Reaction

Which drugs are most reported with General symptom?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,445 reports · 175 co-occurring drugs

As of the last recalculation, General Symptom appears in 7,445 FAERS reports alongside 175 co-occurring drug terms. The strongest observed disproportionality signal is NATALIZUMAB (PRR 47.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Natalizumab	2,192	47.4	47.9
Interferon Beta-1A	1,944	37.7	38.1
Pseudoephedrine Hydrochloride	124	34.3	34.7
Pseudoephedrine Hcl	124	32.0	32.3
Acetaminophen And Codeine	133	31.1	31.4
Dimethyl Fumarate	1,156	30.9	31.2
Calcium Gluconate	123	29.0	29.3
Diclofenac Potassium, Film Coated	81	27.2	27.5
Diclofenac Potassium Tablets	81	27.2	27.4
Desoximetasone	175	26.3	26.5
Chlorhexidine Gluconate	78	24.1	24.3
Diclofenac Potassium	81	21.2	21.3
Peginterferon Beta-1A	91	19.6	19.8
Sarilumab	161	17.4	17.5
Cetirizine Hydrochloride Allergy	165	15.6	15.6
Cetirizine Hydrochloride Tablets	165	15.6	15.6
Quetiapine Fumarate	148	14.3	14.4
Isopropyl Alcohol	162	13.7	13.7
Hydrocortisone Sodium Succinate	44	13.2	13.2
Adalimumab-Fkjp	199	12.3	12.4
Diclofenac Sodium 1%	153	12.2	12.3
Diclofenac Sodium Topical	153	12.2	12.3
Diclofenac Sodium Topical Gel, 1%	153	12.2	12.2
Adalimumab-Aaty	200	12.1	12.2
Methylprednisolone Sodium Succinate	196	12.1	12.1
Adalimumab-Adaz	220	12.0	12.0
Naproxen Sodium Tablet, Coated	57	11.9	11.9
Naproxen Sodium, Coated Tablets	57	11.9	11.9
Naproxen Sodium 220Mg	57	11.8	11.9
Alcohol	161	11.8	11.9
Oxycodone And Acetaminophen Tablets	46	10.9	10.9
Antacid	159	9.5	9.6
Tofacitinib Citrate	43	9.2	9.2
Cetiirizine	135	9.1	9.1
Cortisone Acetate	39	8.9	8.9
Calcium Carbonate	207	8.8	8.9
Pantoprazole Sodium In 0.9% Sodium Chloride	168	7.7	7.7
Pantoprazole Sodium Injection	168	7.7	7.7
Naproxen	210	7.7	7.7
Upadacitinib	213	7.5	7.5
Diclofenac	222	7.4	7.4
Vedolizumab	222	7.4	7.4
Cetirizine	197	7.3	7.3
Sulfasalazine	198	7.2	7.3
Triamcinolone Acetonide Ointment Usp, 0.05%	60	7.2	7.2
Hydroxychloroquine	185	7.1	7.1
Golimumab	206	6.9	6.9
Hydrocortisone Acetate	165	6.5	6.5
Hydroxychloroquine Sulfate	203	6.4	6.4
Leflunomide	227	6.2	6.2
Hydrocortisone	188	6.0	6.0
Alendronate Sodium	210	6.0	6.0
Ustekinumab	212	5.9	5.9
Anti-Itch	140	5.9	5.9
Anti-Pruritic	140	5.9	5.9
Antipruritic (Anti-Itch)	140	5.9	5.9
Cool Relief Gel With Aloe	140	5.9	5.9
Drs. Hydrocortisone	140	5.9	5.9
Hydrocortisone Continuous Spray	140	5.9	5.9
Hydrocortisone Spray	140	5.9	5.9
Anti-Itch Cream	140	5.9	5.9
Hydrocortisone Lotion	140	5.9	5.9
Hydrocortisone Cream 1%	140	5.9	5.9
Hydrocortisone Cream 1/2%	140	5.9	5.9
Hydrocortisone 1%	140	5.9	5.9
Hydrocortisone Cream	140	5.9	5.9
Ascorbic Acid	48	5.8	5.8
Oxycodone And Acetaminophen	46	5.5	5.6
Moxifloxacin Hydrochloride	40	5.5	5.5
Rasagiline Mesylate	22	5.5	5.5
Triamcinolone Acetonide	60	5.5	5.5
Tocilizumab	215	5.4	5.4
Naproxen Sodium	242	4.9	4.9
Dalfampridine	123	4.9	4.9
Vitamin C	156	4.8	4.8
Botulinum Toxin Type A	21	4.7	4.7
