Reaction

Intervertebral Disc Disorder reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,241 reports · 211 co-occurring drugs

As of the last recalculation, Intervertebral Disc Disorder appears in 4,241 FAERS reports alongside 211 co-occurring drug terms. The strongest observed disproportionality signal is BLEOMYCIN SULFATE (PRR 15.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Bleomycin Sulfate	32	15.3	15.4
Alendronate Sodium	217	11.1	11.1
Carisoprodol	41	10.6	10.7
Methocarbamol Tablets	36	10.6	10.7
Methocarbamol	48	10.5	10.5
Tizanidine Hydrochloride	36	9.9	9.9
Hyoscyamine Sulfate	17	9.1	9.1
Risedronate Sodium	55	8.8	8.8
Inclisiran	14	8.6	8.6
Losartan Potassium And Hydrochlorothiazide	18	7.6	7.6
Butalbital, Acetaminophen, And Caffeine	16	7.4	7.4
Baclofen	114	6.7	6.7
Promethazine Hydrochloride	25	6.6	6.6
Valsartan And Hydrochlorothiazide	18	6.5	6.5
Felodipine Extended-Release Tablets	15	6.5	6.5
Felodipine	15	6.5	6.5
Cephalexin	28	6.4	6.4
Liothyronine Sodium	11	6.2	6.2
Diazepam	149	6.2	6.2
Methylprednisolone Acetate	10	6.1	6.1
Captopril	12	6.1	6.1
Cimetidine	12	6.1	6.1
Valsartan Oral	65	5.9	6.0
Interferon Beta-1A	219	5.8	5.8
Celecoxib	151	5.8	5.8
Tizanidine	28	5.8	5.8
Calcium, Magnesium, Potassium, And Sodium Oxybates	10	5.7	5.7
Modafinil	37	5.7	5.7
Diclofenac	96	5.6	5.6
Pregabalin	288	5.5	5.5
Cyclobenzaprine Hydrochloride	10	5.5	5.5
Teriflunomide	49	5.4	5.4
Gemfibrozil	16	5.2	5.2
Cyclobenzaprine	52	5.2	5.2
Pramipexole	16	5.1	5.1
Ibuprofen And Diphenhydramine Citrate	24	5.1	5.1
Morphine	76	5.1	5.1
Psyllium Husk	10	5.0	5.0
Tolterodine Tartrate	9	4.9	4.9
Ezetimibe And Simvastatin	15	4.9	4.9
Diltiazem Hydrochloride	34	4.9	4.9
Dicyclomine Hydrochloride	14	4.8	4.8
Clonidine	50	4.8	4.8
Meperidine Hydrochloride	9	4.8	4.8
Amitriptyline Hydrochloride	17	4.8	4.8
Trazodone Hydrochloride	15	4.7	4.7
Meloxicam	55	4.7	4.7
Meclizine Hcl 12.5Mg	13	4.7	4.7
Meclizine Hcl 25Mg	13	4.7	4.7
Meclizine Hcl 12.5 Mg	13	4.7	4.7
Meclizine Hcl 25 Mg	13	4.7	4.7
Chlorthalidone	11	4.7	4.7
Nebivolol	15	4.6	4.6
Leflunomide	97	4.6	4.6
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	17	4.6	4.6
Sodium Oxybate	61	4.6	4.6
Quinine	8	4.6	4.6
Valsartan	96	4.6	4.6
Vitamin E	29	4.5	4.6
Meclizine	15	4.5	4.5
Clindamycin	26	4.5	4.5
Conjugated Estrogens	53	4.5	4.5
Oxycodone Hydrochloride And Acetaminophen	89	4.5	4.5
Oxybutynin Chloride	8	4.5	4.5
Esomeprazole Magnesium	205	4.5	4.5
Temazepam	34	4.5	4.5
Gabapentin	312	4.5	4.5
Docusate Sodium - Sennosides	29	4.4	4.4
Clindamycin Phosphate	30	4.4	4.4
Estrogens, Conjugated	53	4.4	4.4
Diazepam Oral Solution (Concentrate)	79	4.4	4.4
Diazepam Oral	79	4.4	4.4
Diphenhydramine Hcl	10	4.4	4.4
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	9	4.4	4.4
Citalopram	119	4.4	4.4
Rizatriptan Benzoate	9	4.3	4.4
Primidone	9	4.3	4.3
Rabeprazole Sodium	24	4.3	4.3
Cetirizine Hcl	8	4.3	4.3
Meclizine Hydrochloride	17	4.3	4.3
Nitroglycerin	46	4.2	4.2
Armodafinil	18	4.2	4.2
Ibuprofen Capsule	165	4.2	4.2
Ibuprofen Tablet, Film Coated	165	4.2	4.2
Ibupfrofen	165	4.2	4.2
Ibuprofen Tablets Usp, 200Mg	165	4.2	4.2
Ibuprofen Oral	165	4.2	4.2
Ibuprofen Capsules 200 Mg	165	4.2	4.2
Ibuprofen 200 Mg	165	4.2	4.2
Ibuprofen 200Mg	165	4.2	4.2
Lubiprostone	8	4.2	4.2
Zolpidem Tartrate	112	4.2	4.2
Ziprasidone Mesylate	12	4.1	4.1
Diclofenac Sodium	124	4.1	4.1
Docusate Sodium	48	4.1	4.1
Hydrochlorothiazide	119	4.1	4.1
Indomethacin	11	4.1	4.1
Torsemide	27	4.0	4.0
Lidocaine Hydrochloride And Epinephrine Bitartrate	43	4.0	4.0
