Reaction

Necrotising Fasciitis reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,476 reports · 156 co-occurring drugs

As of the last recalculation, Necrotising Fasciitis appears in 3,476 FAERS reports alongside 156 co-occurring drug terms. The strongest observed disproportionality signal is CANAGLIFLOZIN (PRR 25.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Canagliflozin	123	25.5	25.6
Empagliflozin	251	24.0	24.1
Dapagliflozin	116	22.8	22.9
Clobetasol Propionate Ointment Usp, 0.05%	33	19.4	19.4
Clobetasol Propionate	33	19.3	19.3
Daspone	30	18.6	18.7
Dapsone Gel, 5%	30	18.6	18.6
Clindamycin	79	17.0	17.1
Dapsone	30	17.0	17.0
Clindamycin Phosphate	89	16.3	16.4
Piperacillin Sodium And Tazobactam Sodium	50	15.5	15.5
Azacitidine For	37	12.3	12.3
Meropenem	62	11.8	11.8
Vancomycin	107	11.4	11.4
Azacitidine	55	11.3	11.3
Vancomycin Hydrochloride	120	11.3	11.3
Gentamicin	24	11.1	11.1
Cefepime	26	10.9	11.0
Daptomycin	16	10.4	10.4
Dextrose	22	10.1	10.1
Dextrose Monohydrate	22	9.9	9.9
Cefepime Hydrochloride	26	9.7	9.7
Gentamicin Sulfate	25	9.5	9.5
Basiliximab	18	9.2	9.2
Bupivacaine	13	8.4	8.4
Cefazolin Sodium	16	8.0	8.0
Irinotecan Hydrochloride	17	8.0	8.0
Cefazolin	12	7.9	7.9
Norepinephrine	14	7.9	7.9
Bevacizumab	155	7.8	7.8
Panitumumab	20	7.7	7.7
Piperacillin And Tazobactam	16	7.5	7.5
Ampicillin	10	7.2	7.3
Ampicillin Sodium	10	7.2	7.3
Norepinephrine Bitartrate	17	7.1	7.1
Piperacillin Sodium,Tazobactam Sodium	31	7.1	7.1
Mycophenilic Acid	24	7.0	7.0
Polyethylene Glycol	12	6.7	6.7
Propofol	40	6.6	6.6
Fluorouracil Cream, 0.5%	79	6.3	6.3
Fluorouracil	80	6.3	6.3
Cytarabine	61	6.2	6.2
Prednisolone	177	6.1	6.1
Prednisolone Oral	177	6.1	6.1
Prednisolone Oral Solution	177	6.1	6.1
Bisacodyl Suppositories	13	6.0	6.0
Methylprednisolone Acetate	8	6.0	6.0
Biscodyl	13	6.0	6.0
Vincristine Sulfate	29	6.0	6.0
Ketoprofen	13	6.0	6.0
Linagliptin	18	5.9	5.9
Oxaliplatin	72	5.9	5.9
Diclofenac	83	5.9	5.9
Cephalexin	21	5.8	5.8
Mycophenolate Mofetil	128	5.8	5.8
Midazolam Hydrochloride	26	5.8	5.8
Mycophenolate Mofetil Hydrochloride	128	5.8	5.8
Mupirocin	13	5.8	5.8
Acetylcysteine	9	5.7	5.7
Mupirocin Calcium	13	5.7	5.7
Leucovorin Calcium	18	5.7	5.7
Amikacin	16	5.6	5.6
Bisacodyl	13	5.5	5.6
Midazolam	23	5.5	5.5
Benzonatate	15	5.5	5.5
Sirolimus	12	5.3	5.4
Magnesium Hydroxide	12	5.3	5.4
Tretinoin	7	5.2	5.2
Regorafenib	10	5.2	5.2
Lidocaine Hydrochloride And Epinephrine Bitartrate	45	5.1	5.1
Tocilizumab	95	5.1	5.1
Mycophenolic Acid	27	5.1	5.1
Diclofenac Sodium 1%	30	5.1	5.1
