Reaction

Hyperammonaemia reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,930 reports · 180 co-occurring drugs

As of the last recalculation, Hyperammonaemia appears in 4,930 FAERS reports alongside 180 co-occurring drug terms. The strongest observed disproportionality signal is VALPROIC ACID (PRR 95.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Valproic Acid	624	95.6	97.5
Valproate Sodium	298	64.7	65.7
Basiliximab	95	34.8	35.0
Phenobarbital	114	34.0	34.2
Divalproex Sodium	327	31.7	31.9
Phenytoin	139	28.9	29.1
Clobazam	151	26.9	27.1
Pegaspargase	51	17.8	17.8
Levetiracetam In Sodium Chloride	302	17.5	17.5
Levetiracetam Oral	302	17.5	17.5
Levetiracetam Injection	302	17.5	17.5
Fluorouracil Cream, 0.5%	289	16.9	17.0
Fluorouracil	291	16.8	16.9
Valganciclovir Hydrochloride Powder,	43	15.0	15.1
Zonisamide	49	14.1	14.2
Deferasirox	87	14.1	14.1
Oxaliplatin	232	13.8	13.8
Lactulose	118	13.3	13.3
Midazolam	78	13.3	13.3
Midazolam Hydrochloride	83	13.2	13.3
Levetiracetam	373	12.7	12.7
Lacosamide	108	12.5	12.5
Ganciclovir	30	12.4	12.5
Carbamazepine	187	12.2	12.2
Topiramate	255	12.1	12.2
Ganciclovir Sodium	30	12.0	12.1
Guanfacine	22	11.9	11.9
Irinotecan Hydrochloride	35	11.6	11.6
Lithium	68	11.5	11.6
Lithium Bromatum	68	11.5	11.6
Sorafenib	55	11.3	11.3
Amphotericin B	32	10.8	10.9
Haloperidol	60	10.5	10.6
Valganciclovir	46	10.4	10.4
Valganciclovir Hydrochloride	46	10.4	10.4
Haloperidol Lactate	60	10.3	10.4
Daptomycin	22	10.1	10.1
Rifampicin	24	10.1	10.1
Piperacillin And Tazobactam	30	10.0	10.0
Rifaximin	47	9.6	9.6
Brivaracetam	19	9.0	9.0
Aripiprazole Oral	84	8.7	8.7
Aripiprazole Orally Disintegrating	84	8.7	8.7
Voriconazole Injection	43	8.4	8.4
Fosaprepitant Dimeglumine	27	8.3	8.3
Panitumumab	30	8.1	8.1
Cenobamate	16	8.1	8.1
Propofol	69	8.1	8.1
Leucovorin Calcium	36	8.0	8.0
Ursodiol	40	7.8	7.8
Blinatumomab	19	7.7	7.7
Cefepime	26	7.7	7.7
Melphalan	41	7.7	7.7
Regorafenib	21	7.7	7.7
Melphalan Hydrochloride	45	7.6	7.7
Lamotirigine	126	7.6	7.6
Lamotrigine Extended-Release	126	7.6	7.6
Lamotrigine Chewable Dispersible	126	7.6	7.6
Oxcarbazepine	57	7.5	7.5
Olanzapine	182	7.4	7.4
Cholestyramine	21	7.4	7.4
Tolvaptan	25	7.3	7.3
Piperacillin Sodium,Tazobactam Sodium	45	7.2	7.2
Piperacillin Sodium And Tazobactam Sodium	33	7.1	7.2
Tacrolimus Ointment 0.1%	202	7.1	7.1
Tacrolimus Extended-Release Capsules	202	7.1	7.1
Polyethylene Glycol	18	7.0	7.1
Granisetron Hydrochloride	17	6.9	6.9
Cefepime Hydrochloride	26	6.8	6.9
Lenvatinib	52	6.8	6.8
Voriconazole	47	6.6	6.6
Aprepitant	27	6.2	6.2
Thiamine Hydrochloride	18	6.1	6.1
Rifampin	21	6.1	6.1
Tacrolimus	217	6.1	6.1
Meropenem	45	6.0	6.0
Oxazepam	30	5.9	5.9
Quetiapine Fumarate	41	5.9	5.9
Vancomycin Hydrochloride	89	5.8	5.8
Anti-Thymocyte Globulin (Rabbit)	11	5.8	5.8
Mercaptopurine	23	5.6	5.6
