OpenPV Signal Explorer
FAERS disproportionality dashboard
Reaction

Cardiac Operation reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,382 reports · 203 co-occurring drugs

As of the last recalculation, Cardiac Operation appears in 8,382 FAERS reports alongside 203 co-occurring drug terms. The strongest observed disproportionality signal is RANOLAZINE (PRR 47.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.
DrugCo-reportsPRRROR
Ranolazine19547.548.4
Palivizumab10917.818.0
Bosentan24712.512.6
Sildenafil Powder,1299.19.2
Risankizumab-Rzaa2838.98.9
Patiromer427.67.6
Macitentan1816.66.6
Sildenafil1496.56.5
Dofetilide276.46.4
Fluticasone Propionate And Salmeterol935.65.6
Empagliflozin1475.55.5
Insulin Human875.55.5
Tafamidis255.35.3
Alirocumab525.25.2
Selexipag535.15.1
Riociguat665.15.1
Sildenafil Citrate2535.15.1
Ambrisentan2434.95.0
Valsartan And Hydrochlorothiazide254.64.6
Epoprostenol244.64.6
Evolocumab2884.54.5
Insulin Aspart1184.54.5
Icosapent Ethyl144.14.1
Umeclidinium Bromide And Vilanterol Trifenatate274.04.0
Human Insulin204.04.0
Insulin Glargine3673.83.8
Ibrutinib1223.83.8
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate623.73.7
Insulin Degludec353.73.7
Upadacitinib1203.73.7
Prasugrel Hydrochloride153.73.7
Tolvaptan213.63.6
Insulin Glargine-Yfgn313.53.5
Tadalafil1393.53.5
Insulin Glulisine143.43.4
Clopidogrel2673.43.4
Relugolix323.43.4
Terazosin Hydrochloride123.43.4
Metoroprolol Tartrate883.33.3
Pancrelipase513.33.3
Fluticasone Propionate And Salmeterol Xinafoate773.23.2
Warfarin1583.13.1
Ciclesonide173.13.1
Bosutinib113.03.0
Carvedilol1613.03.0
Dronedarone122.92.9
Bumetanide312.92.9
Oral Semaglutide852.92.9
Sitagliptin And Metformin Hydrochloride252.92.9
Nintedanib362.92.9
Umeclidinium102.82.8
Atorvastatin Calcium2612.72.7
Isosorbide Mononitrate222.62.6
Fluticasone Furoate And Vilanterol Trifenatate382.62.6
Metoprolol Tartrate2812.62.6
Metoprolol Succinate Er Tablets652.62.6
Calcium, Magnesium, Potassium, And Sodium Oxybates92.62.6
Abiraterone142.62.6
Enalapril Maleate252.52.5
Metoprolol Succinate862.52.5
Digoxin712.52.5
Nitroglycerin532.52.5
Metoprolol2472.52.5
Clopidogrel Bisulfate992.42.4
Agalsidase Beta92.42.4
Warfarin Sodium452.42.4
Rivaroxaban1962.42.4
Cinacalcet Hydrochloride442.42.4
Apalutamide112.32.3
Aspirin4812.32.3
Isosorbide Dinitrate182.32.3
Ezetimibe And Simvastatin142.32.3
Insulin Lispro1262.32.3
Belimumab292.32.3
Mepolizumab452.32.3
Rosuvastatin1832.22.2
Sotalol Hydrochloride152.22.2
Aspirin 325 Mg4412.22.2
Aspirin 81 Mg4412.22.2
Ezetimibe652.22.2
Furosemide3392.12.1
Niacin102.12.1
Dutasteride72.12.1
Metoprolol Tartrate Injection1612.12.1
Gemfibrozil132.12.1
Esketamine Hydrochloride152.12.1
Oxycodone And Acetaminophen Tablets102.12.1
Tamsulosin Hydrochloride172.12.1
Cholestyramine102.12.1
Spironolactone1122.02.0
Calcitriol Capsules 0.25 Mcg162.02.0
