Reaction

Maternal Exposure Before Pregnancy reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,706 reports · 139 co-occurring drugs

As of the last recalculation, Maternal Exposure Before Pregnancy appears in 6,706 FAERS reports alongside 139 co-occurring drug terms. The strongest observed disproportionality signal is ETONOGESTREL AND ETHINYL ESTRADIOL (PRR 64.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Etonogestrel And Ethinyl Estradiol	433	64.7	66.0
Certolizumab Pegol	1,691	59.5	60.4
Cladribine	90	29.4	29.7
Brivaracetam	75	26.2	26.4
Ocrelizumab	486	26.1	26.3
Lacosamide	178	15.2	15.3
Calcium Gluconate	44	11.4	11.4
Progesterone	77	10.6	10.6
Levonorgestrel	556	9.3	9.3
Pseudoephedrine Hydrochloride	29	8.8	8.8
Desoximetasone	52	8.5	8.6
Pseudoephedrine Hcl	29	8.2	8.2
Labetalol	33	7.7	7.7
Levetiracetam In Sodium Chloride	182	7.5	7.5
Levetiracetam Oral	182	7.5	7.5
Levetiracetam Injection	182	7.5	7.5
Levetiracetam	291	7.0	7.0
Fingolimod Hcl	188	6.9	6.9
Cetirizine Hydrochloride Allergy	65	6.7	6.7
Cetirizine Hydrochloride Tablets	65	6.7	6.7
Alemtuzumab	41	6.6	6.6
Sulfasalazine	163	6.6	6.6
Desloratadine	22	6.4	6.4
Isotretinoin	96	6.1	6.1
Quetiapine Fumarate	57	6.0	6.0
Botulinum Toxin Type A	24	6.0	6.0
Bimekizumab	38	5.6	5.6
Hydroxychloroquine Sulfate	150	5.2	5.2
Omalizumab	133	4.9	4.9
Fluticasone Furoate	19	4.9	4.9
Folic Acid	373	4.9	4.9
Cortisone Acetate	19	4.8	4.8
Diclofenac Sodium 1%	54	4.7	4.7
Diclofenac Sodium Topical	54	4.7	4.7
Diclofenac Sodium Topical Gel, 1%	54	4.7	4.7
Iron	100	4.7	4.7
Etoposide	108	4.6	4.6
Misoprostol	14	4.5	4.5
Tretinoin	11	4.2	4.2
Lamotirigine	94	4.1	4.1
Lamotrigine Extended-Release	94	4.1	4.1
Lamotrigine Chewable Dispersible	94	4.1	4.1
Etonogestrel	61	4.0	4.0
Letrozole Tablets	59	3.8	3.8
Diclofenac Potassium, Film Coated	10	3.7	3.7
Diclofenac Potassium Tablets	10	3.7	3.7
Adalimumab-Fkjp	53	3.6	3.6
Hydroxychloroquine	85	3.6	3.6
Letrozole	68	3.5	3.5
Raltegravir	18	3.4	3.4
Adalimumab-Aaty	51	3.4	3.4
Clobazam	26	3.3	3.3
Cetirizine	81	3.3	3.3
Adalimumab-Adaz	54	3.2	3.2
Zonisamide	15	3.2	3.2
Filgrastim	38	3.1	3.1
Methylprednisolone Acetate	8	3.1	3.1
Lamotrigine	127	3.0	3.0
Diclofenac	82	3.0	3.0
Fremanezumab-Vfrm	11	3.0	3.0
Hydrocortisone Sodium Succinate	9	3.0	3.0
Azathioprine	82	2.9	2.9
Diclofenac Potassium	10	2.9	2.9
Tofacitinib Citrate	12	2.8	2.8
Leflunomide	95	2.8	2.8
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	135	2.7	2.7
Golimumab	72	2.6	2.6
Iron Sucrose	8	2.6	2.6
Tocilizumab	94	2.6	2.6
Naproxen Sodium Tablet, Coated	11	2.5	2.5
Naproxen Sodium, Coated Tablets	11	2.5	2.5
Naproxen Sodium 220Mg	11	2.5	2.5
Haloperidol Lactate	20	2.5	2.5
Enoxaparin Sodium	46	2.5	2.5
Oxcarbazepine	26	2.5	2.5
Cetirizine Hydrochloride	130	2.5	2.5
Doxepin	8	2.5	2.5
Tranexamic Acid	7	2.4	2.4
Vincristine Sulfate	23	2.4	2.4
Bleomycin Sulfate	8	2.4	2.4
Mycophenilic Acid	16	2.4	2.4
Prednisolone	135	2.3	2.4
Prednisolone Oral	135	2.3	2.4
Prednisolone Oral Solution	135	2.3	2.4
Glatiramer Acetate	45	2.3	2.3
Methotrexate	307	2.3	2.3
Methotrexate Sodium	350	2.3	2.3
Mycophenolic Acid	23	2.2	2.2
Hydroxyurea	15	2.2	2.2
Nifedipine	33	2.2	2.2
Benralizumab	14	2.2	2.2
Prednisolone Acetate	7	2.1	2.1
Rituximab	140	2.1	2.1
Nicotine Polacrilex Mini	10	2.1	2.1
Nicotine Polarilex	10	2.1	2.1
Darunavir	10	2.1	2.1
Haloperidol	16	2.0	2.0
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	22	1.9	1.9
Baricitinib	6	1.9	1.9
Ritonavir	18	1.9	1.9
Infliximab	131	1.9	1.9
Entecavir	7	1.9	1.9
Diclofenac Sodium	88	1.8	1.8
Levocetirizine Dihydrochloride	14	1.8	1.8
Acetaminophen And Codeine	7	1.8	1.8
Secukinumab	91	1.8	1.8
Abatacept	78	1.8	1.8
Sofosbuvir	11	1.7	1.7
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	23	1.7	1.7
Dolutegravir Sodium	5	1.7	1.7
Ritonavir 100 Mg	8	1.7	1.7
Ibuprofen Tablets, Coated	22	1.6	1.6
Ibuprofen Sodium	22	1.6	1.6
Insulin Human	20	1.6	1.6
Inclisiran	4	1.5	1.5
Oseltamivir Phosphate	12	1.5	1.5
Cenobamate	4	1.5	1.5
Ado-Trastuzumab Emtansine	4	1.5	1.5
Interferon Beta-1B	9	1.5	1.5
Tenofovir Disoproxil Fumarate Tablets	4	1.4	1.4
Miconazole Nitrate	4	1.4	1.4
Belimumab	14	1.4	1.4
Drospirenone And Ethinyl Estradiol	19	1.3	1.3
Acetaminophen, Aspirin (Nsaid) And Caffeine	7	1.3	1.3
Velpatasvir And Sofosbuvir	5	1.2	1.2
Erenumab-Aooe	20	1.1	1.1
Ozanimod Hydrochloride	3	1.1	1.1
Galcanezumab-Gnlm	11	1.1	1.1
Vismodegib	3	1.0	1.0
Tenofovir Disoproxil Fumarate	11	1.0	1.0
Acetaminophen, Aspirin, And Caffeine	7	1.0	1.0
Dasatinib	12	1.0	1.0
Sarilumab	8	0.9	0.9
Ofatumumab	10	0.9	0.9
Medroxyprogesterone Acetate	14	0.9	0.9
Methoxy Polyethylene Glycol-Epoetin Beta	3	0.8	0.8
Emtricitabine And Tenofovir Alafenamide	3	0.8	0.8
Copper	7	0.5	0.5
Adapalene	3	0.1	0.1

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.