Reaction

Infusion Site Reaction reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,869 reports · 235 co-occurring drugs

As of the last recalculation, Infusion Site Reaction appears in 2,869 FAERS reports alongside 235 co-occurring drug terms. The strongest observed disproportionality signal is CORTISONE ACETATE (PRR 158.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Cortisone Acetate	246	158.0	161.2
Botulinum Toxin Type A	224	141.9	144.5
Pseudoephedrine Hydrochloride	178	133.9	136.3
Pseudoephedrine Hcl	178	124.9	126.9
Diclofenac Potassium, Film Coated	135	122.1	124.1
Diclofenac Potassium Tablets	135	122.0	124.0
Acetaminophen And Codeine	181	115.0	116.7
Desoximetasone	261	109.2	110.7
Minocycline	152	99.8	101.1
Tretinoin	107	99.3	100.6
Diclofenac Potassium	135	95.1	96.3
Chlorhexidine Gluconate	97	79.7	80.5
Ketoprofen	117	67.4	68.0
Naproxen Sodium Tablet, Coated	102	56.6	57.1
Naproxen Sodium, Coated Tablets	102	56.6	57.1
Calcium Gluconate	91	56.5	57.0
Naproxen Sodium 220Mg	102	56.5	57.0
Tofacitinib Citrate	98	56.1	56.5
Candesartan	247	54.9	55.2
Adalimumab-Fkjp	303	52.9	53.3
Adalimumab-Adaz	337	52.4	52.7
Adalimumab-Aaty	303	51.8	52.1
Mirabegron	238	48.6	48.9
Treprostinil	637	47.1	47.3
Human Immunoglobulin G	124	45.5	45.8
Sarilumab	153	44.3	44.6
Amitriptyline Hydrochloride	101	43.3	43.5
Cetirizine Hydrochloride Allergy	154	38.9	39.1
Cetirizine Hydrochloride Tablets	154	38.9	39.1
Atomoxetine Hydrochloride	122	38.8	39.0
Cyclobenzaprine	228	35.9	36.1
Erenumab-Aooe	246	35.3	35.5
Diclofenac Sodium 1%	164	35.3	35.4
Diclofenac Sodium Topical	164	35.3	35.4
Diclofenac Sodium Topical Gel, 1%	164	35.2	35.4
Sulfasalazine	329	34.3	34.5
Mepolizumab	211	33.2	33.3
Cetiirizine	180	32.8	33.0
Diphenhydramine Hydrochloride Capsule, Liquid Filled	89	31.2	31.3
Cetirizine	293	30.4	30.5
Leflunomide	380	30.2	30.3
Tramadol Hydrochloride	147	29.8	29.9
Bendamustine Hydrochloride	48	29.6	29.7
Magnesium Hydroxide	53	29.0	29.2
Tocilizumab	390	28.5	28.6
Naproxen	264	26.8	26.8
Fluticasone Propionate Nasal	106	26.3	26.4
Diclofenac	279	25.9	26.0
Triamcinolone Acetonide Ointment Usp, 0.05%	81	25.8	25.9
Lidocaine Hydrochloride	193	24.8	24.9
0Xygen	156	24.2	24.3
Oxygen	156	24.2	24.3
Quetiapine Fumarate	92	23.3	23.4
Alendronate Sodium	286	22.7	22.8
Sildenafil Powder,	107	22.6	22.7
Hydroxychloroquine	212	22.2	22.2
Abatacept	365	21.8	21.8
Lamotirigine	200	21.7	21.8
Lamotrigine Extended-Release	200	21.7	21.8
Lamotrigine Chewable Dispersible	200	21.7	21.8
Cyclobenzaprine Hydrochloride	26	21.2	21.2
Adrenalinum	116	21.1	21.1
Doxyclycline Hyclate	48	20.8	20.8
Hydrocortisone Sodium Succinate	26	20.2	20.3
Triamcinolone Acetonide	82	19.8	19.8
