Reaction

Hyperpyrexia reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,092 reports · 139 co-occurring drugs

As of the last recalculation, Hyperpyrexia appears in 4,092 FAERS reports alongside 139 co-occurring drug terms. The strongest observed disproportionality signal is BLEOMYCIN SULFATE (PRR 19.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Bleomycin Sulfate	40	19.9	20.0
Dabrafenib	76	18.7	18.7
Sodium Chloride Tablet	249	18.3	18.3
Sodium Chloride Tablets	249	18.3	18.3
Sodium Chloride	251	17.2	17.2
Trametinib	76	16.3	16.3
Iohexol	24	14.8	14.8
Pertuzumab	76	14.5	14.5
Dextrose	36	14.0	14.1
Dextrose Monohydrate	36	13.8	13.8
Dexamethasone Sodium Phosphate	26	13.1	13.1
Trastuzumab	168	12.9	13.0
Gemcitabine Hydrochloride	105	10.3	10.3
Obinutuzumab	31	9.7	9.7
Zoledronic Acid	74	9.5	9.5
Daratumumab	68	8.8	8.8
Gemcitabine	66	8.6	8.7
Polatuzumab Vedotin	15	7.8	7.9
Anti-Thymocyte Globulin (Rabbit)	12	7.6	7.6
Rasagiline Mesylate	16	7.3	7.3
Cytarabine	82	7.1	7.1
Misoprostol	13	6.8	6.8
Valproate Sodium	27	6.7	6.7
Cetuximab	39	6.4	6.4
Paclitaxel (Aibumin-Bound)	100	6.3	6.3
Vincristine Sulfate	36	6.3	6.3
Paclitaxel	119	6.3	6.3
Oxaliplatin	89	6.2	6.2
Meropenem	38	6.1	6.1
Rifampicin	12	6.0	6.1
Axicabtagene Ciloleucel	11	5.7	5.7
Linezolid	33	5.7	5.7
Piperacillin And Tazobactam	14	5.6	5.6
Gentamicin Sulfate	17	5.5	5.5
Gentamicin	14	5.5	5.5
Ado-Trastuzumab Emtansine	9	5.4	5.4
Pemetrexed Disodium	40	5.4	5.4
Amphotericin B	13	5.3	5.3
Ceftriaxone Sodium	39	5.2	5.2
Piperacillin Sodium,Tazobactam Sodium	27	5.2	5.2
Cyclophosphamide Injection, Solution	173	5.1	5.1
Cyclophosphamide	173	5.1	5.1
Cyclophosphamide For Injection	173	5.1	5.1
Calcium Gluconate	12	5.1	5.1
Sevoflurane	8	4.9	4.9
Blinatumomab	10	4.9	4.9
Levofloxacin	57	4.9	4.9
Levofloxacin In 5% Dextrose	57	4.9	4.9
Ganciclovir Sodium	10	4.8	4.8
Ceftriaxone	30	4.7	4.7
Posaconazole Delayed-Release	10	4.6	4.6
Ganciclovir	9	4.5	4.5
Carbamazepine	57	4.4	4.4
Imatinib	15	4.3	4.3
Pramipexole	13	4.3	4.3
Midazolam	21	4.3	4.3
Fluorouracil Cream, 0.5%	63	4.3	4.3
Vemurafenib	10	4.2	4.2
Propofol	30	4.2	4.2
Fluorouracil	63	4.2	4.2
Midazolam Hydrochloride	22	4.2	4.2
Piperacillin Sodium And Tazobactam Sodium	16	4.2	4.2
Encorafenib	8	4.1	4.1
Vancomycin	46	4.1	4.1
Posaconazole	13	4.1	4.1
Doxorubicin Hydrochloride	26	4.1	4.1
Vancomycin Hydrochloride	52	4.1	4.1
Ropinirole	12	4.0	4.0
Etoposide	57	4.0	4.0
Regorafenib	9	3.9	4.0
Itraconazole	9	3.9	3.9
Fulvestrant	25	3.9	3.9
Carboplatin	94	3.8	3.8
Docetaxel Anhydrous	50	3.8	3.8
Docetaxel	50	3.8	3.8
Pemetrexed	16	3.8	3.8
Diazepam Oral Solution (Concentrate)	65	3.8	3.8
Diazepam Oral	65	3.8	3.8
Doxorubicin	65	3.8	3.8
Haloperidol Lactate	18	3.7	3.7
Mesna Injection	6	3.7	3.7
Mesna	6	3.6	3.6
Micafungin Sodium	6	3.6	3.6
Haloperidol	17	3.6	3.6
Busulfan	11	3.6	3.6
Fludarabine Phosphate	27	3.5	3.5
Bevacizumab	81	3.4	3.4
Levodopa	8	3.4	3.4
Sofosbuvir	13	3.4	3.4
Memantine	9	3.4	3.4
Memantine Hydrochloride	9	3.4	3.4
Daptomycin	6	3.3	3.3
Leucovorin Calcium	12	3.2	3.2
Oseltamivir	5	3.2	3.2
Irinotecan Hydrochloride	8	3.2	3.2
Cisplatin	48	3.2	3.2
Apalutamide	7	3.0	3.0
Lamivudine Oral	15	3.0	3.0
Amantadine	9	3.0	3.0
Bendamustine Hcl	9	3.0	3.0
Pembrolizumab	60	2.9	2.9
Valproic Acid	18	2.9	2.9
Deferasirox	15	2.9	2.9
Ifosfamide	12	2.8	2.8
Gefitinib	5	2.8	2.8
Crizotinib	7	2.8	2.8
Tiotropium Bromide Inhalation Spray	6	2.7	2.7
Amikacin	9	2.7	2.7
Rocuronium Bromide	6	2.6	2.6
Bendamustine Hydrochloride	6	2.6	2.6
Abemaciclib	10	2.5	2.5
Levetiracetam In Sodium Chloride	38	2.5	2.5
Levetiracetam Oral	38	2.5	2.5
Levetiracetam Injection	38	2.5	2.5
Ofatumumab	16	2.5	2.5
Sorafenib	10	2.5	2.5
Trifluridine And Tipiracil	5	2.4	2.4
Methadone Hydrochloride	5	2.4	2.4
Ipilimumab	18	2.1	2.1
Pegfilgrastim	41	2.1	2.1
Capecitabine	38	2.1	2.1
Pegaspargase	5	2.1	2.1
Sunitinib Malate	16	2.1	2.1
Bortezomib	36	2.1	2.1
Erlotinib Hydrochloride	5	2.0	2.0
Brentuximab Vedotin	4	2.0	2.0
Atezolizumab	15	2.0	2.0
Paliperidone	9	2.0	2.0
Azacitidine For	7	2.0	2.0
Peginterferon Beta-1A	5	1.9	1.9
Canakinumab	4	1.9	1.9
Clozapine	46	1.9	1.9
Durvalumab	7	1.8	1.8
Azacitidine	10	1.7	1.7
Alteplase	5	1.7	1.7
Peginterferon Alfa-2A	16	1.5	1.5
Glatiramer Acetate	16	1.4	1.4
Benralizumab	5	1.3	1.3
Palivizumab	3	1.0	1.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.