Reaction

Creatinine Renal Clearance Decreased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,977 reports · 183 co-occurring drugs

As of the last recalculation, Creatinine Renal Clearance Decreased appears in 3,977 FAERS reports alongside 183 co-occurring drug terms. The strongest observed disproportionality signal is QUINAPRIL HYDROCHLORIDE (PRR 394.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Quinapril Hydrochloride	517	394.1	421.8
Diltiazem Hydrochloride Extended-Release Tablets	450	233.3	242.9
Magnesium Hydroxide	518	231.1	240.4
Oxazepam	539	151.6	155.5
Cyclobenzaprine Hydrochloride	241	149.3	153.5
Amitriptyline Hydrochloride	434	145.2	148.9
Bisacodyl Suppositories	282	122.7	125.4
Biscodyl	282	121.6	124.3
Bisacodyl	283	113.2	115.5
Lactulose	555	87.9	89.2
Diltiazem Hydrochloride	462	78.9	80.0
Zinc	322	74.3	75.2
Zinc Chloride	322	73.8	74.7
Rosuvastatin Calcium	359	73.2	74.2
Zinc Gluconate	322	70.0	70.9
Cyclobenzaprine	539	65.3	66.0
Nitroglycerin	496	55.2	55.7
Carbamazepine	559	50.6	51.1
Quinine	77	47.9	48.3
Levofloxacin	463	45.3	45.7
Levofloxacin In 5% Dextrose	463	45.3	45.7
Atropine	61	39.1	39.4
Acetaminophen And Codeine	72	31.5	31.7
Levothyroxine Sodium Anhydrous	523	31.3	31.5
Atropine Sulfate	62	30.5	30.7
Morphine Sulfate	501	24.6	24.7
Phenobarbital	64	23.5	23.6
Psyllium Husk	41	21.9	22.0
Tiotropium Bromide	495	21.5	21.5
Oxcarbazepine	104	17.2	17.2
Antacid	143	16.3	16.4
Albuterol	320	15.1	15.1
Docusate Sodium 100Mg	62	13.8	13.8
Acetaminophen Tablet Extended Release	578	13.7	13.7
Pain Reliever	578	13.7	13.7
Acetaminophen 500Mg	578	13.7	13.7
Furosemide	831	13.5	13.5
Remdesivir	33	13.1	13.1
Amlodipine Besylate	322	12.4	12.4
Dronedarone	23	11.9	11.9
Calcium Carbonate	147	11.9	11.9
Omeprazole	622	11.0	11.0
Levothyroxine Sodium	561	10.7	10.7
Ascorbic Acid	47	10.7	10.7
Sennosides	58	10.3	10.3
Dabigatran Etexilate	144	10.0	10.0
Vitamin C	166	9.8	9.8
Dabigatran Etexilate Mesylate	128	9.5	9.5
Telmisartan	32	9.5	9.5
Omeprazole Magnesium	679	9.4	9.4
Rosuvastatin	338	9.4	9.4
Rivaroxaban	329	8.9	8.9
Deferasirox	42	8.4	8.4
Acetaminophen	599	8.1	8.1
Tenofovir Disoproxil Fumarate	50	8.0	8.0
Fondaparinux Sodium	12	7.8	7.8
Diazepam Oral Solution (Concentrate)	127	7.7	7.7
Diazepam Oral	127	7.7	7.7
Entecavir	17	7.6	7.7
Albuterol Sulfate	395	7.6	7.6
Efavirenz	16	7.5	7.5
Dofetilide	15	7.5	7.5
Pemetrexed Disodium	53	7.4	7.4
Enalapril Maleate	32	6.8	6.8
Amlodipine	320	6.7	6.7
Cefepime	18	6.6	6.6
Enoxaparin Sodium	70	6.5	6.5
Docusate Sodium	69	6.3	6.4
Digoxin	85	6.3	6.3
Sevoflurane	10	6.3	6.3
Cefepime Hydrochloride	19	6.2	6.2
Tobramycin Solution	14	6.1	6.1
Risedronate Sodium	35	5.9	5.9
Tobramycin Sulfate	14	5.9	5.9
Lamivudine	34	5.8	5.8
Olaparib	23	5.8	5.8
Diazepam	130	5.7	5.8
Sotalol Hydrochloride	18	5.7	5.7
Daptomycin	10	5.7	5.7
Aspirin 325 Mg	491	5.6	5.6
Aspirin 81 Mg	491	5.6	5.6
Spironolactone	145	5.6	5.6
Lamivudine Oral	26	5.4	5.4
