Reaction

Diastolic Dysfunction reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,062 reports · 243 co-occurring drugs

As of the last recalculation, Diastolic Dysfunction appears in 3,062 FAERS reports alongside 243 co-occurring drug terms. The strongest observed disproportionality signal is THEOPHYLLINE ANHYDROUS (PRR 53.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Theophylline Anhydrous	94	53.1	53.5
Theophylline	85	51.7	52.1
Tamsulosin Hydrochloride	81	27.7	27.8
Psyllium Husk	37	25.8	25.9
Fluticasone Furoate And Vilanterol Trifenatate	128	25.2	25.3
Quinine	30	24.0	24.1
Docusate Sodium - Sennosides	88	19.1	19.1
Torsemide	85	17.9	18.0
Nystatin Ointment	67	17.7	17.8
Risedronate Sodium	79	17.7	17.8
Nystatin Cream	67	17.7	17.7
Nystatin	68	17.3	17.3
Telmisartan	42	16.2	16.2
Bisoprolol Fumarate	285	15.6	15.7
Esomeprazole Magnesium Capsule, Delayed Release	32	15.1	15.2
Esomeprazole Magnesium Delayed Release Capsules	32	15.1	15.2
Esomeprazole Magnesium Dihydrate	32	15.1	15.1
Doxepin Hydrochloride	25	13.6	13.6
Finasteride	112	13.1	13.1
Doxepin	19	12.8	12.8
Nitroglycerin	97	12.7	12.7
Olmesartan Medoxomil	64	12.3	12.4
Indapamide	32	12.3	12.3
Docusate Sodium	100	12.1	12.2
Captopril	17	12.1	12.1
Candesartan	62	12.0	12.1
Linagliptin	31	11.7	11.7
Amiodarone Hydrochloride	19	11.6	11.6
Atropine	14	11.5	11.6
Eplerenone	21	11.2	11.2
Tafamidis	19	11.0	11.0
Alendronate Sodium	156	11.0	11.0
Metolazone	18	10.9	11.0
Clarithromycin	54	10.9	10.9
Carvedilol	202	10.8	10.8
Apixaban	103	10.8	10.8
Pantoprazole	359	10.8	10.8
Digoxin	110	10.8	10.8
Montelukast	124	10.4	10.4
Albuterol	174	10.4	10.4
Atropine Sulfate	16	10.1	10.1
Fluconazole	101	10.1	10.1
Esomeprazole	88	9.9	9.9
Standardized Senna Concentrate	18	9.8	9.8
Sodium Bicarbonate	33	9.7	9.8
Sodium Bicarbonate Injection,	33	9.7	9.8
Furosemide	491	9.7	9.7
Montelukast Sodium	164	9.6	9.6
Fluticasone Propionate Nasal	41	9.3	9.3
Valsartan Oral	72	9.2	9.2
Tolterodine Tartrate	12	9.1	9.1
Glyburide	32	9.1	9.1
Sevelamer Carbonate	15	8.9	8.9
Zinc	32	8.9	8.9
Estradiol Gel 0.1%	58	8.9	8.9
Estradiol Transdermal	58	8.9	8.9
Amlodipine Besylate And Benazepril Hydrochloride	12	8.9	8.9
Enalapril Maleate	32	8.9	8.9
Zinc Chloride	32	8.8	8.9
Ramipril	151	8.7	8.7
Zinc Gluconate	33	8.7	8.7
Valsartan	125	8.4	8.4
Aspirin 325 Mg	532	8.3	8.4
Aspirin 81 Mg	532	8.3	8.3
Bumetanide	32	8.3	8.3
Dapagliflozin	38	8.3	8.3
Aspirin	550	8.3	8.3
Spironolactone	161	8.2	8.2
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	59	8.2	8.2
Allopurinol	178	8.2	8.2
Basiliximab	14	8.1	8.1
