Reaction

Hyperkeratosis reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,462 reports · 243 co-occurring drugs

As of the last recalculation, Hyperkeratosis appears in 5,462 FAERS reports alongside 243 co-occurring drug terms. The strongest observed disproportionality signal is VEMURAFENIB (PRR 63.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Vemurafenib	192	63.1	64.1
Regorafenib	149	50.3	50.9
Sorafenib	246	47.2	47.8
Cabozantinib	464	40.1	40.5
Sunitinib Malate	238	24.1	24.2
Dabrafenib	85	15.6	15.7
Axitinib	76	15.1	15.1
Chlorhexidine Gluconate	24	10.0	10.1
Epoetin Alfa	26	8.4	8.4
Rosuvastatin Calcium	61	8.3	8.4
Losartan Potassium And Hydrochlorothiazide	25	8.2	8.3
Chlorthalidone	23	7.6	7.6
Terbinafine Hydrochloride	17	7.3	7.3
Lenvatinib	61	7.2	7.2
Trametinib	45	7.1	7.2
Clobetasol Propionate Ointment Usp, 0.05%	19	7.1	7.1
Clobetasol Propionate	19	7.0	7.0
Encorafenib	18	6.9	7.0
Ketoconazole Foam	24	6.2	6.2
Ketoconazole Cream, 2%	24	6.2	6.2
Alendronate Sodium	157	6.1	6.1
Diphenhydramine Hydrochloride Capsule, Liquid Filled	33	5.9	5.9
Human Insulin	19	5.8	5.8
Prochlorperazine Maleate	14	5.8	5.8
Risedronate Sodium	46	5.7	5.7
Terazosin Hydrochloride	13	5.6	5.6
Ketoconazole	25	5.5	5.5
Dicyclomine Hydrochloride	20	5.4	5.4
Pazopanib Hydrochloride	37	5.2	5.2
Triamcinolone Acetonide Ointment Usp, 0.05%	32	5.2	5.2
Nitroglycerin	72	5.2	5.2
Vitamin E	41	5.0	5.0
Sucralfate	31	5.0	5.0
Liothyronine Sodium	11	4.8	4.8
Captopril	12	4.8	4.8
Fexofenadine Hcl	11	4.5	4.5
Leflunomide	119	4.4	4.4
Nystatin	31	4.3	4.3
Triamcinolone Acetonide	35	4.3	4.3
Nifedipine	53	4.3	4.3
Biotin	35	4.3	4.3
Gemfibrozil	17	4.3	4.3
Calcium	163	4.3	4.3
Docusate Sodium - Sennosides	36	4.3	4.3
Psyllium Husk	11	4.2	4.3
Nystatin Ointment	29	4.2	4.2
Nystatin Cream	29	4.2	4.2
Amoxicillin And Clavulanate Potassium	30	4.2	4.2
Diphenoxylate Hydrochloride And Atropine Sulfate	15	4.2	4.2
Amlodipine Besylate And Benazepril Hydrochloride	10	4.1	4.1
Hydrochlorothiazide	152	4.1	4.1
Prochlorperazine	29	4.0	4.0
Hydroxychloroquine	77	4.0	4.0
Tocilizumab	117	4.0	4.0
Mupirocin	14	4.0	4.0
Nivolumab	99	4.0	4.0
Insulin Human	41	4.0	4.0
Loperamide Hydrochloride And Dimethicone	33	3.9	3.9
Glimepiride	40	3.9	3.9
Candesartan Cilexetil	27	3.9	3.9
Metoroprolol Tartrate	67	3.9	3.9
Mupirocin Calcium	14	3.9	3.9
Timolol	12	3.8	3.8
Tretinoin	8	3.8	3.8
Azithromycin	39	3.7	3.7
Methocarbamol Tablets	16	3.6	3.7
Rabeprazole Sodium	26	3.6	3.6
Brimonidine Tartrate	17	3.6	3.6
Meclizine Hcl 12.5Mg	13	3.6	3.6
Meclizine Hcl 25Mg	13	3.6	3.6
Meclizine Hcl 12.5 Mg	13	3.6	3.6
