Reaction

Energy Increased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,860 reports · 189 co-occurring drugs

As of the last recalculation, Energy Increased appears in 5,860 FAERS reports alongside 189 co-occurring drug terms. The strongest observed disproportionality signal is EXENATIDE (PRR 20.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Exenatide	289	20.5	20.6
Naltrexone Hydrochloride And Bupropion Hydrochloride	46	19.3	19.4
Lurasidone Hydrochloride	79	13.6	13.6
Niraparib	73	11.8	11.9
Vortioxetine	50	10.5	10.5
Loratadine And Pseudoephedrine Sulfate	22	9.9	9.9
Buprenorphine Hydrochloride, Naloxone Hydrochloride	51	7.6	7.6
Liothyronine Sodium	18	7.4	7.4
Armodafinil	43	7.3	7.3
Atomoxetine Hydrochloride	48	7.2	7.2
Ruxolitinib	136	6.9	6.9
Desvenlafaxine Succinate	50	6.6	6.6
Lisdexamfetamine Dimesylate	59	6.4	6.4
Ibuprofen And Diphenhydramine Citrate	41	6.3	6.3
Bupropion Hydrochloride	162	6.0	6.0
Ropinirole	25	5.8	5.8
Ledipasvir And Sofosbuvir	30	5.6	5.6
Ziprasidone Mesylate	22	5.5	5.5
Metformin Hcl	84	5.5	5.5
Vilazodone Hydrochloride	14	5.4	5.4
Sacubitril And Valsartan	163	5.1	5.1
Ziprasidone	25	5.1	5.1
Glecaprevir And Pibrentasvir	15	4.9	4.9
Dalfampridine	95	4.8	4.8
Budesonide	78	4.8	4.8
Velpatasvir And Sofosbuvir	17	4.7	4.7
Cariprazine	12	4.6	4.6
Butalbital, Acetaminophen, And Caffeine	13	4.3	4.3
Brexpiprazole	20	4.3	4.3
Naltrexone	37	4.3	4.3
Varenicline Tartrate	93	4.2	4.2
Ofatumumab	38	4.1	4.1
Sodium Oxybate	75	4.1	4.1
Elexacaftor, Tezacaftor, And Ivacaftor	14	4.0	4.0
Lithium Carbonate	19	4.0	4.0
Pioglitazone	47	3.9	3.9
Rasagiline Mesylate	12	3.8	3.8
Human Immunoglobulin G	22	3.8	3.8
Relugolix	25	3.8	3.8
Modafinil	34	3.8	3.8
Lithium	26	3.7	3.7
Lithium Bromatum	26	3.7	3.7
Testosterone	24	3.7	3.7
Tafamidis	12	3.6	3.6
Siponimod	9	3.6	3.6
Testosterone Cypionate	9	3.6	3.6
Orlistat	26	3.6	3.6
Tizanidine Hydrochloride	18	3.5	3.5
Biotin	31	3.5	3.5
Hydroxyurea	21	3.5	3.5
Amitriptyline Hydrochloride	17	3.4	3.5
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	40	3.4	3.4
Sertraline	109	3.3	3.3
Duloxetine Hydrochloride	173	3.3	3.3
Iron	62	3.3	3.3
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	28	3.3	3.3
Aripiprazole	111	3.3	3.3
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	32	3.2	3.2
Teduglutide	12	3.2	3.2
Guanfacine	7	3.2	3.2
Human Insulin	11	3.1	3.1
Fluoxetine Hydrochloride	111	3.1	3.1
Glipizide	53	3.1	3.1
Hyoscyamine Sulfate	8	3.1	3.1
Glyburide	21	3.1	3.1
Sennosides 8.6 Mg Tablets	18	3.1	3.1
Senna	18	3.0	3.0
Melatonin	46	3.0	3.0
Fexofenadine	14	3.0	3.0
Magnesium	69	3.0	3.0
Carbidopa And Levodopa	39	2.9	2.9
Belimumab	26	2.9	2.9
Nicotine	33	2.9	2.9
Venlafaxine Hydrochloride	107	2.9	2.9
Asenapine Maleate	7	2.9	2.9
Nicotine Polacrilex Mini	12	2.8	2.8
Nicotine Polarilex	12	2.8	2.8
Divalproex Sodium	37	2.8	2.8
Clonazepam	126	2.8	2.8
Multivitamin	39	2.8	2.8
Senna Leaf	18	2.8	2.8
Losartan Potassium And Hydrochlorothiazide	9	2.8	2.8
Escitalopram	107	2.7	2.7
Vitamin C	70	2.7	2.7