Norepinephrine	14	5.5	5.5
Entecavir	15	5.4	5.4
Dexamethasone Sodium Phosphate	13	5.4	5.4
Primidone	13	5.4	5.4
Busulfan	20	5.4	5.4
Vincristine Sulfate	37	5.4	5.4
Lamotrigine	161	5.3	5.3
Amiodarone Hydrochloride	14	5.3	5.3
Ursosiol	24	5.2	5.2
Sofosbuvir	24	5.2	5.2
Bevacizumab	146	5.1	5.1
Vancomycin	68	5.0	5.0
Posaconazole Delayed-Release	13	5.0	5.0
Lithium Carbonate	20	5.0	5.0
Mycophenilic Acid	24	4.9	4.9
Linezolid	34	4.8	4.9
Cytarabine	68	4.8	4.8
Clonazepam	177	4.8	4.8
Magnesium Oxide	46	4.7	4.7
Rabeprazole	24	4.6	4.6
Quetiapine	198	4.5	4.5
Risperidone	138	4.5	4.5
Granisetron	11	4.4	4.4
Norepinephrine Bitartrate	15	4.4	4.4
Naltrexone	32	4.4	4.4
Cannabidiol	24	4.3	4.3
Fludarabine Phosphate	40	4.3	4.3
Methadone	43	4.3	4.3
Mycophenolate Mofetil	133	4.2	4.2
Mycophenolate Mofetil Hydrochloride	133	4.2	4.2
Dextrose	13	4.2	4.2
Methylprednisolone	132	4.1	4.1
Dextrose Monohydrate	13	4.1	4.1
Amantadine	15	4.1	4.1
Bupivacaine	9	4.1	4.1
Acetaminophen Tablet Extended Release	233	4.0	4.0
Pain Reliever	233	4.0	4.0
Acetaminophen 500Mg	233	4.0	4.0
Diazepam	113	4.0	4.0
Micafungin Sodium	8	4.0	4.0
Aripiprazole	111	3.9	3.9
Capecitabine	80	3.7	3.7
Oseltamivir	7	3.7	3.7
Bumetanide	23	3.7	3.7
Methadone Hydrochloride	9	3.5	3.5
Mirtazapine	75	3.5	3.5
Amikacin	14	3.5	3.5
Posaconazole	13	3.4	3.4
Diazepam Oral Solution (Concentrate)	70	3.4	3.4
Diazepam Oral	70	3.4	3.4
Febuxostat Tablets 40 Mg	8	3.3	3.3
Febuxostat Tablets 80 Mg	8	3.3	3.3
Cefazolin	7	3.2	3.2
Levofloxacin	46	3.2	3.2
Levofloxacin In 5% Dextrose	46	3.2	3.2
Fexofenadine Hcl	7	3.2	3.2
Mycophenolic Acid	24	3.2	3.2
Gemcitabine	29	3.1	3.1
Sevoflurane	6	3.1	3.1
Gemcitabine Hydrochloride	38	3.0	3.0
Gentamicin Sulfate	11	2.9	2.9
Vigabatrin	10	2.9	2.9
Loperamide Hydrochloride Oral	7	2.9	2.9
Itraconazole	8	2.9	2.9
Terbinafine Hydrochloride	6	2.9	2.9
Duloxetine	46	2.8	2.8
Donepezil Hydrochloride	24	2.8	2.8
Ceftriaxone Sodium	25	2.8	2.8
Cisplatin	50	2.7	2.7
Baclofen	55	2.7	2.7
Atovaquone	5	2.6	2.6
Olanzapine Pamoate	25	2.6	2.6
Ceftriaxone	20	2.6	2.6
Ado-Trastuzumab Emtansine	5	2.5	2.5
Ethyl Alcohol	16	2.5	2.5
Atezolizumab	21	2.3	2.3
Thiotepa	5	2.2	2.2
Cetuximab	16	2.2	2.2
Isopropyl Alcohol	17	2.1	2.1
Fam-Trastuzumab Deruxtecan-Nxki	5	2.1	2.1
Velpatasvir And Sofosbuvir	6	2.0	2.0
Axitinib	9	2.0	2.0
Sunitinib Malate	18	1.9	1.9
Paliperidone	10	1.8	1.8
Bortezomib	38	1.8	1.8
Etoposide	31	1.8	1.8
Brexpiprazole	7	1.8	1.8
Doxorubicin	37	1.8	1.8
Methylphenidate	12	1.8	1.8
Dapagliflozin	13	1.7	1.7
Alcohol	16	1.7	1.7
Clozapine	49	1.7	1.7
Pegvaliase-Pqpz	3	1.5	1.5
Iohexol	3	1.5	1.5
Eltrombopag Olamine	8	1.5	1.5
Encorafenib	3	1.3	1.3
Methoxy Polyethylene Glycol-Epoetin Beta	3	1.1	1.1
Elexacaftor, Tezacaftor, And Ivacaftor	3	1.0	1.0
Ledipasvir And Sofosbuvir	4	0.9	0.9

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.