Buprenorphine	228	19.3	19.4
Methylprednisolone Sodium Succinate	117	19.0	19.1
Hydroxychloroquine Sulfate	215	18.4	18.5
Sildenafil	140	18.4	18.4
Pantoprazole Sodium In 0.9% Sodium Chloride	148	18.2	18.2
Pantoprazole Sodium Injection	148	18.2	18.2
Magnesium	193	18.2	18.2
Golimumab	199	18.0	18.1
Clonidine	121	17.8	17.9
Macitentan	161	17.8	17.9
Topiramate	209	17.5	17.5
Riociguat	75	17.1	17.1
Tadalafil	219	17.1	17.1
Sodium Chloride Tablet	164	17.1	17.1
Sodium Chloride Tablets	164	17.1	17.1
Certolizumab Pegol	253	17.1	17.1
Thiamine Hydrochloride	29	17.1	17.1
Cetirizine Hydrochloride	335	16.6	16.6
Naproxen Sodium	293	16.5	16.5
Vitamin C	195	16.4	16.5
Epinephrine	141	16.4	16.4
Celecoxib	269	16.3	16.3
Infliximab	419	16.1	16.2
Rituximab	405	16.0	16.0
Sodium Chloride	165	16.0	16.0
Lidocaine	123	15.9	16.0
Agalsidase Beta	20	15.8	15.8
Diclofenac Sodium	293	15.6	15.6
Secukinumab	300	14.9	15.0
Buspirone Hydrochloride	22	14.6	14.6
Diphenhydramine	116	13.8	13.9
Lamotrigine	231	13.7	13.8
Fluticasone Propionate	227	13.7	13.7
Lidicaine	89	13.6	13.6
Burn Relief	89	13.6	13.6
Lidocaine Hydrochloride And Epinephrine	89	13.6	13.6
Lidocaine, Menthol	90	13.6	13.6
Diltiazem Hydrochloride Extended-Release Tablets	21	13.5	13.5
Methylprednisolone	236	13.4	13.4
Azathioprine	153	13.3	13.3
Apremilast	243	13.1	13.1
Ambrisentan	208	13.0	13.0
Risedronate Sodium	54	12.8	12.8
Cyanocobalamin	57	12.8	12.8
Ramipril	204	12.8	12.8
Lidocaine Hydrochloride And Epinephrine Bitartrate	89	12.5	12.5
Lidocaine 4%	90	12.3	12.4
Sildenafil Citrate	200	12.2	12.2
Selexipag	41	11.7	11.7
Acetaminophen Tablet Extended Release	360	11.6	11.6
Pain Reliever	360	11.6	11.6
Acetaminophen 500Mg	360	11.6	11.6
Fosaprepitant Dimeglumine	21	11.2	11.2
Icosapent Ethyl	13	11.1	11.1
Tofacitinib	257	11.0	11.0
Hydrocortisone	128	10.8	10.9
Fluticasone Furoate	18	10.8	10.9
Oxycodone	255	10.8	10.8
Ustekinumab	144	10.7	10.7
Hydrocortisone Acetate	100	10.3	10.3
Antacid	66	10.3	10.3
Diphenhydramine Hydrochloride	219	10.3	10.3
Pantoprazole	322	10.3	10.3
Ranitidine Hydrochloride	75	10.3	10.3
Folic Acid	310	10.0	10.0
Metolazone	15	9.7	9.7
Cetirizine Hcl	12	9.5	9.5
Pantoprazole Sodium	180	9.3	9.3
Anti-Itch	81	9.0	9.0
Anti-Pruritic	81	9.0	9.0
Antipruritic (Anti-Itch)	81	9.0	9.0
Cool Relief Gel With Aloe	81	9.0	9.0
Drs. Hydrocortisone	81	9.0	9.0
Hydrocortisone Continuous Spray	81	9.0	9.0
Hydrocortisone Spray	81	9.0	9.0
Anti-Itch Cream	81	9.0	9.0
Hydrocortisone Lotion	81	9.0	9.0
Hydrocortisone Cream 1%	81	9.0	9.0
Hydrocortisone Cream 1/2%	81	9.0	9.0
Hydrocortisone 1%	81	9.0	9.0
Hydrocortisone Cream	81	8.9	9.0
Butalbital, Acetaminophen, And Caffeine	13	8.9	8.9
Bumetanide	32	8.9	8.9
Hydroxyzine Hydrochloride	16	8.9	8.9
