Reaction

Gastrointestinal Motility Disorder reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,233 reports · 207 co-occurring drugs

As of the last recalculation, Gastrointestinal Motility Disorder appears in 5,233 FAERS reports alongside 207 co-occurring drug terms. The strongest observed disproportionality signal is LINACLOTIDE (PRR 26.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Linaclotide	170	26.2	26.3
Polyethylene Glycol 3350	305	13.4	13.5
Terbinafine Hydrochloride	27	12.1	12.2
Magnesium Hydroxide	39	11.6	11.6
Standardized Senna Concentrate	31	9.9	9.9
Rotigotine	35	9.7	9.7
Niraparib	52	9.4	9.4
Psyllium Husk	23	9.3	9.3
Nintedanib	72	9.2	9.3
Teduglutide	31	9.2	9.2
Cabozantinib	109	9.2	9.2
Sevelamer Carbonate	24	8.3	8.4
Amlodipine Besylate And Valsartan	23	8.3	8.3
Rabeprazole	45	8.1	8.2
Regorafenib	23	7.9	7.9
Octreotide Acetate	60	7.9	7.9
Bisacodyl	27	7.7	7.7
Bisacodyl Suppositories	24	7.4	7.4
Biscodyl	24	7.3	7.4
Rucaparib	16	7.2	7.2
Esomeprazole Magnesium Capsule, Delayed Release	26	7.2	7.2
Esomeprazole Magnesium Delayed Release Capsules	26	7.2	7.2
Esomeprazole Magnesium Dihydrate	26	7.1	7.1
Lubiprostone	16	6.7	6.8
Rasagiline Mesylate	18	6.5	6.5
Atropine	13	6.3	6.3
Esomeprazole	94	6.1	6.1
Lanreotide Acetate	12	6.1	6.1
Doxepin Hydrochloride	19	6.0	6.0
Acetylcysteine	14	5.9	5.9
Dicyclomine Hydrochloride	21	5.9	5.9
Loperamide Hydrochloride And Dimethicone	46	5.7	5.8
Docusate Sodium - Sennosides	46	5.7	5.7
Fexofenadine Hcl	13	5.6	5.6
Loperamide Hydrochloride	58	5.2	5.2
Doxepin	13	5.1	5.1
Nebivolol	20	5.0	5.0
Nebivolol Hydrochloride	41	4.9	4.9
Docusate Sodium	69	4.8	4.8
Atropine Sulfate	13	4.8	4.8
Methadone Hydrochloride	13	4.8	4.8
Erythromycin	22	4.7	4.7
Pancrelipase	45	4.7	4.7
Instalax Polyethylene Glycol 3350	14	4.5	4.5
Vedolizumab	96	4.5	4.5
Sucralfate Oral	16	4.5	4.5
Sucralfate Oral Suspension	16	4.5	4.5
Temazepam	42	4.5	4.5
Polyethylene Glycol 400	14	4.4	4.4
Irbesartan	49	4.4	4.4
Sucralfate	26	4.3	4.3
Lactulose	40	4.2	4.2
Sennosides	31	4.1	4.1
Aprepitant	19	4.1	4.1
Infliximab-Dyyb	30	4.1	4.1
Diphenoxylate Hydrochloride And Atropine Sulfate	14	4.1	4.1
Polyethylene Glycol	11	4.0	4.1
Abemaciclib	20	4.0	4.0
Cholestyramine	12	4.0	4.0
Diazepam Oral Solution (Concentrate)	86	3.9	3.9
Diazepam Oral	86	3.9	3.9
Sennosides 8.6 Mg Tablets	20	3.8	3.8
Senna Leaf	22	3.8	3.8
Senna	20	3.8	3.8
Diazepam	112	3.7	3.7
Desloratadine	10	3.7	3.7
Levothyroxine Sodium Anhydrous	92	3.7	3.7
Isosorbide Dinitrate	18	3.7	3.7
Colchicine	24	3.6	3.6
Mirabegron	35	3.6	3.6
Tramadol Hydrochloride	34	3.6	3.6
Acetaminophen And Codeine	11	3.6	3.6
Ondansetron Hydrochloride	108	3.6	3.6
Selexipag	23	3.6	3.6
Tolterodine Tartrate	8	3.5	3.6
Baclofen	76	3.5	3.6
Quinapril Hydrochloride	7	3.5	3.5
Diltiazem Hydrochloride Extended-Release Tablets	10	3.5	3.5
0Xygen	43	3.5	3.5
Oxygen	43	3.5	3.5
Dronabinol	7	3.5	3.5
Mercaptopurine	15	3.4	3.4
Rifaximin	18	3.4	3.4
Fluticasone Propionate Nasal	26	3.4	3.4
Relugolix	20	3.4	3.4
Mesalamine	47	3.3	3.4
Anastrozole Tablets	18	3.3	3.3
Diroximel Fumarate	10	3.3	3.3
Docusate Sodium 100Mg	20	3.3	3.3
Pirfenidone	33	3.2	3.2
Ondansetron	87	3.2	3.2
Ondansetron Tablets	87	3.2	3.2
