Reaction

Heart Rate Abnormal reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,481 reports · 231 co-occurring drugs

As of the last recalculation, Heart Rate Abnormal appears in 5,481 FAERS reports alongside 231 co-occurring drug terms. The strongest observed disproportionality signal is DOFETILIDE (PRR 13.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Dofetilide	37	13.5	13.5
Prochlorperazine	65	9.0	9.0
Diphenhydramine Hydrochloride Capsule, Liquid Filled	48	8.6	8.6
Guanfacine	16	7.7	7.8
Amiodarone Hydrochloride	22	7.5	7.5
Infliximab-Dyyb	57	7.5	7.5
Eplerenone	24	7.1	7.2
Sotalol Hydrochloride	30	6.9	6.9
Sacubitril And Valsartan	198	6.7	6.7
Dimenhydrinate	18	6.4	6.4
Niraparib	37	6.4	6.4
Selexipag	42	6.2	6.2
Tafamidis	19	6.1	6.2
Filgrastim	60	6.1	6.1
Abaloparatide	46	6.0	6.0
Dronedarone	16	6.0	6.0
Diphenhydramine	97	5.9	5.9
Calcium, Magnesium, Potassium, And Sodium Oxybates	13	5.7	5.8
Diphenhydramine Hydrochloride	234	5.6	5.6
Fludarabine Phosphate	55	5.4	5.4
0Xygen	68	5.3	5.3
Oxygen	68	5.3	5.3
Human Immunoglobulin G	28	5.2	5.2
Digoxin	94	5.0	5.0
Metoprolol Succinate	110	4.9	4.9
Metoprolol Succinate Er Tablets	77	4.7	4.7
Thyroid, Porcine	13	4.6	4.6
Metoroprolol Tartrate	79	4.6	4.6
Apixaban	80	4.6	4.6
Diltiazem Hydrochloride	41	4.5	4.5
Modafinil	38	4.5	4.5
Colchicine	31	4.5	4.5
Riociguat	38	4.4	4.5
Bumetanide	29	4.2	4.2
Fingolimod Hcl	92	4.1	4.1
Doxorubicin Hydrochloride	35	4.1	4.1
Meclizine	17	4.0	4.0
Ipratropium Bromide	37	4.0	4.0
Meclizine Hcl 12.5Mg	14	3.9	3.9
Meclizine Hcl 25Mg	14	3.9	3.9
Meclizine Hcl 12.5 Mg	14	3.9	3.9
Meclizine Hcl 25 Mg	14	3.9	3.9
Meclizine Hydrochloride	20	3.9	3.9
Metoprolol	250	3.9	3.9
Terbinafine Hydrochloride	9	3.9	3.9
Psyllium Husk	10	3.8	3.9
Metoprolol Tartrate	263	3.8	3.8
Epoprostenol	13	3.8	3.8
Adrenalinum	41	3.8	3.8
Candesartan Cilexetil	26	3.8	3.8
Quetiapine Fumarate	29	3.7	3.7
Diltiazem Hydrochloride Extended-Release Tablets	11	3.7	3.7
Mirabegron	37	3.6	3.7
Hydrocortisone Sodium Succinate	9	3.6	3.6
Macitentan	65	3.6	3.6
Epinephrine	61	3.6	3.6
Captopril	9	3.6	3.6
Metoprolol Tartrate Injection	173	3.5	3.5
Alemtuzumab	18	3.5	3.5
Latanoprost	46	3.5	3.5
Mometasone Furoate	38	3.5	3.5
Sildenafil	52	3.4	3.4
Clotrimazole	11	3.4	3.4
Zinc	22	3.4	3.4
Tiotropium Bromide Inhalation Spray	10	3.4	3.4
Omalizumab	75	3.4	3.4
Zinc Chloride	22	3.4	3.4
Calcium	128	3.3	3.3
Heparin Sodium	12	3.3	3.3
Magnesium	71	3.3	3.3
Drs. Clotrimazole	10	3.3	3.3
