Reaction

Which drugs are most reported with Second primary malignancy?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,205 reports · 177 co-occurring drugs

As of the last recalculation, Second Primary Malignancy appears in 8,205 FAERS reports alongside 177 co-occurring drug terms. The strongest observed disproportionality signal is BLEOMYCIN SULFATE (PRR 60.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Bleomycin Sulfate	241	60.9	62.4
Vincristine Sulfate	572	53.2	54.2
Octreotide Acetate	513	45.2	46.0
Nilotinib	377	33.9	34.4
Encorafenib	128	33.3	33.7
Imatinib	222	32.8	33.2
Melphalan	261	30.0	30.4
Bosutinib	102	29.2	29.5
Ifosfamide	234	28.4	28.7
Melphalan Hydrochloride	262	27.4	27.6
Doxorubicin Hydrochloride	295	23.7	23.9
Etoposide	620	23.1	23.2
Doxorubicin	710	22.0	22.2
Cyclophosphamide Injection, Solution	1,279	21.5	21.7
Cyclophosphamide	1,279	21.5	21.7
Cyclophosphamide For Injection	1,279	21.5	21.7
Exemestane	166	20.0	20.2
Palbociclib	686	19.8	20.0
Sunitinib Malate	294	19.6	19.8
Letrozole	436	18.9	19.0
Cytarabine	421	18.7	18.8
Fludarabine Phosphate	273	18.2	18.3
Fulvestrant	219	17.3	17.4
Letrozole Tablets	305	16.7	16.8
Axitinib	125	16.5	16.6
Anastrozole Tablets	128	15.4	15.4
Dabrafenib	125	15.3	15.4
Imatinib Mesylate	161	14.9	15.0
Ribociclib	181	14.9	14.9
Brentuximab Vedotin	57	14.2	14.3
Crizotinib	70	14.1	14.2
Cisplatin	404	13.7	13.8
Mesna Injection	43	13.3	13.3
Trametinib	123	13.1	13.2
Thiotepa	49	13.1	13.2
Bendamustine Hcl	79	13.0	13.1
Mesna	43	13.0	13.1
Bendamustine Hydrochloride	61	13.0	13.1
Everolimus	245	12.6	12.6
Mercaptopurine	82	12.1	12.2
Anastrozole	159	11.2	11.2
Paclitaxel (Aibumin-Bound)	311	9.9	10.0
Carboplatin	454	9.5	9.6
Hydroxyurea	77	9.3	9.3
Axicabtagene Ciloleucel	36	9.3	9.3
Gemcitabine Hydrochloride	190	9.3	9.3
Ruxolitinib	253	9.2	9.2
Chlorhexidine Gluconate	33	9.2	9.2
Paclitaxel	335	8.9	8.9
Rituximab	680	8.8	8.8
Tretinoin	28	8.8	8.8
Busulfan	54	8.8	8.8
Docetaxel Anhydrous	207	8.0	8.0
Docetaxel	207	8.0	8.0
Pazopanib Hydrochloride	81	7.7	7.7
Lapatinib	45	7.4	7.4
Ado-Trastuzumab Emtansine	24	7.2	7.3
Fluorouracil Cream, 0.5%	212	7.2	7.2
Fluorouracil	214	7.2	7.2
Olaparib	56	6.8	6.8
Dexamethasone Sodium Phosphate	26	6.5	6.5
Alpelisib	22	6.4	6.4
Obinutuzumab	41	6.3	6.4
Polatuzumab Vedotin	23	6.0	6.0
Irinotecan Hydrochloride	30	5.9	5.9
Filgrastim	83	5.6	5.7
Thalidomide	81	5.6	5.7
Azacitidine For	40	5.6	5.6
Leucovorin Calcium	41	5.5	5.5
Gemcitabine	77	5.0	5.0
Trastuzumab	131	4.9	4.9
Goserelin	25	4.7	4.7
Bortezomib	160	4.6	4.6
Azacitidine	53	4.6	4.6
Dalteparin Sodium	17	4.1	4.1
Dutasteride	13	4.1	4.1
Everolimus Tablets	26	3.9	3.9
Pertuzumab	42	3.9	3.9
Cetuximab	47	3.8	3.8
Extended Phenytoin Sodium	25	3.8	3.8
Dexamethasone 1.5 Mg	419	3.8	3.8
Capecitabine	133	3.7	3.7
Dexamethasone	419	3.7	3.7