Ibuprofen	210	3.9	3.9
Human Insulin	10	3.9	3.9
Sucralfate	19	3.9	3.9
Teriparatide	87	3.8	3.8
Drs. Clotrimazole	9	3.8	3.8
Family Wellness Clotrimazole	9	3.8	3.8
Clotrimazole Topical	9	3.8	3.8
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate	7	3.8	3.8
Alprazolam	156	3.8	3.8
Thalidomide	28	3.8	3.8
Amlodipine Besylate And Benazepril Hydrochloride	7	3.7	3.7
Thyroid, Porcine	8	3.7	3.7
Exemestane	16	3.7	3.7
Fluticasone Furoate	9	3.7	3.7
Dutasteride	6	3.6	3.6
Sumatriptan	28	3.6	3.6
Duloxetine Hydrochloride	135	3.6	3.6
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	36	3.6	3.6
Paroxetine Hydrochloride Hemihydrate	24	3.6	3.6
Paroxetine	24	3.5	3.5
Fluoxetine Hydrochloride	89	3.5	3.5
Buprenorphine Hydrochloride, Naloxone Hydrochloride	17	3.5	3.5
Citalopram Hydrobromide	74	3.4	3.4
Losartan Potassium	54	3.4	3.4
Ziprasidone	12	3.4	3.4
Conjugated Estrogens And Medroxyprogesterone Acetate	16	3.3	3.3
Biotin	21	3.3	3.3
Umeclidinium	6	3.3	3.3
Fulvestrant	22	3.3	3.3
Acetaminophen, Aspirin, And Caffeine	14	3.3	3.3
Hydroxychloroquine Sulfate	60	3.3	3.3
Enoxaparin Sodium	38	3.3	3.3
Lovastatin	17	3.3	3.3
Golimumab	56	3.2	3.2
Adalimumab	433	3.2	3.2
Bupropion Hydrochloride	64	3.2	3.2
Amantadine	10	3.2	3.2
Lisinopril And Hydrochlorothiazide Tablets	5	3.1	3.1
Fluticasone Propionate And Salmeterol Xinafoate	38	3.1	3.1
Hydromorphone Hydrochloride	58	3.1	3.1
Estradiol Gel 0.1%	28	3.1	3.1
Estradiol Transdermal	28	3.1	3.1
Pravastatin Sodium	12	3.0	3.0
Melphalan Hydrochloride	15	2.9	2.9
Bicalutamide	9	2.9	2.9
Insulin Glulisine	6	2.9	2.9
Estradiol	50	2.9	2.9
Insulin Human	23	2.8	2.9
Nilotinib	17	2.8	2.8
Interferon Beta-1B	11	2.8	2.8
Melphalan	13	2.8	2.8
Ribociclib	18	2.8	2.8
Losartan	98	2.8	2.8
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	20	2.8	2.8
Testosterone Cypionate	5	2.7	2.8
Bosutinib	5	2.7	2.7
Upadacitinib	45	2.7	2.7
Dolutegravir Sodium	5	2.7	2.7
Oxycodone	102	2.7	2.7
Etonogestrel And Ethinyl Estradiol	12	2.7	2.7
Natalizumab	95	2.6	2.6
Acetaminophen, Aspirin (Nsaid) And Caffeine	9	2.6	2.6
Cladribine	5	2.6	2.6
Ibuprofen Tablets, Coated	22	2.5	2.5
Ravulizumab	7	2.5	2.5
Abatacept	71	2.5	2.5
Hydrocodone Bitartrate And Acetaminophen	29	2.5	2.5
Tofacitinib	94	2.5	2.5
Romosozumab-Aqqg	7	2.5	2.5
Ibuprofen Sodium	22	2.5	2.5
Oxybutynin	15	2.5	2.5
Ozanimod Hydrochloride	4	2.4	2.4
Naproxen Sodium Tablet	25	2.3	2.3
Oxycodone Hydrochloride	101	2.3	2.3
Etanercept	271	2.3	2.3
Etoposide	34	2.3	2.3
Dalfampridine	33	2.3	2.3
Emtricitabine And Tenofovir Disoproxil Fumarate	21	2.3	2.3
Peginterferon Beta-1A	6	2.2	2.2
Ofatumumab	15	2.2	2.2
Bortezomib	40	2.2	2.2
Denosumab	89	2.2	2.2
Fingolimod Hcl	38	2.2	2.2
Varenicline Tartrate	35	2.2	2.2
Hydrocodone Bitartrate	19	2.2	2.2
Vilazodone Hydrochloride	4	2.1	2.1
Oxycodone And Acetaminophen	10	2.1	2.1
Diroximel Fumarate	5	2.1	2.1
Risankizumab-Rzaa	34	2.0	2.0
Cortisone Acetate	5	2.0	2.0
Pegfilgrastim	39	1.9	1.9
Insulin Lispro	54	1.9	1.9
Azacitidine For	7	1.9	1.9
Glatiramer Acetate	21	1.7	1.7
Fremanezumab-Vfrm	4	1.7	1.7
Ixazomib	10	1.7	1.7
Tenofovir Disoproxil Fumarate	11	1.6	1.6
Dimethyl Fumarate	39	1.6	1.6
Rimegepant Sulfate	4	1.5	1.5
Leuprolide Acetate	21	1.3	1.3
Tafamidis	3	1.3	1.3
Onabotulinumtoxina	19	1.2	1.2
Alirocumab	6	1.2	1.2
Pirfenidone	9	1.1	1.1
Abiraterone Acetate	9	1.1	1.1
Relugolix	5	1.0	1.0
Abaloparatide	6	1.0	1.0
Dulaglutide	17	0.9	0.9
Erenumab-Aooe	9	0.8	0.8
Evolocumab	22	0.7	0.7
Galcanezumab-Gnlm	4	0.6	0.6
Tirzepatide	17	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.