Riociguat	26	3.2	3.2
Levothyroxine Sodium	236	3.1	3.1
Ciprofloxacin Hydrochloride And Hydrocortisone	16	3.1	3.1
Dexlansoprazole	32	3.1	3.1
Ixazomib	22	3.0	3.1
Pravastatin Sodium	15	3.0	3.0
Ruxolitinib	54	3.0	3.0
Teriflunomide	34	3.0	3.0
Olmesartan Medoxomil	27	3.0	3.0
Iron	50	3.0	3.0
Thyroid, Porcine	8	3.0	3.0
Venlafaxine	53	3.0	3.0
Rivastigmine	14	3.0	3.0
Meloxicam	43	3.0	3.0
Carbidopa And Levodopa	35	2.9	2.9
Fesoterodine Fumarate	8	2.9	2.9
Lenvatinib	24	2.9	2.9
Esomeprazole Magnesium	168	2.9	2.9
Prochlorperazine	20	2.9	2.9
Patiromer	10	2.9	2.9
Ropinirole	11	2.9	2.9
Tizanidine	17	2.8	2.8
Amantadine	11	2.8	2.8
Timolol Maleate	7	2.8	2.8
Sitagliptin And Metformin Hydrochloride	15	2.8	2.8
Fentanyl	68	2.8	2.8
Fexofenadine Hydrochloride	15	2.7	2.8
Liothyronine Sodium	6	2.7	2.7
Cetiirizine	29	2.7	2.7
Ezetimibe	51	2.7	2.7
Methadone	29	2.7	2.7
Lansoprazole	119	2.7	2.7
Carbamazepine	45	2.7	2.7
Sorafenib	14	2.7	2.7
Propranolol Hydrochloride	48	2.7	2.7
Treprostinil	82	2.6	2.6
Cetirizine Hcl	6	2.6	2.6
Risankizumab-Rzaa	53	2.6	2.6
Famotidine	75	2.6	2.6
Biotin	20	2.6	2.6
Deferasirox	17	2.6	2.6
Metoclopramide Hydrochloride	49	2.5	2.5
Tamsulosin Hydrochloride	13	2.5	2.5
Erlotinib	6	2.5	2.5
Ozanimod Hydrochloride	5	2.4	2.4
Finasteride	36	2.4	2.4
Goserelin	8	2.4	2.4
Metoprolol Succinate Er Tablets	37	2.4	2.4
Oral Semaglutide	43	2.3	2.3
Loperamide Hydrochloride Oral	6	2.3	2.3
Timolol	7	2.3	2.3
Levodopa	7	2.3	2.3
Estradiol Gel 0.1%	26	2.3	2.3
Estradiol Transdermal	26	2.3	2.3
Panitumumab	9	2.3	2.3
Dofetilide	6	2.3	2.3
Prochlorperazine Maleate	5	2.2	2.2
Upadacitinib	44	2.2	2.2
Agalsidase Beta	5	2.2	2.2
Imatinib Mesylate	15	2.1	2.1
Ibuprofen Tablets, Coated	22	2.1	2.1
Ibuprofen Sodium	22	2.0	2.0
Lenalidomide	204	2.0	2.0
Erenumab-Aooe	27	2.0	2.0
Elexacaftor, Tezacaftor, And Ivacaftor	6	1.9	1.9
Erlotinib Hydrochloride	6	1.9	1.9
Armodafinil	10	1.9	1.9
Cannabidiol	11	1.9	1.9
Selinexor	4	1.8	1.8
Tadalafil	46	1.8	1.8
Voclosporin	4	1.8	1.8
Fluorouracil Cream, 0.5%	35	1.8	1.8
Teriparatide	51	1.8	1.8
Fluorouracil	35	1.8	1.8
Dimethyl Fumarate	55	1.8	1.8
Macitentan	31	1.8	1.8
Testosterone Cypionate	4	1.8	1.8
Gefitinib	4	1.8	1.8
Pembrolizumab	45	1.7	1.7
Dabigatran Etexilate Mesylate	31	1.7	1.7
Ibrutinib	34	1.7	1.7
Morphine Sulfate	50	1.6	1.6
Dabigatran Etexilate	32	1.6	1.6
Dalfampridine	29	1.6	1.6
Nivolumab	38	1.6	1.6
Crizotinib	5	1.6	1.6
Palbociclib	37	1.5	1.5
Tirzepatide	62	1.5	1.5
Ivacaftor	3	1.5	1.5
Enzalutamide	22	1.5	1.5
Oxaliplatin	27	1.4	1.5
Sodium Oxybate	23	1.4	1.4
Olaparib	7	1.3	1.3
Botulinum Toxin Type A	4	1.3	1.3
Ranitidine Hydrochloride	17	1.2	1.2
Velpatasvir And Sofosbuvir	4	1.2	1.2
Suvorexant	4	1.2	1.2
Dulaglutide	27	1.2	1.2
Onabotulinumtoxina	23	1.2	1.2
Ethyl Alcohol	8	1.2	1.2
Paricalcitol	4	1.1	1.1
Buprenorphine	26	1.1	1.1
Ambrisentan	35	1.1	1.1
Alirocumab	6	1.0	1.0
Abaloparatide	7	0.9	0.9
Drospirenone And Ethinyl Estradiol	10	0.9	0.9
Osimertinib	7	0.9	0.9
Ixekizumab	8	0.9	0.9
Pomalidomide	20	0.8	0.8
Bimekizumab	4	0.7	0.7
Guselkumab	6	0.7	0.7
Etonogestrel	8	0.7	0.7
Levonorgestrel	31	0.6	0.6
Apremilast	22	0.6	0.6
Nirmatrelvir And Ritonavir	7	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.