Hydroxyzine Hydrochloride Oral	16	8.9	8.9
Calcium Carbonate	78	8.6	8.6
Acetaminophen	455	8.6	8.6
Oxycodone And Acetaminophen Tablets	14	8.6	8.6
Ascorbic Acid	27	8.5	8.5
Aprepitant	21	8.3	8.3
Potassium Chloride, Dextrose Monohydrate	102	8.2	8.3
Potassium Chloride Oral	102	8.2	8.3
Potassium Chloride Extended-Release	102	8.2	8.3
Levodopa	13	7.8	7.8
Ergocalciferol	364	7.7	7.7
Hydromorphone Hydrochloride	94	7.6	7.6
Torsemide	34	7.5	7.5
Candesartan Cilexetil	27	7.5	7.5
Doxycycline Hyclate	68	7.5	7.5
Bosentan	51	7.5	7.5
Potassium Chloride	113	7.5	7.5
Doxycycline	68	7.4	7.4
Methylprednisolone Acetate	8	7.3	7.3
Metformin Hydrochloride	58	7.2	7.2
Epoprostenol	13	7.2	7.2
Rasagiline Mesylate	11	7.2	7.2
Isopropyl Alcohol	33	7.2	7.2
Methocarbamol Tablets	16	7.0	7.0
Methotrexate	360	7.0	7.0
Metformin Hydrochloride Tablets	54	6.9	6.9
Metformin Hydrochloride Extended-Release Tablets	54	6.9	6.9
Metformin Hydrochloride Tablet	54	6.9	6.9
Methotrexate Sodium	402	6.8	6.8
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	19	6.7	6.7
Naproxen Sodium, Pseudoephedrine Hydrochloride	19	6.7	6.7
Pramipexole	14	6.7	6.7
Ropinirole	14	6.6	6.7
Anakinra	15	6.6	6.6
Trazodone Hydrochloride	14	6.5	6.5
Amiodarone Hydrochloride	10	6.5	6.5
Erythromycin	16	6.2	6.2
Amantadine	13	6.1	6.1
Iron Sucrose	8	6.1	6.1
Meloxicam	48	6.1	6.1
Tizanidine Hydrochloride	15	6.0	6.1
Zinc	20	5.9	5.9
Zinc Chloride	20	5.9	5.9
Zinc Gluconate	21	5.9	5.9
Alcohol	31	5.8	5.9
Methocarbamol	18	5.8	5.8
Levocetirizine Dihydrochloride	19	5.8	5.8
Spironolactone	107	5.7	5.7
Fish Oil	69	5.6	5.7
Methimazole	6	5.6	5.6
Guaifenesin	23	5.5	5.5
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	114	5.3	5.3
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	22	5.3	5.3
Azelastine	13	5.3	5.3
Melatonin	39	5.3	5.3
Loratadine Oral	35	5.2	5.2
Famotidine	80	5.1	5.1
Rotigotine	10	5.0	5.0
Mupirocin	9	4.9	4.9
Tobramycin Solution	8	4.8	4.8
Fexofenadine Hcl	6	4.7	4.7
Tobramycin Sulfate	8	4.7	4.7
Guanfacine	5	4.6	4.6
Ondansetron Hydrochloride	76	4.6	4.6
Atorvastatin Calcium, Film Coated	42	4.4	4.4
Oxycodone And Acetaminophen	14	4.4	4.4
Remdesivir	8	4.4	4.4
Fexofenadine Hydrochloride	13	4.4	4.4
Carbidopa And Levodopa	28	4.3	4.3
Adalimumab	361	4.1	4.1
Ranitidine	107	4.0	4.0
Cetuximab	17	4.0	4.0
Tiotropium Bromide Inhalation Spray	6	3.9	3.9
Rimegepant Sulfate	6	3.4	3.4
Natalizumab	79	3.2	3.2
Etanercept	244	3.1	3.1
Dofetilide	4	2.8	2.8
Ravulizumab	5	2.7	2.7
Oxycodone Hydrochloride	77	2.6	2.6
Carfilzomib	10	2.6	2.6
Travoprost	3	2.5	2.5
Cariprazine	3	2.3	2.3
Onabotulinumtoxina	18	1.7	1.7
Lifitegrast	3	1.3	1.3
Salicylic Acid	9	1.2	1.2
Droxidopa	3	1.0	1.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.