Calcitriol Capsules 0.5 Mcg162.02.0
Romiplostim122.02.0
Calcitriol162.02.0
Brivaracetam71.91.9
Chlorthalidone91.91.9
Glipizide471.91.9
Lanreotide Acetate61.91.9
Amikacin131.91.9
Ixekizumab281.91.9
Mupirocin101.81.8
Iron491.81.8
Fenofibrate261.81.8
Dabigatran Etexilate Mesylate531.81.8
Interferon Beta-1B141.81.8
Erythropoietin151.81.8
Liraglutide361.81.8
Mupirocin Calcium101.81.8
Benzonatate121.81.8
Sarilumab191.81.8
Glimepiride281.81.8
Amiodarone Hydrochloride81.81.8
Tiotropium Bromide Inhalation Spray81.81.8
Losartan Potassium561.81.8
Dabigatran Etexilate551.81.8
Pravastatin Sodium141.81.8
Dicyclomine Hydrochloride101.71.7
Sevelamer Carbonate81.71.7
Treprostinil871.71.7
Droxidopa151.71.7
Atorvastatin Calcium, Film Coated481.71.7
Azelastine121.71.7
Glyburide161.61.6
Sitagliptin471.61.6
Amlodipine Besylate And Benazepril Hydrochloride61.61.6
Enalapril361.61.6
Mometasone Furoate And Formoterol Fumarate Dihydrate101.61.6
Glecaprevir And Pibrentasvir71.61.6
Quinapril Hydrochloride51.61.6
Abiraterone Acetate261.61.6
Ticagrelor201.61.6
Vibegron51.51.5
Olanzapine Pamoate251.51.5
Nilotinib181.51.5
Linagliptin111.51.5
Lisinopril1831.51.5
Losartan1041.51.5
Fish Oil531.51.5
Lisinopril And Hydrochlorothiazide61.51.5
Tobramycin Solution71.41.4
Tofacitinib1071.41.4
Interferon Beta-1A1121.41.4
Finasteride351.41.4
Aflibercept181.41.4
Darbepoetin Alfa311.41.4
Teriparatide641.41.4
Paricalcitol81.41.4
Tobramycin Sulfate71.41.4
Bimekizumab121.41.4
Linaclotide151.41.4
Oxycodone And Acetaminophen131.41.4
Hydrocodone Bitartrate And Acetaminophen311.41.4
Rifampin81.41.4
Raltegravir91.41.4
Metformin Hcl301.31.3
Amlodipine Besylate And Valsartan61.31.3
Pioglitazone231.31.3
Guselkumab191.31.3
Dorzolamide Hydrochloride And Timolol Maleate41.31.3
Tiotropium Bromide691.31.3
Adalimumab3491.21.2
Elexacaftor, Tezacaftor, And Ivacaftor61.21.2
Exenatide251.21.2
Naltrexone Hydrochloride And Bupropion Hydrochloride41.21.2
Etanercept2791.21.2
Imatinib Mesylate131.21.2
Golimumab391.11.1
Venetoclax281.11.1
Denosumab851.01.0
Cenegermin-Bkbj51.01.0
Niraparib91.01.0
Oxycodone Hydrochloride871.01.0
Sodium Oxybate250.90.9
Dupilumab1810.90.9
Ustekinumab380.90.9
Pimavanserin Tartrate200.90.9
Certolizumab Pegol420.90.9
Dornase Alfa70.90.9
Acetaminophen, Aspirin (Nsaid) And Caffeine60.90.9
Bimatoprost100.90.9
Eltrombopag Olamine80.90.9
Vigabatrin50.90.9
Oxymorphone Hydrochloride40.90.9
Apremilast500.80.8
Enzalutamide200.80.8
Ranibizumab90.80.8
Acetaminophen, Aspirin, And Caffeine70.80.8
Teriflunomide150.80.8
Daptomycin30.80.8
Cariprazine30.80.8
Crisaborole30.80.8
Canagliflozin90.70.7
Dimethyl Fumarate370.70.7
Somatropin220.70.7
Palbociclib270.70.7
Abaloparatide80.70.7
Pirfenidone110.70.7
Leuprolide Acetate200.60.6
Brexpiprazole40.60.6
Romosozumab-Aqqg30.50.5
Valbenazine50.50.5
Dulaglutide160.40.4
Voxelotor40.40.4

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.