Magnesium Hydroxide	16	8.1	8.1
Pantoprazole Sodium In 0.9% Sodium Chloride	72	8.1	8.1
Pantoprazole Sodium Injection	72	8.1	8.1
Methoxy Polyethylene Glycol-Epoetin Beta	13	8.0	8.0
Acetylcysteine	11	8.0	8.0
Tiotropium Bromide	152	7.9	7.9
0Xygen	56	7.9	7.9
Oxygen	56	7.9	7.9
Ipratropium Bromide	40	7.7	7.7
Isosorbide Dinitrate	22	7.7	7.7
Chlorthalidone	13	7.6	7.6
Candesartan Cilexetil	29	7.6	7.6
Valsartan And Hydrochlorothiazide	15	7.5	7.5
Ticagrelor	35	7.5	7.5
Carfilzomib	31	7.5	7.5
Trastuzumab	74	7.5	7.5
Metoprolol Succinate Er Tablets	67	7.4	7.4
Cephalexin	23	7.3	7.3
Potassium Chloride	117	7.2	7.2
Labetalol	14	7.2	7.2
Antacid	49	7.1	7.1
Methimazole	8	6.9	6.9
Umeclidinium	9	6.8	6.9
Metoprolol Succinate	85	6.8	6.8
Gemfibrozil	15	6.7	6.8
Doxorubicin Hydrochloride	32	6.7	6.7
Potassium Chloride, Dextrose Monohydrate	89	6.7	6.7
Potassium Chloride Oral	89	6.7	6.7
Potassium Chloride Extended-Release	89	6.7	6.7
Meperidine Hydrochloride	9	6.7	6.7
Enoxaparin Sodium	55	6.6	6.6
Isosorbide Mononitrate	20	6.6	6.6
Sirolimus	13	6.6	6.6
Doxorubicin	84	6.6	6.6
Insulin	53	6.6	6.6
Magnesium Sulfate In Water For	12	6.4	6.4
Hydrocortisone Acetate	67	6.4	6.4
Cimetidine	9	6.4	6.4
Diltiazem Hydrochloride	32	6.3	6.3
Epoetin Alfa	11	6.3	6.3
Hydrochlorothiazide	130	6.3	6.3
Magnesium Sulfate Heptahydrate	12	6.3	6.3
Magnesium Sulfate	12	6.3	6.3
Amlodipine	232	6.2	6.3
Tobramycin Solution	11	6.2	6.2
Clopidogrel Bisulfate	91	6.2	6.2
Sotalol Hydrochloride	15	6.2	6.2
Thiamine Hydrochloride	11	6.0	6.0
Albuterol Sulfate	245	6.0	6.0
Amlodipine Besylate	125	6.0	6.0
Mometasone Furoate	36	5.9	5.9
Fondaparinux Sodium	7	5.9	5.9
Losartan Potassium And Hydrochlorothiazide	10	5.9	5.9
Doxazosin	24	5.9	5.9
Pantoprazole Sodium	123	5.8	5.8
Carboxymethylcellulose Sodium	8	5.8	5.8
Rosuvastatin	166	5.8	5.8
Glipizide	51	5.8	5.8
Mesna Injection	7	5.8	5.8
Sucralfate	20	5.7	5.7
Doxazosin Mesylate	30	5.7	5.7
Metoprolol Tartrate	215	5.7	5.7
Mesna	7	5.7	5.7
Fluticasone Propionate	105	5.7	5.7
Ado-Trastuzumab Emtansine	7	5.7	5.7
Warfarin Sodium	38	5.6	5.6
Estradiol	70	5.6	5.6
Clopidogrel	156	5.6	5.6
Posaconazole Delayed-Release	9	5.6	5.6
Nebivolol	13	5.6	5.6
Nifedipine	38	5.5	5.5
Tobramycin Sulfate	10	5.5	5.5
Meclizine Hcl 12.5Mg	11	5.5	5.5
Meclizine Hcl 25Mg	11	5.5	5.5
Meclizine Hcl 12.5 Mg	11	5.5	5.5
Meclizine Hcl 25 Mg	11	5.5	5.5
Sacubitril And Valsartan	91	5.5	5.5
Meclizine	13	5.4	5.4
Fenofibrate	28	5.4	5.4
Dronedarone	8	5.3	5.3
Nilotinib	23	5.3	5.3
Metoprolol Tartrate Injection	143	5.3	5.3
Simvastatin	186	5.3	5.3
Pertuzumab	21	5.3	5.3
Pioglitazone	33	5.2	5.2
