Reaction

Pigmentation Disorder reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,080 reports · 195 co-occurring drugs

As of the last recalculation, Pigmentation Disorder appears in 6,080 FAERS reports alongside 195 co-occurring drug terms. The strongest observed disproportionality signal is MINOCYCLINE (PRR 32.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Minocycline	108	32.3	32.6
Avapritinib	64	18.3	18.4
Ribociclib	107	11.8	11.8
Panitumumab	37	8.1	8.1
Alemtuzumab	45	8.0	8.0
Secukinumab	351	7.8	7.9
Niacin	23	6.8	6.8
Rabeprazole	43	6.7	6.7
Tretinoin	15	6.3	6.3
Siponimod	16	6.2	6.2
Doxepin	18	6.1	6.1
Niraparib	38	5.9	5.9
Clobetasol Propionate Ointment Usp, 0.05%	17	5.7	5.7
Anastrozole Tablets	35	5.6	5.6
Imatinib Mesylate	45	5.6	5.6
Nilotinib	47	5.5	5.5
Fulvestrant	52	5.4	5.4
Carbamazepine	103	5.3	5.3
Lapatinib	24	5.3	5.3
Clobetasol Propionate	16	5.3	5.3
Capecitabine	134	5.1	5.1
Dabrafenib	31	5.1	5.1
Crisaborole	14	5.0	5.0
Doxepin Hydrochloride	18	4.9	4.9
Octreotide Acetate	43	4.8	4.8
Erythromycin	26	4.8	4.8
Pyrazinamide	13	4.7	4.8
Hydroxyurea	29	4.7	4.7
Triamcinolone Acetonide Ointment Usp, 0.05%	32	4.7	4.7
Trametinib	33	4.7	4.7
Mupirocin	18	4.6	4.6
Omalizumab	112	4.6	4.6
Mupirocin Calcium	18	4.5	4.5
Imatinib	23	4.5	4.5
Paroxetine Hydrochloride Hemihydrate	43	4.4	4.4
Cetirizine Hydrochloride Allergy	39	4.4	4.4
Cetirizine Hydrochloride Tablets	39	4.4	4.4
Anastrozole	47	4.4	4.4
Paroxetine	43	4.4	4.4
Epoetin Alfa	15	4.3	4.3
Triamcinolone Acetonide	38	4.2	4.2
Encorafenib	12	4.2	4.2
Quinine	10	4.0	4.0
Timolol	14	4.0	4.0
Ketoconazole	20	4.0	4.0
Ketoconazole Foam	17	3.9	3.9
Bimatoprost	33	3.9	3.9
Ketoconazole Cream, 2%	17	3.9	3.9
Psyllium Husk	11	3.8	3.8
Fondaparinux Sodium	9	3.8	3.8
Pazopanib Hydrochloride	29	3.7	3.7
Clarithromycin	36	3.6	3.6
Eltrombopag Olamine	24	3.6	3.6
Gefitinib	9	3.4	3.4
Sunitinib Malate	38	3.3	3.3
Sorafenib	20	3.3	3.3
Meclizine Hcl 12.5Mg	13	3.3	3.3
Meclizine Hcl 25Mg	13	3.3	3.3
Meclizine Hcl 12.5 Mg	13	3.3	3.3
Meclizine Hcl 25 Mg	13	3.3	3.3
Hydroxyzine	45	3.2	3.2
Desoximetasone	18	3.2	3.2
Fluorouracil	71	3.2	3.2
Latanoprost	46	3.1	3.1
Cyclosporine	101	3.1	3.1
Ruxolitinib	64	3.1	3.1
Raloxifene Hydrochloride	13	3.1	3.1
Bosutinib	8	3.1	3.1
Rifampicin	9	3.0	3.1
Mometasone	16	3.0	3.0
Fluorouracil Cream, 0.5%	66	3.0	3.0
Meclizine	14	2.9	2.9
Cetirizine	66	2.9	2.9
Dapsone	9	2.9	2.9
Exemestane	18	2.9	2.9
Oxaliplatin	62	2.9	2.9
Everolimus	42	2.8	2.8
Dupilumab	374	2.8	2.8
Alpelisib	7	2.8	2.8
Calcium	114	2.7	2.7
Valproate Sodium	16	2.7	2.7
Teriparatide	86	2.6	2.6
Meclizine Hydrochloride	15	2.6	2.6
Rifampin	11	2.6	2.6
Lamotrigine	98	2.6	2.6
Isoniazid	12	2.5	2.5
Amoxicillin	56	2.5	2.5
Letrozole	45	2.5	2.5
Erlotinib	7	2.5	2.5
Erlotinib Hydrochloride	9	2.5	2.5
Cabozantinib	34	2.4	2.4
Valsartan	74	2.4	2.4
Travoprost	6	2.4	2.4