Family Wellness Clotrimazole	10	3.3	3.3
Clotrimazole Topical	10	3.3	3.3
Treprostinil	107	3.3	3.3
Lurasidone Hydrochloride	18	3.3	3.3
Ibrutinib	69	3.3	3.3
Bupivacaine	8	3.3	3.3
Vincristine Sulfate	25	3.3	3.3
Erythromycin	16	3.2	3.2
Zinc Gluconate	22	3.2	3.2
Telmisartan	15	3.2	3.2
Iron Sucrose	8	3.2	3.2
Acalabrutinib	10	3.1	3.1
Mupirocin	11	3.1	3.1
Buspirone Hydrochloride	9	3.1	3.1
Liothyronine Sodium	7	3.1	3.1
Mupirocin Calcium	11	3.0	3.0
Dexlansoprazole	33	3.0	3.0
Sildenafil Powder,	28	3.0	3.0
Cyclobenzaprine	39	3.0	3.0
Ropinirole	12	3.0	3.0
Linagliptin	14	2.9	2.9
Budesonide, Glycopyrrolate, And Formoterol Fumarate	8	2.9	2.9
Lanreotide Acetate	6	2.9	2.9
Methimazole	6	2.9	2.9
Cetirizine Hcl	7	2.9	2.9
Carvedilol	102	2.9	2.9
Quinapril Hydrochloride	6	2.9	2.9
Lisdexamfetamine Dimesylate	25	2.9	2.9
Agalsidase Beta	7	2.9	2.9
Ticagrelor	24	2.9	2.9
Nebivolol	12	2.9	2.9
Dronabinol	6	2.8	2.8
Doxorubicin	66	2.8	2.8
Spironolactone	103	2.8	2.8
Naproxen Sodium Tablet, Coated	10	2.8	2.8
Naproxen Sodium, Coated Tablets	10	2.8	2.8
Sodium Chloride Tablet	54	2.8	2.8
Sodium Chloride Tablets	54	2.8	2.8
Naproxen Sodium 220Mg	10	2.8	2.8
Valsartan And Hydrochlorothiazide	10	2.8	2.8
Diazepam	88	2.8	2.8
Bisoprolol Fumarate	98	2.8	2.8
Fexofenadine	12	2.8	2.8
Gemfibrozil	11	2.8	2.8
Azelastine	13	2.8	2.8
Ambrisentan	89	2.7	2.7
Sodium Chloride	56	2.7	2.7
Metolazone	8	2.7	2.7
Tadalafil	70	2.7	2.7
Nintedanib	22	2.7	2.7
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	29	2.7	2.7
Diazepam Oral Solution (Concentrate)	62	2.7	2.7
Diazepam Oral	62	2.7	2.7
Budesonide	41	2.7	2.7
Sildenafil Citrate	86	2.6	2.6
Cetirizine	52	2.6	2.6
Pegfilgrastim	66	2.6	2.6
Siponimod	6	2.6	2.6
Teduglutide	9	2.5	2.5
Benzonatate	11	2.5	2.5
Armodafinil	14	2.5	2.5
Cetirizine Hydrochloride Allergy	20	2.5	2.5
Cetirizine Hydrochloride Tablets	20	2.5	2.5
Famotidine	77	2.5	2.5
Quetiapine	125	2.5	2.5
Bicalutamide	10	2.5	2.5
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	23	2.5	2.5
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	27	2.5	2.5
Palivizumab	10	2.5	2.5
Warfarin Sodium	30	2.5	2.5
Fish Oil	58	2.5	2.5
Doxazosin	18	2.4	2.4
Relugolix	15	2.4	2.4
Bosentan	32	2.4	2.4
Warfarin	80	2.4	2.4
Dorzolamide Hydrochloride And Timolol Maleate	5	2.4	2.4
Tizanidine	15	2.4	2.4
Iohexol	5	2.3	2.3
Ozanimod Hydrochloride	5	2.3	2.3
Sevoflurane	5	2.3	2.3
Umeclidinium Bromide And Vilanterol Trifenatate	10	2.3	2.3
