Reaction

Hepatic Necrosis reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,734 reports · 167 co-occurring drugs

As of the last recalculation, Hepatic Necrosis appears in 3,734 FAERS reports alongside 167 co-occurring drug terms. The strongest observed disproportionality signal is ICOSAPENT ETHYL (PRR 25.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Icosapent Ethyl	39	25.8	25.9
Rifampicin	45	25.1	25.2
Pyrazinamide	32	19.1	19.2
Isoniazid	49	17.1	17.1
Busulfan	45	16.1	16.2
Basiliximab	32	15.3	15.3
Posaconazole Delayed-Release	29	14.8	14.9
Progesterone	57	14.1	14.1
Derma Foam Excel Hand Sanitizer	19	13.3	13.3
Ethanol	19	13.3	13.3
Dolutegravir Sodium	18	11.2	11.2
Posaconazole	32	11.1	11.1
Sevoflurane	16	10.8	10.8
Piperacillin And Tazobactam	24	10.5	10.5
Anti-Thymocyte Globulin (Rabbit)	15	10.4	10.4
Acetaminophen Tablet Extended Release	421	10.2	10.3
Pain Reliever	421	10.2	10.3
Acetaminophen 500Mg	421	10.2	10.2
Acetylcysteine	17	10.1	10.1
Zidovudine	24	10.1	10.1
Efavirenz	20	10.0	10.1
Ivacaftor	14	9.9	9.9
Abacavir Sulfate	17	9.8	9.8
Lamivudine	53	9.7	9.7
Amphetamine	14	9.5	9.5
Meropenem	51	9.0	9.0
Lamivudine Oral	39	8.7	8.7
Ursosiol	30	8.7	8.7
Valganciclovir	28	8.3	8.3
Valganciclovir Hydrochloride	28	8.3	8.3
Metronidazole Topical	70	8.3	8.3
Piperacillin Sodium,Tazobactam Sodium	39	8.3	8.3
Ursodiol	32	8.3	8.3
Nevirapine	13	8.1	8.1
Micafungin Sodium	12	7.9	7.9
Methylprednisolone Acetate	11	7.7	7.7
Amphotericin B	17	7.6	7.6
Lopinavir And Ritonavir	18	7.4	7.4
Valganciclovir Hydrochloride Powder,	16	7.3	7.3
Acetaminophen	517	7.3	7.3
Mycophenilic Acid	27	7.3	7.3
Alcohol	50	7.3	7.3
Piperacillin Sodium And Tazobactam Sodium	25	7.1	7.2
Fludarabine Phosphate	49	7.0	7.0
Ganciclovir Sodium	13	6.9	6.9
Phenytoin	25	6.7	6.7
Ceftriaxone	39	6.7	6.7
Dronedarone	12	6.6	6.6
Metronidazole	74	6.6	6.6
Ganciclovir	12	6.6	6.6
Tacrolimus	175	6.5	6.5
Tenofovir Disoproxil Fumarate Tablets	10	6.5	6.5
Ethyl Alcohol	31	6.4	6.4
Ceftriaxone Sodium	43	6.3	6.3
Methylprednisolone	150	6.3	6.3
Imatinib Mesylate	31	6.2	6.2
Ribociclib	35	6.2	6.2
Sirolimus	15	6.2	6.2
Norepinephrine Bitartrate	16	6.2	6.2
Venlafaxine	78	6.2	6.2
Tacrolimus Ointment 0.1%	133	6.1	6.1
Rifampin	16	6.1	6.1
Tacrolimus Extended-Release Capsules	133	6.1	6.1
Estradiol Gel 0.1%	49	6.1	6.1
Estradiol Transdermal	49	6.1	6.1
Ampicillin	9	6.1	6.1
Ampicillin Sodium	9	6.1	6.1
Mycophenolate Mofetil	143	6.1	6.1
Mycophenolate Mofetil Hydrochloride	143	6.1	6.1
Enalapril Maleate	26	5.9	5.9
Thiamine Hydrochloride	13	5.8	5.8
Isopropyl Alcohol	35	5.8	5.8
Naproxen Sodium Tablet, Coated	14	5.8	5.8
Naproxen Sodium, Coated Tablets	14	5.8	5.8
Naproxen Sodium 220Mg	14	5.8	5.8
