Reaction

Gangrene reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,988 reports · 181 co-occurring drugs

As of the last recalculation, Gangrene appears in 5,988 FAERS reports alongside 181 co-occurring drug terms. The strongest observed disproportionality signal is CANAGLIFLOZIN (PRR 153.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Canagliflozin	1,086	153.9	159.7
Methylprednisolone Acetate	180	80.5	82.4
Dimenhydrinate	215	72.7	74.2
Telmisartan	196	39.4	39.9
Diphenhydramine Hydrochloride Capsule, Liquid Filled	167	27.9	28.1
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	238	27.7	27.9
Candesartan Cilexetil	202	27.6	27.8
Esomeprazole Magnesium Capsule, Delayed Release	103	25.1	25.3
Esomeprazole Magnesium Delayed Release Capsules	103	25.1	25.3
Esomeprazole Magnesium Dihydrate	103	25.0	25.2
Prochlorperazine	188	24.3	24.5
Rosuvastatin Calcium	170	21.6	21.7
Norepinephrine Bitartrate	69	16.8	16.9
Irbesartan	198	15.9	16.0
Methylprednisolone Sodium Succinate	204	15.8	15.8
Cyanocobalamin	146	15.8	15.8
Heparin Sodium	57	14.5	14.6
Norepinephrine	42	13.7	13.8
Sitagliptin	259	13.0	13.1
Antacid	167	12.5	12.6
Candesartan	126	12.5	12.6
Prochlorperazine Maleate	31	11.8	11.8
Esomeprazole	195	11.3	11.3
Calcium Carbonate	196	10.5	10.5
Insulin Lispro	369	9.8	9.9
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	23	9.8	9.8
Pantoprazole Sodium In 0.9% Sodium Chloride	168	9.7	9.7
Pantoprazole Sodium Injection	168	9.7	9.7
Epoetin Alfa	32	9.4	9.5
Ezetimibe	195	9.3	9.3
Insulin Human	104	9.2	9.3
Nilotinib	69	8.2	8.2
Insulin Glargine	517	7.9	7.9
Methylprednisolone	281	7.4	7.4
Morphine	148	7.0	7.1
Empagliflozin	131	6.9	6.9
Insulin Glulisine	20	6.9	6.9
Dalteparin Sodium	20	6.6	6.6
Insulin Glargine-Yfgn	41	6.6	6.6
Ustekinumab	186	6.5	6.5
Insulin	102	6.5	6.5
Bisoprolol Fumarate	243	6.4	6.4
Ondansetron Hydrochloride	218	6.4	6.4
Levothyroxine Sodium Anhydrous	177	6.3	6.3
Amlodipine Besylate	247	6.1	6.1
Metformin Hydrochloride	101	6.0	6.0
Zolpidem Tartrate	225	6.0	6.0
Warfarin Sodium	78	5.9	5.9
Human Insulin	21	5.9	5.9
Metformin Hydrochloride Tablets	95	5.8	5.8
Metformin Hydrochloride Extended-Release Tablets	95	5.8	5.8
Metformin Hydrochloride Tablet	95	5.8	5.8
Hydrochlorothiazide	226	5.6	5.6
Atropine	13	5.5	5.5
Insulin Aspart	102	5.4	5.4
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	242	5.4	5.4
Paricalcitol	22	5.4	5.4
Ondansetron	163	5.3	5.3
Ondansetron Tablets	163	5.3	5.3
Meperidine Hydrochloride	14	5.3	5.3
Metolazone	17	5.3	5.3
Diphenhydramine Hydrochloride	239	5.2	5.2
Linagliptin	26	5.0	5.0
Morphine Sulfate	169	5.0	5.0
Rituximab	282	4.8	4.8
Pantoprazole Sodium	199	4.8	4.8
Cefazolin Sodium	16	4.6	4.6
Ramipril	161	4.6	4.6
Cefazolin	12	4.6	4.6
Atropine Sulfate	14	4.5	4.5
Warfarin	160	4.5	4.5
Methoxy Polyethylene Glycol-Epoetin Beta	14	4.4	4.4
Metformin	427	4.4	4.4
Esomeprazole Magnesium	280	4.3	4.3
Insulin Degludec	29	4.3	4.3
Hydroxyurea	26	4.3	4.3
