Reaction

Crepitations reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,963 reports · 166 co-occurring drugs

As of the last recalculation, Crepitations appears in 2,963 FAERS reports alongside 166 co-occurring drug terms. The strongest observed disproportionality signal is METHYLPREDNISOLONE ACETATE (PRR 133.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Methylprednisolone Acetate	145	133.7	136.2
Ciclesonide	106	56.7	57.1
Trimethoprim	53	32.1	32.3
Esomeprazole Magnesium Capsule, Delayed Release	46	22.6	22.7
Esomeprazole Magnesium Delayed Release Capsules	46	22.6	22.7
Esomeprazole Magnesium Dihydrate	46	22.5	22.6
Tofacitinib Citrate	41	22.3	22.3
Meloxicam	170	21.7	21.8
Amitriptyline Hydrochloride	51	20.8	20.8
Diphenhydramine Hydrochloride Capsule, Liquid Filled	48	16.0	16.1
Mepolizumab	103	15.0	15.1
Hydroxychloroquine Sulfate	183	15.0	15.0
Sucralfate Oral	27	13.5	13.5
Sulfasalazine	143	13.4	13.5
Sucralfate Oral Suspension	27	13.4	13.4
Naproxen Sodium Tablet, Coated	25	13.1	13.1
Naproxen Sodium, Coated Tablets	25	13.1	13.1
Naproxen Sodium 220Mg	25	13.1	13.1
Omalizumab	150	13.0	13.0
Leflunomide	180	12.8	12.8
Atropine	15	12.8	12.8
Eplerenone	23	12.7	12.7
Dexlansoprazole	66	11.3	11.4
Epoprostenol	21	11.3	11.4
Esomeprazole	93	10.8	10.9
Metolazone	17	10.7	10.7
Atropine Sulfate	16	10.5	10.5
Temozolomide	31	10.4	10.4
Diclofenac	122	10.3	10.3
Methylprednisolone Sodium Succinate	64	9.9	9.9
Hydrocortisone Sodium Succinate	13	9.8	9.8
Naproxen	105	9.7	9.7
Tocilizumab	150	9.7	9.7
Azathioprine	115	9.5	9.5
Fluticasone Propionate And Salmeterol Xinafoate	79	9.5	9.5
Adalimumab-Fkjp	61	9.4	9.4
Sulfamethoxazole And Trimethoprim	109	9.4	9.4
Nintedanib	41	9.3	9.3
Digoxin	92	9.3	9.3
Sucralfate	31	9.2	9.2
Nifedipine	60	9.1	9.1
Octreotide Acetate	39	9.0	9.1
Amoxicillin	95	9.0	9.0
Hydroxychloroquine	92	8.9	8.9
Adalimumab-Aaty	57	8.6	8.6
0Xygen	59	8.6	8.6
Oxygen	59	8.6	8.6
Alendronate Sodium	115	8.3	8.3
Tiotropium Bromide Inhalation Spray	13	8.2	8.2
Ipratropium Bromide	41	8.2	8.2
Adalimumab-Adaz	59	8.0	8.0
Pantoprazole Sodium In 0.9% Sodium Chloride	69	8.0	8.0
Pantoprazole Sodium Injection	69	8.0	8.0
Human Immunoglobulin G	23	7.9	7.9
Everolimus	56	7.9	7.9
Tofacitinib	192	7.7	7.8
Montelukast Sodium	125	7.5	7.5
Abatacept	141	7.5	7.5
Theophylline	12	7.4	7.4
Tobramycin	25	7.4	7.4
Mometasone Furoate	43	7.3	7.3
Methylprednisolone	136	7.2	7.2
Anti-Thymocyte Globulin (Rabbit)	8	7.0	7.0
Nitroglycerin	52	6.9	6.9
Theophylline Anhydrous	12	6.8	6.8
Cefuroxime	11	6.8	6.8
Indapamide	17	6.7	6.7
Diclofenac Potassium, Film Coated	8	6.7	6.7
Diclofenac Potassium Tablets	8	6.7	6.7
Diclofenac Sodium	136	6.6	6.6
Quinine	8	6.6	6.6
Isoniazid	15	6.5	6.5