Fish Oil	147	4.6	4.6
Pimavanserin Tartrate	86	4.4	4.4
Amantadine	24	4.3	4.4
Diclofenac Sodium	228	4.3	4.3
Abatacept	208	4.3	4.3
Ramipril	183	4.2	4.2
Certolizumab Pegol	172	4.2	4.2
Doxyclycline Hyclate	25	4.1	4.1
Moxifloxacin	20	4.0	4.0
Secukinumab	222	3.9	3.9
Thiamine Hydrochloride	17	3.8	3.8
Tramadol Hydrochloride	51	3.8	3.8
Tretinoin	11	3.8	3.8
Thyroid, Porcine	14	3.7	3.7
Apremilast	189	3.7	3.7
Fosaprepitant Dimeglumine	18	3.7	3.7
Cetirizine Hydrochloride	211	3.7	3.7
Rituximab	259	3.5	3.5
Aprepitant	23	3.5	3.5
Pantoprazole Sodium	176	3.4	3.4
Minocycline	14	3.4	3.4
Oxycodone	218	3.3	3.3
Pancrelipase	45	3.3	3.3
Carbidopa And Levodopa	55	3.3	3.3
Infliximab	248	3.3	3.3
Risedronate Sodium	36	3.2	3.3
Bisacodyl Suppositories	15	3.2	3.2
Biscodyl	15	3.2	3.2
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	180	3.2	3.2
Risankizumab-Rzaa	89	3.1	3.1
Tofacitinib	197	3.0	3.0
Methylprednisolone	148	3.0	3.0
Glatiramer Acetate	64	3.0	3.0
Bisacodyl	15	3.0	3.0
Diltiazem Hydrochloride Extended-Release Tablets	12	3.0	3.0
Lorazepam	186	2.9	2.9
Sulfamethoxazole And Trimethoprim	88	2.9	2.9
Magnesium Hydroxide	14	2.9	2.9
Rabeprazole	23	2.9	2.9
Mesalamine	58	2.9	2.9
Adalimumab	674	2.8	2.8
Atomoxetine Hydrochloride	24	2.8	2.8
Quetiapine	191	2.8	2.8
Cyanocobalamin	33	2.8	2.8
Ibuprofen Capsule	187	2.7	2.7
Ibuprofen Tablet, Film Coated	187	2.7	2.7
Ibupfrofen	187	2.7	2.7
Ibuprofen Tablets Usp, 200Mg	187	2.7	2.7
Ibuprofen Oral	187	2.7	2.7
Ibuprofen Capsules 200 Mg	187	2.7	2.7
Ibuprofen 200 Mg	187	2.7	2.7
Ibuprofen 200Mg	187	2.7	2.7
Lansoprazole	162	2.6	2.6
Mirabegron	35	2.5	2.5
Instalax Polyethylene Glycol 3350	11	2.5	2.5
Pantoprazole	219	2.5	2.5
Polyethylene Glycol 400	11	2.4	2.4
Benralizumab	17	2.4	2.4
Cholestyramine	10	2.3	2.3
Icosapent Ethyl	7	2.3	2.3
Baclofen	70	2.3	2.3
Candesartan	29	2.3	2.3
Ibuprofen	212	2.2	2.2
Folic Acid	193	2.2	2.2
Lisinopril	236	2.2	2.2
Ergocalciferol	291	2.2	2.2
Oxycodone Hydrochloride	165	2.1	2.1
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	23	2.1	2.1
Alendronate Sodium Tablet	14	2.1	2.1
Erenumab-Aooe	38	1.9	1.9
Interferon Beta-1B	13	1.9	1.9
Etanercept	394	1.9	1.9
Mepolizumab	33	1.9	1.9
Avapritinib	8	1.8	1.8
Lanreotide Acetate	5	1.8	1.8
Eculizumab	33	1.7	1.7
Modafinil	19	1.6	1.6
Oxycodone Hydrochloride And Acetaminophen	55	1.6	1.6
Ibuprofen Tablets, Coated	23	1.5	1.5
Ibuprofen Sodium	23	1.5	1.5
Cariprazine	5	1.5	1.5
Rivastigmine	10	1.5	1.5
Etonogestrel And Ethinyl Estradiol	10	1.3	1.3
Rotigotine	6	1.2	1.2
Mometasone Furoate And Formoterol Fumarate Dihydrate	6	1.1	1.1
Fingolimod Hcl	33	1.1	1.1
Linaclotide	10	1.0	1.0
Paricalcitol	5	1.0	1.0
Venetoclax	20	0.9	0.9
Buprenorphine	29	0.9	0.9
Encorafenib	3	0.8	0.8
Glecaprevir And Pibrentasvir	3	0.8	0.8
Diroximel Fumarate	3	0.7	0.7
Onabotulinumtoxina	19	0.7	0.7
Ranitidine Hydrochloride	13	0.7	0.7
Palivizumab	3	0.5	0.5
Etonogestrel	9	0.5	0.5
Droxidopa	4	0.5	0.5
Salicylic Acid	7	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.