Vincristine Sulfate	30	5.7	5.7
Daspone	10	5.7	5.7
Dapsone Gel, 5%	10	5.7	5.7
Clarithromycin	35	5.7	5.7
Nitrofurantoin	16	5.4	5.4
Goserelin	13	5.4	5.4
Nitrofurantoin (Monohydrate/Macrocrystals)	16	5.4	5.4
Amoxicillin	72	5.3	5.3
Dapsone	10	5.2	5.2
Lamotirigine	65	5.1	5.1
Lamotrigine Extended-Release	65	5.1	5.1
Lamotrigine Chewable Dispersible	65	5.1	5.1
Erythromycin	17	5.1	5.1
Cefepime	13	5.1	5.1
Panitumumab	14	5.0	5.0
Levofloxacin	53	5.0	5.0
Levofloxacin In 5% Dextrose	53	5.0	5.0
Mycophenolic Acid	28	4.9	4.9
Cefepime Hydrochloride	14	4.9	4.9
Azithromycin	34	4.7	4.7
Raltegravir	14	4.7	4.7
Norepinephrine	9	4.7	4.7
Ketoprofen	11	4.7	4.7
Propofol	30	4.6	4.6
Azithromycin Monohydrate	34	4.6	4.6
Vancomycin	47	4.6	4.6
Diazepam Oral Solution (Concentrate)	72	4.6	4.6
Diazepam Oral	72	4.6	4.6
Dornase Alfa	16	4.6	4.6
Quinine	7	4.6	4.6
Fenofibrate	28	4.4	4.4
Primidone	8	4.4	4.4
Amoxicillin And Clavulanate Potassium	21	4.3	4.3
Letrozole Tablets	37	4.3	4.3
Vancomycin Hydrochloride	50	4.3	4.3
Bumetanide	20	4.2	4.2
Somatropin	55	4.2	4.2
Midazolam Hydrochloride	20	4.2	4.2
Ritonavir 100 Mg	11	4.1	4.1
Carisoprodol	14	4.1	4.1
Ibuprofen Capsule	142	4.1	4.1
Ibuprofen Tablet, Film Coated	142	4.1	4.1
Ibupfrofen	142	4.1	4.1
Ibuprofen Tablets Usp, 200Mg	142	4.1	4.1
Ibuprofen Oral	142	4.1	4.1
Ibuprofen Capsules 200 Mg	142	4.1	4.1
Ibuprofen 200 Mg	142	4.1	4.1
Ibuprofen 200Mg	142	4.1	4.1
Tobramycin Sulfate	9	4.1	4.1
Sorafenib	15	4.0	4.0
Venlafaxine Hydrochloride	92	3.9	3.9
Cyclophosphamide Injection, Solution	122	3.9	3.9
Cyclophosphamide	122	3.9	3.9
Cyclophosphamide For Injection	122	3.9	3.9
Emtricitabine And Tenofovir Disoproxil Fumarate	32	3.9	3.9
Amikacin	12	3.9	3.9
Varenicline Tartrate	54	3.8	3.8
Imatinib	12	3.8	3.8
Estradiol	57	3.7	3.7
Ritonavir	19	3.6	3.6
Bendamustine Hcl	10	3.6	3.6
Letrozole	39	3.6	3.6
Etoposide	46	3.5	3.5
Eplerenone	8	3.5	3.5
Lamotrigine	80	3.4	3.4
Filgrastim	23	3.4	3.4
Darunavir	9	3.3	3.3
Bicalutamide	9	3.3	3.3
Tobramycin Solution	7	3.3	3.3
Valproic Acid	18	3.2	3.2
Daptomycin	5	3.0	3.0
Bupivacaine	5	3.0	3.0
Tenofovir Disoproxil Fumarate	17	2.9	2.9
Cytarabine	30	2.8	2.8
Blinatumomab	5	2.7	2.7
Temozolomide	10	2.6	2.7
Orlistat	12	2.6	2.6
Oxaliplatin	34	2.6	2.6
Cisplatin	33	2.4	2.4
Interferon Beta-1B	8	2.3	2.3
Fluorouracil Cream, 0.5%	31	2.3	2.3
Canakinumab	4	2.1	2.1
Cetuximab	11	2.0	2.0
Methylphenidate	10	1.9	1.9
Ipilimumab	14	1.8	1.8
Elexacaftor, Tezacaftor, And Ivacaftor	4	1.8	1.8
Carfilzomib	9	1.8	1.8
Atezolizumab	12	1.7	1.7
Nivolumab	29	1.7	1.7
Glatiramer Acetate	17	1.6	1.6
Emtricitabine And Tenofovir Alafenamide	3	1.5	1.5
Abemaciclib	5	1.4	1.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.