Metoprolol	186	5.2	5.2
Fulvestrant	25	5.2	5.2
Prochlorperazine Maleate	7	5.2	5.2
Cyclophosphamide Injection, Solution	130	5.2	5.2
Cyclophosphamide	130	5.2	5.2
Cyclophosphamide For Injection	130	5.2	5.2
Agalsidase Beta	7	5.2	5.2
Norepinephrine	8	5.1	5.1
Dronabinol	6	5.1	5.1
Atovaquone	6	5.1	5.1
Carisoprodol	14	5.0	5.0
Testosterone	17	5.0	5.0
Amlodipine Besylate And Valsartan	8	4.9	4.9
Meclizine Hydrochloride	14	4.9	4.9
Propofol	26	4.9	4.9
Lovastatin	18	4.8	4.8
Esomeprazole Magnesium	157	4.8	4.8
Ketoconazole	12	4.7	4.7
Niacin	8	4.7	4.7
Epoprostenol	9	4.7	4.7
Nebivolol Hydrochloride	23	4.7	4.7
Erythropoietin	14	4.6	4.6
Etonogestrel And Ethinyl Estradiol	15	4.6	4.6
Ketoconazole Foam	10	4.6	4.6
Ketoconazole Cream, 2%	10	4.6	4.6
Atorvastatin Calcium	160	4.6	4.6
Ranolazine	7	4.6	4.6
Ursosiol	13	4.6	4.6
Azelastine	12	4.6	4.6
Carboplatin	82	4.5	4.5
Metoroprolol Tartrate	43	4.5	4.5
Bicalutamide	10	4.5	4.5
Letrozole	40	4.5	4.5
Ursodiol	14	4.4	4.4
Mometasone Furoate And Formoterol Fumarate Dihydrate	10	4.4	4.4
Warfarin	80	4.4	4.4
Human Insulin	8	4.4	4.4
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	13	4.3	4.3
Naproxen Sodium, Pseudoephedrine Hydrochloride	13	4.3	4.3
Empagliflozin	42	4.3	4.3
Imatinib	11	4.3	4.3
Sildenafil Powder,	22	4.2	4.2
Posaconazole	10	4.2	4.2
Clozapine	75	4.1	4.1
Lisinopril	178	4.1	4.1
Ezetimibe	45	4.1	4.1
Valacyclovir Hydrochloride	42	4.1	4.1
Goserelin	8	4.1	4.1
Estrogens, Conjugated	35	4.0	4.0
Atorvastatin Calcium, Film Coated	41	4.0	4.0
Vincristine Sulfate	17	4.0	4.0
Cefepime	8	3.8	3.8
Norepinephrine Bitartrate	8	3.8	3.8
Conjugated Estrogens	32	3.8	3.8
Metformin Hcl	30	3.7	3.7
Darbepoetin Alfa	29	3.7	3.7
Sildenafil	31	3.7	3.7
Iron Sucrose	5	3.6	3.6
Pembrolizumab	54	3.5	3.5
Loratadine And Pseudoephedrine Sulfate	4	3.4	3.4
Tobramycin	12	3.4	3.4
Bortezomib	43	3.3	3.3
Paliperidone	11	3.2	3.2
Thalidomide	17	3.2	3.2
Rivaroxaban	94	3.1	3.1
Miconazole Nitrate	4	3.1	3.1
Paclitaxel (Aibumin-Bound)	37	3.1	3.1
Lapatinib	7	3.1	3.1
Macitentan	31	3.1	3.1
Tiotropium Bromide Inhalation Spray	5	3.0	3.0
Ranitidine Hydrochloride	23	2.9	2.9
Bosentan	21	2.8	2.8
Riociguat	13	2.7	2.7
Paclitaxel	39	2.7	2.7
Crizotinib	5	2.7	2.7
Nintedanib	12	2.6	2.6
Vibegron	3	2.5	2.5
Cenobamate	3	2.4	2.4
Paricalcitol	5	2.4	2.4
Oxycodone Hydrochloride	74	2.3	2.3
Bosutinib	3	2.3	2.3
Ambrisentan	40	2.2	2.2
Brexpiprazole	5	2.0	2.0
Fam-Trastuzumab Deruxtecan-Nxki	3	2.0	2.0
Romosozumab-Aqqg	4	2.0	2.0
Hydrocodone Bitartrate	12	1.9	1.9
Minoxidil Foam 5% (Womens)	5	1.0	1.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.