Methylphenidate Hydrochloride	45	2.7	2.7
Avapritinib	9	2.6	2.6
Levothyroxine Sodium	228	2.6	2.6
Sertraline Hydrochloride	87	2.6	2.6
Oxcarbazepine	24	2.6	2.6
Fluoxetine	49	2.6	2.6
Empagliflozin	49	2.6	2.6
Erythropoietin	15	2.6	2.6
Lamotrigine	94	2.6	2.6
Paroxetine Hydrochloride	65	2.6	2.6
Voxelotor	16	2.5	2.5
Ibuprofen Tablets, Coated	30	2.5	2.5
Ibuprofen Sodium	30	2.5	2.5
Loratadine	75	2.5	2.5
Suvorexant	9	2.5	2.5
Liraglutide	34	2.5	2.5
Alpelisib	6	2.4	2.4
Paroxetine	23	2.4	2.4
Loratadine Oral	33	2.4	2.4
Loratadine Tablet	36	2.4	2.4
Acetaminophen, Aspirin, And Caffeine	14	2.4	2.4
Olanzapine Pamoate	27	2.3	2.4
Sofosbuvir	13	2.3	2.3
Thyroid, Porcine	7	2.3	2.3
Donepezil Hydrochloride	24	2.3	2.3
Amantadine	10	2.3	2.3
Lanreotide Acetate	5	2.3	2.3
Fish Oil	57	2.3	2.3
Aripiprazole Oral	26	2.2	2.2
Aripiprazole Orally Disintegrating	26	2.2	2.2
Nicotine Polacrilex	24	2.2	2.2
Naproxen Sodium Tablet	33	2.2	2.2
Loperamide Hcl	8	2.2	2.2
Selexipag	16	2.2	2.2
Ibrutinib	49	2.2	2.2
Hydroxyzine Hydrochloride	8	2.2	2.2
Hydroxyzine Hydrochloride Oral	8	2.2	2.2
Amphetamine	5	2.1	2.1
Teriflunomide	27	2.1	2.1
Nebivolol Hydrochloride	20	2.1	2.1
Tizanidine	14	2.1	2.1
Levodopa	7	2.1	2.1
Dofetilide	6	2.0	2.0
Nirmatrelvir And Ritonavir	30	2.0	2.0
Dexlansoprazole	23	2.0	2.0
Eszopiclone	14	2.0	2.0
Pseudoephedrine Hcl	6	1.9	1.9
Fingolimod Hcl	46	1.9	1.9
Isopropyl Alcohol	18	1.9	1.9
Clobazam	13	1.9	1.9
Somatropin	39	1.9	1.9
Riociguat	17	1.9	1.9
Regorafenib	6	1.8	1.8
Ethyl Alcohol	14	1.8	1.8
Acalabrutinib	6	1.8	1.8
Pseudoephedrine Hydrochloride	5	1.7	1.7
Tofacitinib	89	1.7	1.7
Ozanimod Hydrochloride	4	1.7	1.7
Oral Semaglutide	33	1.6	1.6
Linaclotide	12	1.6	1.6
Rotigotine	6	1.5	1.5
Methylphenidate	12	1.5	1.5
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	17	1.5	1.5
Palbociclib	39	1.5	1.5
Natalizumab	74	1.5	1.5
Peginterferon Alfa-2A	22	1.4	1.4
Ribavirin	26	1.4	1.4
Emicizumab	5	1.4	1.4
Rimegepant Sulfate	5	1.4	1.4
Alcohol	15	1.4	1.4
Glatiramer Acetate	22	1.3	1.3
Alirocumab	9	1.3	1.3
Diclofenac Potassium, Film Coated	3	1.3	1.3
Diclofenac Potassium Tablets	3	1.3	1.3
Ocrelizumab	22	1.3	1.3
Acetaminophen, Aspirin (Nsaid) And Caffeine	6	1.3	1.3
Nintedanib	11	1.2	1.2
Eculizumab	19	1.2	1.2
Voclosporin	3	1.2	1.2
Pimavanserin Tartrate	19	1.2	1.2
Paliperidone	8	1.2	1.2
Vigabatrin	5	1.2	1.2
Dimethyl Fumarate	42	1.2	1.2
Secukinumab	55	1.2	1.2
Apalutamide	4	1.2	1.2
Conjugated Estrogens And Medroxyprogesterone Acetate	8	1.2	1.2
Brivaracetam	3	1.2	1.2
Dornase Alfa	6	1.1	1.1
Cannabidiol	7	1.1	1.1
Enzalutamide	17	1.0	1.0
Hydrocodone Bitartrate And Acetaminophen	16	1.0	1.0
Leuprolide Acetate	21	1.0	1.0
Tapentadol Hydrochloride	9	1.0	1.0
Benralizumab	5	0.9	0.9
Valbenazine	6	0.8	0.8
Droxidopa	5	0.8	0.8
Buprenorphine	21	0.8	0.8
Pegfilgrastim	21	0.8	0.8
Apremilast	31	0.8	0.8
Abaloparatide	6	0.7	0.7
Erenumab-Aooe	11	0.7	0.7
Paliperidone Palmitate	6	0.7	0.7
Tirzepatide	30	0.7	0.7
Esketamine Hydrochloride	3	0.6	0.6
Evolocumab	20	0.4	0.4

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.