Meclizine Hcl 25 Mg	13	3.6	3.6
Azithromycin Monohydrate	39	3.6	3.6
Timolol Maleate	9	3.5	3.5
Docusate Sodium	52	3.5	3.5
Clotrimazole	11	3.4	3.4
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	27	3.4	3.4
Tolterodine Tartrate	8	3.4	3.4
Raloxifene Hydrochloride	13	3.4	3.4
Doxepin	9	3.4	3.4
Dorzolamide Hydrochloride And Timolol Maleate	7	3.4	3.4
Lidocaine Hydrochloride And Epinephrine Bitartrate	47	3.4	3.4
Tamsulosin Hydrochloride	18	3.4	3.4
Meloxicam	51	3.4	3.4
Cetirizine Hcl	8	3.3	3.3
Lidocaine, Menthol	43	3.3	3.3
Glyburide	21	3.3	3.3
Losartan Potassium	68	3.3	3.3
Lidocaine Hydrochloride	52	3.3	3.3
Amlodipine Besylate	125	3.3	3.3
Drs. Clotrimazole	10	3.3	3.3
Family Wellness Clotrimazole	10	3.3	3.3
Clotrimazole Topical	10	3.3	3.3
Imatinib Mesylate	24	3.3	3.3
Lidicaine	42	3.3	3.3
Burn Relief	42	3.3	3.3
Lidocaine Hydrochloride And Epinephrine	42	3.3	3.3
Glipizide	52	3.3	3.3
Magnesium	70	3.3	3.3
Meclizine	14	3.3	3.3
Azithromycin Dihydrate	50	3.3	3.3
Folic Acid	208	3.3	3.3
Loperamide Hydrochloride	38	3.3	3.3
Hydroxychloroquine Sulfate	77	3.3	3.3
Benzonatate	14	3.2	3.2
Sucralfate Oral	12	3.2	3.2
Sucralfate Oral Suspension	12	3.2	3.2
Polyethylene Glycol	9	3.2	3.2
Methotrexate	334	3.2	3.2
Losartan	142	3.2	3.2
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	128	3.1	3.1
Clindamycin	23	3.1	3.1
Clindamycin Phosphate	27	3.1	3.1
Irbesartan	36	3.1	3.1
Enalapril Maleate	20	3.1	3.1
Hydroxyurea	17	3.1	3.1
Imatinib	14	3.0	3.0
Methocarbamol	18	3.0	3.0
Doxepin Hydrochloride	10	3.0	3.0
Fenofibrate	28	3.0	3.0
Insulin Glulisine	8	3.0	3.0
Methotrexate Sodium	364	3.0	3.0
Lisinopril And Hydrochlorothiazide	8	3.0	3.0
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	39	3.0	3.0
Insulin	43	3.0	3.0
Lidocaine 4%	42	3.0	3.0
Mometasone Furoate	32	2.9	2.9
Insulin Degludec	18	2.9	2.9
Meclizine Hydrochloride	15	2.9	2.9
Panitumumab	12	2.9	2.9
Amlodipine	201	2.9	2.9
Valsartan Oral	41	2.9	2.9
Ergocalciferol	282	2.9	2.9
Iron	50	2.9	2.9
Amoxicillin	57	2.9	2.9
Trifluridine And Tipiracil	8	2.8	2.8
Lisinopril	222	2.8	2.8
Atenolol	98	2.8	2.8
Fondaparinux Sodium	6	2.8	2.8
Ferrous Sulfate	37	2.8	2.8
Famotidine	85	2.8	2.8
Guaifenesin	22	2.8	2.8
Ropinirole	11	2.7	2.7
Sennosides 8.6 Mg Tablets	15	2.7	2.7
Everolimus Tablets	12	2.7	2.7
Metoprolol Tartrate	191	2.7	2.7
Fish Oil	64	2.7	2.7
Senna	15	2.7	2.7
Valsartan	74	2.7	2.7
Paricalcitol	10	2.7	2.7
Cyclosporine	78	2.7	2.7
Metoprolol	176	2.7	2.7
Ziprasidone Mesylate	10	2.7	2.7
Gabapentin	246	2.6	2.6
Calcitriol	14	2.6	2.6
Insulin Aspart	45	2.6	2.6
Multivitamin	34	2.6	2.6
Oxycodone And Acetaminophen Tablets	8	2.6	2.6