Febuxostat Tablets 40 Mg	6	2.2	2.2
Febuxostat Tablets 80 Mg	6	2.2	2.2
Vortioxetine	10	2.2	2.2
Naltrexone Hydrochloride And Bupropion Hydrochloride	5	2.2	2.2
Vemurafenib	7	2.2	2.2
Atorvastatin Calcium, Film Coated	40	2.2	2.2
Ibuprofen Tablets, Coated	24	2.1	2.1
Erenumab-Aooe	31	2.1	2.1
Nebivolol Hydrochloride	19	2.1	2.1
Linaclotide	15	2.1	2.1
Ibuprofen Sodium	24	2.1	2.1
Droxidopa	12	2.1	2.1
Zonisamide	8	2.1	2.1
Suvorexant	7	2.1	2.1
Teriparatide	59	2.0	2.0
Ixazomib	15	2.0	2.0
Teriflunomide	23	1.9	1.9
Ribociclib	16	1.9	1.9
Loratadine And Pseudoephedrine Sulfate	4	1.9	1.9
Sodium Oxybate	33	1.9	1.9
Inclisiran	4	1.9	1.9
Levodopa	6	1.9	1.9
Naproxen Sodium Tablet	26	1.9	1.9
Obinutuzumab	8	1.8	1.8
Elexacaftor, Tezacaftor, And Ivacaftor	6	1.8	1.8
Ranolazine	5	1.8	1.8
Rivastigmine	9	1.8	1.8
Diclofenac Potassium, Film Coated	4	1.8	1.8
Diclofenac Potassium Tablets	4	1.8	1.8
Rimegepant Sulfate	6	1.8	1.8
Venetoclax	29	1.8	1.8
Icosapent Ethyl	4	1.8	1.8
Dabigatran Etexilate Mesylate	34	1.8	1.8
Dabigatran Etexilate	36	1.8	1.8
Mometasone Furoate And Formoterol Fumarate Dihydrate	7	1.7	1.7
Testosterone Cypionate	4	1.7	1.7
Nilotinib	13	1.7	1.7
Vilazodone Hydrochloride	4	1.6	1.6
Rocuronium Bromide	5	1.6	1.6
Atomoxetine Hydrochloride	10	1.6	1.6
Risankizumab-Rzaa	33	1.5	1.5
Pimavanserin Tartrate	22	1.5	1.5
Varenicline Tartrate	31	1.5	1.5
Rivaroxaban	80	1.5	1.5
Diclofenac Potassium	4	1.4	1.4
Acetaminophen, Aspirin (Nsaid) And Caffeine	6	1.3	1.3
Voclosporin	3	1.3	1.3
Brivaracetam	3	1.3	1.3
Crizotinib	4	1.2	1.2
Buprenorphine	29	1.2	1.2
Osimertinib	10	1.2	1.2
Peginterferon Beta-1A	4	1.2	1.2
Axicabtagene Ciloleucel	3	1.2	1.2
Ofatumumab	10	1.1	1.1
Canagliflozin	9	1.1	1.1
Benralizumab	6	1.1	1.1
Glatiramer Acetate	17	1.1	1.1
Paricalcitol	4	1.1	1.1
Pomalidomide	28	1.0	1.0
Fremanezumab-Vfrm	3	1.0	1.0
Dornase Alfa	5	1.0	1.0
Galcanezumab-Gnlm	8	1.0	1.0
Pirfenidone	10	0.9	0.9
Abiraterone Acetate	10	0.9	0.9
Dalfampridine	17	0.9	0.9
Lutetium Lu 177 Vipivotide Tetraxetan	3	0.9	0.9
Nirmatrelvir And Ritonavir	12	0.8	0.8
Enzalutamide	13	0.8	0.8
Paliperidone Palmitate	7	0.8	0.8
Evolocumab	35	0.8	0.8
Vigabatrin	3	0.8	0.8
Dimethyl Fumarate	25	0.8	0.8
Dulaglutide	18	0.8	0.8
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	6	0.7	0.7
Tirzepatide	26	0.6	0.6
Minoxidil	7	0.6	0.6
Minoxidil Foam 5% (Womens)	5	0.6	0.6
Cinacalcet Hydrochloride	7	0.6	0.6
Dupilumab	57	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.