Diclofenac Sodium Topical	30	5.1	5.1
Diclofenac Sodium Topical Gel, 1%	30	5.1	5.1
Ciprofolxacin	59	5.0	5.0
Ciprofloxacin Tablets	59	5.0	5.0
Insulin Glargine-Yfgn	18	4.9	5.0
Metronidazole Topical	39	4.9	4.9
Doxyclycline Hyclate	14	4.9	4.9
Candesartan	29	4.9	4.9
Ciprofloxacin Hydrochloride	78	4.9	4.9
Insulin Aspart	53	4.9	4.9
Metronidazole	51	4.8	4.8
Ibuprofen Oral	154	4.8	4.8
Ibuprofen 200Mg	153	4.8	4.8
Gemfibrozil	12	4.7	4.8
Torsemide	26	4.7	4.7
Ibuprofen Capsule	152	4.7	4.7
Ibuprofen Tablet, Film Coated	152	4.7	4.7
Ibupfrofen	152	4.7	4.7
Ibuprofen Tablets Usp, 200Mg	152	4.7	4.7
Ibuprofen Capsules 200 Mg	152	4.7	4.7
Ibuprofen 200 Mg	152	4.7	4.7
Magnesium Sulfate In Water For	10	4.7	4.7
Aflibercept	24	4.6	4.6
Insulin Degludec	18	4.6	4.6
Magnesium Sulfate Heptahydrate	10	4.6	4.6
Magnesium Sulfate	10	4.6	4.6
Diclofenac Sodium	110	4.5	4.5
Linezolid	22	4.4	4.4
Capecitabine	66	4.4	4.4
Misoprostol	7	4.3	4.3
Docetaxel Anhydrous	48	4.3	4.3
Docetaxel	48	4.3	4.3
Metformin Er 500 Mg	199	4.1	4.1
Metformin Er 750 Mg	199	4.1	4.1
Cyclophosphamide Injection, Solution	119	4.1	4.1
Cyclophosphamide	119	4.1	4.1
Cyclophosphamide For Injection	119	4.1	4.1
Rifampin	10	4.1	4.1
Terazosin Hydrochloride	6	4.0	4.0
Cetuximab	21	4.0	4.0
Nicotine Polacrilex Mini	10	4.0	4.0
Nicotine Polarilex	10	4.0	4.0
Metformin	225	4.0	4.0
Sitagliptin And Metformin Hydrochloride	14	3.9	3.9
Glimepiride	25	3.9	3.9
Busulfan	10	3.8	3.8
Interferon Beta-1B	12	3.8	3.8
Sitagliptin	44	3.7	3.7
Dutasteride	5	3.7	3.7
Ceftriaxone	20	3.7	3.7
Remdesivir	8	3.6	3.6
Rocuronium Bromide	7	3.6	3.6
Rifampicin	6	3.6	3.6
Lenvatinib	19	3.5	3.5
Sorafenib	12	3.5	3.5
Dexamethasone 1.5 Mg	163	3.4	3.4
Miconazole Nitrate	5	3.4	3.4
Pegaspargase	7	3.4	3.4
Dexamethasone	163	3.4	3.4
Pioglitazone	23	3.2	3.2
Liraglutide	26	3.2	3.2
Thalidomide	19	3.1	3.1
Bimekizumab	11	3.1	3.1
Fludarabine Phosphate	20	3.1	3.1
Doxorubicin	45	3.1	3.1
Insulin Lispro	67	2.9	2.9
Bleomycin Sulfate	5	2.9	2.9
Etoposide	35	2.9	2.9
Ixekizumab	17	2.8	2.8
Sunitinib Malate	18	2.8	2.8
Sarilumab	12	2.7	2.7
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	14	2.7	2.7
Insulin Glargine	101	2.5	2.5
Deferasirox	11	2.5	2.5
Carboplatin	50	2.4	2.4
Oral Semaglutide	29	2.4	2.4
Fentanyl Citrate	7	2.3	2.3
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	3	2.2	2.2
Paricalcitol	5	2.1	2.1
Dulaglutide	31	2.1	2.1
Durvalumab	7	2.1	2.1
Venetoclax	20	2.0	2.0
Axicabtagene Ciloleucel	3	1.8	1.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.