Reaction

Hepatosplenomegaly reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,546 reports · 143 co-occurring drugs

As of the last recalculation, Hepatosplenomegaly appears in 2,546 FAERS reports alongside 143 co-occurring drug terms. The strongest observed disproportionality signal is AMPHOTERICIN B (PRR 37.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Amphotericin B	56	37.3	37.5
Zidovudine	58	36.3	36.4
Efavirenz	36	26.8	26.8
Anti-Thymocyte Globulin (Rabbit)	24	24.5	24.6
Lamivudine	89	24.4	24.4
Lamivudine Oral	66	21.9	21.9
Rifampicin	26	21.2	21.3
Abacavir Sulfate	25	21.2	21.2
Nevirapine	23	21.0	21.1
Lopinavir And Ritonavir	34	20.8	20.8
Canakinumab	26	19.8	19.9
Anakinra	38	19.0	19.0
Pyrazinamide	21	18.4	18.5
Alemtuzumab	41	17.6	17.6
Isoniazid	34	17.4	17.4
Valganciclovir	38	16.7	16.7
Valganciclovir Hydrochloride	38	16.7	16.7
Fludarabine Phosphate	78	16.7	16.7
Ganciclovir Sodium	18	14.0	14.0
Hydroxyurea	35	13.7	13.7
Ganciclovir	17	13.7	13.7
Meropenem	51	13.2	13.3
Sodium Bicarbonate	36	12.8	12.8
Sodium Bicarbonate Injection,	36	12.8	12.8
Tamsulosin Hydrochloride	31	12.6	12.6
Obinutuzumab	25	12.5	12.6
Tenofovir Disoproxil Fumarate Tablets	13	12.4	12.4
Mercaptopurine	25	11.9	11.9
Candesartan Cilexetil	37	11.7	11.7
Ifosfamide	30	11.5	11.6
Voriconazole Injection	30	11.4	11.4
Trimethoprim	16	11.2	11.2
Etoposide	96	11.1	11.1
Cytarabine	76	10.6	10.6
Ceftriaxone	42	10.6	10.6
Bendamustine Hcl	20	10.6	10.6
Itraconazole	15	10.6	10.6
Vincristine Sulfate	37	10.5	10.5
Voriconazole	38	10.4	10.4
Thiotepa	12	10.3	10.3
Ritonavir	36	10.2	10.2
Ceftriaxone Sodium	47	10.2	10.2
Ampicillin	10	9.9	9.9
Ampicillin Sodium	10	9.9	9.9
Cefepime	17	9.8	9.8
Torsemide	38	9.5	9.5
Cefuroxime	13	9.3	9.3
Vancomycin	64	9.3	9.3
Cefepime Hydrochloride	18	9.2	9.2
Vancomycin Hydrochloride	72	9.2	9.2
Ursosiol	21	8.9	8.9
Mycophenolic Acid	34	8.8	8.8
Colchicine	28	8.8	8.8
Azathioprine	91	8.7	8.7
Atazanavir	15	8.6	8.6
Captopril	10	8.5	8.5
Carbamazepine	68	8.5	8.5
Doxazosin Mesylate	37	8.5	8.5
Basiliximab	12	8.4	8.4
Busulfan	16	8.4	8.4
Ursodiol	22	8.3	8.3
Ritonavir 100 Mg	15	8.3	8.3
Pegaspargase	12	8.0	8.1
Daptomycin	9	8.0	8.0
Imatinib	17	7.9	7.9
Esomeprazole Magnesium Capsule, Delayed Release	14	7.9	7.9
Esomeprazole Magnesium Delayed Release Capsules	14	7.9	7.9
Filgrastim	36	7.9	7.9
Esomeprazole Magnesium Dihydrate	14	7.9	7.9
Phenytoin	20	7.9	7.9
Tobramycin Solution	11	7.5	7.5
Acalabrutinib	11	7.4	7.5
Terbinafine Hydrochloride	8	7.4	7.4
Tranexamic Acid	8	7.4	7.4
Doxazosin	25	7.4	7.4
Rifampin	13	7.3	7.3
Tobramycin Sulfate	11	7.3	7.3
Dolutegravir Sodium	8	7.3	7.3
Melphalan Hydrochloride	22	7.2	7.2
Amikacin	15	7.2	7.2
Clarithromycin	30	7.2	7.2
Linezolid	26	7.2	7.2
Deferasirox	23	7.1	7.2
Darbepoetin Alfa	45	6.9	6.9
Gentamicin	11	6.9	6.9
Melphalan	19	6.9	6.9
Azacitidine For	15	6.8	6.8
Gentamicin Sulfate	13	6.8	6.8
Cyclosporine	89	6.7	6.7
Sirolimus	11	6.7	6.7
Cyclophosphamide Injection, Solution	138	6.7	6.7
Cyclophosphamide	138	6.7	6.7
Cyclophosphamide For Injection	138	6.7	6.7
Lamotirigine	57	6.6	6.6
Lamotrigine Extended-Release	57	6.6	6.6
Lamotrigine Chewable Dispersible	57	6.6	6.6
Diphenhydramine Hcl	9	6.6	6.6
Tacrolimus	121	6.6	6.6
Tacrolimus Ointment 0.1%	96	6.5	6.5
Tacrolimus Extended-Release Capsules	96	6.5	6.5
Doxepin	8	6.5	6.5
Fluconazole	54	6.4	6.4
Prednisolone	135	6.4	6.4
Prednisolone Oral	135	6.4	6.4
Prednisolone Oral Solution	135	6.4	6.4
Brivaracetam	7	6.4	6.4
Blinatumomab	8	6.3	6.3
Quinapril Hydrochloride	6	6.2	6.2
Mycophenolate Mofetil	100	6.2	6.2
Mycophenolate Mofetil Hydrochloride	100	6.2	6.2
Doxorubicin	64	6.0	6.0
Cladribine	7	6.0	6.0
Daspone	7	5.9	5.9
Dapsone Gel, 5%	7	5.9	5.9
Venetoclax	43	5.8	5.8
Ketoconazole Foam	10	5.5	5.6
Ketoconazole Cream, 2%	10	5.5	5.5
Valganciclovir Hydrochloride Powder,	8	5.4	5.4
Nilotinib	19	5.3	5.3
Azacitidine	19	5.3	5.3
Tenofovir Disoproxil Fumarate	21	5.2	5.2
Zonisamide	9	5.0	5.0
Ruxolitinib	43	5.0	5.0
Micafungin Sodium	5	4.8	4.8
Minoxidil Foam 5% (Womens)	19	4.7	4.7
Emtricitabine And Tenofovir Disoproxil Fumarate	26	4.7	4.7
Doxorubicin Hydrochloride	18	4.5	4.5
Tobramycin	12	4.1	4.1
Thalidomide	18	4.0	4.0
Canagliflozin	13	3.6	3.6
Eltrombopag Olamine	10	3.6	3.6
Dasatinib	16	3.5	3.5
Minoxidil	19	3.5	3.5
Ibrutinib	32	3.3	3.3
Brentuximab Vedotin	4	3.2	3.2
Gemcitabine	15	3.1	3.1
Iohexol	3	3.0	3.0
Bosentan	18	2.9	2.9
Guselkumab	12	2.8	2.8
Romiplostim	5	2.7	2.7
Polatuzumab Vedotin	3	2.5	2.5
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	4	1.8	1.8
Palivizumab	3	1.6	1.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.