Bicalutamide	22	3.7	3.7
Standardized Senna Concentrate	18	3.6	3.6
Prednisolone	252	3.6	3.6
Prednisolone Oral	252	3.6	3.6
Prednisolone Oral Solution	252	3.6	3.6
Prednisone	654	3.5	3.5
Oxaliplatin	101	3.5	3.5
Pemetrexed	29	3.4	3.4
Dasatinib	49	3.4	3.4
Rabeprazole	28	3.2	3.2
Piperacillin And Tazobactam	16	3.2	3.2
Zoledronic Acid	50	3.2	3.2
Blinatumomab	13	3.2	3.2
Clindamycin	35	3.1	3.1
Amoxicillin And Clavulanate Potassium	33	3.1	3.1
Abemaciclib	24	3.1	3.1
Clindamycin Phosphate	40	3.0	3.1
Erythropoietin	23	2.8	2.8
Candesartan Cilexetil	29	2.8	2.8
Carfilzomib	31	2.8	2.8
Loperamide Hydrochloride And Dimethicone	35	2.8	2.8
Fam-Trastuzumab Deruxtecan-Nxki	11	2.8	2.8
Prochlorperazine Maleate	10	2.8	2.8
Pemetrexed Disodium	41	2.7	2.7
Bevacizumab	129	2.7	2.7
Piperacillin Sodium,Tazobactam Sodium	27	2.6	2.6
Methotrexate Sodium	471	2.5	2.5
Piperacillin Sodium And Tazobactam Sodium	19	2.5	2.5
Valacyclovir	40	2.4	2.4
Hydrocortisone Sodium Succinate	9	2.4	2.4
Indapamide	17	2.4	2.4
Deferasirox	25	2.4	2.4
Morphine	70	2.4	2.4
Docusate Sodium - Sennosides	29	2.3	2.3
Pegaspargase	11	2.3	2.3
Allopurinol	138	2.3	2.3
Loperamide Hydrochloride	39	2.2	2.2
Dronabinol	7	2.2	2.2
Enzalutamide	51	2.2	2.2
Ondansetron Hydrochloride	105	2.2	2.2
Cladribine	8	2.1	2.1
Irbesartan	37	2.1	2.1
Metoclopramide	45	2.1	2.1
Ondansetron	88	2.1	2.1
Ondansetron Tablets	88	2.1	2.1
Febuxostat Tablets 40 Mg	8	2.0	2.0
Febuxostat Tablets 80 Mg	8	2.0	2.0
Valacyclovir Hydrochloride	55	2.0	2.0
Prednisolone Acetate	8	2.0	2.0
Epoetin Alfa	9	1.9	1.9
Metoclopramide Hydrochloride	56	1.8	1.8
Lenalidomide	302	1.8	1.8
Sulfamethoxazole And Trimethoprim	61	1.8	1.8
Ezetimibe And Simvastatin	11	1.8	1.8
Ofatumumab	24	1.8	1.8
Leuprolide Acetate	54	1.8	1.8
Methotrexate	285	1.7	1.7
Pembrolizumab	72	1.7	1.7
Prochlorperazine	19	1.7	1.7
Bisoprolol Fumarate	91	1.7	1.7
Granisetron Hydrochloride	7	1.7	1.7
Acalabrutinib	8	1.7	1.7
Metoprolol Tartrate Injection	124	1.7	1.7
Acyclovir	73	1.6	1.6
Human Insulin	8	1.6	1.6
Dorzolamide Hydrochloride And Timolol Maleate	5	1.6	1.6
Ibrutinib	50	1.6	1.6
Denosumab	120	1.5	1.5
Niraparib	13	1.5	1.5
Vemurafenib	7	1.5	1.5
Hydromorphone Hydrochloride	51	1.4	1.4
Darbepoetin Alfa	29	1.4	1.4
Regorafenib	6	1.3	1.3
Abiraterone	7	1.3	1.3
Panitumumab	8	1.3	1.3
Nivolumab	49	1.3	1.3
Daratumumab	20	1.3	1.3
Oxycodone	92	1.3	1.3
Atezolizumab	19	1.2	1.2
Fluticasone Propionate And Salmeterol	19	1.2	1.2
Venetoclax	28	1.2	1.2
Gefitinib	4	1.1	1.1
Temozolomide	9	1.1	1.1
Erlotinib	4	1.0	1.0
Alteplase	6	1.0	1.0
Lutetium Lu 177 Vipivotide Tetraxetan	5	1.0	1.0
Eltrombopag Olamine	8	0.9	0.9
Rucaparib	3	0.9	0.9
Abiraterone Acetate	13	0.8	0.8
Lenvatinib	10	0.8	0.8
Durvalumab	6	0.7	0.7
Pegfilgrastim	26	0.7	0.7
Apalutamide	3	0.6	0.6
Pomalidomide	19	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.