Lisinopril	359	4.3	4.3
Metformin Er 500 Mg	352	4.3	4.3
Metformin Er 750 Mg	352	4.3	4.3
Sevelamer Carbonate	14	4.2	4.2
Secukinumab	192	4.2	4.2
Pregabalin	318	4.2	4.2
Atorvastatin Calcium	277	4.0	4.0
Gentamicin Sulfate	18	4.0	4.0
Acetaminophen Tablet Extended Release	281	4.0	4.0
Pain Reliever	281	4.0	4.0
Acetaminophen 500Mg	281	4.0	4.0
Pantoprazole	269	3.8	3.8
Dapagliflozin	34	3.8	3.8
Bosentan	54	3.7	3.8
Piperacillin Sodium And Tazobactam Sodium	21	3.7	3.7
Diphenhydramine	67	3.7	3.7
Acetaminophen And Codeine	13	3.7	3.7
Torsemide	35	3.7	3.7
Duloxetine Hydrochloride	191	3.6	3.6
Clopidogrel	201	3.6	3.6
Glyburide	25	3.6	3.6
Sodium Bicarbonate	24	3.6	3.6
Sodium Bicarbonate Injection,	24	3.6	3.6
Levothyroxine Sodium	310	3.6	3.6
Aspirin 325 Mg	482	3.5	3.5
Aspirin 81 Mg	482	3.5	3.5
Gentamicin	13	3.5	3.5
Adrenalinum	41	3.5	3.5
Aspirin	493	3.4	3.4
Enalapril Maleate	24	3.4	3.4
Mupirocin	13	3.4	3.4
Glipizide	58	3.3	3.3
Nitroglycerin	51	3.3	3.3
Naproxen	74	3.3	3.3
Mupirocin Calcium	13	3.3	3.3
Cephalexin	20	3.2	3.2
Daspone	9	3.2	3.2
Dapsone Gel, 5%	9	3.2	3.2
Darbepoetin Alfa	48	3.1	3.1
Amlodipine	234	3.1	3.1
Magnesium Hydroxide	12	3.1	3.1
Sitagliptin And Metformin Hydrochloride	19	3.1	3.1
Nifedipine	41	3.0	3.0
Phenytoin	18	3.0	3.0
Clopidogrel Bisulfate	87	3.0	3.0
Gemfibrozil	13	3.0	3.0
Bisacodyl Suppositories	11	3.0	3.0
Dapsone	9	2.9	2.9
Biscodyl	11	2.9	2.9
Erythropoietin	17	2.9	2.9
Digoxin	59	2.9	2.9
Vancomycin Hydrochloride	53	2.8	2.8
Enoxaparin Sodium	45	2.7	2.7
Carvedilol	105	2.7	2.7
Acetaminophen	336	2.7	2.7
Sorafenib	16	2.7	2.7
Imatinib Mesylate	21	2.6	2.6
Mycophenolic Acid	24	2.6	2.6
Vancomycin	43	2.6	2.6
Atorvastatin Calcium, Film Coated	50	2.5	2.5
Amiodarone Hydrochloride	8	2.5	2.5
Rosuvastatin	143	2.5	2.5
Linezolid	21	2.5	2.5
Miconazole Nitrate	6	2.4	2.4
Indapamide	12	2.3	2.3
Bosutinib	6	2.3	2.3
Furosemide	261	2.3	2.3
Alteplase	10	2.3	2.3
Epinephrine	43	2.3	2.3
Enalapril	36	2.3	2.3
Calcitriol Capsules 0.25 Mcg	13	2.3	2.3
Calcitriol Capsules 0.5 Mcg	13	2.3	2.3
Glimepiride	25	2.2	2.2
Quinapril Hydrochloride	5	2.2	2.2
Isosorbide Mononitrate	13	2.2	2.2
Pioglitazone	27	2.2	2.2
Fondaparinux Sodium	5	2.1	2.1
Pegaspargase	7	2.0	2.0
Cinacalcet Hydrochloride	26	1.9	1.9
Dulaglutide	48	1.9	1.9
Agalsidase Beta	5	1.9	1.9
Imatinib	9	1.8	1.8
Metformin Hcl	28	1.8	1.8
Patiromer	7	1.8	1.8
Ranolazine	5	1.7	1.7
Liraglutide	23	1.6	1.6
Thalidomide	17	1.6	1.6
Dasatinib	17	1.6	1.6
Ranibizumab	12	1.6	1.6
Regorafenib	5	1.5	1.5
Interferon Beta-1B	8	1.5	1.5
Gemcitabine Hydrochloride	22	1.4	1.4
Sunitinib Malate	16	1.4	1.4
Romiplostim	6	1.4	1.4
Crizotinib	5	1.4	1.4
Gemcitabine	15	1.3	1.3
Dabigatran Etexilate Mesylate	26	1.2	1.2
Risankizumab-Rzaa	29	1.2	1.2
Sacubitril And Valsartan	40	1.2	1.2
Dabigatran Etexilate	26	1.2	1.2
Eltrombopag Olamine	7	1.1	1.1
Apalutamide	3	0.9	0.9
Enzalutamide	14	0.8	0.8
Aflibercept	6	0.7	0.7
Minoxidil Foam 5% (Womens)	5	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.