Reaction

Anal Fissure reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,268 reports · 158 co-occurring drugs

As of the last recalculation, Anal Fissure appears in 5,268 FAERS reports alongside 158 co-occurring drug terms. The strongest observed disproportionality signal is INFLIXIMAB-DYYB (PRR 176.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Infliximab-Dyyb	1,046	176.2	182.7
Isotretinoin	366	31.3	31.6
Infliximab	1,068	24.0	24.1
Vedolizumab	461	23.1	23.2
Azathioprine	411	19.9	20.0
Mesalamine	258	19.0	19.1
Cholestyramine	56	18.5	18.6
Dimenhydrinate	49	18.3	18.4
Metronidazole	249	16.1	16.2
Anti-Itch	230	14.1	14.2
Anti-Pruritic	230	14.1	14.2
Antipruritic (Anti-Itch)	230	14.1	14.2
Cool Relief Gel With Aloe	230	14.1	14.2
Drs. Hydrocortisone	230	14.1	14.2
Hydrocortisone Continuous Spray	230	14.1	14.2
Hydrocortisone Spray	230	14.1	14.2
Anti-Itch Cream	230	14.1	14.2
Hydrocortisone Lotion	230	14.1	14.2
Hydrocortisone Cream 1%	230	14.1	14.2
Hydrocortisone Cream 1/2%	230	14.1	14.2
Hydrocortisone 1%	230	14.1	14.2
Hydrocortisone Cream	230	14.1	14.1
Hydrocortisone Sodium Succinate	33	14.0	14.0
Hydrocortisone	291	13.6	13.6
Hydrocortisone Acetate	235	13.3	13.4
Desoximetasone	57	11.9	12.0
Metronidazole Topical	139	11.8	11.8
Diphenhydramine	170	11.0	11.0
Ciprofloxacin Hydrochloride	255	10.8	10.9
Ciprofolxacin	182	10.4	10.4
Ciprofloxacin Tablets	182	10.4	10.4
Ciprofloxacin	227	10.2	10.2
Ciprofloxacin Hydrochloride And Hydrocortisone	46	8.8	8.8
Loperamide Hydrochloride And Dimethicone	69	8.6	8.6
Mercaptopurine	37	8.5	8.5
Psyllium Husk	21	8.4	8.4
Iron	135	8.2	8.2
Diphenoxylate Hydrochloride And Atropine Sulfate	27	7.8	7.8
Budesonide	114	7.8	7.8
Instalax Polyethylene Glycol 3350	24	7.7	7.7
Polyethylene Glycol 400	24	7.5	7.5
Loperamide Hydrochloride	82	7.3	7.4
Prednisone	794	7.2	7.2
Pantoprazole Sodium In 0.9% Sodium Chloride	102	6.6	6.6
Pantoprazole Sodium Injection	102	6.6	6.6
Adalimumab-Adaz	86	6.5	6.5
Dicyclomine Hydrochloride	23	6.4	6.4
Diphenhydramine Hydrochloride	232	5.7	5.7
Rabeprazole	32	5.7	5.7
Misoprostol	14	5.7	5.7
Adalimumab-Fkjp	64	5.5	5.5
Iron Sucrose	13	5.4	5.4
Felodipine Extended-Release Tablets	15	5.2	5.2
Felodipine	15	5.2	5.2
Methotrexate	508	5.2	5.2
Abemaciclib	26	5.2	5.2
Folic Acid	305	5.1	5.1
Antacid	60	5.0	5.0
Methotrexate Sodium	554	4.9	4.9
Calcium	173	4.7	4.7
Sulfasalazine	91	4.7	4.7
Loperamide Hydrochloride Oral	12	4.7	4.7
Acetaminophen Tablet Extended Release	282	4.6	4.6
Pain Reliever	282	4.6	4.6
Acetaminophen 500Mg	282	4.6	4.6
Goserelin	15	4.4	4.4
Cyanocobalamin	36	4.3	4.3
