Reaction

Osteolysis reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,024 reports · 117 co-occurring drugs

As of the last recalculation, Osteolysis appears in 2,024 FAERS reports alongside 117 co-occurring drug terms. The strongest observed disproportionality signal is CHLORHEXIDINE GLUCONATE (PRR 48.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Chlorhexidine Gluconate	42	48.2	48.5
Melphalan	90	42.5	42.7
Melphalan Hydrochloride	94	40.4	40.5
Zoledronic Acid	135	37.0	37.1
Goserelin	47	36.8	37.0
Desoximetasone	65	36.2	36.3
Fulvestrant	107	35.1	35.2
Exemestane	60	29.7	29.7
Daratumumab	108	29.3	29.4
Carfilzomib	73	27.5	27.6
Bortezomib	198	25.1	25.2
Ribociclib	73	24.6	24.7
Thalidomide	81	23.6	23.6
Letrozole	127	22.6	22.6
Anastrozole	74	21.5	21.5
Anastrozole Tablets	41	20.0	20.1
Meperidine Hydrochloride	17	19.1	19.2
Clindamycin	50	18.5	18.6
Clindamycin Phosphate	57	18.0	18.1
Bicalutamide	25	17.1	17.1
Letrozole Tablets	76	16.8	16.9
Dexamethasone 1.5 Mg	392	16.8	16.8
Erythropoietin	33	16.8	16.8
Dexamethasone	392	16.6	16.6
Pyrazinamide	15	16.5	16.6
Filgrastim	52	14.6	14.6
Dexamethasone Sodium Phosphate	14	14.3	14.3
Febuxostat Tablets 40 Mg	14	14.2	14.3
Febuxostat Tablets 80 Mg	14	14.2	14.3
Epoetin Alfa	16	14.0	14.0
Amoxicillin And Clavulanate Potassium	34	13.1	13.1
Docusate Sodium - Sennosides	40	13.0	13.0
Cimetidine	12	12.9	12.9
Doxorubicin Hydrochloride	40	12.8	12.8
Canagliflozin	34	11.9	11.9
Nystatin Ointment	29	11.5	11.5
Nystatin Cream	29	11.5	11.5
Nystatin	30	11.4	11.4
Diphenoxylate Hydrochloride And Atropine Sulfate	15	11.3	11.3
Isoniazid	17	10.9	10.9
Bendamustine Hcl	16	10.7	10.7
Polatuzumab Vedotin	10	10.6	10.6
Cephalexin	22	10.6	10.6
Enoxaparin Sodium	57	10.5	10.5
Mesna Injection	8	10.0	10.0
Magnesium Hydroxide	13	10.0	10.0
Mesna	8	9.8	9.8
Darbepoetin Alfa	49	9.6	9.6
Temazepam	34	9.4	9.4
Rifampicin	9	9.2	9.2
Pertuzumab	24	9.2	9.2
Lenalidomide	319	9.0	9.0
Cyclophosphamide Injection, Solution	143	8.9	8.9
Cyclophosphamide	143	8.9	8.9
Cyclophosphamide For Injection	143	8.9	8.9
Capecitabine	76	8.8	8.8
Pomalidomide	85	8.8	8.8
Doxorubicin	73	8.7	8.7
Febuxostat	14	8.6	8.6
Gemcitabine	32	8.5	8.5
Enalapril Maleate	20	8.4	8.4
Leflunomide	81	8.3	8.3
Ifosfamide	17	8.2	8.2
Leucovorin Calcium	15	8.1	8.1
Moxifloxacin	11	8.1	8.1
Pazopanib Hydrochloride	21	8.1	8.1
Trastuzumab	52	8.0	8.0
Ibuprofen And Diphenhydramine Citrate	17	7.6	7.6
Acyclovir	81	7.6	7.6
Metformin Hydrochloride Tablets	41	7.5	7.5
Metformin Hydrochloride Extended-Release Tablets	41	7.5	7.5
Metformin Hydrochloride Tablet	41	7.5	7.5
Amoxicillin	54	7.4	7.4
Metformin Hydrochloride	41	7.3	7.3
Ixazomib	20	7.2	7.2
Prochlorperazine	19	7.1	7.1
Gemcitabine Hydrochloride	36	7.1	7.1
Tocilizumab	76	7.1	7.1
Docetaxel Anhydrous	44	6.8	6.8
Docetaxel	44	6.8	6.8
Heparin Sodium	9	6.8	6.8
Lapatinib	10	6.7	6.7
Dorzolamide Hydrochloride And Timolol Maleate	5	6.5	6.5
Oxycodone Hydrochloride And Acetaminophen	61	6.5	6.5
Morphine Sulfate	73	6.4	6.4
Rifampin	9	6.4	6.4
Ritonavir 100 Mg	9	6.2	6.2
Rocuronium Bromide	7	6.1	6.1
Naproxen Sodium Tablet, Coated	8	6.1	6.1
Naproxen Sodium, Coated Tablets	8	6.1	6.1
Naproxen Sodium 220Mg	8	6.1	6.1
Paclitaxel (Aibumin-Bound)	47	6.0	6.0
Etoposide	41	5.8	5.8
Paclitaxel	54	5.7	5.7
Denosumab	101	5.3	5.3
Erlotinib	5	5.3	5.3
Sunitinib Malate	20	5.3	5.3
Erlotinib Hydrochloride	6	4.9	4.9
Ado-Trastuzumab Emtansine	4	4.9	4.9
Cisplatin	36	4.8	4.8
Daptomycin	4	4.5	4.5
Venetoclax	26	4.4	4.4
Carboplatin	53	4.4	4.4
Golimumab	36	4.4	4.4
Oxycodone Hydrochloride	82	4.0	4.0
Abatacept	52	3.9	3.9
Pemetrexed	8	3.8	3.8
Abiraterone	5	3.8	3.8
Atezolizumab	14	3.7	3.7
Nivolumab	34	3.7	3.7
Selinexor	3	3.6	3.6
Ustekinumab	35	3.6	3.6
Certolizumab Pegol	38	3.4	3.4
Palbociclib	28	3.0	3.0
Olaparib	6	3.0	3.0
Cabozantinib	13	2.8	2.8
Apremilast	35	2.5	2.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.