide Inhalation Spray	10	2.4	2.4
Cetirizine Hydrochloride	144	2.3	2.3
Doxyclycline Hyclate	15	2.3	2.3
Cabozantinib	42	2.3	2.3
Azithromycin	35	2.3	2.3
Multivitamin	43	2.3	2.3
Omalizumab	73	2.3	2.3
Magnesium	70	2.3	2.3
Selexipag	22	2.3	2.3
Azithromycin Monohydrate	35	2.2	2.2
Oxycodone And Acetaminophen Tablets	10	2.2	2.2
Ibuprofen Tablets, Coated	35	2.2	2.2
Lovastatin	21	2.2	2.2
Anastrozole	30	2.2	2.2
Ibuprofen Sodium	35	2.2	2.2
Montelukast	68	2.2	2.2
Vitamin C	74	2.1	2.1
Liothyronine Sodium	7	2.1	2.1
Biotin	25	2.1	2.1
Fish Oil	72	2.1	2.1
Latanoprost	40	2.1	2.1
Ezetimibe	59	2.1	2.1
Nitrofurantoin	13	2.1	2.1
Drs. Clotrimazole	9	2.1	2.1
Family Wellness Clotrimazole	9	2.1	2.1
Clotrimazole Topical	9	2.1	2.1
Nitrofurantoin (Monohydrate/Macrocrystals)	13	2.1	2.1
Amantadine	12	2.1	2.1
Triamcinolone Acetonide Ointment Usp, 0.05%	18	2.0	2.0
Eptinezumab-Jjmr	7	2.0	2.0
Fulvestrant	25	2.0	2.0
Ergocalciferol	286	2.0	2.0
Naproxen Sodium Tablet	40	2.0	2.0
Estradiol Gel 0.1%	34	2.0	2.0
Estradiol Transdermal	34	2.0	2.0
Tadalafil	75	2.0	2.0
Mepolizumab	37	2.0	2.0
Lubiprostone	7	2.0	2.0
Irbesartan	33	2.0	2.0
Sildenafil Powder,	26	1.9	1.9
Metoclopramide Hydrochloride	56	1.9	1.9
Ambrisentan	90	1.9	1.9
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	115	1.9	1.9
Iohexol	6	1.9	1.9
Niraparib	16	1.9	1.9
Fluticasone Propionate And Salmeterol	30	1.9	1.9
Palbociclib	68	1.9	1.9
Atenolol	93	1.9	1.9
Alpelisib	6	1.8	1.8
Letrozole Tablets	33	1.8	1.8
Estradiol	59	1.8	1.8
Letrozole	42	1.8	1.8
Macitentan	47	1.8	1.8
Terbinafine Hydrochloride	6	1.8	1.8
Brimonidine Tartrate	12	1.8	1.8
Finasteride	40	1.8	1.8
Sildenafil Citrate	83	1.7	1.7
Exemestane	14	1.7	1.7
Fesoterodine Fumarate	7	1.7	1.7
Lapatinib	10	1.7	1.7
Dalfampridine	46	1.7	1.7
Secukinumab	103	1.7	1.7
Sumatriptan Succinate	16	1.7	1.7
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	22	1.7	1.7
Axitinib	12	1.6	1.6
Nirmatrelvir And Ritonavir	33	1.6	1.6
Nintedanib	19	1.6	1.6
Alirocumab	15	1.6	1.6
Losartan	102	1.6	1.6
Fluticasone Furoate And Vilanterol Trifenatate	21	1.5	1.5
Timolol	7	1.5	1.5
Budesonide, Glycopyrrolate, And Formoterol Fumarate	6	1.5	1.5
Trastuzumab	39	1.5	1.5
Testosterone Cypionate	5	1.5	1.5
Gefitinib	5	1.5	1.5
Tiotropium Bromide	75	1.5	1.5
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	22	1.4	1.4
Sorafenib	11	1.4	1.4
Acetaminophen, Aspirin (Nsaid) And Caffeine	9	1.4	1.4
Acetaminophen, Aspirin, And Caffeine	11	1.4	1.4
Panitumumab	8	1.4	1.4
Mirabegron	19	1.3	1.3
Rimegepant Sulfate	6	1.3	1.3
Travoprost	4	1.2	1.2
Atomoxetine Hydrochloride	11	1.2	1.2
Rucaparib	4	1.2	1.2
Tofacitinib	82	1.2	1.2
Brivaracetam	4	1.2	1.2
Fremanezumab-Vfrm	5	1.2	1.2
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	18	1.2	1.2
Vilazodone Hydrochloride	4	1.1	1.1
Oxycodone And Acetaminophen	10	1.1	1.1
Sodium Oxybate	28	1.1	1.1
Orlistat	11	1.1	1.1
Umeclidinium Bromide And Vilanterol Trifenatate	7	1.1	1.1
Nicotine Polacrilex	16	1.1	1.1
Docetaxel Anhydrous	27	1.1	1.1
Docetaxel	27	1.1	1.1
Abemaciclib	8	1.1	1.1
Bimatoprost	11	1.0	1.0
Vibegron	3	1.0	1.0
Diclofenac Potassium	4	1.0	1.0
Pseudoephedrine Hcl	4	1.0	1.0
Onabotulinumtoxina	28	1.0	1.0
Cenobamate	3	1.0	1.0
Ixekizumab	13	0.9	0.9
Cetuximab	11	0.9	0.9
Etanercept	207	0.9	0.9
Teriparatide	37	0.9	0.9
Cariprazine	3	0.9	0.9
Elexacaftor, Tezacaftor, And Ivacaftor	4	0.8	0.8
Peginterferon Alfa-2A	17	0.8	0.8
Sarilumab	8	0.8	0.8
Benralizumab	6	0.8	0.8
Pirfenidone	12	0.8	0.8
Dupilumab	128	0.7	0.7
Evolocumab	40	0.7	0.7
Minoxidil	10	0.6	0.6
Dimethyl Fumarate	27	0.6	0.6
Minoxidil Foam 5% (Womens)	7	0.6	0.6
Galcanezumab-Gnlm	6	0.5	0.5
Apremilast	23	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.