Olmesartan Medoxomil	39	4.3	4.3
Teduglutide	14	4.1	4.1
Dexlansoprazole	43	4.1	4.1
Methylprednisolone Sodium Succinate	46	3.9	3.9
Pegaspargase	12	3.9	3.9
Telmisartan	17	3.8	3.8
Venlafaxine	67	3.7	3.7
Leucovorin Calcium	18	3.7	3.7
Irinotecan Hydrochloride	12	3.7	3.7
Loperamide Hcl	12	3.7	3.7
Calcium Carbonate	62	3.7	3.7
Pantoprazole	227	3.7	3.7
Adalimumab-Aaty	43	3.6	3.6
Acetaminophen	378	3.5	3.5
Azacitidine	26	3.5	3.5
Candesartan	31	3.4	3.5
Sorafenib	18	3.4	3.4
Tretinoin	7	3.4	3.4
Minocycline	10	3.4	3.4
Pantoprazole Sodium	123	3.3	3.3
Ustekinumab	85	3.3	3.3
Irbesartan	37	3.3	3.3
Adalimumab	545	3.3	3.3
Rifampin	12	3.3	3.3
Midazolam Hydrochloride	22	3.2	3.2
Midazolam	20	3.1	3.1
Lisdexamfetamine Dimesylate	26	3.1	3.1
Ceftriaxone Sodium	30	3.1	3.1
Eplerenone	10	3.1	3.1
Tolterodine Tartrate	7	3.1	3.1
Methimazole	6	3.0	3.0
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	118	3.0	3.0
Fluticasone Furoate	9	2.9	2.9
Fluorouracil	57	2.9	2.9
Lubiprostone	7	2.9	2.9
Fluorouracil Cream, 0.5%	56	2.9	2.9
Pertuzumab	20	2.9	2.9
Polatuzumab Vedotin	7	2.8	2.8
Azacitidine For	13	2.8	2.8
Sunitinib Malate	28	2.8	2.8
Venlafaxine Hydrochloride	93	2.8	2.8
Bevacizumab	85	2.7	2.7
Letrozole Tablets	33	2.7	2.7
Citalopram Hydrobromide	72	2.7	2.7
Lurasidone Hydrochloride	14	2.6	2.6
Hydroxychloroquine Sulfate	60	2.6	2.6
Gemfibrozil	10	2.6	2.6
Peginterferon Alfa-2A	35	2.6	2.6
Fesoterodine Fumarate	7	2.6	2.6
Dutasteride	5	2.4	2.4
Regorafenib	7	2.4	2.4
Sumatriptan Succinate	15	2.3	2.3
Letrozole	36	2.3	2.3
Cabozantinib	28	2.3	2.3
Ribavirin	37	2.3	2.3
Ranolazine	6	2.3	2.3
Granisetron Hydrochloride	6	2.3	2.3
Filgrastim	21	2.2	2.2
Nilotinib	16	2.1	2.1
Bupropion	24	2.1	2.1
Ribociclib	17	2.1	2.1
Linaclotide	14	2.1	2.1
Polyethylene Glycol 3350	49	2.0	2.0
Vincristine Sulfate	15	2.0	2.0
Lanreotide Acetate	4	2.0	2.0
Orlistat	13	2.0	2.0
Mesna Injection	4	1.9	1.9
Cetuximab	15	1.9	1.9
Mesna	4	1.9	1.9
Vortioxetine	8	1.9	1.9
Upadacitinib	38	1.8	1.8
Lapatinib	7	1.8	1.8
Risankizumab-Rzaa	33	1.6	1.6
Oxaliplatin	29	1.5	1.5
Drospirenone And Ethinyl Estradiol	17	1.5	1.5
Oral Semaglutide	28	1.5	1.5
Pazopanib Hydrochloride	10	1.5	1.5
Rocuronium Bromide	4	1.3	1.3
Lenvatinib	11	1.3	1.3
Bosutinib	3	1.3	1.3
Pemetrexed	7	1.3	1.3
Obinutuzumab	5	1.2	1.2
Hydrocodone Bitartrate And Acetaminophen	17	1.2	1.2
Dasatinib	11	1.2	1.2
Avapritinib	3	1.0	1.0
Hydrocodone Bitartrate	9	0.8	0.8
Paliperidone Palmitate	5	0.6	0.6
Tirzepatide	21	0.5	0.5
Erenumab-Aooe	7	0.5	0.5
Salicylic Acid	4	0.3	0.3
Adapalene	4	0.1	0.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.