Canakinumab	10	6.5	6.5
Oxycodone And Acetaminophen Tablets	11	6.5	6.5
Azithromycin Dihydrate	53	6.4	6.4
Spironolactone	124	6.4	6.4
Ciprofolxacin	63	6.3	6.3
Ciprofloxacin Tablets	63	6.3	6.3
Umeclidinium	8	6.3	6.3
Budesonide And Formoterol Fumarate Dihydrate	83	6.2	6.2
Teriparatide	95	6.1	6.1
Bupivacaine	8	6.0	6.0
Pantoprazole	204	6.0	6.0
Enalapril Maleate	21	6.0	6.0
Clarithromycin	29	6.0	6.0
Naproxen Sodium	117	5.9	6.0
Albuterol Sulfate	233	5.9	5.9
Diclofenac Potassium	9	5.9	5.9
Tobramycin Solution	10	5.9	5.9
Rabeprazole	18	5.7	5.7
Alendronate Sodium Tablet	15	5.7	5.7
Tobramycin Sulfate	10	5.7	5.7
Efavirenz	9	5.7	5.7
Ciprofloxacin Hydrochloride	77	5.7	5.7
Rituximab	163	5.7	5.7
Exemestane	17	5.6	5.6
Rifampicin	8	5.6	5.6
Telmisartan	14	5.5	5.5
Piperacillin And Tazobactam	10	5.5	5.5
Celecoxib	100	5.5	5.5
Ciprofloxacin	70	5.5	5.5
Nevirapine	7	5.5	5.5
Ceftriaxone	25	5.4	5.4
Furosemide	281	5.3	5.3
Methotrexate	293	5.3	5.3
Desoximetasone	14	5.2	5.2
Ceftriaxone Sodium	28	5.2	5.2
Methotrexate Sodium	324	5.1	5.1
Sevoflurane	6	5.1	5.1
Piperacillin Sodium,Tazobactam Sodium	19	5.1	5.1
Diphenhydramine Hcl	8	5.1	5.1
Lapatinib	11	5.0	5.0
Doxyclycline Hyclate	12	5.0	5.0
Fluticasone Furoate And Vilanterol Trifenatate	25	4.9	4.9
Doxycycline Hyclate	46	4.8	4.8
Gentamicin	9	4.8	4.8
Insulin Glargine-Yfgn	15	4.8	4.8
Ranitidine Hydrochloride	37	4.8	4.8
Doxycycline	46	4.8	4.8
Allopurinol	102	4.7	4.7
Isosorbide Dinitrate	13	4.7	4.7
Glyburide	16	4.7	4.7
Pregabalin	172	4.7	4.7
Cortisone Acetate	8	4.6	4.6
Pyrazinamide	6	4.5	4.5
Golimumab	53	4.4	4.4
Diclofenac Sodium 1%	22	4.4	4.4
Diclofenac Sodium Topical	22	4.4	4.4
Diclofenac Sodium Topical Gel, 1%	22	4.3	4.3
Pirfenidone	25	4.3	4.3
Asfotase Alfa	6	4.2	4.2
Zidovudine	8	4.2	4.2
Lamivudine Oral	15	4.2	4.2
Latanoprost	29	4.1	4.1
Tenofovir Disoproxil Fumarate Tablets	5	4.1	4.1
Brinzolamide	5	4.0	4.1
Norepinephrine	6	3.9	4.0
Norepinephrine Bitartrate	8	3.9	3.9
Lamivudine	17	3.9	3.9
Tiotropium Bromide	74	3.9	3.9
Anakinra	9	3.8	3.8
Dornase Alfa	10	3.6	3.6
Selexipag	13	3.5	3.5
Fondaparinux Sodium	4	3.5	3.5
Ranitidine	95	3.4	3.4
Capecitabine	43	3.3	3.3
Oxycodone And Acetaminophen	11	3.3	3.3
Certolizumab Pegol	54	3.3	3.3
Macitentan	31	3.2	3.2
Vilazodone Hydrochloride	4	3.0	3.0
Riociguat	13	2.8	2.8
Secukinumab	63	2.8	2.8
Etanercept	223	2.7	2.7
Pseudoephedrine Hydrochloride	4	2.7	2.7
Abiraterone	5	2.6	2.6
Asenapine Maleate	3	2.4	2.4
Bosutinib	3	2.3	2.3
Gefitinib	3	2.3	2.3
Palivizumab	5	2.3	2.3
Daptomycin	3	2.3	2.3
Treprostinil	39	2.2	2.2
Pseudoephedrine Hcl	3	1.9	1.9
Benralizumab	5	1.8	1.8
Ambrisentan	30	1.7	1.7
Romosozumab-Aqqg	3	1.6	1.6
Adapalene	4	0.2	0.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.