Reaction

Blood Pressure Systolic Decreased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,464 reports · 215 co-occurring drugs

As of the last recalculation, Blood Pressure Systolic Decreased appears in 4,464 FAERS reports alongside 215 co-occurring drug terms. The strongest observed disproportionality signal is RIOCIGUAT (PRR 33.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Riociguat	220	33.0	33.3
Octreotide Acetate	166	26.2	26.3
Diphenhydramine Hydrochloride Capsule, Liquid Filled	103	23.0	23.1
Ado-Trastuzumab Emtansine	39	21.7	21.8
Eplerenone	53	19.5	19.6
Sacubitril And Valsartan	368	16.0	16.1
Methylprednisolone Acetate	21	12.3	12.3
Ciclesonide	34	11.7	11.7
Selexipag	64	11.7	11.7
Metolazone	28	11.7	11.7
Esomeprazole Magnesium Capsule, Delayed Release	35	11.3	11.4
Esomeprazole Magnesium Delayed Release Capsules	35	11.3	11.4
Esomeprazole Magnesium Dihydrate	35	11.3	11.3
Sevoflurane	20	11.3	11.3
Methylprednisolone Sodium Succinate	108	11.1	11.1
Cefazolin	21	10.8	10.8
Atropine Sulfate	24	10.4	10.4
Rocuronium Bromide	26	10.3	10.4
Rabeprazole	47	10.0	10.0
Epoprostenol	27	9.7	9.7
0Xygen	94	9.1	9.1
Oxygen	94	9.1	9.1
Cefazolin Sodium	23	8.9	9.0
Diphenhydramine Hydrochloride	297	8.9	8.9
Bumetanide	49	8.7	8.7
Risedronate Sodium	57	8.6	8.7
Bupivacaine	17	8.5	8.5
Treprostinil	219	8.5	8.5
Pertuzumab	49	8.5	8.5
Macitentan	122	8.4	8.4
Bisoprolol Fumarate	231	8.3	8.3
Rosuvastatin Calcium	49	8.2	8.2
Cetirizine Hydrochloride Allergy	52	8.1	8.1
Cetirizine Hydrochloride Tablets	52	8.1	8.1
Colchicine	45	8.0	8.0
Vitamin E	53	7.9	8.0
Atropine	14	7.9	7.9
Dexlansoprazole	69	7.8	7.8
Tolterodine Tartrate	15	7.8	7.8
Human Immunoglobulin G	34	7.7	7.7
Norepinephrine Bitartrate	23	7.5	7.5
Methylprednisolone	209	7.3	7.4
Methoxy Polyethylene Glycol-Epoetin Beta	17	7.2	7.2
Droxidopa	33	7.2	7.2
Dimenhydrinate	16	7.0	7.0
Propofol	54	7.0	7.0
Tocilizumab	163	6.9	6.9
Torsemide	48	6.8	6.8
Magnesium	115	6.7	6.7
Esomeprazole	87	6.7	6.7
Spironolactone	193	6.6	6.7
Sildenafil	81	6.6	6.6
Sevelamer Carbonate	16	6.5	6.5
Heparin Sodium	19	6.5	6.5
Hydrocortisone Sodium Succinate	13	6.5	6.5
Iron Sucrose	13	6.4	6.4
Diphenhydramine	80	6.0	6.0
Diphenhydramine Hcl	14	5.9	5.9
Enalapril Maleate	30	5.7	5.7
Metoroprolol Tartrate	79	5.7	5.7
Isosorbide Mononitrate	25	5.6	5.7
Ramipril	143	5.5	5.5
Tolvaptan	17	5.5	5.5
Felodipine Extended-Release Tablets	13	5.3	5.3
Felodipine	13	5.3	5.3
Rituximab	230	5.3	5.3
Acetaminophen Tablet Extended Release	272	5.2	5.2
Pain Reliever	272	5.2	5.2
Acetaminophen 500Mg	272	5.2	5.2
Anti-Thymocyte Globulin (Rabbit)	9	5.2	5.2
Dutasteride	9	5.2	5.2
Duloxetine	75	5.1	5.1
Amiodarone Hydrochloride	12	5.0	5.0
Ketoprofen	14	5.0	5.0
Micafungin Sodium	9	5.0	5.0
Nifedipine	49	4.9	4.9
Valsartan Oral	56	4.9	4.9
Irbesartan	46	4.8	4.8
Warfarin Sodium	47	4.8	4.8
Valproate Sodium	21	4.8	4.8
Pantoprazole Sodium In 0.9% Sodium Chloride	62	4.7	4.7
Pantoprazole Sodium Injection	62	4.7	4.7
Midazolam Hydrochloride	27	4.7	4.7
Vibegron	8	4.7	4.7
Cetirizine	76	4.6	4.6
Warfarin	123	4.6	4.6
Sildenafil Powder,	35	4.6	4.6
Digoxin	70	4.6	4.6
Valsartan	101	4.6	4.6
Tadalafil	95	4.5	4.5
Enalapril	53	4.5	4.5
Carboxymethylcellulose Sodium	9	4.5	4.5
Candesartan	34	4.5	4.5
Furosemide	360	4.5	4.5
Standardized Senna Concentrate	12	4.5	4.5
Cetiirizine	40	4.4	4.4
Propranolol Hydrochloride	67	4.4	4.4
Sildenafil Citrate	116	4.3	4.3
