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Which drugs are most reported with Defaecation urgency?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,882 reports · 206 co-occurring drugs

As of the last recalculation, Defaecation Urgency appears in 6,882 FAERS reports alongside 206 co-occurring drug terms. The strongest observed disproportionality signal is VEDOLIZUMAB (PRR 68.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Vedolizumab	1,521	68.3	69.5
Infliximab-Dyyb	324	35.1	35.5
Mesalamine	583	34.2	34.6
Orlistat	202	24.3	24.4
Linaclotide	100	11.5	11.5
Loperamide Hydrochloride And Dimethicone	109	10.4	10.5
Azathioprine	272	9.7	9.7
Lanreotide Acetate	24	9.3	9.3
Loperamide Hydrochloride	121	8.3	8.3
Dimenhydrinate	29	8.3	8.3
Iron	173	8.0	8.0
Budesonide	143	7.5	7.5
Cholestyramine	29	7.3	7.3
Octreotide Acetate	73	7.3	7.3
Diphenoxylate Hydrochloride And Atropine Sulfate	32	7.1	7.1
Infliximab	480	7.1	7.1
Psyllium Husk	23	7.1	7.1
Prednisone	943	6.4	6.4
Ozanimod Hydrochloride	17	6.2	6.2
Teduglutide	26	5.9	5.9
Diroximel Fumarate	23	5.9	5.9
Chlorhexidine Gluconate	17	5.6	5.6
Hydrocortisone	160	5.5	5.5
Pancrelipase	67	5.3	5.3
Upadacitinib	130	4.9	4.9
Pantoprazole Sodium In 0.9% Sodium Chloride	99	4.9	4.9
Pantoprazole Sodium Injection	99	4.9	4.9
Adalimumab	985	4.7	4.8
Dicyclomine Hydrochloride	22	4.7	4.7
Instalax Polyethylene Glycol 3350	19	4.6	4.6
Mercaptopurine	26	4.5	4.6
Polyethylene Glycol 400	19	4.5	4.5
Hydrocortisone Acetate	107	4.5	4.5
Nintedanib	46	4.5	4.5
Trimethoprim	17	4.4	4.4
Polyethylene Glycol 3350	136	4.4	4.4
Dexlansoprazole	59	4.3	4.3
Calcium	205	4.3	4.3
Naltrexone Hydrochloride And Bupropion Hydrochloride	12	4.3	4.3
Anti-Itch	89	4.1	4.1
Anti-Pruritic	89	4.1	4.1
Antipruritic (Anti-Itch)	89	4.1	4.1
Cool Relief Gel With Aloe	89	4.1	4.1
Drs. Hydrocortisone	89	4.1	4.1
Hydrocortisone Continuous Spray	89	4.1	4.1
Hydrocortisone Spray	89	4.1	4.1
Anti-Itch Cream	89	4.1	4.1
Hydrocortisone Lotion	89	4.1	4.1
Hydrocortisone Cream 1%	89	4.1	4.1
Hydrocortisone Cream 1/2%	89	4.1	4.1
Hydrocortisone 1%	89	4.0	4.1
Hydrocortisone Cream	89	4.0	4.0
Adalimumab-Adaz	68	3.9	3.9
Hydrocortisone Sodium Succinate	12	3.9	3.9
Midazolam Hydrochloride	34	3.8	3.8
Methylprednisolone Acetate	10	3.8	3.8
Ustekinumab	121	3.6	3.6
Rifaximin	25	3.6	3.6
Magnesium	97	3.6	3.6
Doxepin	12	3.6	3.6
Loperamide Hydrochloride Oral	12	3.6	3.6
Teriflunomide	52	3.5	3.5
Adalimumab-Fkjp	53	3.5	3.5
Alendronate Sodium Tablet	21	3.4	3.4
Rabeprazole	25	3.4	3.4
Drs. Clotrimazole	13	3.4	3.4
Family Wellness Clotrimazole	13	3.4	3.4
Adalimumab-Aaty	53	3.4	3.4
Clotrimazole Topical	13	3.4	3.4
Doxepin Hydrochloride	14	3.4	3.4
Ciclesonide	15	3.3	3.3
Hyoscyamine Sulfate	10	3.3	3.3
Rivastigmine	20	3.2	3.2
Clotrimazole	13	3.2	3.2
Lubiprostone	10	3.2	3.2
Metronidazole	67	3.2	3.2
Candesartan	37	3.1	3.2
Cyanocobalamin	34	3.1	3.1
Zinc	25	3.1	3.1
Zinc Chloride	25	3.1	3.1
Lamivudine Oral	25	3.0	3.0
Risankizumab-Rzaa	80	3.0	3.0
Vilazodone Hydrochloride	9	3.0	3.0
Zinc Gluconate	25	2.9	2.9
Pantoprazole	236	2.9	2.9
Ergocalciferol	354	2.9	2.9
Tofacitinib	171	2.8	2.9
Loperamide Hcl	12	2.8	2.8
Tofacitinib Citrate	12	2.8	2.8
Midazolam	23	2.8	2.8
Ciprofloxacin	82	2.7	2.7
Ciprofolxacin	64	2.7	2.7
Ciprofloxacin Tablets	64	2.7	2.7