Oxymorphone Hydrochloride	12	5.4	5.4
Aspirin	493	5.3	5.3
Eplerenone	13	5.3	5.3
Gentamicin	13	5.2	5.2
Morphine	72	5.1	5.1
Zoledronic Acid	39	5.1	5.1
Febuxostat	16	5.0	5.0
Acetylcysteine	9	5.0	5.0
Gentamicin Sulfate	15	5.0	5.0
Ganciclovir Sodium	10	5.0	5.0
Ritonavir 100 Mg	14	4.9	4.9
Captopril	9	4.9	4.9
Ritonavir	27	4.9	4.9
Candesartan Cilexetil	24	4.8	4.8
Vancomycin	52	4.8	4.8
Selexipag	23	4.7	4.7
Nebivolol	14	4.6	4.6
Linezolid	26	4.6	4.6
Rivastigmine	16	4.5	4.5
Zidovudine	11	4.3	4.3
Abacavir Sulfate	8	4.3	4.3
Sodium Bicarbonate	19	4.3	4.3
Sodium Bicarbonate Injection,	19	4.3	4.3
Piperacillin Sodium And Tazobactam Sodium	16	4.3	4.3
Enalapril	45	4.3	4.3
Lopinavir And Ritonavir	11	4.3	4.3
Vancomycin Hydrochloride	53	4.3	4.3
Valsartan And Hydrochlorothiazide	11	4.2	4.3
Tenofovir Disoproxil Fumarate Tablets	7	4.2	4.3
Metolazone	9	4.2	4.2
Doxepin	8	4.1	4.1
Indapamide	14	4.1	4.1
Ganciclovir	8	4.1	4.1
Valsartan Oral	41	4.0	4.0
Cisplatin	58	3.9	3.9
Bisoprolol Fumarate	100	3.9	3.9
Dextrose Monohydrate	10	3.9	3.9
Amlodipine Besylate And Valsartan	8	3.8	3.8
Polatuzumab Vedotin	7	3.8	3.8
Emtricitabine And Tenofovir Disoproxil Fumarate	32	3.7	3.7
Piperacillin And Tazobactam	9	3.7	3.7
Abemaciclib	14	3.7	3.7
Atazanavir	10	3.6	3.7
Salmeterol Xinafoate	6	3.6	3.6
Insulin Glargine-Yfgn	15	3.6	3.6
Lisinopril And Hydrochlorothiazide	7	3.6	3.6
Dextrose	9	3.6	3.6
Lutetium Lu 177 Vipivotide Tetraxetan	9	3.6	3.6
Bosutinib	6	3.5	3.5
Tobramycin	16	3.5	3.5
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	12	3.5	3.5
Clopidogrel Bisulfate	66	3.4	3.4
Allopurinol	99	3.4	3.4
Amphotericin B	8	3.3	3.3
Propofol	23	3.3	3.3
Hydroxyurea	13	3.2	3.2
Letrozole Tablets	29	3.2	3.2
Letrozole	37	3.2	3.2
Bleomycin Sulfate	6	3.0	3.0
Oseltamivir Phosphate	14	3.0	3.0
Thalidomide	21	3.0	3.0
Dapagliflozin	18	3.0	3.0
Paricalcitol	8	3.0	3.0
Piperacillin Sodium,Tazobactam Sodium	15	3.0	3.0
Pemetrexed	12	2.9	2.9
Gefitinib	5	2.9	2.9
Canagliflozin	16	2.8	2.8
Darunavir	8	2.8	2.8
Metformin Hcl	29	2.8	2.8
Ledipasvir And Sofosbuvir	10	2.7	2.7
Baricitinib	5	2.7	2.7
Sofosbuvir	10	2.7	2.7
Imatinib Mesylate	14	2.6	2.6
Oseltamivir	4	2.6	2.6
Bendamustine Hydrochloride	6	2.6	2.6
Ixazomib	14	2.6	2.6
Iohexol	4	2.5	2.5
Tolvaptan	7	2.5	2.5
Micafungin Sodium	4	2.5	2.5
Palbociclib	44	2.4	2.4
Nevirapine	4	2.3	2.3
Fosaprepitant Dimeglumine	6	2.3	2.3
Macitentan	29	2.2	2.2
Belimumab	13	2.2	2.2
Paliperidone Palmitate	13	2.1	2.1
Crizotinib	5	2.1	2.1
Paclitaxel (Aibumin-Bound)	31	2.0	2.0
Azacitidine	11	1.9	1.9
Ribavirin	23	1.9	1.9
Emtricitabine And Tenofovir Alafenamide	4	1.8	1.8
Durvalumab	7	1.8	1.8
Alpelisib	3	1.8	1.8
Azacitidine For	6	1.7	1.7
Axitinib	6	1.6	1.6
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	3	1.6	1.6
Sacubitril And Valsartan	34	1.5	1.5
Dalfampridine	21	1.5	1.5
Lenalidomide	122	1.5	1.5
Osimertinib	6	1.0	1.0
Voxelotor	4	0.9	0.9

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.