Aripiprazole Oral	38	4.3	4.3
Aripiprazole Orally Disintegrating	38	4.3	4.3
Moxifloxacin	13	4.3	4.3
Rabeprazole Sodium	25	4.3	4.3
Calcium	132	4.2	4.2
Tramadol Hydrochloride	34	4.2	4.2
Carvedilol	120	4.2	4.2
Sotalol Hydrochloride	15	4.2	4.2
Labetalol	12	4.2	4.2
Terazosin Hydrochloride	8	4.2	4.2
Epinephrine	58	4.2	4.2
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	139	4.1	4.2
Quinapril Hydrochloride	7	4.1	4.1
Acetaminophen	371	4.1	4.1
Dalteparin Sodium	9	4.0	4.0
Metoprolol	208	4.0	4.0
Iohexol	7	3.9	3.9
Moxifloxacin Hydrochloride	17	3.9	3.9
Candesartan Cilexetil	22	3.9	3.9
Atorvastatin Calcium, Film Coated	58	3.9	3.9
Infliximab-Dyyb	24	3.8	3.8
Metoprolol Tartrate	217	3.8	3.8
Daspone	8	3.8	3.8
Dapsone Gel, 5%	8	3.8	3.8
Clindamycin	23	3.8	3.8
Valsartan And Hydrochlorothiazide	11	3.8	3.8
Atenolol	106	3.8	3.8
Nitroglycerin	43	3.8	3.8
Metformin Hydrochloride	46	3.7	3.7
Ferrous Sulfate	39	3.6	3.6
Sodium Chloride	61	3.6	3.6
Clopidogrel Bisulfate	78	3.6	3.6
Magnesium Sulfate Heptahydrate	10	3.6	3.6
Magnesium Sulfate	10	3.6	3.6
Dapsone	8	3.5	3.5
Tapentadol Hydrochloride	25	3.5	3.5
Trastuzumab	51	3.5	3.5
Quetiapine Fumarate	22	3.5	3.5
Amlodipine	193	3.4	3.4
Aspirin 325 Mg	353	3.4	3.4
Aspirin 81 Mg	353	3.4	3.4
Potassium Chloride	82	3.4	3.4
Misoprostol	7	3.4	3.4
Midazolam	18	3.3	3.3
Famotidine	82	3.3	3.3
Magnesium Sulfate In Water For	9	3.3	3.3
Insulin	39	3.3	3.3
Aspirin	357	3.3	3.3
Sodium Chloride Tablet	51	3.3	3.3
Sodium Chloride Tablets	51	3.3	3.3
Ambrisentan	86	3.3	3.3
Fentanyl	68	3.3	3.3
Metoprolol Tartrate Injection	129	3.2	3.2
Pitavastatin Calcium	7	3.2	3.2
Bosentan	34	3.2	3.2
Empagliflozin	45	3.1	3.1
Nintedanib	21	3.1	3.1
Hydroxychloroquine Sulfate	60	3.1	3.1
Norepinephrine	7	3.1	3.1
Metoprolol Succinate Er Tablets	40	3.0	3.0
Human Insulin	8	3.0	3.0
Loratadine Tablet	34	3.0	3.0
Hydromorphone Hydrochloride	58	3.0	3.0
Guanfacine	5	3.0	3.0
Bupropion	28	2.9	2.9
Derma Foam Excel Hand Sanitizer	5	2.9	2.9
Loperamide Hydrochloride And Dimethicone	20	2.9	2.9
Paclitaxel (Aibumin-Bound)	51	2.9	2.9
Ethanol	5	2.9	2.9
Lansoprazole	109	2.9	2.9
Fondaparinux Sodium	5	2.9	2.9
Isoniazid	10	2.9	2.9
Fentanyl Citrate	11	2.9	2.9
Oxybutynin	18	2.9	2.9
Doxazosin Mesylate	22	2.9	2.9
Hydroxyzine Hydrochloride	8	2.8	2.8
Hydroxyzine Hydrochloride Oral	8	2.8	2.8
Metoclopramide	33	2.8	2.8
Canagliflozin	18	2.8	2.8
Alteplase	9	2.8	2.8
Lovastatin	15	2.7	2.7
Omalizumab	49	2.7	2.7
Ranolazine	6	2.7	2.7
Granisetron Hydrochloride	6	2.7	2.7
Sitagliptin	41	2.7	2.7
Paclitaxel	55	2.6	2.6
Dapagliflozin	16	2.4	2.4
Fosaprepitant Dimeglumine	7	2.4	2.4
Apixaban	33	2.3	2.3
Budesonide, Glycopyrrolate, And Formoterol Fumarate	5	2.2	2.2
Granisetron	5	2.2	2.2
Icosapent Ethyl	4	2.2	2.2
Remdesivir	6	2.1	2.1
Cetuximab	14	2.1	2.1
Rivaroxaban	92	2.1	2.1
Agalsidase Beta	4	2.0	2.0
Capecitabine	39	2.0	2.0
Brexpiprazole	7	2.0	2.0
Levodopa	5	1.9	1.9
Carboplatin	51	1.9	1.9
Cisplatin	31	1.9	1.9
Morphine Sulfate	46	1.8	1.8
Dofetilide	4	1.8	1.8
Ticagrelor	12	1.8	1.8
Tafamidis	4	1.6	1.6
Clozapine	42	1.6	1.6
Alcohol	13	1.6	1.6
Obinutuzumab	5	1.4	1.4
Pazopanib Hydrochloride	8	1.4	1.4
Ethyl Alcohol	8	1.4	1.4
Lenvatinib	9	1.3	1.3
Buprenorphine	22	1.1	1.1
Abaloparatide	5	0.8	0.8
Nirmatrelvir And Ritonavir	9	0.8	0.8
Pirfenidone	6	0.7	0.7
Erenumab-Aooe	8	0.7	0.7
Tirzepatide	23	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.