Magnesium Hydroxide	12	2.7	2.7
Primidone	9	2.7	2.7
Ciprofloxacin Hydrochloride	85	2.7	2.7
Ibuprofen Tablets, Coated	37	2.6	2.6
Ciprofloxacin Hydrochloride And Hydrocortisone	18	2.6	2.6
Ibuprofen Sodium	37	2.6	2.6
Ferrous Sulfate	43	2.6	2.6
Abemaciclib	17	2.6	2.6
Temazepam	32	2.6	2.6
Lisdexamfetamine Dimesylate	28	2.6	2.6
Sotalol Hydrochloride	14	2.5	2.6
Iron Sucrose	8	2.5	2.5
Colchicine	22	2.5	2.5
Nebivolol Hydrochloride	28	2.5	2.5
Pantoprazole Sodium	122	2.5	2.5
Irbesartan	37	2.5	2.5
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	131	2.5	2.5
Fluticasone Furoate	10	2.5	2.5
Vortioxetine	14	2.5	2.5
Multivitamin	41	2.5	2.5
Metronidazole Topical	39	2.5	2.5
Rosuvastatin Calcium	23	2.5	2.5
Nebivolol	13	2.5	2.5
Lamivudine	25	2.5	2.5
Vitamin C	73	2.4	2.4
Diphenhydramine	50	2.4	2.4
Desoximetasone	15	2.4	2.4
Rosuvastatin	158	2.4	2.4
Dimethyl Fumarate	94	2.3	2.3
Methimazole	6	2.3	2.3
Cetiirizine	32	2.3	2.3
Ramipril	92	2.3	2.3
Venlafaxine	53	2.2	2.2
Fesoterodine Fumarate	8	2.2	2.2
Pertuzumab	20	2.2	2.2
Selexipag	19	2.2	2.2
Loratadine Oral	36	2.2	2.2
Ixekizumab	27	2.2	2.2
Relugolix	17	2.2	2.2
Duloxetine	49	2.1	2.1
Felodipine Extended-Release Tablets	8	2.1	2.1
Felodipine	8	2.1	2.1
Lovastatin	18	2.1	2.1
Valsartan Oral	38	2.1	2.1
Oral Semaglutide	51	2.1	2.1
Losartan Potassium And Hydrochlorothiazide	8	2.1	2.1
Citalopram Hydrobromide	72	2.0	2.0
Conjugated Estrogens	39	2.0	2.0
Sertraline	78	2.0	2.0
Levodopa	8	2.0	2.0
Estrogens, Conjugated	39	2.0	2.0
Amantadine	10	2.0	2.0
Losartan	112	2.0	2.0
Testosterone	15	1.9	1.9
Elexacaftor, Tezacaftor, And Ivacaftor	8	1.9	1.9
Rasagiline Mesylate	7	1.9	1.9
Ezetimibe	47	1.9	1.9
Donepezil Hydrochloride	23	1.9	1.9
Modafinil	20	1.9	1.9
Dutasteride	5	1.9	1.9
Carbidopa And Levodopa	29	1.9	1.9
Apremilast	89	1.9	1.9
Fish Oil	54	1.8	1.8
Apalutamide	7	1.8	1.8
Clobetasol Propionate Ointment Usp, 0.05%	6	1.8	1.8
Clobetasol Propionate	6	1.8	1.8
Exenatide	30	1.7	1.7
Tramadol Hydrochloride	21	1.7	1.7
Rotigotine	8	1.7	1.7
Linagliptin	10	1.7	1.7
Paclitaxel (Aibumin-Bound)	44	1.6	1.6
Glatiramer Acetate	31	1.6	1.6
Oxaliplatin	38	1.6	1.6
Oxybutynin	15	1.6	1.6
Vibegron	4	1.5	1.5
Timolol	6	1.5	1.5
Apixaban	33	1.5	1.5
Dalfampridine	35	1.5	1.5
Trifluridine And Tipiracil	5	1.4	1.4
Travoprost	4	1.4	1.4
Paclitaxel	45	1.4	1.4
Oseltamivir Phosphate	11	1.4	1.4
Regorafenib	5	1.3	1.3
Avapritinib	5	1.2	1.2
Brimonidine Tartrate	7	1.2	1.2
Irinotecan Hydrochloride	5	1.2	1.2
Lapatinib	6	1.2	1.2
Golimumab	32	1.1	1.1
Riociguat	12	1.1	1.1
Guselkumab	13	1.1	1.1
Drospirenone And Ethinyl Estradiol	16	1.1	1.1
Iohexol	3	1.1	1.1
Dabigatran Etexilate	28	1.1	1.1
Naltrexone	11	1.1	1.1
Bosutinib	3	1.0	1.0
Treprostinil	41	1.0	1.0
Dabigatran Etexilate Mesylate	23	1.0	1.0
Voxelotor	7	0.9	0.9
Abaloparatide	9	0.9	0.9
Pazopanib Hydrochloride	8	0.9	0.9
Glecaprevir And Pibrentasvir	3	0.8	0.8
Cabozantinib	13	0.8	0.8
Canagliflozin	8	0.8	0.8
Palbociclib	25	0.8	0.8
Fremanezumab-Vfrm	3	0.8	0.8
Isotretinoin	12	0.7	0.7
Dulaglutide	21	0.7	0.7
Tirzepatide	36	0.7	0.7
Nirmatrelvir And Ritonavir	12	0.7	0.7
Dornase Alfa	4	0.6	0.6
Ranitidine Hydrochloride	11	0.6	0.6
Esketamine Hydrochloride	3	0.5	0.5
Cinacalcet Hydrochloride	5	0.3	0.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.