Mercaptopurine	12	2.4	2.4
Prasugrel Hydrochloride	7	2.4	2.4
Pitavastatin Calcium	7	2.3	2.3
Apalutamide	8	2.3	2.3
Sulfasalazine	53	2.3	2.3
Bleomycin Sulfate	7	2.3	2.3
Lifitegrast	11	2.3	2.3
Vemurafenib	8	2.3	2.3
Valsartan And Hydrochlorothiazide	9	2.3	2.3
Ibuprofen Tablets, Coated	28	2.3	2.3
Ibuprofen Sodium	28	2.2	2.2
Fosaprepitant Dimeglumine	9	2.2	2.2
Prochlorperazine Maleate	6	2.2	2.2
Levofloxacin	39	2.2	2.2
Levofloxacin In 5% Dextrose	39	2.2	2.2
Amikacin	11	2.2	2.2
Alirocumab	16	2.2	2.2
Carboxymethylcellulose Sodium	6	2.2	2.2
Iron Sucrose	6	2.2	2.2
Ixazomib	18	2.1	2.1
Lovastatin	16	2.1	2.1
Oxcarbazepine	20	2.1	2.1
Fingolimod Hcl	53	2.1	2.1
Cetuximab	19	2.1	2.1
Sitagliptin And Metformin Hydrochloride	13	2.1	2.1
Regorafenib	7	2.1	2.1
Teriflunomide	27	2.0	2.0
Osimertinib	19	2.0	2.0
Bevacizumab	73	2.0	2.0
Letrozole Tablets	28	2.0	2.0
Estradiol Gel 0.1%	26	2.0	2.0
Valacyclovir	24	2.0	2.0
Estradiol Transdermal	26	2.0	2.0
Voclosporin	5	2.0	2.0
Losartan	98	1.9	1.9
Azelastine	10	1.9	1.9
Dolutegravir Sodium	5	1.9	1.9
Raltegravir	9	1.9	1.9
Multivitamin	27	1.9	1.9
Belimumab	17	1.8	1.8
Deferasirox	14	1.8	1.8
Ofatumumab	17	1.8	1.8
Dasatinib	19	1.8	1.8
Linezolid	15	1.7	1.7
Pemetrexed Disodium	19	1.7	1.7
Inclisiran	4	1.7	1.7
Irinotecan Hydrochloride	6	1.6	1.6
Cisplatin	36	1.6	1.6
Empagliflozin	31	1.6	1.6
Fexofenadine Hydrochloride	10	1.6	1.6
Fremanezumab-Vfrm	5	1.5	1.5
Lenalidomide	181	1.5	1.5
Pembrolizumab	44	1.4	1.4
Asfotase Alfa	4	1.4	1.4
Romiplostim	6	1.4	1.4
Fam-Trastuzumab Deruxtecan-Nxki	4	1.4	1.4
Sarilumab	10	1.3	1.3
Loratadine And Pseudoephedrine Sulfate	3	1.3	1.3
Enzalutamide	22	1.3	1.3
Vibegron	3	1.3	1.3
Docetaxel Anhydrous	25	1.3	1.3
Docetaxel	25	1.3	1.3
Diclofenac Potassium	4	1.3	1.3
Apremilast	53	1.2	1.2
Iohexol	3	1.2	1.2
Axitinib	7	1.2	1.2
Diclofenac Potassium, Film Coated	3	1.2	1.2
Diclofenac Potassium Tablets	3	1.2	1.2
Golimumab	30	1.2	1.2
Durvalumab	7	1.2	1.2
Nivolumab	33	1.2	1.2
Olaparib	7	1.1	1.1
Peginterferon Alfa-2A	18	1.1	1.1
Acalabrutinib	4	1.1	1.1
Isotretinoin	16	1.1	1.1
Cariprazine	3	1.1	1.1
Ranitidine	60	1.0	1.0
Sacubitril And Valsartan	35	1.0	1.0
Abemaciclib	6	1.0	1.0
Benralizumab	6	1.0	1.0
Relugolix	7	1.0	1.0
Ravulizumab	4	1.0	1.0
Romosozumab-Aqqg	4	1.0	1.0
Glatiramer Acetate	17	1.0	1.0
Bimekizumab	6	1.0	1.0
Trifluridine And Tipiracil	3	1.0	1.0
Lenvatinib	9	0.9	0.9
Palbociclib	26	0.9	0.9
Emtricitabine And Tenofovir Alafenamide	3	0.9	0.9
Ledipasvir And Sofosbuvir	5	0.9	0.9
Drospirenone And Ethinyl Estradiol	10	0.8	0.8
Voxelotor	5	0.8	0.8
Somatropin	16	0.7	0.7
Cinacalcet Hydrochloride	10	0.7	0.7
Levonorgestrel	42	0.7	0.7
Adapalene	36	0.7	0.7
Palivizumab	3	0.7	0.7
Pomalidomide	19	0.6	0.6
Minoxidil Foam 5% (Womens)	6	0.6	0.6
Etonogestrel	8	0.6	0.6
Minoxidil	6	0.5	0.5
Salicylic Acid	7	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.