Capecitabine	61	2.6	2.6
Granisetron Hydrochloride	7	2.6	2.6
Enalapril	37	2.5	2.5
Estradiol	57	2.5	2.5
Metoprolol Succinate	57	2.5	2.5
Linagliptin	12	2.5	2.5
Ezetimibe And Simvastatin	10	2.5	2.5
Fexofenadine Hydrochloride	14	2.5	2.5
Metoprolol Succinate Er Tablets	40	2.5	2.5
Insulin Glargine-Yfgn	14	2.4	2.4
Doxazosin Mesylate	23	2.4	2.4
Lisinopril And Hydrochlorothiazide Tablets	5	2.4	2.4
Adalimumab	429	2.4	2.4
Simvastatin	156	2.4	2.4
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	13	2.4	2.4
Naproxen Sodium, Pseudoephedrine Hydrochloride	13	2.4	2.4
Desoximetasone	12	2.4	2.4
Secukinumab	100	2.4	2.4
Lovastatin	16	2.4	2.4
Oxycodone Hydrochloride And Acetaminophen	61	2.4	2.4
Dutasteride	5	2.3	2.3
Doxazosin	17	2.3	2.3
Metoprolol Tartrate Injection	114	2.3	2.3
Pravastatin Sodium	12	2.3	2.3
Mesna Injection	5	2.3	2.3
Sitagliptin And Metformin Hydrochloride	13	2.3	2.3
Ezetimibe	45	2.3	2.3
Mesna	5	2.3	2.3
Atorvastatin Calcium, Film Coated	41	2.2	2.2
Niraparib	13	2.2	2.2
Erythropoietin	12	2.2	2.2
Metformin Er 500 Mg	171	2.2	2.2
Metformin Er 750 Mg	171	2.2	2.2
Latanoprost	29	2.2	2.2
Risankizumab-Rzaa	47	2.2	2.2
Oseltamivir Phosphate	14	2.2	2.2
Miconazole Nitrate	5	2.2	2.2
Canagliflozin	17	2.2	2.2
Ziprasidone	10	2.2	2.2
Loratadine Tablet	30	2.1	2.1
Testosterone Cypionate	5	2.1	2.1
Bosutinib	5	2.1	2.1
Pioglitazone	24	2.1	2.1
Everolimus	28	2.1	2.1
Thalidomide	20	2.1	2.1
Nilotinib	16	2.1	2.1
Insulin Glargine	132	2.1	2.1
Etanercept	304	2.0	2.0
Insulin Lispro	71	2.0	2.0
Ibrutinib	41	1.9	1.9
Loratadine And Pseudoephedrine Sulfate	4	1.9	1.9
Avapritinib	6	1.9	1.9
Pembrolizumab	51	1.9	1.9
Bimatoprost	14	1.9	1.9
Darbepoetin Alfa	25	1.8	1.8
Travoprost	4	1.8	1.8
Fesoterodine Fumarate	5	1.8	1.8
Fluticasone Propionate And Salmeterol	19	1.7	1.7
Lapatinib	7	1.7	1.7
Isotretinoin	22	1.7	1.7
Medroxyprogesterone Acetate	21	1.6	1.6
Interferon Beta-1B	8	1.6	1.6
Crisaborole	4	1.6	1.6
Erlotinib	4	1.6	1.6
Paclitaxel (Aibumin-Bound)	32	1.5	1.5
Blinatumomab	4	1.5	1.5
Ixekizumab	14	1.4	1.4
Bimekizumab	8	1.4	1.4
Abatacept	51	1.4	1.4
Teriparatide	40	1.4	1.4
Dasatinib	13	1.3	1.3
Ipilimumab	14	1.2	1.2
Cortisone Acetate	4	1.2	1.2
Ustekinumab	33	1.2	1.2
Conjugated Estrogens And Medroxyprogesterone Acetate	7	1.1	1.1
Exenatide	14	1.0	1.0
Dupilumab	121	1.0	1.0
Alirocumab	6	0.9	0.9
Osimertinib	7	0.8	0.8
Hydrocodone Bitartrate	8	0.7	0.7
Cinacalcet Hydrochloride	8	0.7	0.7
Salicylic Acid	9	0.6	0.6
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	5	0.6	0.6
Apremilast	22	0.6	0.6
Adapalene	12	0.2	0.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.